The 9th International Leptospirosis Society Meeting, Semarang 2015 SCIENTIFIC PROGRAM

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1 The 9th International Leptospirosis Society Meeting, Semarang 2015 SCIENTIFIC PROGRAM Time Wednesday, 7 October Poster Mounting REGISTRATION OPENING CEREMONY COFFEE BREAK SESSION 1 : Plenary lecture Chair: Muhammad Hussein Gasem Mohamad Subuh. Situation and Policy of Leptospirosis Control in Indonesia SESSION 2 : One Health. Ecology & Beyond Part 1. Chair/co-chair: Claudia Munoz-Zanzi / Rudy Hartskeerl Rudy Hartskeerl. The Global Leptospirosis Environmental Action Network (GLEAN): A One Health Approach against Leptospirosis Claudia Munoz-Zanzi. Epidemiology of Leptospirosis in Distinct Community Settings Federico Costa. Ecoepidemiology of leptospirosis: Patterns of pathogenic Leptospira shedding in Rattus norvegicus from a Brazilian urban slum community LUNCH BREAK Part 2. Chair / co-chair: Federico Costa / Katherine Prager Cord Heuer. Can vaccination of animals protect humans against leptospirosis? Pablo Tortosa. Exploration of pathogenic Leptospira in a biodiversity hotspot highlights endemic and introduced lineages of medical importance Yann Gomard. Pathogenic Leptospira sheltered by Malagasy bats display stringent host specificity Part 3. Chair/co-chair: Cord Heuer / Gustavo Monti Gustavo Monti. Modelling multiple host-leptospira transmission dynamics within dairy farms Kathryn Allan. Livestock, livelihoods and leptospirosis: insights from East Africa

2 Katherine Prager. Leptospira interrogans serovar Pomona in California sea lions an unlikely case study for examining pathogen dynamics in a reservoir) COFFEE BREAK Poster discussion and removal WELCOME PARTY Time Thursday, 8 October Poster Mounting SESSION 1 : Genomics & Molecular Approaches to Understanding Virulence Part 1. Chair/co-chair: Ben Adler / Mathieu Picardeau Mathieu Picardeau. Development of genetic tools for virulence analysis of Leptospira interrogan Manish Kumar. A Novel Cas2 Protein of CRISPR/Cas system in Leptospira interrogans displaying Dual Nuclease Activity Jie Yan. HslUV proteasome contributes to the survival of Leptospira interrogans in hosts and the transmission of leptospirosis Wei-Lin Hu. FhlA, a transcriptional activator of sigma factor RpoN, regulates nitrogen metabolism, cell morphology and virulence in L. Interrogans COFFEE BREAK Part 2. Chair / co-chair : Mathieu Picardeau / Ben Adler Julie Collins-Emerson. Whole genome sequence and rmlst analysis of New Zealand strains of Leptospira David A. Haake. High Throughput Parallel Sequencing for Determining Fitness of Leptospiral Transposon Mutants Vanina Varni. Whole-genome sequencing of Argentinean isolates of Leptospira: SNPs analysis for epidemiological purposes SESSION 2 : Epidemiology of Veterinary Leptospirosis Part 1. Chair/co-chair: Peter Wilson / Bibiana Brihuega Marvin Villanueva. Investigation of Leptospira infection and its circulation in one intensivetype water buffalo farm in the Philippines: its economic and zoonotic implications Yuni Yupiana. Epidemiological investigation of leptospiral infection in a non-vaccinated dairy cattle herd associated with three affected workers

3 Miguel Salgado. Is the hare (Lepus europaeus) a spillover host for pathogenic Leptospira infection from livestock? Miguel Salgado. Detection and characterization of Leptospira spp. isolated from dairy cattle with and without history consistent with Leptospira infection in Southern Chile LUNCH BREAK Part 2. Chair / co-chair : Kathryn Allan / Cord Heuer Cord Heuer. HARDJO vs. POMONA Two pathogens with different ecological risk Kathryn Allan. Exploring Leptospira infection diversity in East African livestock Victor Montes. Transmission dynamics of pathogenic Leptospira spp. within dairy cattle in Chilean dairy farms SESSION 3 : Vaccines & Immunology Chair/co-chair: Jackie Benschop / Peter Wilson Kanitha Patarakul. Subunit Vaccine of LigA (domain 11-13), LipL32, and Loa22 against acute lethal infection of pathogenic Leptospira in hamsters Juan Sanhueza. Meta-analysis of Leptospira vaccine efficacy in farm animals Theeraya Barthpo. Live attenuated LPS mutant showed cross-protection against COFFEE BREAK Poster discussion and removal Taxonomic Subcommittee Meeting ( ) Time Friday, 9 October 2015 SESSION 1 : Clinical Leptospirosis Part 1. Chair/co-chair: David A. Haake/ Muhammad Hussein Gasem David A. Haake. Review Leptospirosis in Human Marga Goris. Diagnostic Tests for Human Leptospirosis Lynsey Earl. Acute human leptospirosis in New Zealand: suspects, symptoms and diagnostic tests COFFEE BREAK Part 2. Chair / co-chair : Muhammad Hussein Gasem / David A. Haake

4 Rahajeng Tunjungputri. Thrombocytopathy contributes to the development of bleeding complications in human leptospirosis Narmada Fernando. Inflammatory cytokine responses in Sri Lankan patients with leptospirosis and the effect of antibiotic treatment Arif Budiman. Weil s Disease With Multiple Organ Failure In A Child Living In Dengue Endemic Area Part 3. Chair/co-chair: Roderick Chappel / Ahmed Ahmed Ahmed Ahmed. A Step Toward Multiplex Assay Using TaqMan Standard Protocol: Development and Optimization of Real Time PCR for Leptospires Detection Eapen Chubdamannil. Proteinuria In Early Human Leptopirosis Used For Simple Cheap Test For Leptospirosis Watcharee Saisongkorh. Development Technique for Detecting Common and Uncommon Vector-Borne Diseases and Zoonoses LUNCH BREAK SESSION 2 : Host Pathogen Interactions in Leptospirosis Chair/co-chair: Pablo Tortosa / Marga Goris Sarinya Kumpunya. A cyclophosphamide-treated C57BL/6 mice : a novel animal models for Leptospirosis-associated Acute Kidney Injury Lourdes Isaac. Interaction of Properdin With Pathogenic And Non-Pathogenic Leptospira. Contribution To Effector Mechanisms of The Complement System In Innate Immunity Shijun Li. Effects of Leptospira interrogans on the inos expression and NO level of murine and human mononuclear macrophages Lisa Tenriesa Muslich. Characterization of Leptospira infection in suckling and weaning rat pups COFFEE BREAK ILS Annual General Meeting Time Saturday, 10 October 2015 SESSION 1 : Epidemiology of Human Leptospirosis Part 1. Chair/co-chair: I Nyoman Kandun / Claudia Munoz-Zanzi Rita Traxler. Current Perspectives and Future Directions of Leptospirosis Surveillance and Prevention in the United States

5 Farida Handayani. Leptospirosis Outbreak Investigation In Sampang District-Madura, East Java, Indonesia Claudia Munoz-Zanzi. Outbreak investigation COFFEE BREAK Part 2. Chair / co-chair : Rudy Hartskeerl / Michael Matthias Maria Laura Calero. Impact assessment of leptospirosis for Manabí's province population, Ecuador, measured by the DALY indicator Renee Galloway. Whole genome sequence analysis of human Leptospira isolates from Utah Naohiko Matsushita. The relationships between climate factors and leptospirosis in the Philippines Part 3. Chair/co-chair: Marga Goris / Renee Galloway Juan Sanhueza. Leptospirosis and sources of infection in New Zealand farmers Anou Dreyfus. Leptospira Sero-prevalence in Health Centre Patients in Hoima, Uganda - Preliminary Results Marga Goris. Marked increase in autochthonous leptospirosis in humans and dogs in the Netherlands, CLOSING CEREMONY & FAREWELL LUNCH Optional Tour

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