Sex-linked Inheritance
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1 Sex-linked Inheritance
2 Some Review: Autosomes: Non-sex chromosomes (#1-22 homologous pairs) Sex Chromosomes: Chromosome pair #23 Female XX Male X
3 Sex Inheritance Gametes X X X XX XX X X
4 Sex-linkage Trait is carried on the X chromosome. The chromosome is too small to carry other traits besides the one determining the male sex characteristics.
5 Ex. In Drosophila (fruit flies): P: White-eyed male x Red-eyed female F1: All Red eyed F2: ¾ red eyes, ¼ white (all male)
6
7 **you know you are dealing with a sexlinked trait when mostly MALES exhibit the trait!!!**
8 **you know you are dealing with a sexlinked trait when mostly MALES exhibit the trait!!!** Carrier: Only females have two X chromosomes a carrier is heterozygous and carries a recessive trait but shows the dominant trait Therefore the recessive trait is masked and not exhibited but the gene is still there to be passed on. X R X r
9
10 We can also use Punnett squares in questions concerning sex-linked traits
11 We can also use Punnett squares in questions concerning sex-linked traits Instead of using a lone letter to represent each allele, we connect it to the sex chromosome.
12 We can also use Punnett squares in questions concerning sex-linked traits Instead of using a lone letter to represent each allele, we connect it to the sex chromosome. Ex. X A X a or X A
13 We can also use Punnett squares in questions concerning sex-linked traits Instead of using a lone letter to represent each allele, we connect it to the sex chromosome. Ex. X A X a or X A X A or X A or X a The dominant allele is written as a capital letter and the recessive allele as a lowercase letter this is a form of complete dominance.
14 We can also use Punnett squares in questions concerning sex-linked traits Instead of using a lone letter to represent each allele, we connect it to the sex chromosome. Ex. X A X a or X A The dominant allele is written as a capital letter and the recessive allele as a lowercase letter just like in complete dominance. The has no allele attached.
15 X F X f X F X F X F X F X f X F X f
16 Human examples (notice that all are recessive traits): Color Blindness: X c (X C = normal color vision) Ex. Two normal-visioned parents produce a color blind son. What are the genotypes of the parents? What are the chances of their next child being a color-blind daughter?
17 X C
18 X C X C
19 X C X C X c
20 X C X C X C X c
21 X C X C X C X C X C X c
22 X C X c X C X C X C X C X c
23 X C X c X C X C X C X C X c X C X c
24 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy?
25 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c
26 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C
27 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X c
28 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c
29 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c
30 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c X C
31 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c X C X c
32 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c X C X c
33 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c X C X c
34 Ex. If a color blind man marries a woman whose father was color blind; what is the probability of their first child being a color blind boy? X c X C X C X c X c X c X c X C X c Color Blind Boy = 1/4
35 Hemophilia: X h (X H = normal blood clotting) Ex. a man, whose father was a hemophiliac but who s clotting time was normal, marries a woman with no record of hemophilia in her ancestry. What are the chances of hemophilia in their children?
36 Hemophilia: X h (X H = normal blood clotting) Ex. a man, whose father was a hemophiliac but who s clotting time was normal, marries a woman with no record of hemophilia in her ancestry. What are the chances of hemophilia in their children? X H X H 0% chance X H
37 Ex. A woman whose father was a hemophiliac, but who is not herself a bleeder, marries a normal man. What is the chance of hemophilia in their children?
38 Ex. A woman whose father was a hemophiliac, but who is not herself a bleeder, marries a normal man. What is the chance of hemophilia in their children? Hemophilia Children = 1/4
39 Ex. If a boy s father has hemophilia and his mother s cells have one gene for the disease, what is the chance the boy will inherit the disease?
40 Ex. If a boy s father has hemophilia and his mother s cells have one gene for the disease, what is the chance the boy will inherit the disease? X H X H ½ or 50% chance X H
41 Ex. If a woman who is not a carrier of genes for hemophilia is married to a man who is a hemophiliac, what percentage of their male offspring could be expected to be hemophiliac?
42 Ex. If a woman who is not a carrier of genes for hemophilia is married to a man who is a hemophiliac, what percentage of their male offspring could be expected to be hemophiliac? 0% chance
43 Muscular Dystrophy: Xm (XM = normal)
44 Muscular Dystrophy: Xm (XM = normal) X M
45 Muscular Dystrophy: Xm (XM = normal) X M X m X M
46 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M
47 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M X M X m
48 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M X M X m X M
49 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M X M X m X M X m
50 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M X M X m X M X m
51 Muscular Dystrophy: Xm (XM = normal) X M X m X M X M X M X M X m X M X m
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