The Human Genome. Chapter 14 Human Heredity Human Chromosomes. Factors to Consider in Pedigrees. Pedigree. Sex Chromosomes and Autosomes
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1 Sex Chromosomes and Autosomes The Human Genome Chapter 14 Human Heredity Human Chromosomes Two of the 46 chromosomes in humans are known as the sex chromosomes. X Chromosome Y Chromosome The remaining 44 chromosomes (22 pairs) are known as autosomes. X and Y chromosomes Factors to Consider in Pedigrees Is the trait located on a sex chromosome or an autosome? Autosomal not on a sex chromosome Sex Linkage located on one of the sex chromosomes Y-linked - only males carry the trait. X-linked (recessive) - sons inherit the disease from normal parents Factors to Consider in Pedigrees How is the trait expressed? Dominant - the trait is expressed in every generation. Recessive - expression of the trait may skip generations. Pedigree A pedigree is a chart which shows the relationships within a family, often highlighting g g the inheritance of a particular trait (such as heart disease or a widow s peak hairline). 1
2 Basic Symbols Pedigree Diagrams: I Pedigree Diagrams: II Basic Symbols for offspring and the expression of a trait. The offspring are depicted below the parents. Filling the symbol with black indicates the expression of the studied trait. Pedigrees Draw the pedigree for a family in which: A man with unattached earlobes (the trait of interest) and a woman with attached earlobes have three children; first a boy, then a girl, then another boy. The two boys have attached earlobes, the daughter has unattached earlobes. ABO bloodtypes Human blood type is controlled by multiple alleles. There are 3 alleles: codominant I A I B i Recessive to Genotypes and Phenotypes for ABO blood groups (alleles I A, I B, i) Genotypes I A I A I A i I B I B I B i I A I B ii Phenotypes Type A blood Type B blood Type AB blood Type O blood Blood types Antibodies are protective proteins in the blood that identify invaders, (things that don t belong) and attack them. The antibody name identifies what it will attack. Antigens are chemical signals that identify self from non-self. Think of as a flag on the surface of the cell. Antibodies will attack any cell that has the wrong antigen ( wrong flag ). 2
3 YOU RE DEAD!! YOU RE DEAD!! NO YOU RE FINE!! 3
4 YOU RE DEAD!! Summary of Blood types I A i X I B i What blood types are these? What blood types might their offspring have? Summary of Blood types Type O blood (neither A nor B ) can donate to any blood type (universal donor). Type AB (no A or B antibodies) can receive blood from any donor (universal recipient). Types of Genetic Disorders Autosomal Recessive Autosomal Dominant Autosomal Codominant Sex-Linked (X-linked) Recessive Chromosomal Disorders Autosomal Recessive Genetic Trait revealed only in homozygous recessive individuals. In equal numbers of males and females. Two unaffected heterozygous parents can have affected children. 4
5 Autosomal Recessive Genetic Examples: Albinism lack of pigment in skin, hair, eyes Cystic fibrosis excess mucus in lungs Phenylketonuria (PKU) accumulation of phenylalanine in tissues, mental retardation Tay-Sachs disease lipid accumulation in brain cells, early death Autosomal Dominant Genetic Trait is revealed in every individual with a dominant gene. In equal numbers of males and females. Every affected individual id has at least one affected parent. Autosomal Dominant Genetic Examples Achondroplasia dwarfism (one form) Huntington s disease causes mental deterioration and uncontrolled movements. Hypercholesterolemia excess cholesterol in blood. Autosomal Codominant Genetic Trait caused by both alleles (neither allele is masked). Most important autosomal codominant genetic disorder is Sickle Cell Disease. Bent and twisted (sickle-shaped) red blood cells tend to get stuck in capillaries. This damages tissues (brain, heart, spleen) and may be fatal. Homozygotes and heterozygotes are affected to differing degrees. Sex-Linked (X-linked) Recessive Genetic Trait caused by genes found on the X- chromosome (entirely absent from the y chromosome). Because males have only one X chromosome, a single recessive allele (X a ) will cause the disorder. Females must have 2 copies of the disease allele (homozygous recessive) to have the disorder. Sex-Linked (X-linked) Recessive Genetic Examples of sex-linked recessive Colorblindness Hemophilia Duchenne Muscular Dystrophy 5
6 Chromosomal Disorders In normal meiosis, homologous chromosomes separate from one another. In nondisjunction, the homologues fail to separate, resulting in gametes with too many or too few chromosomes. Chromosomal Disorders Down Syndrome, also known as Trisomy 21, is a chromosomal disorder resulting from the nondisjuction of chromosome 21 in humans (the person has an extra chromosome 21) 6
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