KYORITSU SEIYAKU CORPORATION CORPORATE PROFILE

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1 KYORITSU SEIYAKU CORPORATION CORPORATE PROFILE

2 KS Group Annual Sales KYORITSU SEIYAKU CORPORATION CORPORATE PROFILE Fiscal Year Established: May, Activities Production, Distribution, Import and Export of Animal Health Products Sales Turnover (Actual Sales from June to May 2016) JPY 41 billion USD 373 million (USD 1= JPY 110) EUR 328 million (EUR 1= JPY 125) Employees 548 : Kyoritsu Seiyaku Corporation 1,313: Total KS Group (Oct. 31,2016) million JPY Animal Health Human Health Emvironmental Hygiene Representative Takaaki Takai, President Headquarters Kudan-kita, Chiyoda-ku, Tokyo, Japan Strength of Production Extensive portfolio of products: including biological products (vaccines), pharmaceuticals, feed additives, in feed and other medical devices. Three manufacturing sites: specialised by dosage form Effective production of small-volume medicines Advanced technology to ensure high quality, reliable supply

3 Companion Animal Product Range Production Animal Product Range Medicines Bovine/Swine Vaccine Adrestan, Dorbene, Atipame, Delvosteron, PimobeHeart, Ofloxacin Anti Inflammatory Canine /Feline Vaccine Interferon Canivac KC-3 Canivac 5 Rabies TC Vaccine Intercat Interdog Flea & Tick M Preventative My Flea Guard My Flea Guard α Heartworm Preventative MoxiHeart Tab KS Others: Nutraceutical products, Diagnostic kit, Royal Canin Veterinary Diet, Care tool Metacam(Meloxicam) Sulpirin (Salicylic Acid, etc) Andress ointment Dexamethasone Injection KMK Prednisolone Injection KMK Bovivac 5 (IBR+BVD Ia&II+PI3+BRSV) Bovivac B5 (IBR+BVD Ib&II+PI3+BRSV) Swivac BPE (AR+ Pasturella+Recombinant SE) Swivac ERA(Recombinant SE) Suvaxyn Aujeszky (AD) Salmonella Trivalent(SE+ST+SI, Inactivated) Poulvac MDcvi Poulvac IB H120 Poulvac COMBI (ND+IB) LT-VAX (ILT) Avivac BD(Gumboro) Diagnostic Kit / Medium Sulfonamide Trioprin inj. (Sulfadoxin / TMP) S T powder (Sulfamethoxasol) Poultry Vaccine Fel-O-Vax3 (RCP) Antimicrobial Florfenicol (Premix, Inj.) Cefazolin (Inj.) Amoxicillin (Water Soluble) Mycillin Sol (PC / SM Inj.) CTC-S20F Colistin 10 and others JOHNELISA Ⅱ(M. paratub. ELISA) JOHNELISA Screening KS Johne First (Extraction Kit) Mycobactin Herrold s Egg Yolk medium with Mycobactin Mycolisa MH (M. Hyo. ELISA)

4 This image cannot currently be displayed. Production Animal Product Range 2 Aquaculture Product Range Anti Metabolic E-S-E (Vitamin E / Selen) Vita Long Forte (AD3E) Electroplus A (Electrolyte) Neorunogen (Propylene Glycol) Iron 100/200 (Dextran) Newglon (Ca) Ketoplex inj (Propionic Acid) Mastitis Dicloxa syringe/jet/ointment SP ointment syringe (PC/SM) Neopenitube (NM/PC) Kayaten (NF) Cefazolin (CEZ) Anthelmintic Asedist Fine Granules (Bromophos) Noromectin (Ivermectin) Levamisole powder Hormone Estomal/Receptal (GnRH) Dalmazin(PGF2α) Spornen (GnRH) Antrin R(FSH) Gestoron (HCG) Ovapron V (Progesteron, IVD) Poston (Oxytocin) Serarumon (PMS) Fel-O-Vax3 Digestive (RCP) Takaberine (Berberine) Geritomin powder (Berberine) Gastoline (Menthol) Fish Vaccine PISCIVAC PISCIVAC LVPR/Oil (Lacto / Vibrio / Irido / Photobact inj. for yellowtail) PISCIVAC LVS ( Lacto / Vibrio / Strepto inj. for amberjack) PISCIVAC Three ways ( Lacto / Vibrio / Irido inj. for yellowtail & amberjack) PISCIVAC Vibrio + Rensa (Lacto / Vibrio inj. for yellowtail) PISCIVAC Vibrio (Immersion use for salmonids) Feed / Premix Ursodeoxycholic acid Glutathione powder Nifurstylenate powder Lincomycin powder OTC powder Oxolinic acid powder Erythromycin powder Ampicillin powder Fish Vaccine M-Vac M-Vac Iniae (Streptococcus iniae for flounder fish) M-VAC Rensa (Lacto inj. for yellowtail) M-VAC S.I.P 3 (S. iniae / S. Parauberis I & II for flounder fish )

5 Tsukuba Factory Global Supply Partners Tsukuba factory manufactures biological products (vaccines), diagnostic drugs, medium additives for bacteria and hormones. Our vaccines are targeted at poultry, swine, bovine and aquaculture. They are manufactured as freeze-dried, liquid and frozen with 3 production lines. Established 1967 Location Tsukuba-shi, Ibaraki-ken Site Area 29,419 square metres Employees 72 Number of products Vaccines 59 Hormones 18 Diagnostic Drugs, medium additives etc 38 EUROPE UK -Dechra Pharmaceuticals -Norbrook ITALY -Fatro -Agrolabo HOLLAND -Akzo Nobel FRANCE -Royal Canin -Vétoquinol SPAIN -Hipra -Syva FINLAND -Vetcare JAPAN -Elanco Animal Health -Suntory -ASKA Pharmaceutical -Toray Industries -Idemitsu Kosan -Matsuken Pharmaceutical Industry -Adtec Company -PVG Japan -PIC BIO ASIA KOREA -Yuhan TAIWAN -Institute for Microbial Resources VIETNAM -Navetco NORTH AMERICA USA -Zoetis -Pet-Ag -Milk Specialties -Addison Biological Laboratory -Animal Health Options -Vétoquinol USA South America Argentina -Syntex

6 Current Top 15 Animal Health Companies in the World Ranking Company 2016 sales (million USD) Change (%) 1 Zoetis (US) 4, Merck/MSD Animal Health (US) 3, Elanco (US) 3, Merial (US) 2, Bayer Animal Health (Germany) 1, IDEXX Laboratories (US) 1, Boehringer Ingelheim Animal Health (Germany) 1, Ceva Sante Animale (France) 1, Virbac (France) Phibro Animal Health (US) Kyoritsu Seiyaku (Japan) Huvepharma (Bulgaria) Vetoquinol (France) Dechra Pharmaceuticals (UK) Norbrook Laboratories (UK) Source:Animal Pharm May 10, 2017c Animal Health Company Top 10 Animal Health Companies in Japan for FY 2014 Total PA CA (Pharmaceuticals +Neutraceuticals) 140, % 65, % 75, % 1 Kyoritsu Seiyaku Corporation 40, % 9, % 31, % 2 ZENOAQ 16, % 7, % 9, % 3 DS Pharma 13, % 1, % 12, % 4 Zoetis 9, % 4, % 5, % 5 Intervet 8, % 6, % 1, % 6 Kyoto Biken Laboratories 6, % 5, % 1, % 7 Meiji Seika Pharma 6, % 5, % 1, % 8 Boehringer Ingelheim 6, % 4, % 1, % 9 Novartis Animal Health 5, % % 4, % 10 Bayer Health Care 4, % 3, % 1, % PA: Production Animals CA: Companion Animals Unit: Million JPY; Ex- Wholesaler

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