Cascade. Guide for veterinarians if NO authorised medicinal product is available. Federation of Veterinarians of Europe
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1 Cascade Guide for veterinarians if authorised medicinal product is available Federation of Veterinarians of Europe
2 FOOD PRODUCING ANIMALS & COMPANION ANIMALS Is there an authorised product for this species and indication? Under exceptional circumstances and in particular to avoid unacceptable suffering the veterinarian is allowed to use the Cascade. Is this the case? Is there a suitable product authorised for another species /condition in your Member State? Use authorised product Use this authorised product Specific precautions for food producing animals: Only substances on table 1 of Commission Regulation (EU) N o 37/2010 can be used. Withdrawal periods have to be specified. Administration of a product under the cascade is permitted to one animal or small number of animals at a particular holding. Unless already indicated for the species concerned, withdrawal periods have to be at least: - 7 days for eggs - 7 days for milk - 28 days for meat degree-days for fish meat Specific precautions for food producing animals & companion animals: The veterinarian can only use the cascade under his/her direct responsibility. The veterinarian has to keep records for minimal 3 years (see law in your country): - Date of examination - Details of the owner - Species - Number of animals treated - Diagnosis - Medicinal product prescribed and for food producing animals: - Doses administered - Duration of treatment - Recommended withdrawal period Is there a human product authorized in your country or a veterinary medicinal product authorized in another EU Member State? Is it possible to extemporaneously prepare a product? Use either one of these products Prepare extemporaneously No treatment with a medicinal product possible 2 FVE CASCADE FVE CASCADE 3
3 HORSES Is there an authorised product for this species and indication? Under exceptional circumstances and in particular to avoid unacceptable suffering the veterinarian is allowed to use the Cascade. Is this the case? Use authorised product Is this a food-producing horse? Use the Cascade as for companion animals Non-food-producing horses: Is it possible to find a substance through the use of the Cascade for food-producing animals? Use the Cascade as for food producing animals and specify a withdrawal period of at least 28 days Use a substance from the list of substances essential for horses, record in horse passport and specify withdrawal period 6 months For a horse to be considered as a non-food-producing animal, the horse has to be declared in the horse passport as not being intended for slaughter for human consumption, in accordance with Regulation 504/2008. No treatment with a medicinal product possible 4 FVE CASCADE FVE CASCADE 5
4 HORSES List of substances essential for horses Anaesthesia, analgesics and substances used in association with anaesthesia Sedation and premedication: - Acepromazine - Atipamezole - Diazepam - Flumazenil - Midazolam - Naloxone - Propofol - Sarmazenil - Tiletamine - Zolazepam Hypotension or respiratory stimulation during anaesthesia: - Dobutamine - Dopamine - Ephedrine - Glycopyrrolate - Noradrenaline (norepinephrine) Analgesia: - Buprenorphine - Fentanyl - Morphine - Pethidine Muscle relaxants and associated substances: - Atracurium - Edrophonium - Guaifenesin Inhalation anaesthetics: - Sevoflurane Local anaesthetics: - Bupivacaine - Oxybuprocaine - Prilocaine Anti-inflammatory substances Corticosteroids: - Triamcinolone acetonide - Flumethasone Anti-endotoxins: - Pentoxifylline - Polymyxin B Cardiovascular medicines - Amiodarone - Allopurinol - Vasopressin - Digoxin - Quinidine sulfate and quinidine gluconate - Procainamide - Propranolol Convulsions - Phenytoin - Primidone Gastrointestinal agents - Bethanechol - Codeine - Loperamide - Metoclopramide - Phenoxy-benzamine - Propantheline bromide - Ranitidine - Sucralfate Rhabdomyolysis - Dantrolene sodium Antimicrobials Klebsiella spp. Infections: - Ticarcillin Rhodococcus equi infections: - Azithromycin - Rifampicin Septic arthritis: - Amikacin Respiratory medicines - Ambroxol - Budesonide - Fluticasone - Ipratropium bromide - Oxymetazolin Antiprotozoal agents - Isometamidium - Ponazuril - Pyrimethamine Ophthalmic medicines Ocular ulcers: - Acyclovir - Idoxuridine Glaucoma: - Phenylephrine - Tropicamide - Dorzolamide - Latanoprost - Timolol maleate - Cyclosporin A - Ketorolac - Ofloxacin - Fluoresceine - Rose Bengal Hyperlipaemia - Insulin Fungal infections - Griseofulvin - Ketoconazole - Miconazole - Nystatin Diagnostic imaging Commission Regulation (EU) N o 122/ Radiopharma-ceutical Tc99m Miscellaneous - Carbamazepine - Cyproheptadine - Domperidone - Gabapentin - Hydroxyethyl-starch - Imipramine - Thyrotropin releasing hormone - Barium sulphate - Iohexol - Iopamidol 6 FVE CASCADE FVE CASCADE 7
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