動物咬傷 衛生署疾病管制局 中區傳染病防治醫療網 王任賢指揮官
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1 動物咬傷 衛生署疾病管制局 中區傳染病防治醫療網 王任賢指揮官
2 Overview About half of all persons will incur an animal bite sometime in their life. Not all bite wounds need medical attention, but severe bite wounds and those at high risk of infection are frequent reasons for emergency department visits.
3 Epidemiology Dog bites account for majority(80%- 90%) of animal bite wounds treated in the ER, followed by cat bites (10%) and human bites (3%)
4 Animal Bites 3-6 millions animal bites year Estimated 300,000 annual ER visits due to dog bites 6,000 yearly hospital admissions and 20 deaths due to dog bites Dogs 70-93% of bites Cats 3-15% of bites Infection rate 2-10% dog bites Higher infection rate for cats, up to 30-50%
5 Epidemiology - Dog Dogs are responsible for more than 80% of animal bite wounds The peak incidence is between 5 and 9 years of age Their own pet Most often on the extremities. Facial bites
6 Epidemiology - Dog 4% to 25% of dog bite wounds become infected The median time from bite to appearance of first symptoms of infection is 24 hours
7 Dog Bites: Crush injury are common and enhances for infection. Rarely lethal, but may produce significant damage. Fatalities occur at a rate of deaths per year in the US, majority occurring in children. Tend to occur in the late afternoon and early morning, more occurring in the summer.
8 Dog Bites: Victims are more likely to be male and young, with a peak incidence with 5- to 9-year-old age group. (Boys >> Girls) Location of bites: Adult dog bite victims are more likely to be bitten on their extremities, while children are likely on the head and neck. (upper extremities > lower extremities > head & neck > trunk)
9 Dog Bites: Puncture wounds occur in 13%-34%, lacerations in 31%-45%, and superficial abrasions in 30%- 43% of dog bite injuries. Victims presenting to the ER can be divided into two groups: within 8-12 hrs of injury who are primarily concerned about wound management and rabies after 12 hrs with signs and symptoms of infection.
10 Epidemiology Cat bites more commonly in women, 30% to 50% of cat bite injuries become infected, appearance of first symptoms of infection is 12 hours Human bites occur during fights command become infected Other animal bites
11 Cat Bites: 5-18% of reported animal bites (US). Unlike dog bite victims, cat bite victims tend to be female and older, with a mean age of 19.5 years. The majority of cat bites are inflicted by the pet of the victim or victim s acquaintance.
12 Cat Bites: Approximately two-thirds of cat bite injuries occur on the upper extremity, frequently involving the hand. Due to cat s sharp, slender teeth, which easily penetrate skin and other structures. (Up to 80% of bites become infected) Therefore, over half of all cat bite injuries are puncture wounds (57-86%), with lacerations (5-17%) and abrasions (9-25%) occurring less frequently.
13 Common bacteria- cat & dog Aerobic and anaerobic bacteria Pasteurella species - facultatively anaerobic, gram-negative coccoobacilli rods, 50% to 75% of cat bites and 20% to 50% of dog bites Streptococci, staphylococci, and Moraxella, Corynebacterium, and Neisseria species, Bergeyella zoohelcum, Capnocytophaga species Fusobacterium, Porphyromonas
14 Human Bites: Males are more likely to be victims of human bites, with a peak incidence in the 10- to 34- year-old age group. Tend to occur during the summer months, typically on weekends, and most often involve acts of aggression.
15 Human Bites: The hands and upper extremities are the most commonly bitten location (60%-75%), followed by the head and neck (15%-20%), trunk (10%-20%), and lower extremities (5%). For various reasons, including embarrassing circumstances and possible legal repercussions, many adult human bite victims delay seeking medical care until a complication ensues.
16 Human Bites: Divided into two categories: occlusional and clenched-fist injuries (CFIs). Occlusional bites: closure of the perpetrator s teeth onto the victim s skin. CFIs (or fight bites ): injuries to the dorsum of the metacarpophalangeal region of the fist as it strikes the teeth of an adversary and most occur in young adult males with drinking.
17 Common bacteria - human S aureus, Staphylococcus epidermidis, viridans streptococci, Eikenella corrodens, Haemophilus influenzae, and beta-lactamase-producing anaerobic bacteria
18 Pathophysiology: Local wound infections account for approximately 95% of complications following a dog, cat, or human bite. Infections caused by Pasteurella species occur shortly after the bite, typically developing within 24 hours. Infections presenting more than 24 hrs after the bite are more likely cause by Staphylococcus and Streptococcus species.
19 Pathophysiology: Cellulitis and abscess formation are the most common, although bites may damage deep structures, including arteries, nerves, tendons, joints, and bones. Osteomyelitis, tenosynovitis, and septic arthritis occur, especially with hand bites. Sepsis, DIC, meningitis, endocarditis, and tetanus can develop after animal bites, and transmission of HIV and hepatitis B and C is possible from human bites.
20 Pathophysiology: Puncture wounds, perhaps because of their deep inoculation of bacteria into the tissue, are at higher risk for infection as compared with other types of bites. One study of mammalian bites found a 30% infection rate for punctures, 15% for lacerations, and 0% for superficial wounds such as abrasions.
21 Bite wounds at increased risk for infection Puncture wounds Hand and upper-extremity bites Full-thickness bites Bites requiring debridement Bites in patients over 50 Bites causing damage to deep structures
22 Cat Zoonoses Infectious Saliva Bartonella henselae Pasteurella multocida Rabies Caphocytophagia Tularemia Cowpox
23 Dog Zoonoses Infectious Saliva Rabies Pasteurella Capnocytophaga Brucella (B. canis)
24 Wound Culture Bacteriologic analysis of infected dog and cat bites Average 5 organisms per culture 56% (of 107) were mixed aerobic and anaerobic infections Pasturella species most common bacteria in dog and cat bite cultures (50 and 75%)
25 Bacteria Isolated Pasteurella species Streptococcus Staphylococcus Neisseria Cornyebacterium Moraxella Enterococcus Bacillus Pseudomonas Fusobacterium Bacteroides Porphyromous Prevotella Dog 50% 46% 46% 16% 12% 10% 10% 8% 6% 32% 35% 28% 28% Cat 75% 46% 35% 19% 28% 35% 12% 10% 5% 33% 28% 30% 19%
26 Pasturella Multocida Small gram negative, non-motile, aerobic coccobacilli Common commensal in the upper respiratory tract of healthy and diseased fowls and mammals. Species include P. multocida, P. septica, P. canis, P. dagmatic, and P. stomatis
27 History First isolated from wild hogs 1878 Characterized by Louis Pasteur in 1880 Human disease 1918 bacterial empyema from influenza A pneumonia
28 Route of Inoculation Bite Scratch Lick Inhalation or aspiration Unknown
29 Clinical Manifestations Local soft tissue infections Respiratory tract infections Other serious or systemic infections
30 Soft Tissue Infections Most often results in local infections Inflammation, pain, swelling, and erythema within hours Abscess, cellulitis, lymphadenopathy, tenosynovitis. Often in hand/finger after a cat bite due to direct inoculation Septic arthritis associated with chronic disease, Rh arthritis, DJD, corticosteroid use, or prosthetic joints. Affects joints distal to the bite
31 Osteomyelitis Several reports involving the hand and digits, acute and subacute presentation Due to direct inoculation and penetration of the periosteum Few reports vertebral osteomyelitis due to hematogenous spread No reported cases of sternal osteomyelitis Treated with surgical debridement and longterm antibiotics
32 Respiratory Infections 2 nd most common pasteurella infection Upper and lower respiratory tract infections One series 107 patients Pneumonia 47%, tracheobronchitis 37%, empyema 25%, lung abscess 3% Underlying disease present 93% cases. Smokers, elderly population Mortality 29%
33 Sepsis Review sited 46 case reports of sepsis due to Pasteurella Often affects patients with underlying illness: cirrhosis, diabetes mellitus, malignancy, COPD Most often due to cellulitis, arthritis, meningitis, peritonitis, pneumonia
34 Cardiovascular involvement 15 reported cases endocarditis Affects both native and prosthetic valves Often underlying valvular and chronic disease Associated with bacteremia Mortality 30%
35 Pasteurella Meningitis 29 documented adult cases in English literature Classic presentation including fever, headache, nuchal rigidity, altered mental status Animal contact 89%, 15% reported animal bites CSF revealed elevated protein, leukocytosis, decreased glucose, positive gram stain Associated with bacteremia 63%, otitis media 24%
36 GI/GU Spontaneous bacterial peritonitis most often associated with cirrhosis and found in peritoneal dialysis pateints Bacteremia and tubo-ovarian abscess Chorioamnionitis Newborn meningitis due to vertical transmission
37 Ocular and ENT One report of acute suppurative thyroiditis with thyrotoxicosis Corneal ulceration, orbital and periorbital cellulitis, and endophthalmitis Epiglotitis, sinusitis, tonsillitis
38 Pasteurella and HIV Increased susceptibility to zoonoses in immunocompromised patients Few reports associated with HIV Including: pneumonia, meningitis, peritonitis, local soft-tissue infections, and malakoplakia of the lung
39 Prehospital care: With the exception of bites causing only superficial abrasions, all dog, cat, and human bites should receive medical evaluation. A sterile dressing should be applied to all open wounds and direct pressure should be used to control bleeding. Intravenous access is suggested when a significant amount of blood loss has occurred.
40 ER Evaluation I Bite victims should be evaluated shortly after arrival to the ER, as time to treatment is one of the main determinants of infection. History: the circumstances of the attack, information about the bite source, and information about the bite victim. Ask about the timing of the bite. As a general rule, untreated bites more than 6-12 hrs old are at high risk for infectious complications.
41 ER Evaluation II When treating an animal bite, determine whether the bite was provoked or unprovoked, as this may influence the decision to administer rabies prophylaxis. When dealing with dog and cat bites, information about the bite source should include ownership and immunization status, as well as the current location of the animal.
42 ER Evaluation III With human bites, attempt to determine the HIV and hepatitis B status of the bite source, or if they are in a high-risk group for these illnesses. Ask about the bite victim s past medical history, current medications and allergies, as well as his or her tetanus status.
43 Factors associated with increased risk of bite wound infection Chronic illness: cirrhosis, renal failure, SLE and other immune disorders and diabetes mellitus Medications: corticosteroids, methotrexate and other immunosuppressive drugs Alcoholism, Asplenia, Peripheral vascular disease, HIV, Conditions causing chronic edema of the bitten part (mastectomy, CHF with pedal edema)
44 Physical Examination: Vital signs often give valuable clues to biterelated pathology. Hypotension with tachycardia suggests hemorrhagic shock when significant blood loss has occurred. Fever is often associated with systemic infection.
45 Physical Examination: Note the location, size, and depth of all wounds and carefully assess the vascular status distal to all extremity bites. Check motor and sensory function of all nerves distal to the wound; specifically, the median, radial, and ulnar nerve in the hand and the tibial and deep and superficial peroneal nerves in the foot.
46 Diagnostic Studies: Obtain radiographs if there is a considerable amount of edema and tenderness around the wound, or if there is any possibility of bony damage or a foreign body. Teeth and tooth fragments can be left behind in bite wounds, with resultant infectious complications.
47 Diagnostic Studies: When reviewing x-rays, look for air in the joint, which indicates penetration of the capsule. With older infected wounds, assess for osteomyelitis and softtissue gas. Angiography is indicated if the bite is near a major artery and there is evidence of vascular injury(e.g., expanding hematoma, pulsatile mass or diminished peripheral pulses)
48 Treatment: Analgesia: Adequate analgesia is vital to allow for appropriate examination and wound care of bite wounds. Procedural sedation may be necessary in extremely anxious patients, those with large or complex wounds, and children. Wound care: Cleaning, debridement, and irrigation are the most important factors in preventing bite wound infections and optimizing outcomes.
49 Treatment: Repair (To close or not to close): Primary closure is recommended for: Simple bite wounds of the trunk and extremities (excluding hands and feet) less than six hours old; and Simple bite wounds of the head and neck less than 12 hours old.
50 Treatment: Primary closure is not recommended for: CFIs; puncture wounds; hand and foot bites; bites with extensive crush injury; and bite wounds more than 12 hours old or that are clinically infected.
51 Treatment: Repair (The best way to close the wound): Use a standard percutaneous closure technique with non-absorbable suture such as monofilament nylon or polypropylene. Avoid multiple layer closures if possible and avoid subcutaneous sutures unless they are absolutely necessary.
52 Treatment: When to call for specialty consultation? If there is a significant amount of tissue missing and skin grafting may be indicated If there is known or potential damage to important underlying structures (e.g., tendons, arteries, nerves, bones, or joints) If general anesthesia will be required to allow for appropriate wound care Patient or family request
53 Treatment: Antimicrobial Prophylaxis: The value of prophylactic antibiotics given for dog, cat, and human bites remains highly controversial. Consider prophylactic antibiotics in the following situations: Bites requiring repair in the operating room Human and cat bites that extend through the dermis
54 Management - antibiotic Moderate to severe wounds High risk of infection on the hand, head, neck, or genital region puncture wounds, crush injuries injuries in which a deeper structure -bone or joint patients with specific conditions (eg, diabetes, liver disease) bite wounds that require surgical repair from a human or cat.
55 Management - antibiotic Cat/dog should be directed against Pasteurella, Streptococcus, Staphylococcus and anaerobes For human bites, antibiotic coverage should be directed against Streptococcus and Staphylococcus species, anaerobes, and E corrodens.
56 Management - antibiotic Augmentin 875/125 mg PO bid or 500/125 mg PO tid Doxycycline in patients allergic to penicillin
57 Indications for admission after a bite injury Structural: Injury to deep structures (bones, joints, tendons, arteries, or nerves) Injuries requiring reconstructive surgery Injuries requiring general anesthesia for appropriate wound care
58 Indications for admission after a bite injury Infectious: Rapidly spreading cellulitis Significant lymphangitis, lymphadenitis or evidence of sepsis Infection in patient at high risk for complications (e.g., diabetic, immunocompromised, noncompliant) Infections involving bones, joints, or tendons Infection with failed outpatient therapy
59 Management Rabies and tetanus consideration of tetanus and rabies prophylaxis Rabies - eradicated in Taiwan Tetanus - dependent on the wound classification and immunization status of the patient
60 Dog or cat bite in U.S. to human (continuation of animal bite algorithm) No Is animal available for testing or quarantine? Yes Attempt to locate animal; report to animal control (or observe patient calling animal control, as details provided directly from bite victim will increase chances of locating animal) educate patient on how rare rabies is in dogs & cats in Arizona (e.g. last rabid dog in Arizona: stray puppy in 2002 from Graham County; last rabid dog in Maricopa County was over 30 years ago; rabid cats have been confirmed in 2005 & 2006 from Santa Cruz & Coconino counties) advise patient to wait to hear back from animal control if animal is not located, encourage patient to discuss with local health department; provide local health and state health department phone numbers Dog/cat is not located; risk assessment provided by public health officials provided to patient and/or physician, based on a combinations of factors: most important factor: geographic area of state (e.g. metro area is considered low risk, PEP usually not recommended unless animal exhibited neurological signs vs. stray animals from rural areas with known rabies epizootics is considered as increased risk) healthy acting is low risk vs. acute neurological symptoms is high risk provoked vs. unprovoked (provoked: PEP is usually not recommended) known animal vs. stray (Animal with a collar indicates a level of care which is likely to include previous rabies vaccination and thus a lower risk. Stray cats routinely seen within bite victim s neighborhood can be observed from a distance for 10 days for health status) If animal dies or develops signs of rabies, test brain tissue Withhold PEP & Quarantine animal for 10 days (Ferret = 14 days) Negative result, no further action needed; PEP not indicated If animal remains healthy, PEP not indicated Positive result, initiate PEP If risk is low, public health will not encourage vaccination If risk is increased, public health will encourage vaccination If risk is high, public health will track patient, may assist in coordinating PEP & document completion of rabies PEP Examples of factors considered within risk assessment by public health officials are provided within the text above. Patients are advised to combine risk assessment with discussion with a physician. For a risk assessment, call your local health department or Arizona Department of Health Services (ADHS), Vector-Borne & Zoonotic Disease Section at (602) or
61 Summary Animal and human bites are common. Basic bite wound care should be performed, including cleansing and irrigation of the wound. A good understanding of bite wound bacteriology and the situations in which antibiotics may be indicated is important. Rabies and tetanus prophylaxis should be considered and appropriate follow-up care ensured.
62 懇請賜教
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