BRUCELLOSIS. Morning report 7/11/05 Andy Bomback

Size: px
Start display at page:

Download "BRUCELLOSIS. Morning report 7/11/05 Andy Bomback"

Transcription

1

2 BRUCELLOSIS Morning report 7/11/05 Andy Bomback

3 Also called undulant, Mediterranean, or Mata fever, brucellosis is an acute and chronic infection of the reticuloendothelial system gram negative facultative intracellular coccobacilli 4 species: B. melitensis, B. abortus, B. suis, B. canis

4 Humans acquire brucellosis from exposure to infected animals (direct contact with infected animal parts) or contaminated animal products (unpasteurized animal-milk products, such as raw milk, soft cheese, butter, and ice cream); the disease is also spread by inhalation of infected aerosolized particles

5

6 in US, most cases occur in slaughterhouse workers, farmers, veterinarians, and other animal handlers (including micro lab personnel)

7 The disease also presents in US Hispanic populations and is probably related to illegal importation of unpasteurized dairy products from Mexico Number of reported cases of human brucellosis in Hispanic and non- Hispanic California residents, by year,

8 The relationship between the disease and individual socioeconomic status is exemplified in the US, where programs to eradicate brucellosis have successfully limited the annual incidence of the disease, which now predominantly occurs in CA and TX (which account for >50% of US cases) with relatively high rates of incidence in NC, IL, FL, WY, IA, and AZ.

9 Country Azerbaijan Italy Mexico Turkey 11,427 11,462 10,742 15,510 17,553 14,435 USA

10 What the Republicans don t want you to know about brucellosis!!!

11 Clinical picture Brucellosis is a well documented cause of FUO with variable symptomatology fever (can be spiking and accompanied by rigors), sweats (often malodorous), malaise, anorexia, fatigue, weight loss, depression. Onset can be abrupt or insidious developing over several days to weeks. Despite multiple patient complaints, the physical exam findings (other than fever) are usually minimal to none can see minimal LAN and occasional HSM

12 Almost all organ systems can be involved with brucellosis localization of disease can cause focal symptoms or findings of 530 cases studies prospectively, 32% developed a complication; major risk factor for developing focal disease was duration of symptoms > 30 days

13 most common sites for localization: o Osteoarticular, especially sacroiliitis (20-30%) and peripheral arthritis o GU, especially epididymoorchitis (2-40% males) o Neurobrucellosis, usually presenting as meningitis (1-2%) o Endocarditis, left-sided and 2/3 on previously damaged valves (1%); remains the principle cause of mortality in the course of brucellosis and typically requires immediate surgical valve replacement o Hepatic abscess (1%)

14 Undiagnosed and untreated brucellosis can be symptomatic for months and some previously treated patients may relapse In the 1950 s, a syndrome called chronic brucellosis malaise, weakness, depression was a relatively common diagnosis; these patients likely represent the current population receiving diagnoses of chronic fatigue syndrome or chronic Lyme disease

15 MED H

16 Diagnostic work-up Consider brucellosis in patients with otherwise unexplained chronic fever and nonspecific complaints, particularly if there has been exposure to Brucella by contact with animal tissues or ingestion of unpasteurized milk or cheese.

17 WBC usually normal to low (can see pancytopenia); minor LFT abnormalities are fairly common Routine Labs

18 ideally, the diagnosis is made by isolation of the organism from cultures of blood or other sites (liver biopsies, bone marrow aspirates, pleural fluid, CSF) Cultures

19 classic serologic testing for brucellosis uses standard tube agglutination testing. In general, a single titer of >1:160 in the presence of compatible illness supports the diagnosis; titers should be repeated over the next 4-12 weeks, as a fourfold or greater increase or decrease provides even stronger evidence of the diagnosis other diagnostic serologic tests: ELISA, antibrucella Coombs, complement fixation, Rose Bengal agglutination Serologic Testing

20 P. C. freaking R. PCR identified 97% of fluid and tissue samples in patients with focal complications of brucellosis compared to only 29% by culture a combination of PCR-ELISA may turn out to be the most sensitive and specific method for diagnosis

21 Treatment After ingestion, the majority of brucellae are rapidly eliminated by phagolysosome fusion. Of those bacteria, 15-30% survive in gradually evolving brucellae-containing compartments, in which rapid acidification takes place. How this unique environment is formed is incompletely understood, but it is responsible for limiting antibiotic action and explains the discrepancy between in vitro studies and in vivo events.

22

23 All monotherapies have unacceptably high relapse rate, so combination regimens of antibiotics that can penetrate macrophages and act in the acidic intracellular environment are necessary.

24 1986 WHO guidelines for the treatment of brucellosis Regimen A: doxycycline 100 mg PO bid for 6 weeks + streptomycin 1 g IM qd for the first days Regimen B: doxycycline 100 mg PO bid + rifampin 600 to 900 mg (15 mg/kg) PO qd for 6 weeks

25 same relative efficacy of both regimens (including time to defervescence and relapse rate), but regimen B is obviously easier to implement other drugs (used in combination with doxycycline and/or rifampin): gentamicin, ofloxacin, ciprofloxacin, TMP- SMX

26 Relapses Most relapses occur within 3 months of stopping therapy and almost all within 6 months rate of relapse is about 10%. Relapses are often milder in severity than the initial disease and can be treated with a repeat course of the usual antibiotic regimen

27 Closing slide with picture of children to elicit sympathy from the audience

Outlines. Introduction Prevalence Resistance Clinical presentation Diagnosis Management Prevention Case presentation Achievements

Outlines. Introduction Prevalence Resistance Clinical presentation Diagnosis Management Prevention Case presentation Achievements Amal Meas Al-Anizi, PharmD Candidate KSU, Infectious Disease Rotation 2014 Outlines Introduction Prevalence Resistance Clinical presentation Diagnosis Management Prevention Case presentation Achievements

More information

BRUCELLOSIS BRUCELLOSIS. CPMP/4048/01, rev. 3 1/7 EMEA 2002

BRUCELLOSIS BRUCELLOSIS. CPMP/4048/01, rev. 3 1/7 EMEA 2002 BRUCELLOSIS CPMP/4048/01, rev. 3 1/7 General points on treatment Four species are pathogenic to man: B. melitenis (acquired from goats), B. suis (pigs), B. abortus (cattle) and B. canis (dogs). The bacteria

More information

Brucellosis is a bacterial zoonosis transmitted directly or indirectly to humans from infected animals,

Brucellosis is a bacterial zoonosis transmitted directly or indirectly to humans from infected animals, Definition Brucellosis is a bacterial zoonosis transmitted directly or indirectly to humans from infected animals, predominantly domesticated ruminants and swine. The disease is known colloquially as undulant

More information

Update on brucellosis: therapeutic challenges

Update on brucellosis: therapeutic challenges Update on brucellosis: therapeutic challenges Javier Solera To cite this version: Javier Solera. Update on brucellosis: therapeutic challenges. International Journal of Antimicrobial Agents, Elsevier,

More information

Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & 2002

Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & Case Study Brucellosis: 2001 & 2002 Potential Exposure to Attenuated Vaccine Strain Brucella abortus RB51 During a Laboratory Proficiency Test Harvey T. Holmes, PhD Chief, Laboratory Response Branch Division Bioterrorism Preparedness and

More information

Brucellosis in Kyrgyzstan

Brucellosis in Kyrgyzstan Centers for Disease Control and Prevention Case Studies in Applied Epidemiology No. 053-D11 Brucellosis in Kyrgyzstan Participant's Guide Learning Objectives After completing this case study, the participant

More information

Organism History Epidemiology Transmission Disease in Humans Disease in Animals Prevention and Control Actions to Take

Organism History Epidemiology Transmission Disease in Humans Disease in Animals Prevention and Control Actions to Take Brucellosis Overview Organism History Epidemiology Transmission Disease in Humans Disease in Animals Prevention and Control Actions to Take The Organism Brucella spp. Gram negative, coccobacilli bacteria

More information

Surveillance of animal brucellosis

Surveillance of animal brucellosis Surveillance of animal brucellosis Assoc.Prof.Dr. Theera Rukkwamsuk Department of large Animal and Wildlife Clinical Science Faculty of Veterinary Medicine Kasetsart University Review of the epidemiology

More information

ESCMID Online Lecture Library. by author

ESCMID Online Lecture Library. by author BRUCELLOSIS Hakan Erdem ESCMID Postgraduate Training Course September 2014, Izmir Presentation Plan The pathogen Epidemiology Transmission Diagnosis Clinical presentation Treatment Outcome HE-2 Aerobic

More information

Jialin Jin Fudan University Huashan Hospital Department of infectious diseases

Jialin Jin Fudan University Huashan Hospital Department of infectious diseases Jialin Jin Fudan University Huashan Hospital Department of infectious diseases Nov. 2014 It is term used as a convenient description for all phases of the disease caused by a bacteria called Brucella.

More information

Medical Bacteriology- Lecture 14. Gram negative coccobacilli. Zoonosis. Brucella. Yersinia. Francesiella

Medical Bacteriology- Lecture 14. Gram negative coccobacilli. Zoonosis. Brucella. Yersinia. Francesiella Medical Bacteriology- Lecture 14 Gram negative coccobacilli Zoonosis Brucella Yersinia Francesiella 1 Zoonosis: A disease, primarily of animals, which is transmitted to humans as a result of direct or

More information

Accidental Exposure to Cattle Brucellosis Vaccines in Wyoming, Montana, and Idaho Veterinarians

Accidental Exposure to Cattle Brucellosis Vaccines in Wyoming, Montana, and Idaho Veterinarians Accidental Exposure to Cattle Brucellosis Vaccines in Wyoming, Montana, and Idaho Veterinarians Kerry Pride, DVM, MPH, DACVPM Brucellosis Meeting April 3, 2013 Veterinary Occupational Exposure 1 needle

More information

The Salmonella. Dr. Hala Al Daghisatni

The Salmonella. Dr. Hala Al Daghisatni 1 Dr. Hala Al Daghisatni The Salmonella Salmonellae are often pathogenic for humans or animals when acquired by the oral route. They are transmitted from animals and animal products to humans, where they

More information

Biological Threat Fact Sheets

Biological Threat Fact Sheets Biological Threat Fact Sheets Anthrax Agent: Bacillus anthracis There are three clinical forms of B. anthracis which are determined by route of entry: Pulmonary or Inhalation BT implications Cutaneous

More information

RELAPSED HUMAN BRUCELLOSIS AND RELATED RISK FACTORS

RELAPSED HUMAN BRUCELLOSIS AND RELATED RISK FACTORS Original Article RELAPSED HUMAN BRUCELLOSIS AND RELATED RISK FACTORS Syed Muhammad Alavi 1, Syed Mohammad Reza Alavi 2, Leil Alavi 3 ABSTRACT Objectives: To determine risk factors of relapse among outpatient

More information

ENTERIC BACTERIA. 1) salmonella. Continuation of the Enteric bacteria : A) We have mentioned the first group of salmonella (salmonella enterica ):

ENTERIC BACTERIA. 1) salmonella. Continuation of the Enteric bacteria : A) We have mentioned the first group of salmonella (salmonella enterica ): Continuation of the Enteric bacteria : ENTERIC BACTERIA 1) salmonella A) We have mentioned the first group of salmonella (salmonella enterica ): Salmonella is an obligate pathogen ; food poisoning due

More information

Central Nervous System Infections

Central Nervous System Infections Central Nervous System Infections Meningitis Treatment Bacterial meningitis is a MEDICAL EMERGENCY. ANTIBIOTICS SHOULD BE STARTED AS SOON AS THE POSSIBILITY OF BACTERIAL MENINGITIS BECOMES EVIDENT, IDEALLY

More information

CHAPTER - I INTRODUCTION

CHAPTER - I INTRODUCTION CHAPTER - I INTRODUCTION Zoonotic infections are infections which are naturally transmitted between vertebrate animals and man, with or without an arthropod intermediate. Zoonotic infections represent

More information

The Brucellae, Yersinia and Leptospira. By : Nader Alaridah MD, PhD

The Brucellae, Yersinia and Leptospira. By : Nader Alaridah MD, PhD The Brucellae, Yersinia and Leptospira By : Nader Alaridah MD, PhD THE BRUCELLAE The brucellae are obligate parasites of animals and humans and are characteristically located intracellularly. They are

More information

Clinical Manifestations and Treatment of Plague Dr. Jacky Chan. Associate Consultant Infectious Disease Centre, PMH

Clinical Manifestations and Treatment of Plague Dr. Jacky Chan. Associate Consultant Infectious Disease Centre, PMH Clinical Manifestations and Treatment of Plague Dr. Jacky Chan Associate Consultant Infectious Disease Centre, PMH Update of plague outbreak situation in Madagascar A large outbreak since 1 Aug 2017 As

More information

Food safety related to camelids products: Brucellosis and its impact on Public Health and the consumers as an example

Food safety related to camelids products: Brucellosis and its impact on Public Health and the consumers as an example DIRECCION GENERAL DE LABORATORIOS Y CONTROL TECNICO Food safety related to camelids products: Brucellosis and its impact on Public Health and the consumers as an example Third Global Conference of OIE

More information

Effective host defense depends mainly upon cell-mediated immunity.

Effective host defense depends mainly upon cell-mediated immunity. Brucella G.G. Alton J.R.L. Forsyth General Concepts Clinical Manifestations Brucellosis is a severe acute febrile disease caused by bacteria of the genus Brucella. Relapses are not uncommon; focal lesions

More information

Classificatie: intern

Classificatie: intern Classificatie: intern Animal Health Service Deventer Jet Mars part 1: Paratuberculosis ParaTB approach In the NL: control program, not an eradication program Quality of dairy products as starting point

More information

I n v e s t i g at i o n o f t h e s p r e a d o f b r u c e l l o s i s a m o n g

I n v e s t i g at i o n o f t h e s p r e a d o f b r u c e l l o s i s a m o n g S u rve i ll a n c e a n d o u t b r e a k r e p o r t s I n v e s t i g at i o n o f t h e s p r e a d o f b r u c e l l o s i s a m o n g h u m a n a n d a n i m a l p o p u l at i o n s i n s o u t

More information

Enteric Bacteria. Prof. Dr. Asem Shehabi Faculty of Medicine University of Jordan

Enteric Bacteria. Prof. Dr. Asem Shehabi Faculty of Medicine University of Jordan Enteric Bacteria Prof. Dr. Asem Shehabi Faculty of Medicine University of Jordan Enteric Bacteria General Characteristics: Gram-ve Bacilli, Facultative Anaerobes, Intestinal Normal Flora.. Humans, Animals,

More information

Guideline for Prevention of Brucellosis in Meat Packing Plant Workers

Guideline for Prevention of Brucellosis in Meat Packing Plant Workers Guideline for Prevention of Brucellosis in Meat Packing Plant Workers Introduction Brucellosis is a disease which may spread from animals to man. There is no evidence for person to person transmission.

More information

EPIDEMIOLOGY OF BRUCELLOSIS IN HIGH RISK GROUP & PUO PATIENTS OF WESTERN RAJASTHAN

EPIDEMIOLOGY OF BRUCELLOSIS IN HIGH RISK GROUP & PUO PATIENTS OF WESTERN RAJASTHAN ORIGINAL ARTICLE. EPIDEMIOLOGY OF BRUCELLOSIS IN HIGH RISK GROUP & PUO PATIENTS OF WESTERN RAJASTHAN Prabhu Prakash 1, Suman Bhansali 2, Ekta Gupta 3, Dinesh Kothari 4, Arvind Mathur 5, Sneha Ambuwani

More information

DISEASE DETECTION OF BRUCELLOSIS IN GOAT POPULATION IN NEGERI SEMBILAN, MALAYSIA. Abstract

DISEASE DETECTION OF BRUCELLOSIS IN GOAT POPULATION IN NEGERI SEMBILAN, MALAYSIA. Abstract 7 th Proceedings of the Seminar in Veterinary Sciences, 27 February 02 March 2012 DISEASE DETECTION OF BRUCELLOSIS IN GOAT POPULATION IN NEGERI SEMBILAN, MALAYSIA Siti Sumaiyah Mohd Yusof, 1,3 Abd. Wahid

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,800 116,000 120M Open access books available International authors and editors Downloads Our

More information

Sentinel Level Laboratory Protocols

Sentinel Level Laboratory Protocols Sentinel Level Laboratory Protocols Melissa Bossie, MT (ASCP), CLS (NCA), M. S. Sentinel Laboratory Training 1 Sentinel Laboratory Training 2 Anthrax Is a zoonotic disease in animals Spores can survive

More information

New Insights into the Treatment of Leishmaniasis

New Insights into the Treatment of Leishmaniasis New Insights into the Treatment of Leishmaniasis Eric Zini Snow meeting, 14 March 2009 Few drugs available for dogs Initially developed to treat human leishmaniasis, later adopted in dogs None eradicates

More information

Federal Expert Select Agent Panel (FESAP) Deliberations

Federal Expert Select Agent Panel (FESAP) Deliberations Federal Expert Select Agent Panel (FESAP) Deliberations FESAP and Biennial Review Established in 2010 and tasked with policy issues relevant to the security of biological select agents and toxins Per recommendations

More information

Coccidioidomycosis Nothing to disclose

Coccidioidomycosis Nothing to disclose Coccidioidomycosis Nothing to disclose Disclosure Greg Melcher, M.D. Professor of Clinical Medicine Division of HIV, ID and Global Medicine Zuckerman San Francisco General Hospital University of California,

More information

Gianluca Russo, MD, PhD. Brucellosis

Gianluca Russo, MD, PhD. Brucellosis Gianluca Russo, MD, PhD Brucellosis Generality Epidemiology of brucellosis - is the most common bacterial zoonosis: > 500.000 new cases annually and prevalence rates in some countries exceeding ten cases

More information

Human brucellosis: An evaluation of antibiotics in the treatment of brucellosis

Human brucellosis: An evaluation of antibiotics in the treatment of brucellosis Postgrad. med. J. (August 1967) 43, 520-526. Human brucellosis: An evaluation of antibiotics in the treatment of brucellosis JoHN RIZZO-NAUDI M.D., B.Sc., M.R.C.P.(Ed.) Lecturer in Medicine, Royal University

More information

Cefazolin vs. Antistaphyloccal Penicillins: The Great Debate

Cefazolin vs. Antistaphyloccal Penicillins: The Great Debate Cefazolin vs. Antistaphyloccal Penicillins: The Great Debate Annie Heble, PharmD PGY2 Pediatric Pharmacy Resident Children s Hospital Colorado Microbiology Rounds March 22, 2017 Image Source: Buck cartoons

More information

Wisconsin Bovine TB Update

Wisconsin Bovine TB Update Wisconsin Bovine TB Update Dr. Darlene Konkle Assistant State Veterinarian Wisconsin Department of Agriculture, Trade and Consumer Protection (DATCP) Division of Animal Health Mycobacterium species M.

More information

Clinical manifestations of brucellosis and leptospirosis

Clinical manifestations of brucellosis and leptospirosis Clinical manifestations of brucellosis and leptospirosis Department of Internal Medicine Division of Infectious Diseases Medical University of Vienna Fever after sexual intercourse admissional status 25-year

More information

64 year old retired male (former millwright)

64 year old retired male (former millwright) Cheryl Main 2013 None! 64 year old retired male (former millwright) Past medical history Type II Diabetes with Chronic Kidney Disease Sjogren s syndrome treated with plaquenil Autoimmune hemolytic anemia

More information

CHALLENGE SET EXERCISE FALL 2008

CHALLENGE SET EXERCISE FALL 2008 CHALLENGE SET EXERCISE FALL 2008 Scenario 1 Fifteen year old female presents to clinic with cat bite to hand. Aerobic wound culture ordered No Gram Stain Organism 1 Characteristics Growth on Blood and

More information

Circular 298 September 1989 Alabama Agricultural Experiment Station Auburn University Lowell T. Frobish, Director Auburn University, Alabama

Circular 298 September 1989 Alabama Agricultural Experiment Station Auburn University Lowell T. Frobish, Director Auburn University, Alabama z SF f. i" f: Y~ c;;; -- Af --- Circular 298 September 1989 Alabama Agricultural Experiment Station Auburn University Lowell T. Frobish, Director Auburn University, Alabama Information contained herein

More information

Tularemia. Information for Health Care Providers. Physicians D Nurses D Laboratory Personnel D Infection Control Practitioners

Tularemia. Information for Health Care Providers. Physicians D Nurses D Laboratory Personnel D Infection Control Practitioners Tularemia Information for Health Care Providers Physicians D Nurses D Laboratory Personnel D Infection Control Practitioners Tularemia Caused by Francisella tularensis, a small, pleomorphic, gram-negative

More information

New Mexico Department of Agriculture

New Mexico Department of Agriculture Veterinary Diagnostic Services New Mexico Department of Agriculture The New Mexico Organic Farming Conference 2018 New Mexico Scientific Laboratories New Mexico Department of Agriculture Veterinary Diagnostic

More information

A collaborative effortan investigation of suspect canine brucellosis

A collaborative effortan investigation of suspect canine brucellosis A collaborative effortan investigation of suspect canine brucellosis NJDOH Regional Epidemiologist: Sonya E. Frontin, MPH Warren County Health Department Public Health Planner: Sarah Perramant, MPH April

More information

Canine Anaplasmosis Anaplasma phagocytophilum Anaplasma platys

Canine Anaplasmosis Anaplasma phagocytophilum Anaplasma platys Canine Anaplasmosis Anaplasma phagocytophilum Anaplasma platys It takes just hours for an infected tick to transmit Anaplasma organisms to a dog. What is canine anaplasmosis? Canine anaplasmosis is a disease

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research   ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Brucellosis! An Unusual Etiology in PUO! Satyajeet K Pawar 1*, M.V. Ghorpade 2, R.D. Totad

More information

Procedures for the Taking of Prevention and Eradication Measures of Brucellosis in Bovine Animals

Procedures for the Taking of Prevention and Eradication Measures of Brucellosis in Bovine Animals Republic of Latvia Cabinet Regulation No. 881 Adopted 18 December 2012 Procedures for the Taking of Prevention and Eradication Measures of Brucellosis in Bovine Animals Issued in accordance with Section

More information

Diabetic Foot Infection. Dr David Orr Consultant Microbiologist Lancashire Teaching Hospitals

Diabetic Foot Infection. Dr David Orr Consultant Microbiologist Lancashire Teaching Hospitals Diabetic Foot Infection Dr David Orr Consultant Microbiologist Lancashire Teaching Hospitals History of previous amputation [odds ratio (OR)=19.9, P=.01], Peripheral vascular disease (OR=5.5, P=.007)

More information

Seroprevalence of Brucellosis and Risk Factors Related to High Risk Occupational Groups in Kazeroon, South of Iran

Seroprevalence of Brucellosis and Risk Factors Related to High Risk Occupational Groups in Kazeroon, South of Iran Original Article Seroprevalence of Brucellosis and Risk Factors Related to High Risk Occupational Groups in Kazeroon, South of Iran S Beheshti, 1 GR Rezaian, 1 F Azad, 1 Z Faghiri, 1 F Taheri 2 Abstract

More information

Antimicrobial Stewardship in Continuing Care. Urinary Tract Infections Clinical Checklist

Antimicrobial Stewardship in Continuing Care. Urinary Tract Infections Clinical Checklist Antimicrobial Stewardship in Continuing Care Urinary Tract Infections Clinical Checklist December 2014 What is Antimicrobial Stewardship? Using the: right antimicrobial agent for a given diagnosis at the

More information

EPIDEMIOLOGY REPORT. Bovine brucellosis: what is going on?

EPIDEMIOLOGY REPORT. Bovine brucellosis: what is going on? EPIDEMIOLOGY REPORT VETERINARY SERVICES October 2016 Volume 8 Issue 10 Bovine brucellosis: what is going on? In the veterinary community, brucellosis is a well-known zoonotic disease and the importance

More information

ANTHRAX. INHALATION, INTESTINAL and CUTANEOUS ANTHRAX

ANTHRAX. INHALATION, INTESTINAL and CUTANEOUS ANTHRAX INHALATION, INTESTINAL and CUTANEOUS ANTHRAX CPMP/4048/01, rev. 3 1/7 General points on treatment Anthrax is an acute infectious disease caused by Bacillus anthracis, that may be infecting man via cutaneous

More information

Tick-borne Disease Testing in Shelters What Does that Blue Dot Really Mean?

Tick-borne Disease Testing in Shelters What Does that Blue Dot Really Mean? Tick-borne Disease Testing in Shelters What Does that Blue Dot Really Mean? 2017 ASPCA. All Rights Reserved. Your Presenter Stephanie Janeczko, DVM, MS, DABVP, CAWA Senior Director of Shelter Medical Programs

More information

Rational management of community acquired infections

Rational management of community acquired infections Rational management of community acquired infections Dr Tanu Singhal MD, MSc Consultant Pediatrics and Infectious Disease Kokilaben Dhirubhai Ambani Hospital, Mumbai Why is rational management needed?

More information

A STUDY ON THE SEROPREVALENCE OF BRUCELLOSIS IN HUMAN AND GOAT POPULATIONS OF DISTRICT BHIMBER, AZAD JAMMU AND KASHMIR ABSTRACT

A STUDY ON THE SEROPREVALENCE OF BRUCELLOSIS IN HUMAN AND GOAT POPULATIONS OF DISTRICT BHIMBER, AZAD JAMMU AND KASHMIR ABSTRACT Din et al. The Journal of Animal and Plant Sciences, 23(1 Suppl.): 2013, J Anim Page: Plant 113-118 Sci, 23(Sup 1): 2013 ISSN: 1018-7081 A STUDY ON THE SEROPREVALENCE OF BRUCELLOSIS IN HUMAN AND GOAT POPULATIONS

More information

Interactive session: adapting to antibiogram. Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe

Interactive session: adapting to antibiogram. Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe Interactive session: adapting to antibiogram Thong Phe Heng Vengchhun Felix Leclerc Erika Vlieghe Case 1 63 y old woman Dx: urosepsis? After 2 d: intermediate result: Gram-negative bacilli Empiric antibiotic

More information

Association between Brucella melitensis DNA and Brucella spp. antibodies

Association between Brucella melitensis DNA and Brucella spp. antibodies CVI Accepts, published online ahead of print on 16 March 2011 Clin. Vaccine Immunol. doi:10.1128/cvi.00011-11 Copyright 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All

More information

Perichondritis: Source: UpToDate Ciprofloxacin 10 mg/kg/dose PO (max 500 mg/dose) BID Inpatient: Ceftazidime 50 mg/kg/dose q8 hours IV

Perichondritis: Source: UpToDate Ciprofloxacin 10 mg/kg/dose PO (max 500 mg/dose) BID Inpatient: Ceftazidime 50 mg/kg/dose q8 hours IV Empiric Antibiotics for Pediatric Infections Seen in ED NOTE: Choice of empiric antibiotic therapy must take into account local pathogen frequency and resistance patterns, individual patient characteristics,

More information

Epidemiology - Animal Tracing Exercise. Gregory Ramos DVM, MPVM Area Epidemiology Officer USDA/APHIS/VS

Epidemiology - Animal Tracing Exercise. Gregory Ramos DVM, MPVM Area Epidemiology Officer USDA/APHIS/VS Epidemiology - Animal Tracing Exercise Gregory Ramos DVM, MPVM Area Epidemiology Officer USDA/APHIS/VS Thanks to. Tanya Beaucaire AHT -- USDA Bill Grigsby AHT USDA Dennis Wilson DVM, MPVM, PhD -- CDFA

More information

Suggested vector-borne disease screening guidelines

Suggested vector-borne disease screening guidelines Suggested vector-borne disease screening guidelines SNAP Dx Test Screen your dog every year with the SNAP Dx Test to detect exposure to pathogens that cause heartworm disease, ehrlichiosis, Lyme disease

More information

Feline zoonoses. Institutional Animal Care and Use Committee 12/09

Feline zoonoses. Institutional Animal Care and Use Committee 12/09 Feline zoonoses Institutional Animal Care and Use Committee 12/09 Cat scratch disease Bacterial infection caused by Bartonella henselae Associated with a cat bite or scratch Infection at point of injury,

More information

Fungal Disease. What is a fungus?

Fungal Disease. What is a fungus? Fungal Disease What is a fungus? A fungus is a living organism. It goes through a complicated life cycle and is able to spread in the environment by producing large numbers of spores that are easily dispersed

More information

Significance of brucellosis in backache patients

Significance of brucellosis in backache patients Original article: Significance of brucellosis in backache patients (1) Dr Ravindra S Mohite, (2)Dr Dhanashree Deshpande, ( 3)Dr V A Kulkarni, (4)Dr Pankaj Joshi, (5)Dr R D Kulkarni, (6) Dr Shilpa Shah,

More information

Welcome to Pathogen Group 9

Welcome to Pathogen Group 9 Welcome to Pathogen Group 9 Yersinia pestis Francisella tularensis Borrelia burgdorferi Rickettsia rickettsii Rickettsia prowazekii Acinetobacter baumannii Yersinia pestis: Plague gram negative oval bacillus,

More information

11-ID-10. Committee: Infectious Disease. Title: Creation of a National Campylobacteriosis Case Definition

11-ID-10. Committee: Infectious Disease. Title: Creation of a National Campylobacteriosis Case Definition 11-ID-10 Committee: Infectious Disease Title: Creation of a National Campylobacteriosis Case Definition I. Statement of the Problem Although campylobacteriosis is not nationally-notifiable, it is a disease

More information

An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009

An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 2009 An Outbreak of Brucella melitensis among Goat Farmers in Thailand, December 29 Vilaiporn Wongphruksasoong 1,*, Santayakorn S 1, Sitthi W 1, Chuxnum T 1, Pipatjaturong N 2, Kunthu A 3, Phuyathon B 4, Prasert

More information

Australian and New Zealand College of Veterinary Scientists. Membership Examination. Small Animal Medicine Paper 1

Australian and New Zealand College of Veterinary Scientists. Membership Examination. Small Animal Medicine Paper 1 Australian and New Zealand College of Veterinary Scientists Membership Examination June 2015 Small Animal Medicine Paper 1 Perusal time: Fifteen (15) minutes Time allowed: Two (2) hours after perusal Answer

More information

HYDATID CYST DISEASE

HYDATID CYST DISEASE HYDATID CYST DISEASE Hydatid disease, also called hydatidosis or echinococcosis, is a cystforming disease resulting from an infection with the metacestode, or larval form, of parasitic dog tapeworms from

More information

Risk Factors for Relapse of Human Brucellosis

Risk Factors for Relapse of Human Brucellosis Global Journal of Health Science; Vol. 8, No. 7; 206 ISSN 96-9736 E-ISSN 96-9744 Published by Canadian Center of Science and Education Risk Factors for Relapse of Human Brucellosis Mohammad Reza Hasanjani

More information

Seroprevalence of human brucellosis in Erbil city

Seroprevalence of human brucellosis in Erbil city Seroprevalence of human brucellosis in Erbil city Received : 10/8/2011 Accepted: 7/1/2012 Dlsoz Kareem Rasul* Isam Yousif Mansoor * Abstract Background and objectives: Brucellosis is an acute or chronic

More information

CLINICAL USE OF AMINOGLYCOSIDES AND FLUOROQUINOLONES

CLINICAL USE OF AMINOGLYCOSIDES AND FLUOROQUINOLONES CLINICAL USE OF AMINOGLYCOSIDES AND FLUOROQUINOLONES Douglas Black, Pharm.D. Associate Professor School of Pharmacy University of Washington dblack@u.washington.edu THE AMINOGLYCOSIDES: 1944-1975 Drug

More information

Salmonella. Serological. Salmonella. food poisoning. Use of pasteurized milk and milk products Improvement of hygiene. Proper storage of foods

Salmonella. Serological. Salmonella. food poisoning. Use of pasteurized milk and milk products Improvement of hygiene. Proper storage of foods Character Habitat Serological Pathogenicity Salmonella food poisoning Salmonella Gram ve facultative anaerobes, non lactose fermenter bacilli Intestinal tracts of humans and animals Salmonella: >1000 species

More information

Surveillance of Brucella Antibodies in Camels of the Eastern Region of Abu Dhabi, United Arab Emirates

Surveillance of Brucella Antibodies in Camels of the Eastern Region of Abu Dhabi, United Arab Emirates Proceedings of the Third Annual Meeting for Animal Production UnderArid Conditions, Vol. 1: 160-166 1998 United Arab Emirates University. Surveillance of Brucella Antibodies in Camels of the Eastern Region

More information

What s Your Diagnosis? By Sohaila Jafarian, Class of 2018

What s Your Diagnosis? By Sohaila Jafarian, Class of 2018 Signalment: Greeley, 3 yo MC DSH Presenting Complaint: ADR History: What s Your Diagnosis? By Sohaila Jafarian, Class of 2018 Patient is an indoor/outdoor cat. Previously healthy and up to date on vaccines

More information

Zoonoses in West Texas. Ken Waldrup, DVM, PhD Texas Department of State Health Services

Zoonoses in West Texas. Ken Waldrup, DVM, PhD Texas Department of State Health Services Zoonoses in West Texas Ken Waldrup, DVM, PhD Texas Department of State Health Services Notifiable Zoonotic Diseases Arboviruses* Anthrax Brucellosis Bovine Tuberculosis Creutzfeldt-Jacob disease (variant)

More information

Disease Outbreak Investigation Protocol: Brucellosis Case Study MONOGRAPH

Disease Outbreak Investigation Protocol: Brucellosis Case Study MONOGRAPH 2. Disease Outbreak Investigation Protocol: Brucellosis Case Study MONOGRAPH Protocol for conducting an outbreak investigation A. Goals for outbreak investigation 1. Stop the occurrence of disease with

More information

Chronic Brucellosis and Persistence of Brucella melitensis DNA

Chronic Brucellosis and Persistence of Brucella melitensis DNA JOURNAL OF CLINICAL MICROBIOLOGY, July 2009, p. 2084 2089 Vol. 47, No. 7 0095-1137/09/$08.00 0 doi:10.1128/jcm.02159-08 Copyright 2009, American Society for Microbiology. All Rights Reserved. Chronic Brucellosis

More information

See Important Reminder at the end of this policy for important regulatory and legal information.

See Important Reminder at the end of this policy for important regulatory and legal information. Clinical Policy: Doxycycline Hyclate (Acticlate, Doryx), Doxycline (Oracea), Minocycline (Solodyn, Ximino) Reference Number: CP.CPA.120 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business:

More information

Public Health Risks in Asia s Growing Dairy Sector

Public Health Risks in Asia s Growing Dairy Sector Public Health Risks in Asia s Growing Dairy Sector Joachim Otte (FAO, Bangkok) Dairy Asia Towards Sustainability Bangkok, Thailand, 22 May 2014 Building Bridges, Supporting Livelihoods Hazards and characteristics

More information

EUROPEAN COMMISSION HEALTH & CONSUMERS DIRECTORATE-GENERAL. Unit G5 - Veterinary Programmes

EUROPEAN COMMISSION HEALTH & CONSUMERS DIRECTORATE-GENERAL. Unit G5 - Veterinary Programmes EUROPEAN COMMISSION HEALTH & CONSUMERS DIRECTORATE-GENERAL Unit G5 - Veterinary Programmes SANCO/10853/2012 Programmes for the eradication, control and monitoring of certain animal diseases and zoonoses

More information

Clinical and therapeutic features of brucellosis: An 11-year study at a tertiary care hospital in Riyadh, Saudi Arabia

Clinical and therapeutic features of brucellosis: An 11-year study at a tertiary care hospital in Riyadh, Saudi Arabia Tropical Biomedicine 34(4): 977 982 (2017) Clinical and therapeutic features of brucellosis: An 11-year study at a tertiary care hospital in Riyadh, Saudi Arabia Somily, A.M. 1, Alahaideb, A. 2, Ridha,

More information

Introduction to Chemotherapeutic Agents. Munir Gharaibeh MD, PhD, MHPE School of Medicine, The university of Jordan November 2018

Introduction to Chemotherapeutic Agents. Munir Gharaibeh MD, PhD, MHPE School of Medicine, The university of Jordan November 2018 Introduction to Chemotherapeutic Agents Munir Gharaibeh MD, PhD, MHPE School of Medicine, The university of Jordan November 2018 Antimicrobial Agents Substances that kill bacteria without harming the host.

More information

How to talk to clients about heartworm disease

How to talk to clients about heartworm disease Client Communication How to talk to clients about heartworm disease Detecting heartworm infection early generally allows for a faster and more effective response to treatment. Answers to pet owners most

More information

Management of Native Valve

Management of Native Valve Management of Native Valve Infective Endocarditis 2005 AHA 2015 Baddour LM, et al. Circulation. 2015;132(15):1435-86 2009 ESC 2015 Habib G, et al. Eur Heart J. 2015;36(44):3075-128 ESC 2015: Endocarditis

More information

Canine and Feline Distemper. Description. The following chart indicates the animals which are susceptible to infection by canine and feline distemp

Canine and Feline Distemper. Description. The following chart indicates the animals which are susceptible to infection by canine and feline distemp Canine and Feline Distemper Description Canine and feline distemper are diseases affecting many wild and domestic carnivo The following chart indicates the animals which are susceptible to infection by

More information

Microbial Hazards in Dairy Industry Ceren Zeytinci

Microbial Hazards in Dairy Industry Ceren Zeytinci Ceren Zeytinci cerenzeytinci@hotmail.com 1 After completing this course, the participants know about the microorganisms that are threating the dairy industry. They are capable of eliminating and preventing

More information

Subacute Adenitis. Ann M. Loeffler, MD

Subacute Adenitis. Ann M. Loeffler, MD Subacute Adenitis Ann M. Loeffler, MD Lymphadenitis Swelling and hyperplasia of sinusoidal lining cells Infiltration of leukocytes +/- abscess formation Granulomatous or non-granulomatous Pyogenic adenitis

More information

Three patients with fever and rash after a stay in Morocco: infection with Rickettsia conorii

Three patients with fever and rash after a stay in Morocco: infection with Rickettsia conorii Three patients with fever and rash after a stay in Morocco: infection with Rickettsia conorii Stylemans D 1, Mertens R 1, Seyler L 1, Piérard D 2, Lacor P 1 1. Department of Internal Medicine, UZ Brussel

More information

A rapid test for evaluating B. melitensis infection prevalence in an Alpine ibex (Capra ibex) reservoir in the French Alps

A rapid test for evaluating B. melitensis infection prevalence in an Alpine ibex (Capra ibex) reservoir in the French Alps European Union Reference Laboratory for Brucellosis A rapid test for evaluating B. melitensis infection prevalence in an Alpine ibex (Capra ibex) reservoir in the French Alps EU Reference Laboratory for

More information

Lyme disease: diagnosis and management

Lyme disease: diagnosis and management National Institute for Health and Care Excellence Final Lyme disease: diagnosis and management [D] Evidence review for the management of erythema migrans NICE guideline 95 Evidence review April 2018 Final

More information

Zoonotic Diseases. Department of Tropical Diseases. Faculty of Veterinary Science. Make today matter

Zoonotic Diseases. Department of Tropical Diseases. Faculty of Veterinary Science. Make today matter Faculty of Veterinary Science Fakulteit Veeartsenykunde Lefapha la Diseanse tša Bongakadiruiwa Zoonotic Diseases Department of Tropical Diseases Make today matter I 3 Anthrax 5 Bovine Tuberculosis 7 Brucellosis

More information

PIGEON FEVER (Corynebacterium pseudotuberculosis Infection)

PIGEON FEVER (Corynebacterium pseudotuberculosis Infection) PIGEON FEVER (Corynebacterium pseudotuberculosis Infection) Definition Clinical Signs Incubation Period Risk Factors Transmission Diagnostic Sampling, Testing and Handling Environmental Persistence Specific

More information

Discuss the reservoirs and vectors of the causative organisms of Lyme disease and other tick-borne

Discuss the reservoirs and vectors of the causative organisms of Lyme disease and other tick-borne Brian S. Murphy, MD, MPH November 5, 2008 40th Annual Family Medicine Review Discuss the reservoirs and vectors of the causative organisms of Lyme disease and other tick-borne diseases Discuss the distribution

More information

EVALUATION AND IMPORTANCE OF SELECTED MICROBIOLOGICAL METHODS IN THE DIAGNOSIS OF HUMAN BRUCELLOSIS

EVALUATION AND IMPORTANCE OF SELECTED MICROBIOLOGICAL METHODS IN THE DIAGNOSIS OF HUMAN BRUCELLOSIS & EVALUATION AND IMPORTANCE OF SELECTED MICROBIOLOGICAL METHODS IN THE DIAGNOSIS OF HUMAN BRUCELLOSIS Maida Šiširak*, Mirsada Hukić Institute of Microbiology, Immunology and Parasitology, University of

More information

INVESTIGATING EFFICIENCY OF PCR METHOD IN DIAGNOSIS OF BRUCELLOSIS, COMPARING TO SEROLOGIC METHODS

INVESTIGATING EFFICIENCY OF PCR METHOD IN DIAGNOSIS OF BRUCELLOSIS, COMPARING TO SEROLOGIC METHODS ISSN: 0976-2876 (Print) ISSN: 2250-0138(Online) INVESTIGATING EFFICIENCY OF PCR METHOD IN DIAGNOSIS OF BRUCELLOSIS, COMPARING TO SEROLOGIC METHODS HOJAT AHMADI a, EHSAN HOSSEINI b1, KEYVAN HOMAYONIKEYSAMI

More information

Septicaemia Definitions 1

Septicaemia Definitions 1 Septicaemia Definitions 1 Term Definition Bacteraemia Systemic Inflammatory response (SIRS) Sepsis Bacteria that can be cultured from the blood stream The systemic response to a wide range of stresses.

More information

Gastric Dilatation-Volvulus

Gastric Dilatation-Volvulus Gastric Dilatation-Volvulus The term "ACVS Diplomate" refers to a veterinarian who has been board certified in veterinary surgery. Only veterinarians who have successfully completed the certification requirements

More information

EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH

EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH ejpmr, 2018,5(6), 642-646 EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH www.ejpmr.com SJIF Impact Factor 4.897 Research Article ISSN 2394-3211 EJPMR KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) ASSOCIATED

More information

Abortions and causes of death in newborn sheep and goats

Abortions and causes of death in newborn sheep and goats Abortions and causes of death in newborn sheep and goats Debrah Mohale What is abortion? Abortion is the result of a disturbance in the functioning of the afterbirth (placenta). This causes the premature

More information