Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences. GENO Breeding and A. I. Association, Ås, NORWAY

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1 Session CG.2.7. Coesponding autho: Bjøg Heingstad, Genetic coelations between clinical mastitis, milk feve, ketosis, and etained placenta within and between the fist thee lactations of Nowegian Red (NRF) Bjøg Heingstad,2, Yu-Mei Chang 3, Daniel Gianola,3 and Gunna Klemetsdal Depatment of Animal and Aquacultual Sciences, Nowegian Univesity of Life Sciences 2 GENO Beeding and A. I. Association, Ås, NORWAY 3 Depatment of Daiy Science, Univesity of Wisconsin, Madison, USA 56 th Annual meeting of the EAAP, Uppsala, Sweden, June 5-8, 25 Commission on Animal Genetics, Session: Functional taits in cattle, CG.2.7.

2 Intoduction Clinical mastitis (CM), milk feve (MF), ketosis (KET), and etained placenta (RP) ae among the most fequent diseases affecting daiy cattle Of all veteinay teatments in daiy cows (Noway 23): 44% CM, 9% MF, 9% KET, and 5 % RP Seveal studies have epoted heitability estimates but vey few studies of the genetic associations between these diseases

3 Objective Infe heitability and genetic coelations between CM, MF, KET, and RP within and between the fist thee lactations of Nowegian Red (NRF)

4 Data Daughtes of 24 NRF sies Pogeny-tested Fist-cop daughtes only Fist calving in hed-5-yea classes with at least fistlactation cows Recods of 372,227 cows of which 247,692 had a 2 nd lactation, and 47,5 had a 3 d lactation

5 Data Fo each cow, all cases of veteinay teated CM, MF, KET, and RP in the fist thee lactations wee included. Within each lactation, absence o pesence of each of the fou diseases was scoed as o, espectively, based on whethe o not the cow had at least one veteinay teatment ecoded in the inteval: -5 to 2 d fo CM and KET -5 to 3 d fo MF to 5 d fo RP

6 Table. Mean fequency of clinical mastitis (CM), milk feve (MF), ketosis (KET) and etained placenta (RP), by lactation. st lactation 2 nd lactation 3 d lactation No of cows 372, ,692 47,5 Mean CM fequency, % Mean MF fequency, % Mean KET fequency, % Mean RP fequency, %

7 Methods Bayesian appoach using MCMC methods A 2-vaiate (3 lactations 4 diseases) theshold liability model assuming that each disease was a diffeent tait in each lactation Same model as used in Heingstad et al., 24. J. Daiy Sci. 87:

8 = X + Model Z h + Z s + h s whee λ : a vecto of the unobseved liabilities; he β : a vecto of systematic effects (season y of calving and age at calving ( st lact.), mo y of calving and calving inteval (2 nd and 3 d lact)); h : a vecto of hed-5-yea effects; s : a vecto of sie tansmitting abilities; e : the vecto of esidual effects; and X, Z h, and Z s : the coesponding incidence matices e

9 Residuals wee coelated within lactation and independent between lactations: ), ( ~ I R e N =,2,2, 9,2 9, 9, 7,8 6,8 6,7 5,8 5,7 5,6 3,4 2,4 2,3,4,3,2 R

10 Pios Independent pope unifom pios assigned to each element of β Multivaiate nomal pios assigned to effects of hed-5-yea and sie tansmitting abilities: h ~ N (, H I)) s ~ N(, G A) Invese Wishat pio distibutions used fo the 2 2 (co)vaiance matices of hed-5-yea (H ) and sie effects (G ) Bounded unifom pios assigned to non-zeo esidual coelations

11 Results Heitability Posteio means: CM: MF: KET: RP:.8 Posteio SD:.5.2

12 35 Posteio distibutions of heitability of liability to 35 CM CM2 CM3,3,4,5,7,8,9,,,3,4,5,6,7,9,2,3,4,5,7,8,9,,,3,4,5,6,7,9,2 35 Heitability Heitability 35 KET KET2 KET3 MF MF2 MF3,3,4,5,7,8,9,,,3,4,5,6,7,9,2,3,4,5,7,8,9,,,3,4,5,6,7,9,2 Clinical mastitis Milk feve Ketosis Retained placenta Heitability Heitability RP RP2 RP3

13 Posteio distibutions of heitability of liability to clinical mastitis (CM), milk feve (MF), ketosis (KET), and etained placenta (RP) in fist lactation 35 CM MF KET RP,3,4,5,7,8,9,,,3,4,5,6,7,9,2 Heitability

14 Genetic coelations Table 2. Posteio means of genetic coelations between liability to clinical mastitis (CMi), milk feve (MFi), ketosis (KETi), and etained placenta (RPi) in the fist thee lactations (i=, 2, 3) MF KET RP CM2 MF2 KET2 RP2 CM3 MF3 KET3 RP3 CM MF KET RP CM MF KET RP CM MF KET3 -.5 Bold blue indicate genetic coelations between the same disease in diffeent lactations Italic indicate that posteio mean - 2SD <

15 Genetic coelations within disease between lactations Clinical mastitis Milk feve -,45 -,33 -,2 -,9,3,5,27,39,5,63,75,87 -,45 -,33 -,2 -,9,3,5,27,39,5,63,75,87 Genetic coelation Genetic coelation CM-CM2 CM-CM3 CM2-CM3 MF-MF2 MF-MF3 MF2-MF3 Ketosis Retained placenta -,45 -,33 -,2 -,9,3,5,27,39,5,63,75,87 -,45 -,33 -,2 -,9,3,5,27,39,5,63,75,87 Genetic coelation Genetic coelation KET-KET2 KET-KET3 KET2-KET3 RP-RP2 RP-RP3 RP2-RP3 Figue 6. Posteio distibutions of the genetic coelations between liability to clinical mastitis (CMi), milk feve (M Fi), ketosis (KETi), and etained placenta (RPi) in lactation i=,

16 Genetic coelations between diseases Taits Range posteio means CM-MF CM-KET CM-RP MF-KET MF-RP KET-RP Highest KET-MF2:.4 Lowest MF-RP3: -.

17 Genetic coelations Posteio means ange fom. to.86 Highe within disease between lactations than between diseases Genetic coelations suggest: MF diffeent tait in fist and late lactations KET may be consideed the same tait in all thee lactations All genetic coelations between RP and othe diseases wee small Genetic coelations involving MF had high SD

18 Genetic coelations Low o modeate genetic coelations between diseases (fom. to.4) Vey diffeent diseases CM is an infection of the udde MF and KET ae metabolic diseases RP is a fetility disode All genetic coelations that could be consideed to be diffeent fom wee positive thee may exist some geneal disease esistance o obustness with a genetic component

19 Heingstad, B., Y. M. Chang, D. Gianola, and G. Klemetsdal. 25. Genetic analysis of Clinical Mastitis, Milk Feve, Ketosis, and Retained Placenta in the fist thee lactations of Nowegian Red (NRF) cows with a Multivaiate Theshold Model. Jounal of Daiy Science (accepted).

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