August 2015 CURRICULUM VITAE

Transcription

1 Robert M. Jacobs, DVM, PhD Diplomate ACVP Professor Emeritus Department of Pathobiology Ontario Veterinary College University of Guelph Guelph, Ontario Canada N1G 2W1 Phone , ext Mobile August 2015 CURRICULUM VITAE Degrees Specialist in Veterinary Pathology, Canadian Veterinary Medical Association, 1982 Diplomate, Board Certification, American College of Veterinary Pathologists, 1981 PhD, Experimental Pathology, Department of Pathology, University of Guelph, Ontario, 1980 DVM, Veterinary Medicine, University of Guelph, Ontario, 1976 BSc, General Science, University of Toronto, 1972 Employment Professor Emeritus, Retired Sep 2016 Chair, Department of Pathobiology, Ontario Veterinary College, University of Guelph, Sep 2008 to Aug 2013 see below for details Assistant Dean Research and Graduate Affairs, Ontario Veterinary College, University of Guelph, Jan 2005 to May 2008 see below for details -1-

2 Full Professor and member of the Graduate Faculty, Department of Pathology/Pathobiology, Ontario Veterinary College, University of Guelph, May 1994 to present Associate Professor and member of the Graduate Faculty, Department of Pathology, Ontario Veterinary College, University of Guelph, Sep 1985 to Apr 1994 Assistant Professor and member of the Graduate Faculty, Department of Pathology, College of Veterinary Medicine, The Ohio State University, Jan 1980 to Sep1985 Honours 1999, Teacher of the Year, Students of the Canadian Veterinary Medical Association 1999, Distinguished Teacher Award, Pfizer/Carl J. Norden , Adjunct faculty, The Ohio State University, College of Veterinary Medicine 1978, Commonwealth Bureau of Animal Health Prize 1978, Charles Louis Davis Foundation Scholarship in Veterinary Pathology , Medical Research Council Fellowship Memberships International Society for Animal Clinical Biochemistry Canadian Veterinary Medical Association Licensed Veterinarian, College of Veterinarians of Ontario American Society for Veterinary Clinical Pathology International Academy of Pathology American College of Veterinary Pathologists Veterinary Cancer Society -2-

3 Sigma Xi Conference of Research Workers in Animal Disease Details - Chair, Department of Pathobiology (Sep 2008 to Aug 2013) Represent the Department within the College and broader University in all research, teaching, and service activities, 26 faculty, 4 administrative staff, 20 research/technical staff, 70 graduate students in Diploma, MSc, DVSc, and PhD programs, approximately $4 million annual research funding, annual departmental budget outside of research including salaries approximately $12 million. Meet with all faculty members annually regarding promotion and tenure and lead the departmental meetings making recommendations to the college committee. Internal review of the department s undergraduate teaching program. Successful review. External review of the department s graduate & research programs by the Ontario Council of Graduate Studies. Hosting of external reviewers. Very complimentary review. Completed the design phase of the new Pathobiology AHL building ($65 million) started by the previous Chair and orchestrated the implementation phase (approximately 1 year). Worked with faculty and staff to choose, order and put in place new equipment (approximately $2 million). Lead the move and settling-in of approximately 400 individuals to the new building. Took an additional 2 years of effort to work with engineers, contractors, and architects to overcome building deficiencies. Worked closely with the AHL Director to resolve many building issues. Conceived and initiated Pathobiology s Poultry Health Research Network (PHRN). Transitioned the leadership of this program to Dr. S. Sharif, a prominent poultry immunologist/virologist. The PHRN is a College initiative and has start-up funds to further build the program. Wrote the text for departmental programs for the Program Prioritization Process (PPP). University-wide program aimed at rating academic and non-academic programs/units. Member College Curriculum Review Committee -3-

4 Produce research, graduate student, teaching reports for the College and University. Recruited and hired 4 new faculty members. Member of Dean s Council. Details - Assistant Dean Research and Graduate Affairs (Jan 2005 May 2008) Represent the College in all research matters including animal care, approximately 100 faculty, research support staff, and up to 300 graduate students in Diploma, MSc, DVSc and PhD programs, approximately $15 million annual research funding Liaise with Dean, other College Assistant Deans, Department Chairs, and Department Graduate Co-ordinators Administer College-wide interdepartmental Doctor of Veterinary Science (DVSc) graduate program Attend DVSc qualifying examinations, read theses and attend final defenses (approximately 40/year), Established a more uniform program across college departments and standardized the assessment Administer the College Graduate Fellowship program Administer Summer Leadership and Research Program (SLRP) in conjunction with Merck Merial Scholars Program Schofield Lecture in conjunction with Graduate Student Research Day Chappel Lecture Manage annual or twice annual Pet Trust competition for research funding. Doubled the annual amount of research funding available to researchers through Pet Trust. Chair Magnetic Resonance Imaging Management Committee Member Laboratory for Translational Biomedical Discovery Management Committee Member Research Services Committee under the direction of Associate Vice President Research, biweekly meetings -4-

5 Member Advanced Analysis Centre Management Committee Member Equine Guelph Board Pet Trust Board Member Member of Dean s Council Produce research summaries for Pet Trust advancement Produce Ontario Council for Graduate Studies report, host external reviewers, formulation College response resulting in a strong approval for the continuation of the DVSc program Participate on faculty search committees, attend seminars, meet with candidates Read OR-5 and review grants, signatures Attend University/OMAFRA executive meetings Annual Veterinary Continuing Education Program reports Liaise and report generation, projections for Graduate Program Services and Graduate Studies Dean used for reporting research activity to governmental agencies and maintaining graduate funding going forward Administer programs for summer studentships in conjunction with URAs and USRAs Graduate Students (degree, thesis title, year completed, employment) for which I was Graduate Advisor or Co-Advisor 1. Michal Neta (PhD). Pathogenesis of canine histiocytic proliferative disease (diagnostic pathologist, private sector, Brighton, UK) 2. Gerardo Quiroz-Rocha (DVSc). Disease prediction based upon blood biochemical analysis of dairy cattle in the transition period (university professor, Mexico City) 3. Masako Mizuno (Diploma). Clinical Pathology. Analysis of the cytological data from adult dogs with chest masses (veterinary practice, private sector, Vancouver, BC) -5-

6 4. Sonya Keller (DVSc). Pathogenesis of type 2 BVDV infection in cattle (diagnostic pathologist, private sector, Markham, Ontario) 5. Marianne Van Den Heuvel (PhD). Regulation of expression of bovine leukemia virus (post-doctoral fellow, research scientist, London, Ontario) 6. Paula Krimer (DVSc). Assessment of relevance of various isoenzymes of alkaline phosphatase in dogs (institutional diagnostic pathologist, Georgia, US) 7. Darren Wood (DVSc). Pathogenesis of type 2 BVDV infections in cattle (university professor, Ontario) 8. Jatain Sondhi (Diploma). Clinical Pathology. Retrospective analysis of polyarthritis in the dog (veterinary practice, private sector, California, US) 9. Oliver Trochta (MSc). Immunohistochemical and gene expression of basic-fgf in canine hemangiosarcoma (chiropractor, private sector, Ontario) 10. Einar Jorundsson (Diploma). Clinical Pathology. Special staining and morphometry in neoplasia (university professor, Norway/Iceland) 11. Krystyna Grodecki (DVSc). Hereditary Nephritis Biochemistry (diagnostic pathologist, private sector, Ontario) 12. Malcolm Gains (DVSc). Hereditary Nephritis Morphometry (diagnostic pathologist, private sector, Quebec) 13. Dorothee Bienzle (MSc). Retorviral Vector Bone Marrow (university professor, Ontario) 14. Helen Smith (MSc). Bovine immunodeficiency virus in sheep (research scientist, private sector, Iowa) 15. Judith Taylor (DVSc). Factors affecting bovine leukemia virus expression (diagnostic pathologist, private sector, Ontario) 16. Mary Schnurr (MSc). Karyotypic analysis of bovine lymphomas (animal care technician, Ontario) 17. William Vernau (DVSc). Immunophenotypes and morphometry in bovine lymphomas (university professor, California) -6-

7 18. Barbara Kalow (DVSc). Lymphocyte calcium metabolism Roger Ellison (MSc). Alkaline phosphatase isoenzymes in the horse (diagnostic pathologist, private sector, New Zealand) 20. Catherine Rae (Diploma). Clinical Pathology (veterinary specialist, private sector, Ontario) 21. Robert Murtaugh (MSc). Canine isoamylases (internal medicine specialist and corporate veterinary practice management, US) -7-

8 Teaching - Contact Hours Academic Year Number of Courses Contact Hours Lecture Lab Clinical Grad Diagnostic Pathology Total

9 Undergraduate Course Participation Principles of Disease Systems Pathology Health Management Phase 4 Rotation Graduate Course Participation Applied Clinical Pathology I Applied Clinical Pathology II Applied Clinical Pathology III Special Topics in Pathobiology Clinical Pathology II Clinical Pathology I Pathophysiology in Small Animal Surgery Mechanisms of Disease Research Grants Years Source Title PI (if not R. Jacobs) 2011/12 Pet Trust Immunofluorescent and confocal analyses of granule polarization In canine histiocytic diseases Am t/yr 14, /06 OMAFRA, Livestock Research Fund research including operating, technical support, animals & per diem, Use of BVDV isolates of known virulence in studies aimed at evaluating their potential as vaccines and to elucidate the mechanisms causing characteristic hematological changes 62, /03 Canadian Institute of research including operating, technical support, animals & per P. Thorner 112,381-9-

10 Health Research 1998/99 OMAFRA, Livestock Research Fund diem, Gene therapy in X-linked Alports Syndrome research including operating, technical support, animals & per diem, Pathogenesis of Type II BVDV infections 57, /98 Pet Trust Search for retroviruses in canine granulomatous meningoencephalitis 5, /98 Pet Trust and Boehringer Mannheim Corp. Interferences caused by lipemia, hemoglobinemia, and bilirubinemia on 18 serum analytes determined on the Hitachi 911 automated chemistry analyzer in four animal species 7, /99 Dairy Farmers of Canada and NSERC Characterization of virulence factors in Type II BVDV by the formation of chimeras 1996/97 OMAFRA Prevalence, determined by serology and proviral detection, of BIV in bulls 1996/97 OMAFRA Characterization of plasma factors blocking the expression of bovine leukemia virus 1996/97 Pet Trust Establishment of canine hemangiosarcoma cell lines and expression of FGF receptor 60,000 5,000 5,000 6, /98 Medical Res. Council of Canada Gene therapy in X-linked canine hereditary nephritis P. Thorner 65, /96 OMAFRA BIV in bull studs in Ontario 4, /96 OMAFRA Plasma blocking factor in cattle 4, /95 Hills Pet Nutrition, Inc 1994/96 Canadian Association of Animal Support for canine colony for hereditary nephritis studies Prevalence studies of BIV in dairy bulls 26,000 4,

11 Breeders 1994/98 NSERC Operating 1993/94 NSERC Operating Characterization of plasma blocking factor Interaction of Bovine Retroviruses in the Production of Disease 20,000 20, /93 Ontario Milk Marketing Board 1992/93 Ontario Milk Marketing Board Development and validation of a herd level BLV testing program Identification of factors important in resistance to the development of chronic S. aureus mastitis in dairy cows D. Kelton 10,000 K. Leslie 8, /93 Pet Trust Effects of an ACE-inhibitor on the development of renal failure 1992/93 Pet Trust A pilot study attempting to demonstrate retroviral sequences in canine lymphomas using PCR with primers crossreactive with known mammalian retroviruses 1991/94 Medical Res. Council of Canada Renal disease in Samoyed dogs as a model for human x-linked hereditary nephritis 1991/92 Pet Trust Effects of hypotension on the development of Samoyed hereditary glomerulopathy 3,500 5,300 R. Baumal 278,513 5, /92 NSERC Strategic, Livestock Research Fund Pathogenesis of bovine immunodeficiency-like virus in a sheep model 60, /90 Univ. of Guelph Research Enhancement Fund Development of a serological test and DNA probe for the detection of bovine immunodeficiency-like virus-infected cattle 30, /89 Ontario Milk Development of a serological test 5,

12 Marketing Board, Dean's Award for the detection of bovine immunodeficiency-like virusinfected cattle 1988/89 Medical Res. Council of Canada, Dean s Discretionary Funds 1987/90 NSERC Operating 1987/90 Ontario Ministry of Agriculture and Food Renal disposition of canine amylase, lipase, and lysozyme. Prevalence and pathogenetic significance of genetic variants of Bovine Leukemia Virus. Host target cell characteristics and viral genetic variation in the pathogenesis of Bovine Leukemia Virus-Associated syndromes. 3,400 72, , /88 Univ. of Guelph Research Excellence 1987/88 Agriculture Can. Dean's Discretionary Fund 1986/87 Canadian Veterinary Research Trust Fund 1986/87 Univ of Guelph Research Board 1986/87 American Animal Hospital Association Restriction endonuclease analysis of Bovine Leukemia Virus genetic variants. Isoelectric focusing of alkaline phosphatase from equine tissues and sera. Canine isoamylases in the discrimination of pancreatic and non-pancreatic diseases. Pancreatic specificity of canine isoamylases. A comparative study of efficacy and deleterious effects associated with various immunosuppressive therapies for primary Coombs positive anemias 26,000 4,000 8,500 10,000 US 10,

13 1986/87 Univ. of Guelph President's Special Fund 1985/86 American Animal Hospital Association 1985/86 Ohio State Univ. Canine Res. Fund 1985/86 Ohio State Univ. Canine Res. Fund 1985/86 Canine Res. Fund 1984/85 Canine Res. Fund High performance liquid chromatography system for Departments of Pathology and VMI A micro-elisa procedure for platelet associated IgG. Serum calcium fractions in normal dogs and dogs with renal failure. In vitro staining of canine parathyroid gland & pancreatic tissues with intravenous methylene blue. Studies on canine isoamylases: 1. Proof of specificity of isoamylase-3 for canine pancreas, 2. Heat lability of canine isoamylase. Lithium as a myeloprotective agent during anticancer chemotherapy in the normal dog. 10,000 US 9,900 D. Chew US 7,414 D. Smeak US 7,489 US 6,720 C. Couto US 7, /85 Glenn Barber Res. Foundation 1984/85 Univ. Seed Grant 1984 Equine Res. Fund 1983/84 Canine Res. Fund 1982/83 Equine Res. Fund Isoamylase changes in the dog associated with diseases other then pancreatitis. The distribution and binding affinity of lectins in normal and neoplastic tissues from dogs. Transient iron deficiency in foals and RBC-G6PD as an index of erythroid turnover in foals. Detection of retrovirus in canine lymphoma. Platelet aggregation in the horse. Effects of non-steroidal antiinflammatory drugs. US 5,600 US 5,000 C. Kohn US 15,000 G. Kociba US 7,500 US 5,

14 1982/83 Canine Res. Fund 1982/83 Canine Res. Fund Experimental pancreatitis and isoamylase changes in the dog. Isoamylases in clinically normal and diseased dogs. US 7,500 US 2,000 PUBLICATIONS: Life-time summary (count) according to the following categories: - Books and book chapters Letters, Notes and Short Communications in Refereed Journals.12 - Papers in refereed journal Papers in refereed conference proceedings Abstracts and/or papers read Invited presentations at professional meetings and continuing education.55 Books and book chapters 1. Valli, V. E. O. and Jacobs, R. M. Structure, Function, and Disorders of Lymphoid Tissue. In Schalm s Veterinary Hematology, 6 th edition, Lea & Febiger. pp Jacobs, R. M. Chapter reviewer: Normal and benign reactive hematopoietic tissues. In Veterinary Comparative Hematopathology by V. E. Valli. Blackwell Publishing Meuten D, Thomson K, Jacobs RM. Urinary tract tumors of domestic animals. Armed Forces Institute Pathology in cooperation with the American Registry of Pathology and The World Health Organization Collaborating Center for Comparative Oncology Valli, V. E., R. M. Jacobs, A. L. Parodi, W. Vernau. Histological classification of hematopoietic tumors of domestic animals. Armed Forces Institute of Pathology in cooperation with the American Registry of Pathology and The World Health Organization Collaborating Center for Comparative Oncoloy Valli, V. E. and R. M. Jacobs. Structure and function of the hemopoietic system. In: Schalm s Veterinary Hematology, 5 th edition, Lea & Febiger

15 6. Jacobs, R. M., V. E. Valli, and J. B. Messick. Tumors of the hemolymphatic system. In: Moulton s Tumors in Domestic Animals, 4 th edition. University of California Press Jacobs, R. M., J. H. Lumsden, J. A. Taylor. Canine and feline reference values. Current Veterinary Therapy XIII, W. B. Saunders Co., Philadelphia, pp , Jacobs, R.M., B. Jefferson, and D. Suarez. Prevalence, determined by serology and proviral detection, of bovine immunodeficiency-like virus (BIV) in bulls. Dairy Research Report sponsored by OMAFRA and Agriculture and Agri-Food Canada, University of Guelph, May Jacobs, R. M. Applying cytology in your practice: when to use it, getting the sample, the cytological approach to getting an answer. Proceedings of the World Small Animal Veterinary Association, Jerusalem, October, Jacobs, R. M. Lesions the practitioner can confidentally identify using cytology and Ahow to communicate with your pathologist@. Proceedings of the World Small Animal Veterinary Association, Jerusalem, October, Grodecki, K.M. M.J. Gains and R.M. Jacobs. The effect of an angiotensin converting enzyme inhibitor on the progression of Samoyed Hereditary Glomerulonephritis. Pet Trust Clinical Factsheet, University of Guelph, May, Jacobs, R.M., Lumsden, J.H. and W. Vernau. Canine and feline reference values. Current Veterinary Therapy XII, Jacobs R., H.E. Smith, C.A Whetstone, D.L. Suarez and B. Jefferson. Hematological and lymphocyte subset analyses in sheep inoculated with bovine immunodeficiency-like virus. Dairy Research Report sponsored by OMAFRA and Agriculture and Agri-Food Canada, University of Guelph, May Jacobs, R.M., W.B. McNab, F.L. Pollari and B. Jefferson. A serological survey of bovine syncytial virus in Ontario: Associations with bovine leukemia and immunodeficiency-like viruses, production records, and management practices. Dairy Research Report, University of Guelph, May Jacobs, R.M., Z. Song, H. Poon, J.L. Heeney, J.A. Taylor, B. Jefferson, W. Vernau and V.E.O. Valli. Proviral detection and serology in bovine leukemia virus-exposed normal cattle and cattle with lymphoma. Dairy Research Report, Univeristy of Guelph, May,

16 16. Jacobs, R.M., H.E. Smith, B. Gregory, V.E.O. Valli and C.A. Whetstone. Detection of multiple retroviral infections in cattle and cross-reactivity of bovine immunodeficiency-like virus and human immunodeficiency virus type 1 proteins using bovine and human sera in a Western blot assay. Dairy Research Report, Univeristy of Guelph, May, Jacobs, R.M., J.L. Heeney, M.A. Godkin, K.E. Leslie, J.A. Taylor, C. Davies and V.E.O. Valli. Production and related variables in bovine leukemia virus-infected cows. Dairy Research Report, Univeristy of Guelph, May, McNab, W.B., R.M. Jacobs and H.E. Smith. A serological survey for bovine immunodeficiency-like virus in Ontario dairy cattle and associations between test results, production records, and management practices. Dairy Research Report, Univeristy of Guelph, May, Jacobs, R.M. Evaluation of hepatocyte integrity and hepatic function. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M. Water, electrolyte, and acid-base disorders. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M. Renal system: glomerular and tubular function. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M. Anemia - Diagnostic approach and classification. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M. Leukocyte changes in non-neoplastic diseases. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M. Cytology for the practitioner. Clinical Pathology: A Symposium for Veterinarians, Post Graduate Committee in Veterinary Science, University of Sydney, February, Jacobs, R.M., Lumsden, J.H. and W. Vernau. Canine and feline reference values. Current Veterinary Therapy XI,

17 26. Jacobs, R.M., J.H. Lumsden and E. Grift. Evaluation of interferences in non-human specimens. "Towards Perfection in Clinical Chemistry Analyses. Reducing the Impact of Non-specific Results Due to Interferences" by M.R. Glick, K.W. Rider, December Jacobs, R.M. Hyperglycemia and hypoglycemia. Small Animals Medicine, ed. D.G. Allan, J.B. Lippincott Co., Philadelphia, Jacobs, R.M. Interpretation of serum titers. Small Animal Medicine, ed. D.G. Allan, J.B. Lippincott Co., Philadelphia, Jacobs, R.M. Anemia. Small Animal Medicine, ed. D.G. Allan, J.B. Lippincott Co., Philadelphia, Jacobs, R.M. Polycythemia. Small Animal Medicine, ed. D.G. Allan, J.B. Lippincott Co., Philadelphia, Veterinary Teaching Hospital Manual - Clinical Pathology Section. Updated annually. 32. Jacobs, R.M. (Guest Editor). Cytology of the Dog and Cat. Seminars in Veterinary Medicine and Surgery (Small Animal). Grune and Stratton, Couto, C.G. and R.M. Jacobs. Disorders of Leukocytes and Leukopoiesis. In The Cat: Diseases and Clinical Management. ed. R. Sherding. Churchill Livingstone, New York, 1989, pp Jacobs, R.M Bovine lymphoma. In Comparative Pathobiology of Viral Diseases, eds. R. Olsen, S. Krakowka, J. Blakeslee. CRC Reviews, Baton Rouge, pp Jacobs, R.M. and R.L. Hall. Bovine lymphoma: A self-instructional program. Division of Educational Resources, College of Veterinary Medicine, The Ohio State University, 1935 Coffey Road, Columbus, OH Letters, Notes and Short Communications in Refereed Journals 1. Jacobs, R.M., J. Gross-Sobol, E. Grift, and J.H. Lumsden. Cost cutting: A false economy. Canadian Veterinary Journal, April, Jacobs, R.M. Commercial kit for prothrombin time. Advances in Small Animal Medicine and Surgery, 9:4-6,

18 3. Rand, J.S., J. Parent and R.M. Jacobs. Reference intervals for feline CSF. Journal of Veterinary Internal Medicine, 3: 118, Rand, J.S., J. Parent and R.M. Jacobs. CSF analysis in 61 cats with CNS disease. Journal of Veterinary Internal Medicine, 3: 118, Jacobs, R.M. Quantitative buffy coat analysis. Advances in Small Animal Medicine and Surgery, 1: 1-2, Jacobs, R.M. The Coombs' test in canine immune hemolytic anemia (letter). Compendium Small Animal Medicine, July Jacobs, R.M. Ophthalmologic Cytology. Seminars in Veterinary Medicine and Surgery (Small Animal). May Jacobs, R.M. Amylase in canine salivary gland (letter). Research Communications Chemical Pathology and Pharmacology. March Jacobs, R.M. Experimental canine pancreatitis (letter). Journal American Animal Hospital Association 22: 147, Jacobs, R.M. and M.L. Wellman. Canine serum alkaline phosphatases (note). Journal Veterinary Clinical Pathology 24: 4, Jacobs, R.M. and R.J. Murtaugh. Comments on isoamylases (letter). American Journal Veterinary Research 46: , Hayes, T. and R.M. Jacobs. Myoglobinuria in the horse (letter). Compendium Continuing Education 7: , 1985 Papers in refereed journals 1. Quiroz-Rocha GF, S LeBlanc, T Duffield, B Jefferson, D Wood, KE Leslie and RM Jacobs. Short Communication: Effect of sampling time relative to the first daily feeding on interpretation of serum fatty acid and betahydroxybutyrate concentrations in dairy cattle. Journal of Dairy Science 93: , Quiroz-Rocha GF, S LeBlanc, T Duffield, B Jefferson, D Wood, KE Leslie and RM Jacobs. Reference limits for biochemical and hematological analytes of dairy cows one week before and one week after parturition. Canadian Veterinary Journal 50: 383-8, Quiroz-Rocha GF, S LeBlanc, T Duffield, D Wood, KE Leslie and RM Jacobs. Evaluation of prepartum serum cholesterol and fatty acid -18-

19 concentrations as predictors of postpartum retention of the placenta in dairy cows. Journal American Veterinary Medical Association 234: 790-3, Bartleman AP, Jacobs R, Kirkland JB. Niacin supplementation decreases the incidence of alkylation-induced nonlymphocytic leukemia in Long- Evans rats. Nutrition and Cancer 60: 251-8, VanDenHeuvel M, Copeland KF, Cates EC, Jefferson B, Jacobs RM. Defibrinated bovine plasma inhibits retroviral transcription by blocking p52 activation of the NfkappaB element in the long terminal repeat. Canadian Journal of Veterinary Research, 71: , Whiteside DP, Barker IK, Conlon PD, Tesoro A, Thiessen JJ, Mehren KG, Jacobs RM, Spino M. Pharmacokinetic disposition of the oral iron chelator deferiprone in the domestic pigeon (Columbia livia). Journal Avian Medicine Surgery. 21: 121-9, Whiteside DP, Barker IK, Conlon PD, Tesoro A, Thiessen JJ, Mehren KG, Jacobs RM, Spino M. Pharmacokinetic disposition of the oral iron chelator deferiprone in the white leghorn chicken. Journal Avian Medicine Surgery. 21: , Perry J, Ho M, Viero S, Zheng K, Jacobs R, Thorner PS. The intermediate filament nestin is highly expressed in normal human podocytes and podocytes in glomerular disease. Pediatric and Developmental Pathology. 10: , Harvey SJ, Perry J, Zheng K, Chen D, Sado Y, Jefferson B, Jacobs R, Thorner PS. Type IV collagen induces podocytic features in bone marrow stromal stem cells in vitro. Journal American Society Nephrology 17: 66-76, Harvey SJ, Perry J, Zheng K, Chen D, Sado Y, Jefferson B, Ninomiya Y, Jacobs RM, Hudson BG, Thorner PS. Sequential expression of type IV collagen networks: Testis as a model and relevance to spermatogenesis. American Journal Pathology 168: , Perry J, Tam S, Zheng K, Sado Y, Dobson H, Jefferson B, Jacobs R, Thorner PS. Type IV collagen induces podocytic features in bone marrow stromal stem cells in vitro. Journal American Society of Nephrology 17(1):66-76, Keller SL, Jefferson BJ, Jacobs RM, Wood DR. Effects of noncytopathic type 2 Bovine viral diarrhea virus on proliferation of bone marrow progenitor cells. Canadian Journal of Veterinary Research 70:20-27,

20 13. Zheng K, Perry J, Harvey SJ, Sado Y, Ninomiya Y, Jefferson B, Jacobs R, Hudson BG, Thorner PS. Regulation of collagen type IV genes is organspecific: evidence from a canine model of Alport syndrome. Kidney International. 68(5): , van den Heuvel MJ, Jefferson BJ, Jacobs RM. Purified bovine plasma blocking factor decreases Bovine leukemia virus p24 expression while increasing protein synthesis and transcriptional activity of peripheral blood mononuclear cells in short-term culture. Canadian Journal Veterinary Research 69(3):186-92, van den Heuvel MJ, Jefferson BJ, Jacobs RM. Isolation of a bovine plasma fibronectin-containing complex which inhibits the expression of bovine leukemia virus p24. Journal of Virology 79(13): , Jacobs RM. Serum angiotensin-converting enzyme activity is not a useful biomarker for canine splenic haemangiosarcoma. Journal of Comparative Clinical Pathology, 13:86-7, Keller SL, Wood RD, Jefferson BJ, Jacobs RM. Use of a commercial methylcellulose medium with and without recombinant bovine granulocyte colony-stimulating factor for culturing bovine bone marrow cells. Canadian Journal of Veterinary Research 68:157-9, Tant, MS, Lumsden JH, Jacobs RM, Bonnett BN. Evaluation of acanthocyte count as a diagnostic test for canine hemangiosarcoma. Journal Comparative Clinical Pathology 12: , Deregt D, Jacobs RM, Carman PS, Tessaro SV. Attenuation of a virulent type 2 bovine viral diarrhea virus. Veterinary Microbiology 100:151-61, Whiteside DP, Barker IK, Mehren KG, Jacobs RM, Conlon PD. Clinical evaluation of the oral iron chelator deferiprone for the potential treatment of iron overload in bird species. J Zoo Wildl Med Mar;35(1): Wood RD, Goens SD, Carman PS, Deregt D, Jefferson B, Jacobs RM. Effect on hematopoietic tissue of experimental infection of cavles with non-cytopathic type 2 bovine virual diarrhea virus. Canadian Journal of Veterinary Research 68:42-48, VanDenHeuvel M, Portetelle D, Jefferson B, Jacobs RM. Adaptation of a sandwich enzyme-linked immunosorbent assay to determine the -20-

21 concentration of bovine leukemia virus p24 and optimal conditions for p24 expression in short-term cultures of peripheral blood mononuclear cells. Journal of Virological Methods 111:61-7, Harvey SJ, Zheng K, Jefferson B, Moak P, Sado Y, Naito I, Ninomiya Y, a canine model of Alport syndrome. American Journal of Pathology 162: , Chen, D., Jefferson, B., Harvey, S., Zheng, K., Bartley, C., Jacobs, R., and P. Thorner. Cyclosporine A slows the progressive renal disease of Alport syndrome (X-linked hereditary nephritis): Results from a canine model. Journal American Society of Nephrology, 14: 690-8, Boyonoski, A.C., J.C. Spronck, R.M. Jacobs, G.M. Shah, G.G. Poirier, and J.B. Kirkland. Pharmacological intakes of niacin increase bone marrow poly(adp-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats. Journal of Nutrition 132: , Boyonoski, A.C., J.C. Spronck, L.M. Gallacher, R.M. Jacobs, G.M. Shah, G.G. Poirier, and J.B. Kirkland. Niacin deficiency decreases bone marrow poly(adp-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats. Journal of Nutrition 132: , Harvey SJ, Mount R, Sado Y, Naito I, Ninomiya Y, Harrison R, Jefferson B, Jacobs R, Thorner PS. The inner ear of dogs with X-linked nephritis provides clues to the pathogenesis of hearing loss in X-linked Alport syndrome. Am J Pathol. 159: , Gonzalez, G.C, J.B. Johnston, D.D. Nickel, R. M. Jacobs, M. Olson, and C. Power. Absence of bovine immunodeficiency virus in Western Canada. Can. J. Vet. Res. 65:73-6, Valli, V. E. O., R. Jacobs, A. Norris, G. Couto, W. Morrison, D. McCaw, S. Cotter, G. Ogilvie, A. Moore. The histologic classification of 602 cases of feline lymphoprolferative disease using the National Cancer Institute working formulation. J. Vet. Diagnostic Investigation 12, , Boyonoski, A., Gallacher, L. M., ApSimon, M. M., Jacobs, R. M., Shah, G. M., Poirier, G.G., and J. B. Kirkland. Niacin deficiency in rats increases the severity of ethylnitrosourea-induced anemia and leukopenia. J. Nutrition 130, ,

22 31. Boyonoski, A., L. Gallacher, M. ApSimon, R. Jacobs, G.M. Shah, G.G. Poirier, and J.B. Kirkland. Niacin deficiency increases the sensitivity of rats to the short and long term effects of ethylnitrosourea treatment. Molecular and Cellular Biochemistry 193, 83-87, Jorundsson, E., J. Lumsden, R. Jacobs. Rapid staining techniques in cytopathology: A review and comparison of modified protocols for H & E, Papanicolaou and Romanowsky stains. Vet. Clin. Path. 28, , Abed, Y., G. St-Laurent, H. Zhang, R. Jacobs, D. Archambault. Development of a Western blot assay for detection of bovine immunodeficiency like virus using capsid and transmembrane envelope protein expressed from recombinant baculovirus. Clinical and Diagnostic Laboratory Immunology 6, , Trochta, O., R.M. Jacobs, B.Jefferson. Isolation and short-term culture of canine adrenal microvascular endothelial cells. Canadian Journal of Veterinary Research 63, 1-4, Zheng, K., S. Harvey, Y. Sado, I. Naito, Y. Ninomiya, R. Jacobs, and P. Thorner. Absence of alpha 5(IV) in Alports syndrome is related to failure at the protein assembly level and does not result in diffuse leiomyomatosis. American Journal of Pathology 154, , Saini, S.S., Allore, B., Jacobs, R.M., and A. Kaushik. Exceptionally long CDR3H region with multiple cysteine residues in functional bovine IgM antibodies. European Journal of Immunology 29, , Harvey, S.J., K. Zheng, Y. Sado, I. Naito, Y. Ninomiya, R.M. Jacobs, B.G. Hudson, and P.S. Thorner. The role of distinct type IV collagen networks in glomerular development and function. Kidney International 54, , Vernau, W., R.M. Jacobs, C. Davies, R.F. Carter and V.E.O. Valli. A morphometric analysis of bovine lymphomas. Journal of Comparative Pathology, 118: , Jacobs. R.M., B.J. Jefferson, and D.L. Suarez. Prevalence, determined by serology and proviral detection, of bovine immunodeficiency-like virus in bulls. Canadian Journal of Veterinary Research 62: , Vernau, W., R.M. Jacobs, V.E.O. Valli and J.L. Heeney. The immunophenotypic characterization of bovine lymphomas. Veterinary Pathology 34: ,

23 41. Grodecki, K., M.J. Gains, R. Baumal, D.H. Osmond, B. Cotter, V.E.O. Valli and R.M. Jacobs. ACE inhibitor treament of X-linked hereditary nephritis in Samoyed dogs. Journal of Comparative Pathology, 117: , Straw, R., B. Powers, J. Klauser, R. A. Henderson, W. Morrison, D. L. McCaw, H. J. Harvey, R. M. Jacobs, and J. R. Berg. Canine mandibular osteosarcoma: 51 cases ( ). J American Animal Hospital Association 32, , Thorner, P.S., K. Zheng, R. Kalluri, R. Jacobs and B.G. Hudson. Coordinate gene expression of the α3, α4, and α5 chains of collagen type IV. Journal of Biological Chemistry 271: , Jacobs, R. M., W. B. McNab, F. L. Pollari and B. Jefferson. A serological survey for bovine immunodeficiency-like, bovine leukemia, and bovine syncytial viruses in Ontario dairy cattle and associations between test results, production records, and management practices. Canadian Journal of Veterinary Research 59: , Jacobs, R. M., H. E. Smith, L. J. McCutcheon and V. E. O. Valli. Histopathological Changes in the Lymphoid Tissues of Sheep Exposed to the Bovine Immunodeficiency-Like Virus. Journal of Comparative Pathology 114:23-30, Valli VE, Norris A, Jacobs RM, Laing E, Withrow S, Macy D, Tomlinson J, McCaw D, Ogilvie GK, Pidgeon G, Henderson RA. Pathology of canine bladder and urethral cancer and correlation with tumor progression and survival. Journal of Comparative Pathology 113: , Gains, M.J., K. M. Grodecki, R. M. Jacobs, D. Dyson, R. A. Foster. Comparison of direct and indirect blood pressure measurements in anaesthetized dogs. Canadian Journal of Veterinary Research 59: , Jacobs RM, Smith HE, Whetstone CA, Suarez DL, Jefferson B, Valli VEO. Hematological and lymphocyte subset analyses in sheep inoculated with bovine immunodeficiency-like virus. Veterinary Research Communications 18: , Smith HE, Jacobs RM, Mallard B. Cell-mediated and humoral immunity in sheep exposed to bovine immunodeficiency-like virus. Comparative Immunology, Microbiology and Infectious Disease 17:29-39,

24 50. Bienzle D., R.M. Jacobs, J.H. Lumsden, E. Grift, L. Tarasov. Comparison of two automated multichannel haematology analyzers in domestic animals. Comparative Hematology International 4: , Schnurr, M.W., R.F. Carter, I.D. Dube, V.E. Valli and R.M. Jacobs. Nonrandom chromosomal abnormalities in bovine lymphoma. Leukemia Research 18:91-99, Smith, H.E., R.M. Jacobs and C. Smith. Flow cytometric analysis of ovine peripheral blood lymphocytes. Canadian Journal of Veterinary Research 58: , Bienzle, D., Abrams-Ogg, A.C.G., Kruth, S.A., Ackland-Snow, J., Carter, R.F., Dick, J.E., Jacobs, R.M., Kamel-Reid, S. and I.D. Dubé. Gene transfer into hematopoietic stem cells: Long-term maintenance of in vitro activated progenitors without marrow ablation. Proceedings National Academy of Science 91: , McNab W. B., R. M. Jacobs and H. E. Smith. A serological survey for bovine immunodeficiency-like virus in Ontario dairy cattle and associations between test results, production records, and management practices. Canadian Journal of Veterinary Research 58:36-41, Rand, J. S., J. Parent, D. Percy and R. M. Jacobs. Clinical, cerebrospinal fluid, and histological data from 34 cats with primary non-inflammatory central nervous system disease. Canadian Veterinary Journal 35: , Rand, J. S., J. Parent, D. Percy and R. M. Jacobs. Clinical, cerebrospinal fluid, and histological data from 27 cats with primary inflammatory central nervous system disease. Canadian Veterinary Journal 35: , Bienzle D., R.M. Jacobs, J.H. Lumsden. Relationship of serum total calcium to serum albumin in dogs, cats, horses, and cattle. Canadian Veterinary Journal 34: , Nadin-Davis, S. A., S. C. Chang, H. E. Smith and R. M. Jacobs. Detection of bovine immunodeficiency-like virus by polymerase chain reaction. Journal of Virological Methods 42: , Taylor, J. A. and R. M. Jacobs. Effects of plasma and serum on the in vitro expression of bovine leukemia virus. Laboratory Investigation 69: ,

25 60. Smith, H. E. and R. M. Jacobs. Serological evidence of bovine immunodeficiency-like virus infection in a sheep. Canadian Journal of Veterinary Research 57: , Poon, H., E. Jimenez, Z. Song, B. Jefferson and R.M. Jacobs. Bovine leukemia viral RNA detection in serum using the polymerase chain reaction. Journal of Virological Methods 41: , Thorner, P. S., R. Baumal, V. E. O. Valli, D. Mahuran, P. M. Marrano and R. M. Jacobs. Production of anti-nc1 antibody by affected male dogs with X-linked hereditary nephritis: a probe for assessing the NC1 domain of collagen type IV in dogs and humans with hereditary nephritis. Virchows Arch (A) 421: , Jacobs, R.M., H.E. Smith, B. Gregory, V.E.O. Valli and C.A. Whetstone. Detection of multiple retroviral infections in cattle and crossreactivity of BIV and HIV-1 proteins using bovine and human sera in a Western blot assay. Canadian Journal of Veterinary Research 56: , Jacobs, R.M., Z. Song, H. Poon, J.L. Heeney, J.A. Taylor, B. Jefferson, W. Vernau and V.E.O. Valli. Proviral detection and serology in bovine leukemia virus-exposed normal cattle and cattle with lymphoma. Canadian Journal of Veterinary Research 56: , Jacobs, R.M., J.H. Lumsden, and E. Grift. Effects of bilirubinemia, hemolysis, and lipemia on clinical chemistry anlaytes in bovine, canine, equine, and feline sera. Canadian Veterinary Journal 33: , Heald, M.T.S., D. Waltner-Toews, R.M. Jacobs and W.B. McNab. The prevalence of anti-bovine leukemia virus antibodies in dairy cows and associations with farm management practices, production and culling in Ontario. Veterinary Preventive Medicine 14:45-55, Bloomberg R. M., H. A. Pook, R.M. Jacobs and J. M. VanGorder. Human recombinant erythropoietin therapy in a cat with chronic renal failure. Canadian Veterinary Journal 33: , Heeney, J.L., P.J.S. Valli, R.M. Jacobs and V.E.O. Valli. Evidence for bovine leukemia virus infection of peripheral blood monocytes and limited antigen expression in bovine lymphoid tissue. Laboratory Investigation 66: , Norris, A.M., E.J. Laing, V.E.O. Valli, S.J. Withrow, D.W. Macy, G.K. Ogilvie, J. Tomlinson, D. McCaw, G. Pidgeon and R.M. Jacobs. Canine bladder and urethral tumors: A retrospective study of 115 cases ( ). Journal of Veterinary Internal Medicine 6: ,

26 70. Vernau, W., V.E.O. Valli, T.W. Dukes, R.M. Jacobs, M. Shoukri and J.L. Heeney. Classification of 1,198 cases of bovine lymphoma using the National Cancer Institute Working Formulation for human non-hodgkin's lymphomas. Veterinary Pathology 29: , Baumal, R., P. Thorner, V.E.O. Valli, R. McInnes, P. Marrano, R. Jacobs, A. Binnington and A. Bloedow. Renal disease in carrier female dogs with x-linked hereditary nephritis implications for female patients with this disease. American Journal of Pathology 139: , Jacobs, R.M., J.L. Heeney, M.A. Godkin, K.E. Leslie, J.A. Taylor, C. Davies and V.E.O. Valli. Production and related variables in bovine leukaemia virus-infected cows. Veterinary Research Communications 15: , O'Brien, P.J., B.I. Kalow, B.D. Brown, J.H. Lumsden and R.M. Jacobs. Porcine malignant hyperthermia susceptibility: Halothane-induced increase in cytoplasmic free calcium in lymphocytes. American Journal of Veterinary Research 50: , Valli, V.E.O., R. Baumal, P. Thorner, R. Jacobs, P. Marrano, C. Davies, B. Qizilbash and H. Clarke. Dietary modification reduces splitting of glomerular basement membranes and delays death due to renal failure in canine x-linked hereditary nephritis. Laboratory Investigation 65:67-73, Jacobs, R.M., J.H. Lumsden, J.A. Taylor and E. Grift. Effects of interferents on the kinetic Jaffé reaction and an enzymatic colorimetric test for serum creatinine concentration determination in cats, cows, dogs and horses. Canadian Journal of Veterinary Research 55: , Jacobs, R.M., J.H. Lumsden, J.A. Taylor and E. Grift. Analyte comparisons on the Coulter Dacos and Kodak Ektachem DT-60 clinical chemistry analyzers. Canadian Veterinary Journal 32:30-34, Lumsden, J.H., R.M. Jacobs and P. Physick-Sheard. Contribution of delta bilirubin to the interpretation of hyperbilirubinemia in the horse - a pilot study. Canadian Veterinary Journal 32: , Rand, J.S., J. Parent, R.M. Jacobs and D. Percy. Reference intervals for feline cerebrospinal fluid: cell counts and cytologic features. American Journal of Veterinary Research 51: , Rand, J. S., J. Parent, R.M. Jacobs and R. Johnson. Reference intervals for feline cerebrospinal fluid: biochemical and serologic variables, IgG -26-

27 concentration, and electrophoretic fractionation. American Journal of Veterinary Research 51: , Kohn, C.W., R.M. Jacobs, D. Knight, W. Hueston, A.A. Gabel and S.M. Reed. Microcytosis, hypofferremia, hypoferritemia, and hypertransferrinemia in Standardbred foals from birth to 4 months of age. American Journal of Veterinary Research 51: , Jacobs, R.M., S. M. Cochrane, J.H. Lumsden and A.M. Norris. Relationship of cerebrospinal fluid protein concentration determined by dye-binding and urinary dipstick methodologies. Canadian Veterinary Journal 31: , Ellison, R.S. and R.M. Jacobs. An attempt to determine the tissue origins of equine serum alkaline phosphatase by isoelectric focusing. Canadian Journal of Veterinary Research 54: , Ellison, R.S. and R.M. Jacobs. The isoelectric focusing properties of serum alkaline phosphatase in disease and following prednisolone and phenylbutazone administration in the horse. Canadian Journal of Veterinary Research 54: , Jacobs, R.M., G.J.D. Smith, V.E.O. Valli, C. Dupont and W.A. McCormick. A program for storage and retrieval of demographic, sample, clinical laboratory, and restriction endonuclease map data. Computer Methods and Programs in Biomedicine 29: , Lumsden, J.H. and R.M. Jacobs. Clinical Chemistry: In-clinic analysis, quality control, reference values, and system selection. Veterinary Clinics of North America: Small Animal Practice 19: , Jacobs, R.M., A.M. Norris, J.H. Lumsden and V.E.O. Valli. Laboratory diagnosis of malassimilation. Veterinary Clinics of North America: Small Animal Practice 19: , Taylor, J.A., R.M. Jacobs, J.H. Lumsden and B.N. Bonnett. Perspectives on the diagnosis of feline hyperthyroidism. Canadian Veterinary Journal 30: , Rae, C.A., R.M. Jacobs and C.G. Couto. A comparison between the cytological and histological characteristics in thirteen canine and feline thymomas. Canadian Veterinary Journal 30: , Jacobs, R.M. Relationship of urinary amylase activity and proteinuria in the dog. Veterinary Pathology 26: ,

28 90. Jacobs, R.M. The origins of canine serum amylases and lipase. Veterinary Pathology 26: , Jacobs, R.M. Renal disposition of amylase, lipase, and lysozyme in the dog. Veterinary Pathology 25: , Wellman, M.L., S. Krakowka, R.M. Jacobs and G.J. Kociba. A macrophage-monocyte cell line from a dog with malignant histiocytosis. In Vitro Cellular and Developmental Biology 24: , Jacobs, R.M., C.L. Swenson, D.J. Davenport and R.J. Murtaugh. Sensitivity and specificity of canine serum total amylase and isoamylase activity determinations. Canadian Journal of Veterinary Research 52: , Jacobs, R.M. and V.E.O. Valli. Bone marrow biopsies: Principles and perspectives of interpretation. Seminars in Veterinary Medicine and Surgery (Small Animal) 3: , Fingeroth, J.M., D.D. Smeak and R.M. Jacobs. Intravenous methylene blue infusion for intraoperative identification of parathyroid gland and pancreatic islet cell tumors in dogs. Part 1: Experimental determination of dose-related staining efficacy and toxicity. Journal of the American Animal Hospital Association 24: , Swenson, C.L., G.J. Kociba, D.A. O'Keefe, M.S. Crisp, R.M. Jacobs and J.L. Rojko. Cyclic hematopoiesis associated with feline leukemia virus infection in two cats. Journal of the American Veterinary Medical Association 191:93-96, Jacobs, R.M., J.H. Lumsden and E. Willet. Potential inadequacy of the TSH stimulation test in the diagnosis of canine hypothyroidism. Canadian Veterinary Journal 28: , O'Keefe, D.A., C.G. Couto, C. Burke-Schwartz and R.M. Jacobs. Systemic mastocytosis in 16 dogs. Journal of Veterinary Internal Medicine 1:75-80, Seide, R.K., R.M. Jacobs, T.N. Dobblestein and J.M. Kehoe. Characterization of a homogeneous paraprotein from a horse with spontaneous multiple myeloma syndrome. Veterinary Immunology and Immunopathlogy 17:69-78, Jacobs, R.M., J.T. Boyce and G.J. Kociba. Flow cytometric and radioisotopic determinations of platelet survival time in normal cats and feline leukemia virus-infected cats. Cytometry 7:64-69,

29 101. Jacobs, R.M., R.J. Murtaugh and R.H. Fertel. Platelet function in experimentally induced pancreatitis in the dog. Thrombosis and Haemostasis 55: , Stirtzinger, T., V.E.O. Valli, R.M. Jacobs, L. Beiner and B. Jansen. In vitro response of purified ovine peripheral blood lymphocytes to phytohemagglutinin-m. Canadian Journal of Veterinary Research 50: , Boyce, J.T., G.J. Kociba, R.M. Jacobs and M.G. Weiser. Feline leukemia virus-induced thrombocytopenia and macrothrombocytosis in cats. Veterinary Pathology 23:16-20, Jacobs, R.M., C.G. Couto and M.L. Wellman. Biclonal gammopathy in a dog with myeloma and cutaneous lymphoma. Veterinary Pathology 23: , Jacobs, R.M., R.J. Murtaugh, R.G. Sherding and T.M. O'Dorisio. Effects of xylazine administration on serum amylase, pancreas-specific isoamylase and pancreatic polypeptide in normal dogs. Canadian Journal of Veterinary Research 50: , Fossum, T.W., S.J. Birchard and R.M. Jacobs. Chylothorax in 34 dogs. Journal of the American Veterinary Medical Association 188: , Swenson, C. and R.M. Jacobs. Spherocytosis associated with anaplasmosis in two cows. Journal of the American Veterinary Medical Association 188: , Fossum, T.W., R.M. Jacobs and S.J. Birchard. Evaluation of cholesterol and triglyceride concentrations in differentiating chylous and nonchylous pleural effusions in dogs and cats. Journal of the American Veterinary Medical Association 188:49-51, Jacobs, R.M., R.J. Murtaugh and W.D. Dehoff. Review of the clinicopathological findings of acute pancreatitis in the dog: Use of an experimental model. Journal of the American Animal Hospital Association 21: , Wellman, M.L., D.J. Davenport, D. Morton and R.M. Jacobs. Malignant histiocytosis in four dogs. Journal of the American Veterinary Medical Association 187: ,