MIP778B Pathobiology of Laboratory Animals Tues 1:00-2:00PM & Thurs 12:30-2:00PM Fall 2015 Micro B120

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1 Overview: Laboratory Animal pathology is a subspecialty of veterinary pathology focusing on diagnosis and characterization of naturally-occurring and induced diseases in animal models for human disease. As these models have become increasingly sophisticated, particularly with the advent of transgenic mouse technologies, the need for clinicians with specific expertise in this field has greatly expanded. Similarly, demand for veterinarians with expertise in the specialty of Laboratory Animal Medicine has increased dramatically over the past decade. MIP778B is the primary post-graduate didactic exposure to pathobiology of laboratory animals offered at CSU. Course Description: This course will provide an overview of unique biology, spontaneous and induced diseases, and animal model use in the most common laboratory animal species. Clinical, diagnostic, and pathologic features of diseases will be emphasized. After completion of the course, students will be able to: 1. Describe the natural biology and anatomical features unique to common laboratory animal species (mice, rats, guinea pigs, hamsters, rabbits); 2. Describe how these species are used in biomedical research; 3. Describe clinical signs and management of common laboratory animal diseases as relevant to case history and diagnostics; 4. Describe gross, morphologic and clinical pathologic features of induced and spontaneous laboratory animal diseases in species listed above, and in nonhuman primate species used most commonly in biomedical research; 5. Describe amphibian and fish diseases pertinent to laboratory animal medicine. Reference Texts: American College of Laboratory Animal Medicine Textbook Series Pathology of Laboratory Rabbits and Rodents, 3 rd Edn. D. H. Percy, S. W. Barthold, 2007 Additional study materials: AFIP slide sets, Veterinary Pathology, Comparative Medicine Instructional Methodology: Three hours of didactic lecture will be delivered weekly, with the exception of weeks when guest lecturers are visiting, when the schedule may be altered to accommodate guest itineraries. Individual instructors will determine content and style. The course is designed to require two hours minimum outside work for each contact hour in achieving the learning objectives through the readings, assignments, projects or other activities as assigned. Methods of Evaluation: A midterm exam (30%) and final exam (60%) will be administered at appropriate times. The midterm will be short answer or essay format. The final exam will be (1) multiple choice, short answer, essay questions reviewing didactic material for participants who are not enrolled in residency program, and/or (2) clinical and diagnostic information/materials for case/laboratory evaluation in a board preparatory format. Class participation will account for 10% of the final grade. Homework may be assigned by some instructors as a study guide, but will not be graded.

2 Grading: Students will be assigned a letter grade as follows: =A; =B; =C; Students with a final average % will receive a U grade (unsatisfactory) and will need to complete a make-up assignment to pass. Students with an average grade <65% will receive an F (fail) grade. Academic Integrit. This course will adhere to the CSU Academic Integrity Policy as found in the General Catalog - 1.6, pages 7-9. ( and the Student Conduct Code ( ). At a minimum, violations will result in a grading penalty in this course and a report to the Office of Conflict Resolution and Student Conduct Services. Coordinator: Lon, X15903, lon.kendall@colostate.edu

3 DATE TOPIC LECTURER COMMENTS T-25- Introduction & Course Overview Aug Mouse Biology & Husbandry R-27- Mouse Biology & Husbandry Aug T-1- Mouse Genetics Weil R-3- Murine Immunology Schenkel T-8- Transgenic Production Techniques Bowen Confirmed R-10- Mouse Disease/Pathology Discussion T-15- Mouse Disease/Pathology Discussion R-17- Rodent Necropsy Demonstration T-22- Mouse models Class R-24- Rat Biology & Use T-29- Rat Diseases/Pathology Discussion R-1- Rabbit Biology & Use Rosenbaum Confirmed T-6- Rabbit Models Class R-8- Rabbit Pathology Rosenbaum T-13- Health monitoring programs R-15- Clinical Pathology of Laboratory Animals Brown 1-4 PM (10/15) T-20- Guinea Pig Biology & Use Ayers R-22- Hamster/Gerbil Biology and Use Ayers T-27- Guinea Pig Pathology Basaraba R-29- Hamster/Gerbil Pathology Ehrhart T-3- National AALAS/midterm no class R-5- National AALAS/midterm no class T-10- Large animals models Ayers R-12- Clinical Pathology of Laboratory Animals Brown 1-4 PM (10/15) T-17- Molecular Imaging Modalities in Research Manuel R-19- Fish and Amphibians Pathology Schaffer T-24- Thanksgiving R-26- Thanksgiving

4 T-1-Dec NHP Biology and Taxonomy R-3-Dec Husbandry Effects on Research Results Leszczynski T-8-Dec Primate Pathology* Wilkerson 1-5 PM 12/12 R-10- Dec Primate Pathology* Wilkerson 1-5 PM 12/12- T-15- Dec Final (in class practical) *University of Missouri Comparative Medicine Residents participated via teleconference.

5 Pathology of Laboratory Rodents and Rabbits has become a standard text for both veterinary pathologists and veterinarians in laboratory animal medicine. Newly recognized infectious diseases continue to emerge and molecular methods for studying infectious agents are becoming widely used for the classification of these and previously known pathogens. With the ongoing development and perfection of genetic engineering techniques, the use of genetically engineered mice in the research laboratory continues to grow exponentially. This new edition features updates throughout with increased emphasis on timely topics such as infectious diseases in genetically engineered mice. Diseases covered include viral infections, bacterial infections, parasitic diseases, nutritional and metabolic disorders, behavioral disorders, aging and degenerative disorders, environment-related disease, and neoplasms. Organized by species, coverage includes mice, rats, hamsters, gerbils, guinea pigs, and rabbits. Veterinary pathologists, laboratory animal veterinarians, and students will appreciate the concise organization and easily accessible information on key diagnostic features, differential diagnoses, and significance of diseases. Special Features: * General reference of common diseases of laboratory animals * New edition features nearly 400 images of gross and microscopic pathology * Increased emphasis on geneticallyengineered mice and infectious diseases Table of Contents: Chapter 1 Mouse Chapter 2 Rat Chapter 3 Hamster Chapter 4 Gerbil Chapter 5 Guinea Pig Chapter 6 Rabbit About the Authors: Dean H. Percy, DVM, MSc, PhD, DipACVP, is Professor Emeritus and former department chair of the Pathobiology Department, Ontario Veterinary College, Guelph, Ontario. Stephen W. Barthold, DVM, PhD, DipACVP, is Professor and Director, Center for Comparative Medicine, University of California, Davis. ISBN: ISBN10: Availability: Estimated Due Date (subject to change): 9/15/2007 Publication Date: 2007 Size: 396 pages; 8.5 x 11 Binding: Hardback Publisher: B