Table 2 Structures and properties of the study compounds with full citations < (ectoparasiticide)

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1 Table 2 tructures and properties of the study compounds with full citations Compound CA Molecular Log Kow pka Log Koc 1 oil DT50 1 tructure weight (l/kg) (days) Amoxicillin 26787-78-0 365.4 0.87 2 2.8, 7.2 3 865.5 4 0.16 0.29 H H 2 H H Diazinon 333-41-5 304.35 3.81 5 <2.5 6 229 1549 7 1.7 112 (ectoparasiticide) P Enrofloxacin 93106-60-6 359.4 0.7 6.0, 8.8 8 15800 9 - Florfenicol 73241-34-2 358.21-0.04 4-24-52 10 4-27 10 Cl H Cl H F H F

Compound CA Molecular Log Kow pka Log Koc 1 oil DT50 1 tructure weight (l/kg) (days) Levamisole 14769-73-4 204.3 1.84-8652 - (endoparasiticide) xytetracycline 79-57-2 460.44-0.9 2 3.3, 7.3, 9.9 11 2872 16 18 12 H H H H H 56060000 6 H H H Phenylbutazone 50-33-9 308.4 3.16-15800 - (antinflammatory) ulfadiazine 68-35-9 250.3-0.09 5 6.48 13 H H 2 H 2

2 Compound CA Molecular Log Kow pka Log Koc 1 oil DT50 1 weight (l/kg) (days) Trimethoprim 738-70-5 290.32 0.91 5 7.2 13 Tylosin 1401-69-0 916.12 1.63 7.1 14 200 7988 15 3.3 105 15 tructure H H 2 H 2 H H H H

2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 1 - Boxall ABA, Fogg LA, Baird DJ, Telfer T, Lewis C, Gravell A, Boucard T. 2005. Targeted Monitoring tudy for Veterinary Medicines. Environment Agency R&D Technical Report, Bristol, UK, Environment Agency 2 - angster J. 1994. LGKW Databank: A Databank of Evaluated ctanol-water Partition Coefficients (Log P) on Microcomputer Diskette, Montreal, Canada, angster Research Laboratories 3 - U Pharmacopeia. 2003a. Amoxicillin and Clavulanate: Veterinary-ystemic. From: UP Veterinary Pharmaceutical Information Monographs, Rockville MD, UA, U Pharmacopeia, available [June 2005a] at http://http://www.usp.org/ 4 - RC. 2004. PCKWI Version 1.6: Program for Windows 3.1, yracuse Y, UA, RC 5 - Hansch C, Leo A, Hoekman D. 1995. Exploring QAR: Hydrophobic, Electronic and teric Constants (AC Professional Reference Book), Washington DC, UA, American Chemical ociety 6 - ougaku. 1989. Pesticide Data Book, Tokyo, Japan, oft cience 7 - inclair CJ, Boxall ABA. 2005. creening Level Exposure Assessment for Pesticide Metabolites, York, UK, Pesticide afety Directorate 8 - U Pharmacopeia. 2003b. Fluoroquinolones: Veterinary-ystemic. From: UP Veterinary Pharmaceutical Information Monographs, Rockville MD, UA, U Pharmacopeia, available [July 2005b] at http://http://www.usp.org/ 9 - Bayer (1996) Environmental Assessment for Enrofloxacin - BAYTRIL 3.23% Concentrate Antimicrobial olution (ADA 140-828EA), Rockville MD, UA, U Food and Drug Administration, Center for Veterinary Medicine, Available [July 2005] at; http://www.fda.gov/cvm/fi/ea.htm

17 18 19 20 21 22 23 24 25 26 27 28 29 30 10 - chering Plough Animal Health. 1996. Environmental Assessment for the Use of uflor Injectable olution in Cattle (ADA 141-063EA), Rockville MD, UA, U Food and Drug Administration, Center for Veterinary Medicine, Available [July 2005] at; http://www.fda.gov/cvm/fi/ea.htm 11 - U Pharmacopeia. 2003e. Tetracyclines: Veterinary-ystemic. From: UP Veterinary Pharmaceutical Information Monographs, Rockville MD, UA, U Pharmacopeia, available [July 2005e] at http://http://www.usp.org/ 12 - Blackwell PA, Boxall ABA, Kay P, oble H. 2005. Evaluation of a lower tier exposure assessment model for veterinary medicines. J Agric Food Chem 53: 2192-2201. 13 - U Pharmacopeia. 2003d. ulfonamides: Veterinary-ystemic. From: UP Veterinary Pharmaceutical Information Monographs, Rockville MD, UA, U Pharmacopeia, available [July 2005d] at http://http://www.usp.org/ 14 - U Pharmacopeia. 2003c. Macrolides: Veterinary-ystemic. From: UP Veterinary Pharmaceutical Information Monographs, Rockville MD, UA, U Pharmacopeia, available [July 2005c] at http://http://www.usp.org/ 15 - Carlson JC, Mabury A. 2004. Degradation kinetics and mobility of chlortetracycline, tylosin and monensin agricultural soils. Abstracts Papers American Chemical ociety 228: 236