Recent Topics of Brucellosis
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1 Recent Topics of Brucellosis Koichi IMAOKA BrucellosisBrucella spp Brucella, B. abortus, B. suis, B. canis Bruce Micrococcus Brucella B. biovar... B. B. suisb. abortus Department of Veterinary Science, National Institute of Infectious Diseases ( Toyama, Shinjuku-ku, Tokyo)
2 B. canis B. pinnipedialisb. ceti B. ovis B. neotomaeb. microti 1 3 B. B. abortus B. suis smooth-typelps o-side chain B. canis rough-type LPS o-side chain , 3, 4 B. B. abortus 1-6, 9 B. 1-3 B. suis 1, 3 2 4B. rangiferi 5 B. canis B. ovis B. neotomae B. pinnipedialis B. ceti B. microti
3 B , 97, 20, B. abortusb. B. suisoie OIE 1 1, 2, 5 B. abortus B , 2, , 4, 6 B B.ovis OIEMultiannual Animal Diseases Status 5
4 1940 B. abortus B. suis 100 B. B. canis 8 B. canis B. abortus B. B. suis B. canis , B. canis 14, B. abortus B. abortus B. 20, , 22 B. canis B. canis ,
5 2.0693, B. canis B. abortuss-lps 24, 25 B. 2 26, 27 B. aboruts PCR PCR PCR abortus suis abortus abortus canis abortus abortus abortus abortus PCR canis canis canis abortus B.abortusB.canisB.abortus40B.canis160 24
6 B. B. aboruts 9 B. canis B. canis 5 24, B. canis B. canis 28 1B S rrna BA : 160 BC : A DOXY GM 2B. canis B. canis PCRB. canis DOXY SM DOXY RFP 37 B. canis 14 5 B. canis DOXY RFP , 6 B. canis , 30
7 B. canis , PCR Moraxella phenylpyruvica 1 1, 3, 7 1 SAT 7, 31 smooth-lps B. abortus rough- LPS B. canis B. canis Yersinia enterocolitica O9
8 100 Ochrobactrum intermedium MAT MAT SAT 15 SAT 2 1 3, 7, Trypticase Soy AgarTS Agar 5 Sheep Blood AgarSBASerum Dextrose Agar5 vv equinebovine serum1 wv dextrosesmoothtype roughtype mm 0.4 x 0.8um 1, 7 3 PCR 1, 2, 32, 33 B. abortus BCSP31 PCR 32 16S ribosomal RNA IS711 BCSP31 2 OMP2OMP31 PCR 4 7, 33 1, WHO DOXY RFP 34 1, 35 RFP DOXY 2 WHO mg ST WHO mgkg 40mgkg mgkg g mgkg600900mg42 8mgkg40mgkg mgkg600900mg 45 15mgkg600900mg42 30mgkg 5mgkg
9 DOXY SM GM SM DOXY GM GMSM RFP DOXY GM RFP 1 1 B. canis B. canis 37 1 Brucellosis in humans and animals. WHOCDSEPR deliberatewho_cds_epr 2006_7enWHO, Manual of Diagnostic Tests and Vaccines for Terrestrial Animals A_summry.htmOIE, Brucellosis. CDC, Pappas G., Papadimetriou P., Akritidis N., et al.: The new global map of human brucellosis. Lancet Infect Dis, : 91-99, Multiannual animal disease status, Bovine brucellosis. Caprine and ovine brucellosisexcluding B. ovis Memish Z.A., H.Balkhy H.H.: Brucellosis and international travel. J Travel Med, : 49-55, in,, , Greene, C.E. and Carmichael, L.E. Canine brucellosis. pp in : Greene CE.ed, Infectious diseases of the dog and cat, 3rd ed. Elsevier, Inc., Canada, in :,,, 8: , Munford R.S., Weaaver R.E., Patton C., et al.: Human disease caused by Brucella canis. A clinical and epidemiologic study of two cases. JAMA, : , Polt S.S., Dismukes W.E., Flint A., et al.: Human brucellosis caused by Brucella canis. Clinical features and immune response. Ann Intern Med, : , Lucero N.E., Jacob N.O., Ayala S.M., et al.: Unusual clinical presentation of brucellosis caused by Brucella canis. J Med Microbiol, : , ,,.., : , , : , Kimura, M., Imaoka, K., Suzuki, M., et al.: Evaluation of a microplate agglutination testmatfor serological diagnosis of canine brucellosis. J. Vet. Med. Sci, : , , : 23-24, , : , ,,. Brucella abortus 4 1., : , Takahashi, H., Tanaka, S., Yoshida K., et al.: An unusual case of brucellosis in Japan : Difficulties in the differential diagnosis from pulmonary tuberculosis. Internal Med., : , ,,. Brucella biotype 3., : 336, ,,. 2., :
10 22Kato, Y., Masuda, G., Itoda, I., et al.: Brucellosis in a returned traveler and his wife : probable person-to-person transmission of Brucella. J. Travel Med., : , ,,. Brucella canis 1., : , in,,, 8: , go.jpiasr28330kj3302.html 25.. Info Vets, 8: 12-16, in :,,, 10: , html 27. in :,,, 5: , html 28,,. Brucella canis,. 83,, A patient with prolonged fever in Germany. Eurosurveillance Weekly, 34, Sewell D.L.: Laboratory-associated infections and biosafety. Clin Microbiol Rev, : , MacMillan, A.: Conventional serological tests. pp In : Nielsen, K and Duncan, J.R.eds, Animal bruecllosis. CRC Press, Inc. Florida Baily, G.G., Krahan, J.B., Drasar, B.S. and Stoker, N.G. : Detection of Brucella and Brucella abortus by DNA amplification. J. Trop. Med. Hyg. : Imaoka, K., Kimura, M., Suzuki, M., et al.: Simultaneous detection of the genus Brucella by combinatorial PCR. Jpn. J. Inf. Dis., : , Joint FAOWHO expert committee on brucellosis 6th report. WHO, Geneva, Skalsky K., Bishara J., Pitlik S., et al.: Treatment of human brucellosis : systematic review and meta-analysis of randomized controlled trials. Br Med J, : , MMJ, 9: , , kaku-kansenshou1102.html#2
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