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1 ORIGINAL ARTICLE Screening and Treatment of Methicillin-Resistant Staphylococcus aureus in Children Undergoing Open Airway Surgery Scan for Author Audio Interview Melissa McCarty Statham, MD; Alessandro de Alarcon, MD, MPH; Janet N. Germann, MSN, CNP; Meredith E. Tabangin, MPH; Aliza P. Cohen, MA; Michael J. Rutter, FRACS Objectives: (1) To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in children undergoing open airway surgery using a screening protocol; (2) to examine the rates of postoperative infection in this cohort; and (3) to determine adherence to a MRSA antibiotic protocol. Design: Retrospective cohort study. Setting: Tertiary pediatric referral center. Patients: The study population comprised 180 children undergoing 197 open airway operations from January 2007 to March 2009 at the Cincinnati Children s Hospital Medical Center. Intervention: Methicillin-resistant Staphylococcus aureus screening and treatment protocol. Main Outcome Measures: Prevalence of MRSA colonization, postoperative infection rates, colonization rates by site, and adherence to antibiotic protocol. Results: A total of 180 patients who underwent 197 operations were included in the study. The overall prevalence of MRSA was 32.5%. There were no significant differences betweenmrsa-colonizedandnoncolonizedpatientsregarding age at surgery, sex, gestational age at birth, or comorbidities. Postoperative infection rates were similar between the 2 groups (16% MRSA colonized; 17% MRSA noncolonized). Three patients who developed postoperative MRSA infections were MRSA negative on preoperative screening. Intraoperative adherence was high in both groups. Conclusions: We describe a MRSA screening and treatment protocol for children undergoing open airway surgery. We found a high prevalence (32.5%) of MRSA colonization in these patients. Treatment of MRSAcolonized patients resulted in postoperative infection rates similar to those in MRSA-noncolonized patients. Treatment of MRSA-colonized patients resulted in no MRSAassociated postoperative infections, graft loss, or dehiscence. MRSA screening and treatment protocols may be helpful in minimizing MRSA-associated postoperative infections in these patients. Arch Otolaryngol Head Neck Surg. 2012;138(2): Author Affiliations: Department of Otolaryngology Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia (Dr McCarty Statham); and Division of Pediatric Otolaryngology Head and Neck Surgery (Drs de Alarcon and Rutter and Mss Germann, Tabangin, and Cohen), Aerodigestive and Sleep Center (Drs de Alarcon and Rutter and Ms Germann), and Division of Biostatistics and Epidemiology (Ms Tabangin), Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio. THE OVERUSE OF ANTIBIOTICS has been a major contributingfactorinthedevelopment of resistant strains of bacteria such as methicillinresistantstaphylococcusaureus(mrsa). 1 This phenomenon is well documented and accepted in the international medical community. Numerous epidemiologic studies conducted over the past decade indicate an increase in MRSA colonization and infection. 2-8 The literature reflects a general consensusthatthisincreaseisassociatedwith a concomitant increase in morbidity and mortality rates in both the general and hospital-based populations. According to a study by Song et al, 9 some strains of MRSA are associated with a 40% increase in mortality risk in neonatal intensive care units (ICUs). Furthermore, MRSA infection is independentlyassociatedwitha40-dayincrease in ICU stay. 9 Increased morbidity and mortalityrateshaveinturnledtoincreasedhealth care costs. A study conducted by Anderson etal 10 estimatesthattheadditionalper-patient cost of hospitalization due to MRSA surgical site infections is approximately $ CME available online at and questions on page 111 An advisory statement issued by the National Surgical Infection Prevention Project in 2005 recommended that all patients with known MRSA colonization receive prophylactic treatment with vancomycin. 11 In the field of otolaryngology, Polubothu et al
2 Preoperative Protocol Pediatric Candidates for Open Neck Airway Surgery Nares Axilla Perianal Gastrostomy tube swab (if present) MRSA positive (or history of MRSA) Preoperative DSTS + intranasal mupirocin Perioperative vancomycin or sensitive antibiotic Postoperative DSTS MRSA Screening Must have 3 negative screens to be considered MRSA negative advised that an antibiotic prophylactic protocol for airway reconstruction should include intraoperative as well as postoperative antibiotic therapy and should be carried out on all patients known to be colonized with MRSA. In our experience, MRSA infection in open airway procedures can be a devastating complication, resulting in dehiscence, graft loss, and weakening of the cartilaginous structure of the laryngotracheal complex. Given the high index of suspicion for MRSA in patients undergoing open airway surgery, the development and institution of a screening and treatment antibiotic protocol was essential in proactively managing care of this vulnerable population. The overall aim of the present study was to retrospectively examine the effect of the protocol in this group of patients. Our specific objectives were 3-fold: (1) to determine the prevalence of MRSA colonization; (2) to examine the rate of postoperative infection in this cohort; and (3) to determine adherence to our antibiotic protocol. METHODS We identified all patients who underwent open airway surgery at Cincinnati Children s Hospital Medical Center from January 2007 to March We reviewed the medical records of these patients to obtain demographic data and information pertaining to operative procedures, comorbidities, adherence to MRSA protocol, antibiotic use, postoperative infections, and graft failure. Patients without documented evidence of MRSA screening were excluded from the study. We received approval for this study from our institutional review board. MRSA SCREENING PROTOCOL Tracheotomy aspirate (if present) MRSA negative Perioperative cephazolin Figure. Treatment algorithm for methicillin-resistant Staphylococcus aureus (MRSA) screening and treatment. DSTS indicates double-strength trimethoprim-sulfamethoxazole. *Alternate drug chosen for antibiotic allergy. Prior to the present study, a MRSA screening and treatment protocol was developed and implemented by two of the authors (J.N.G. and M.J.R.) in consultation with the director of the infection control program at our institution. This protocol is summarized in the Figure. All candidates for open airway procedures underwent initial MRSA screening according to the protocol. Patients known to be colonized with MRSA or with a history of MRSA without evidence of negative culture status were considered to be colonized. Surveillance cultures of MRSA were obtained from the nares, perianal area, axilla, gastrostomy tube site (if present), and tracheotomy tube aspirate (if present). These cultures were obtained on initial airway evaluation in patients deemed appropriate candidates for open airway procedures. If MRSA screening was carried out within 3 to 6 months of surgery, it was not repeated preoperatively. Based on sensitivities of MRSA in both nosocomial and community-acquired organisms, the decision to use doublestrength trimethoprim-sulfamethoxazole (DSTS) as an empirical preoperative antibiotic to decrease the risk of MRSAassociated infection was made. Patients colonized with MRSA received 6 to 12-mg/kg DSTS, divided twice daily, for 72 hours prior to surgery. In patients with an allergy to sulfa drugs or in those who were resistant to these drugs on initial screening, clindamycin was chosen as the alternate antibiotic. Patients who had positive nasal cultures also received intranasal mupirocin twice daily for 72 hours before surgery. Perioperative Protocol During the perioperative phase of care, patients received intravenous vancomycin. To achieve peak serum levels, administration of this drug was completed approximately 1 hour prior to skin incision. It was then administered every 6 to 8 hours until the surgical site drains were removed. Patients with an allergy to vancomycin received clindamycin. Patients who tested MRSA negative, and those with a history of MRSA in whom 3 subsequent cultures were negative, received perioperative intravenous cefazolin. Postoperative Protocol MRSA colonized patients were treated for 14 days postoperatively with the same antibiotic regimen that was used preoperatively. CRITERIA FOR TRANSITION FROM MRSA COLONIZED TO MRSA NONCOLONIZED For MRSA-colonized patients to be considered MRSA noncolonized, 3 negative cultures were required, commencing at least 2 weeks after the cessation of systemic antibiotics. DATA ANALYSIS We examined the baseline characteristics (including demographics, procedure type, tracheotomy placement, and comorbidities) for differences between MRSA-colonized and MRSAnoncolonized patients to determine possible confounders within our study population. Differences in continuous variables were tested using the Wilcoxon rank sum test. Differences in categorical variables were tested using 2 or the Fisher exact test. Analyses were conducted at the procedural or event level. We defined postoperative infection as any infection documented and treated during the postoperative period. Infections were categorized as follows: MRSA vs non-mrsa, deep wound (neck abscess), graft failure associated with infection, ventilator-associated pneumonia, urinary tract infection, and parotitis. We then compared infection rates between the MRSAcolonized and noncolonized patients using the Fisher exact test. Adherence to the complete protocol as well as to the preoperative, intraoperative, perioperative, and postoperative components of the complete protocol was determined. Patients were 154
3 Table 1. Study Population Characteristics Characteristic Study Population Treatment Group P Value Age at surgery, median (IQR), y 4.1 ( ) 4.1 ( ) 4.2 ( ).50 Male, No (%) 113 (57.4) 32 (50.0) 52 (39.1).15 Gestational age, median (IQR), wk a 33 (26-40) 34 (26-40) 32 (26-40).36 Gestational age 36 wk, No (%) 122 (61.9) 39 (60.9) 83 (62.4).84 Gestational age 32 wk, No (%) 100 (50.8) 29 (45.3) 71 (53.4).29 Double-stage procedure, No (%) 123 (62.4) 37 (57.8) 86 (64.7).35 Procedure type, No (%) LTR and grafts 149 (75.6) 46 (71.9) 103 (77.4) Resection of stenosis 31 (15.7) 11 (17.2) 20 (15.0) LTE cleft 8 (4.1) 2 (3.1) 6 (4.5).20 TEF repair 7 (3.6) 5 (7.8) 2 (1.5) LT separation 2 (1.0) 0 2 (1.5) History of tracheotomy 173 (87.8) 56 (87.5) 117 (88.0).92 Indwelling tracheotomy at surgery 136 (69.0) 47 (73.4) 89 (66.9).35 Comorbidities Pulmonary disease 138 (70.1) 47 (73.4) 91 (68.4).47 Gastrointestinal disease 152 (77.2) 52 (81.3) 100 (75.2).34 Cardiac disease 65 (33.0) 22 (34.4) 43 (32.3).78 Endocrine disease 9 (4.6) 3 (4.7) 6 (4.5).99 b Abbreviations: IQR, interquartile range; LT, laryngotracheal; LTE, laryngotracheoesophageal; LTR, laryngotracheal reconstruction; MRSA, methicillin-resistant Staphylococcus aureus; TEF, tracheoesophageal fistula. a Gestational age missing, n=16. b Fisher exact test. considered to be adherent to the complete protocol when there was no discrepancy between the protocol and the antibiotic actually administered. Patients were considered partially adherent in the perioperative period when they received at least 1 of the protocol antibiotics. These proportions were then compared between the MRSA-colonized and the MRSAnoncolonized groups using the Fisher exact test for individual period comparisons and the 2 test over all periods, adjusting for multiple tests using the Bonferroni method. A 2-tailed P value of.05 was considered statistically significant. For comparisons of adherence by operative period, a P value less than.008 was considered statistically significant. All analyses were performed using SAS version 9.2 (SAS Institute Inc). RESULTS A total of 180 patients underwent 202 open airway operations. Of these, 5 patients were excluded owing to unclear documentation of screening; the remaining 197 operations were included in this study. Demographic data and baseline characteristics of this study population are presented in Table 1. As shown, there were no significant differences between MRSA-positive patients and MRSA-negative patients with regard to age at surgery, sex, gestational age at birth, or comorbidities. In addition, there were no significant differences between these 2 groups with regard to the percentage of patients who underwent 2-stage vs single-stage procedures or the percentage of those with a history of tracheotomy placement. COLONIZATION AND MRSA PREVALENCE Table 2. Colonization Sites in 54 MRSA-Positive Procedures Site No. (%) Nares 43 (79.6) Axilla 11 (20.4) Perianal 19 (35.2) BAL/tracheotomy aspirate 27 (50.0) Gastrostomy tube 4 (7.4) No. of sites colonized 1 18 (33.3) 2 22 (40.7) 3 14 (25.9) Abbreviations: BAL, bronchoalveolar lavage; MRSA, methicillin-resistant Staphylococcus aureus. The overall prevalence of MRSA in the study was 32.5%. Site-specific colonization for the MRSA-colonized patients is described in Table 2. The prevalence of MRSA in patients with a tracheotomy at the time of surgery was not significantly different from the prevalence in patients without a tracheotomy (P=.35). MRSA TREATMENT AND POSTOPERATIVE INFECTION Postoperative infection in the MRSA-colonized and MRSA-noncolonized patients is presented in Table 3. As shown, postoperative infection rates were similar between the 2 groups. However, the 3 patients who developed postoperative MRSA infections were MRSA negative on preoperative screening. One MRSA-colonized patient underwent a laryngotracheal separation but was not treated according to protocol. This patient developed a surgical site MRSA abscess that resolved after incision, drainage, and a course of intravenous vancomy- 155
4 Table 3. Postoperative Infections by Treatment Group Variable Total Population, No. (%) Treatment Group, No. (%) P Value Any postoperative infection a 33 (16.9) 10 (15.9) 23 (17.4).79 MRSA infection a 3 (1.5) 0 3 (2.3).55 b Deep wound infections a 4 (2.0) 0 4 (3.0).31 b Graft failures 2 (1.0) 0 2 (1.5).99 b Abbreviation: MRSA, methicillin-resistant Staphylococcus aureus. a Unknown infection status in 2 procedures: MRSA positive (n = 1); MRSA negative (n = 1). b Fisher exact test. Table 4. Adherence to Antibiotic Protocol by Operative Period Variable Total Population, No. (%) Treatment Group, No. (%) P Value a Preoperative b Complete adherence 171 (88.6) 39 (63.9) 132 (100).001 Partial adherence 188 (97.4) 56 (91.8) 132 (100).003 Intraoperative 185 (93.9) 60 (93.8) 125 (94.0).10 Perioperative b 168 (88.9) 61 (98.4) 107 (84.3).004 Postoperative b 181 (92.8) 57 (91.9) 124 (93.2).005 All periods combined 130 (66.0) 32 (50.0) 97 (73.7).001 Abbreviation: MRSA, methicillin-resistant Staphylococcus aureus. a Fisher exact test P value reported for individual periods; 2 test P value reported for all periods combined. Statistically significant P values after Bonferroni adjustment for multiple tests are in bold. b Unknown adherence: preoperative, n=4;perioperative, n=8;postoperative, n=2. cin. Nineteen of the 23 postoperative infections in MRSA-noncolonized patients and all 10 infections in MRSA-colonized patients were caused by nosocomial non-mrsa organisms. Two laryngotracheal reconstruction cartilage graft failures and 1 dehiscence occurred. None of these events occurred in MRSA-colonized patients. One graft failure was attributed to corticosteroid administration and impaired wound healing. Another was attributed to -hemolytic Streptococcus. The dehiscence was attributed to Haemophilus influenzae. ADHERENCE TO PROTOCOL Adherence to the complete protocol and to perioperative components of the protocol is presented in Table 4. Adherence was especially problematic (complete, 63.9%, vs partial, 91.8%) in patients who had nasal colonization and did not receive the nasal mupirocin. Intraoperative adherence was high both in the MRSA-colonized and MRSA-noncolonized groups. COMMENT Toourknowledge, this is the first study to describeascreening and treatment MRSA protocol for pediatric patients undergoing open airway surgery. Based on prior experience, we considered these patients to be at high risk for colonization and the development of MRSA-associated surgical site infections. As anticipated, the prevalence of MRSA was high (32.5%). It was considerably higher than prevalence ratesreportedinpatientsundergoingothertypesofsurgery. 6,13 Moreover, it was higher than reported prevalence rates for other nonairway patients considered to be at high risk. 14 We attribute this largely to the characteristics of our study population. Specifically, 61.9% of the children were premature; 87.8% had been tracheotomized; and many had serious comorbidities such as pulmonary, gastrointestinal, and cardiac disease (Table 1). We consider these factors to be proxies for frequent hospitalization and exposure to antibiotics. This is consistent with reports that MRSA colonization may be greater in patients who have previously spent more than 5 days in an institutional setting and who have had frequent exposure to antibiotics. 4,15,16 During the study period, there were no MRSAassociated postoperative infections in patients treated according to our antibiotic protocol, which is consistent with reported findings in other studies. 17,18 Also, there were no graft losses or dehiscences in patients who were MRSAcolonized. The 3 cases of postoperative MRSA infection occurred in patients who were previously MRSA negative, suggesting that MRSA was acquired during hospitalization. Two patients treated according to protocol experienced graft loss or dehiscence associated with non-mrsa infection. This suggests that despite a screening and treatment protocol, there is an inherent risk of graft loss and dehiscence in all patients who undergo airway surgery. Infections other than MRSA may be causative factors. 156
5 Although complete adherence to all aspects of the protocol was lower than anticipated (66.0%), this can primarily be attributed to the particularly low adherence preoperatively (Table 4). Unlike preoperative adherence, intraoperative, perioperative, and postoperative adherence was high (93.9%, 88.9%, 92.8%, respectively). Our study has several limitations. Because it is a retrospective analysis of our protocol, it is subject to the inherent limitations associated with all retrospective studies. Missing data, such as infections or complications, may have occurred but may not have been documented. As well, a historical control group for direct comparison before institution of the protocol was not available. Prior to this time, screening of patients was not performed. The protocol was instituted only after multiple catastrophic airway reconstruction failures concomitantly occurred with an associated MRSA infection. In view of this, clinicians believed that the risk of catastrophic airway failure merited the introduction of a standardized MRSA treatment protocol. Despite the described limitations, our data demonstrate a high prevalence of MRSA in this patient population, suggesting a high risk of postoperative MRSA infection and the need for a MRSA protocol. Future prospective studies in this patient population should further examine postoperative infection rates and specific treatment protocols. In conclusion, our study describes a screening and treatment MRSA protocol for pediatric patients undergoing airway surgery. We found a high prevalence (32.5%) of MRSA colonization in these patients. Treatment of MRSAcolonized patients resulted in postoperative infection rates that were similar to those in MRSA-noncolonized patients. Furthermore, treatment of MRSA-colonized patients resulted in no MRSA-associated postoperative infections, graft loss, or dehiscence. In view of our results, we advise instituting MRSA screening and treatment protocols in patients undergoing airway surgery. Submitted for Publication: June 25, 2011; final revision received September 21, 2011; accepted November 16, Correspondence: Alessandro de Alarcon, MD, MPH, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 2018, Cincinnati, OH (alessandro.dealarcon@cchmc.org). Author Contributions: Drs Statham, de Alarcon, and Tabangin had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: McCarty Statham, de Alarcon, Germann, and Rutter. Acquisition of data: McCarty Statham. Analysis and interpretation of data: McCarty Statham, de Alarcon, Tabangin, Cohen, and Rutter. Drafting of the manuscript: McCarty Statham, de Alarcon, Germann, Cohen, and Rutter. Critical revision of the manuscript for important intellectual content: de Alarcon, Tabangin, and Rutter. Statistical analysis: de Alarcon and Tabangin. Administrative, technical, and material support: McCarty Statham, de Alarcon, and Germann. Study supervision: de Alarcon and Rutter. Financial Disclosure: Dr Rutter has the following relationships to disclose: Acclarent (scientific advisory board), Gyrus/Olympus (consultant), Boston Medical Products (consultant), Hood Laboratories (consultant), Bryan Medical (consultant), and Karl Storz (consultant). Previous Presentation: This study was presented at the annual meeting of the American Society of Pediatric Otolaryngology; May 2, 2010; Las Vegas, Nevada. Online-Only Material: Visit to listen to an author podcast about this article. Additional Contributions: Beverly Connelly, MD, director of the infection control program, assisted in the development of our antibiotic protocol. REFERENCES 1. Grundmann H, Aires-de-Sousa M, Boyce J, Tiemersma E. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat. Lancet. 2006;368(9538): Inman JC, Rowe M, Ghostine M, Fleck T. Pediatric neck abscesses: changing organisms and empiric therapies. Laryngoscope. 2008;118(12): Kaoutar B, Joly C, L Hériteau F, et al; French Hospital Mortality study group. Nosocomial infections and hospital mortality: a multicentre epidemiology study. J Hosp Infect. 2004;58(4): Kuehnert MJ, Hill HA, Kupronis BA, Tokars JI, Solomon SL, Jernigan DB. Methicillinresistant Staphylococcus aureus hospitalizations, United States. Emerg Infect Dis. 2005;11(6): Kuehnert MJ, Kruszon-Moran D, Hill HA, et al. Prevalence of Staphylococcus aureus nasal colonization in the United States, J Infect Dis. 2006; 193(2): Merrer J, Pisica-Donose G, Leneveu M, Pauthier F. Prevalence of methicillinresistant Staphylococcus aureus nasal carriage among patients with femoral neck fractures: implication for antibiotic prophylaxis. Infect Control Hosp Epidemiol. 2004;25(6): Naseri I, Jerris RC, Sobol SE. Nationwide trends in pediatric Staphylococcus aureus head and neck infections. Arch Otolaryngol Head Neck Surg. 2009;135 (1): Thomason TS, Brenski A, McClay J, Ehmer D. The rising incidence of methicillinresistant Staphylococcus aureus in pediatric neck abscesses. Otolaryngol Head Neck Surg. 2007;137(3): Song X, Perencevich E, Campos J, Short BL, Singh N. Clinical and economic impact of methicillin-resistant Staphylococcus aureus colonization or infection on neonates in intensive care units. Infect Control Hosp Epidemiol. 2010;31(2): Anderson DJ, Kaye KS, Chen LF, et al. Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multicenter matched outcomes study. PLoS One. 2009;4(12):e Bratzler DW, Houck PM; Surgical Infection Prevention Guideline Writers Workgroup. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Am J Surg. 2005;189(4): Polubothu S, Harrison S, Clement A, Kubba H. An audit of prophylactic antibiotic use in laryngeal reconstruction surgery. Int J Pediatr Otorhinolaryngol. 2009; 73(8): Murthy A, De Angelis G, Pittet D, Schrenzel J, Uckay I, Harbarth S. Costeffectiveness of universal MRSA screening on admission to surgery. Clin Microbiol Infect. 2010;16(12): Kaiser ML, Thompson DJ, Malinoski D, Lane C, Cinat ME. Epidemiology and risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus among burn patients. J Burn Care Res. 2011;32(3): Sattler CA, Mason EO Jr, Kaplan SL. Prospective comparison of risk factors and demographic and clinical characteristics of community-acquired, methicillinresistant versus methicillin-susceptible Staphylococcus aureus infection in children. Pediatr Infect Dis J. 2002;21(10): Drinka PJ, Stemper ME, Gauerke CD, Miller JE, Goodman BM, Reed KD. Clustering of multiple endemic strains of methicillin-resistant Staphylococcus aureus in a nursing home: an 8-year study. Infect Control Hosp Epidemiol. 2005; 26(2): Merrer J, Desbouchages L, Serazin V, Razafimamonjy J, Pauthier F, Leneveu M. Comparison of routine prophylaxis with vancomycin or cefazolin for femoral neck fracture surgery: microbiological and clinical outcomes. Infect Control Hosp Epidemiol. 2006;27(12): Bode LG, Kluytmans JA, Wertheim HF, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362(1):
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