Gynaecological Surgery in Adults Surgical Antibiotic Prophylaxis
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1 Gynaecological Surgery in Adults Surgical Antibiotic Prophylaxis Full Title of Guideline: Author (include and role): Division & Speciality: Scope (Target audience, state if Trust wide): Review date (when this version goes out of date): Explicit definition of patient group to which it applies (e.g. inclusion and exclusion criteria, diagnosis): Changes from previous version (not applicable if this is a new guideline, enter below if extensive): Summary of evidence base this guideline has been created from: Guideline For Antibiotic Prophylaxis Within Gynaecological Surgery For Adult Patients Dr Vivienne Weston: Consultant Microbiologist Mr David Nunns, Consultant Gynaecological Oncologist Lauren Rose, Specialist Clinical Pharmacist, Antimicrobials and Infection Control Evelyn Wan, Senior Clinical Pharmacist Antimicrobials Gynaecology Microbiology Doctors, Pharmacists, Nurses April 2022 Adult patients undergoing gynaecological surgical procedures outlined within the guideline Updates reflect recent literature SIGN 104. Guidelines on Surgical Antibiotic Prophylaxis 2008 updated April 2014 available from NICE surgical site infection. Prevention and treatment of surgical site infection. Oct 2008 Recommended best practice based on clinical experience of guideline developers NICE Quality standard 49, Surgical Site Infection, October 2013 ACOG practice bulletin No. 195: Prevention of infection after gynecologic procedures. Obstet Gynecol 2018; 131:e172. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 2013; 70:195. This guideline has been registered with the trust. However, clinical guidelines are guidelines only. The interpretation and application of clinical guidelines will remain the responsibility of the individual clinician. If in doubt contact a senior colleague or expert. Caution is advised when using guidelines after the review date or outside of the Trust. Nottingham Antimicrobial Guidelines Committee Page 1 of 5 Written April 2019
2 GUIDELINE FOR ANTIBIOTIC PROPHYLAXIS WITHIN GYNAECOLOGY SURGERY FOR ADULT PATIENTS Contents Page 1. Introduction 3 2 Risk of infection 3 3 Antibiotic Prophylaxis - Principles Timing for Administration 3.2 Additional Intra-operative doses 3.3 Post-operative antibiotic prophylaxis 3.4 Risk of Endocarditis 4 Gynaecology Surgery Antibiotic Prophylaxis Regimens 5 Nottingham Antimicrobial Guidelines Committee Page 2 of 5 Written April 2019
3 1.Introduction: Surgical site infection (SSI) is one of the most common healthcare associated infections resulting in an average additional hospital stay of 6.5 days per case. Studies have shown that the administration of prophylactic antibiotics after wound closure do not reduce infection rates further and can result in harm (see below). Administration of antibiotics also increases the prevalence of antibiotic-resistant bacteria and predisposes the patient to infection with organisms such as Clostridium difficile, a cause of antibiotic-associated colitis. This risk increases with the duration that antibiotics are given for and is higher in the elderly, immunosuppressed, patients who have a prolonged hospital stay or who have received gastro-intestinal surgery. 2. Risk of infection: The risk of SSI depends on a number of factors; these can be related to the patient or the operation and some of them are modifiable (see Table 1): Patient Operation Age Nutritional status Diabetes Smoking Obesity Coexistent infections at a remote body site Colonisation with microorganisms (e.g. Staph. aureus) Immunosuppression (inc. taking glucocorticoid steroids or immunosuppressant drugs) Length of preoperative stay Co-existent severe disease that either limits activity or is incapacitating. Malignancy Table 1 Risk factors that increase the rate of SSI Duration of surgical scrub / Skin antisepsis Preoperative shaving/ preoperative skin prep. Length of operation Appropriate antimicrobial prophylaxis Operating room ventilation Inadequate sterilization of instruments Foreign material in the surgical site Surgical drains Surgical technique inc. haemostasis, poor closure, tissue trauma Post-operative hypothermia The risk is also related to the amount of contamination with microorganisms the socalled class of the operation (see Table 2): Class Clean Definition Operations in which no inflammation is encountered and the respiratory, alimentary or genitourinary tracts are not entered. There is no break in aseptic operating theatre technique. Clean-contaminated Operations in which the respiratory, alimentary or genitourinary tracts are entered but without significant spillage. Contaminated Operations where acute inflammation (without pus) is encountered, or where there is visible contamination of the wound. Examples include gross spillage from a hollow viscus during the operation or compound/open injuries operated on within four hours Dirty Operations in the presence of pus, where there is a previously perforated hollow viscus, or compound/open injuries more than four hours old. Table 2 Definitions of operation class. Peri-operative antibiotics are generally recommended for clean surgery involving the placement of a prosthesis or implant, clean-contaminated or contaminated surgery. Dirty operations generally require treatment with antibiotics. Nottingham Antimicrobial Guidelines Committee Page 3 of 5 Written April 2019
4 Antibiotic Prophylaxis 3.1 Timing for Administration Antibiotic prophylaxis administered too early or too late increases the risk of SSI. Studies suggest that antibiotics are most effective when given 30 minutes before skin is incised. The pragmatic approach is to administer prophylaxis towards the end of induction and ensure that surgery starts within 30 minutes of this time wherever possible. 3.2 Additional Intra-operative doses Antibiotic High antibiotic levels, at the site of incision, for the duration of the operation, are Cefuroxime essential for effective prophylaxis. Patients who experience major blood loss Gentamicin (greater than 1500ml) should have fluid Metronidazole resuscitation, followed by re-dosing with the Teicoplanin recommend prophylaxis regimen for that operation (see section 4 and 5). For operations lasting > 4 hours re-dosing may be necessary (see table 3) 3.3 Post-operative antibiotic prophylaxis Studies have shown that giving additional antibiotic prophylaxis after wound closure does not reduce infection rates further. Post-operative antibiotics should only be given to treat active/on-going infection (e.g. perforated appendectomy) unless specifically recommended against the surgical procedure. 3.4 Risk of endocarditis Patients with specific cardiac pathologies (see table 4) are at higher risk of developing endocarditis. In March 2008 NICE reviewed the evidence and now recommends that the risks of prophylaxis outweigh the benefits in most cases. This suggests that if patients at high-risk of endocarditis undergoes a Gynaecology procedure involving an infected site, the regimen chosen should also be active against bacteria that may lead to endocarditis. Recommended re-dosing interval/dose to give 4 hours, give 1.5g IV 4 hours, give 1.2g IV re-dosing not recommended 8 hours, give 500mg IV re-dosing not recommended Table 3: Recommend re-dosing interval Previous episode of infective endocarditis Prosthetic cardiac valves Structural congenital heart disease (including surgically corrected or palliated structural conditions, but excluding isolated atrial septal defect, fully repaired septal defect, fully repaired patent ductus arteriosus, and closure devices considered to be endothelialised) Acquired valvular heart disease with stenosis or regurgitation Hypertrophic cardiomyopathy Table 4: Cardiac conditions that are high risk for predisposition to endocarditis. The antibiotic regimens below have been separated into Standard low endocarditis risk regimens (section 4.1) recommended for those without any of the conditions in table 4 and Regimens for patients at moderate/high risk of endocarditis (see section 4.2) for patients who do. Nottingham Antimicrobial Guidelines Committee Page 4 of 5 Written April 2019
5 4.1 Gynaecology Surgery Antibiotic Prophylaxis Regimens standard Low endocarditis risk regimens (see 3.4 above) Procedure Antibiotic dose/route Laparoscopic procedures, D&C, tubal surgery without PID are extensive or with infection. Patient at LOW risk 1 of MRSA are extensive or with infection. Patients at HIGH risk 1 of MRSA Mild Penicillin allergy (Not to be used in serious penicillin allergy, e.g. urticarial rash within the first 72 hours, anaphylaxis or angioedema) Severe peniciilin allergy (e.g. urticarial rash within 72 hours, anaphylaxis or angioedema) Or cephalosporin allergy No prophylaxis routinely indicated, although doses may be given as below if Laparoscopy uncovers inflammation. 1.2g IV Given at induction 1.2g IV Gentamicin 2mg/kg IV Given at induction Cefuroxime 1.5g IV Cefuroxime 1.5g IV 1 Pts at high risk MRSA: Known colonisation with MRSA; Nursing home resident with long term leg ulcers, pressure sore or urinary catheter; or inpatient > 1 week. 4.2 Gynaecology Surgery Antibiotic Prophylaxis Regimens moderate/high endocarditis risk regimens (see 3.4 and table 4 above) Procedure Antibiotic dose/route Mild or severe allergy to penicillins/cephalosporin Laparoscopic procedures, D&C, tubal surgery without PID are extensive with active infection at the site. No prophylaxis routinely indicated, although doses may be given as below if Laparoscopy uncovers inflammation. Use standard regimens in 4.1 Teicoplanin 800mg IV Nottingham Antimicrobial Guidelines Committee Page 5 of 5 Written April 2019
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