Orit Chai February 2017 ORIT CHAI - CURRICULUM VITAE

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1 ORIT CHAI - CURRICULUM VITAE 1. Personal Details: Date of birth: 27/04/72 Country of birth: Israel Identify number: Address: Home: Maale Haerez 3, Moza Elit Work: Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot , Israel Tel: Fax: orit18m@gmail.com License: Licensed to practice Veterinary Medicine in Israel, License number Higher Education BSc in Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem DVM, Koret School of Veterinary Medicine, Hebrew University of Jerusalem Rotating Internship in Small Animal Medicine and Surgery, Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Beit Dagan Residency in Neurology, Veterinary Teaching Hospital, Koret School of Veterinary Medicine Diplomate, European College of Veterinary Neurology (ECVN). 3. Appointments at the Hebrew University/Veterinary Teaching Hospital: Clinical appointment, Neurology and Neurosurgery Dept., Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Beit Dagan Clinical Instructor, Veterinary Teaching Hospital, Koret School of Veterinary Medicine. 4. Additional Functions/Tasks at the Hebrew University/Veterinary Teaching Hospital: Supervising case presentation course, fourth year veterinary students Coordinator of the weekly physiology seminars attended by residents and senior staff of the Veterinary Teaching Hospital present Head of Neurology and Neurosurgery Dept., Veterinary Teaching Hospital, Koret School of Veterinary Medicine. 5. Service in other Academic and Research Institutions:. 6. Other Activity: 1

2 . 7. Research Grants: 8. Teaching at the Hebrew University: a) Supervision of Master s and doctoral degree students DVM with thesis Co-Supervising (with Prof. Merav Shamir) residents in neurology and neurosurgery for the European College of Veterinary Neurology (ECVN): Dr. Itay Srugo: Diplomate of the ECVN (2012) Dr. Itai Barnoon: Diplomate of the ECVN (2013) Dr. Yael Chamisha: Diplomate of the ECVN (2016) Dr. Yael Merbl: will take the certification exam this year : Co-supervising (with Prof. Merav Shamir) neurology residents research projects: Dr. Itay Srugo: Association of cerebrospinal fluid analysis findings with clinical signs and outcome in acute nonambulatory thoracolumbar disc disease in dogs Dr. Itai Barnoon: Retrospective evaluation of combined mycophenolate mofetil and prednisone treatment for meningoencephalomyelitis of unknown etiology in dogs: 25 cases Dr. Yael Chamisha: The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation Dr. Yael Merbl: Tumor necrosis factor-α and interleukin-6 concentrations in cerebrospinal fluid of dogs following seizure Co-supervising (with Dr. Efrat Kelmer and Prof. Merav Shamir) student s final thesis: Efrat Moskovich, "Computed Tomography Findings and Clinicopathological Parameters as Possible Prognostic Factors for Canine Traumatic Brain Injury (TBI)" b) Post-doctoral Fellows and Visitors (6 months or longer): c) Courses Taught by Candidate Teaching assistant, clinical methods course, second year veterinary students Teaching assistant, neuro-anatomy course, first year veterinary students Course coordinator and teaching, elective course in pathophysiology of epilepsy, third year veterinary students 2

3 Supervising case presentation course, fourth year veterinary students Teaching, elective course in neuro-emergency, third year veterinary students Course coordinator and teaching, elective course in neuroemergency, third year veterinary students Teaching basic pharmacology (3 hours), second year veterinary students Teaching physiology (6 hours), first and second year veterinary students Course coordinator; Clinical exposure course B, second year veterinary students 3

4 1. Doctoral Dissertation: 2. Books 3. Books Edited 4. Chapters in Collections: Review Articles: 5. Articles: List of publications Legend: PI Principal Investigator; S Student; C Co-researcher; T Technician/lab assistant The numbers at the end of each article denote the impact factor; ranking of the journal in its field; and the number of citations excluding self-citations. Research articles: 1. Shamir, HM. PI Goelman, G. T and Chai, O. PI (2004). Post anesthetic cerebellar dysfunction in cats. J. Vet. Intern. Med. 18; ;19/138 (Veterinary Sciences);3. 2. Chai, O. PI, Johnston, ED. C and Shamir, HM. PI (2008). Bite wounds involving the spine Characteristics, therapy and outcome in seven cases. Vet. J. 175: ;26/138 (Veterinary Sciences);6. 3. Shamir, HM. PI, Chai, O. C and Leob, E. C (2008). A new method for intervertebral space distraction prior to stabilization combined with complete ventral slot for the treatment of disc associated wobbler syndrome in dogs - A long term follow-up. Vet. Surg. 37: ;37/138 (Veterinary Sciences);17 4. Gross-Tsubery, R. PI Chai, O. C Shilo, Y. C Miara, L. C Horowitz, I. C Shmueli, A. C Aizenberg, I. C Hoffman, C. C Reifen, R. C and Shamir, HM. PI (2010). Computed tomography analysis of skull malformation suspected to be related to vitamin A deficiency in captive lions (Panthera leo). Vet. Radiol. Ultrasound 51: ;64/138(Veterinary Sciences);5. 5. Srugo, I. PI Aroch, I. C Christopher, MM. C Chai, O. C Goralnik, L. S Bdolah- Abram, T. T and Shamir, HM. PI (2011). Association of cerebrospinal fluid analysis findings with clinical signs and outcome in acute nonambulatory thoracolumbar disc disease in dogs. J. Vet. Intern. Med. 25: ;19/138 (Veterinary Sciences);9. 4

5 6. Chai, O. PI Sommer, A. PI Zimmerman, G. C Soreq, H. C Friedman, A. C Bdolah-Abram, T. T Aroch, I. C and Shamir, HM. PI (2013). Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures. Vet. J. 198: ;26/138 (Veterinary Sciences);0. 7. Merbl, Y. PI Sommer, A. PI Chai, O. C Aroch, I. C Zimmerman, G. C Friedman, A. C Soreq, H. C and Shamir, HM. PI. (2014). Tumor necrosis factor-α and interleukin-6 concentrations in Cerebro-Spinal Fluid of dogs following seizure. J. Vet. Intern. Med. 28; ;19/138 (Veterinary Sciences);0. 8. Chamisha, Y. PI Aroch, I. C Kuzi, S. C Srugo, I. C Bdolah-Abram, T. T Chai, O. C Christopher, MM. C Merbl, Y. C Rothwell, K. S and Shamir, HM. PI (2015). The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. Res. Vet. Sci. 100: ;31/138 (Veterinary Sciences);0. 9. Barnoon, I. PI Shamir, HM. C Aroch, I. C Bdolah-Abram, T. T Srugo, I. C Konstantin, L. T and Chai, O. PI (2016). Retrospective evaluation of combined mycophenolate mofetil and prednisone treatment for Meningoencephalomyelitis of unknown etiology in dogs: 25 cases ( ). J. Vet. Emerg. Crit. Care 26: ;49/138 (Veterinary Sciences); Chai, O. PI Harrosh, T. S Bdolah-Avram, T. T Mazaki-Tovi, M. C and Shamir, HM. PI (2016). Characteristics and risk factors for intervertebral disc extrusions in Pekingese dogs. accepted to J. Am. Vet. Med. Assoc ;32/138(Veterinary Sciences). 11. Chai, O. PI Peery, D. C Bdolah-Abram, T. T Moscovich, E. S Kelmer, E. C Klainbart, S. C Milgram, J. C and Shamir, HM. PI (2016). Computerized tomography findings in canine head trauma and a novel prognostic CT-based scoring index. Am. J. Vet. Res. (in press, accepted 12/2016) 1.504;31/138 (Veterinary Sciences). Case reports: 1. Dvir, E. PI Perl, S. C Loeb, E. C Shklar-Hirsch, S. S Chai, O. C Mazaki-Tovi, M. C Aroch, I. C and Shamir, HM. PI (2007). Spinal Intramedullary Aberrant Spirocerca lupi Migration in 3 Dogs. J. Vet. Intern. Med. 21: ;19/138 (Veterinary Sciences); Shamir, HM. PI Shilo, Y. C Friedman, A. C Chai, O. C Reifen, R. C Miara, L. C (2008). Sub-occipital craniectomy in a lion ((panthera leo) with occipital bone malformation and hypovitaminosis A. J. Zoo Wildl. Med. 39: ;104/138 (Veterinary Sciences);6. 3. Chai, O. PI Sheleph, I. C Brenner, O. C Dogadkin, O. T Aroch, I. C and Shamir, HM. PI (2008). Magnetic resonance imaging findings of spinal intramedullary 5

6 spirocercosis in two dogs. Vet. Radiol. Ultrasound 49: ;64/138 (Veterinary Sciences);8. 4. Aharonson-Raz, K. PI Milgram, J. C Chai, O. C and Abells Sutton, G. PI (2009). Masseter fibrosis leading to trismus and dysphagia in a mare. Vet. Rec. 9;164: ;23/138 (Veterinary Sciences);0. 5. Srugo, I. PI Chai, O. C Yaakov, D. C Sharon, L. C and Shamir, HM. PI. (2010). Successful medical management of lumbar intervertebral disc prolapse in a ferret. J. Small Anim. Pract. 51: O.976;59/138 (Veterinary Sciences);6. 6. Barnoon, I. PI Chai, O. C Srugo, I. C Peeri, D. C Konstantin, L. T Brenner, O. C and Shamir, HM. PI (2012). Spontaneous intradural disc herniation with focal distension of the subarachnoid space in a dog. Can. Vet. J. 53: ;90/138 (Veterinary Sciences);2. 7. Merbl, Y. PI Shilo-Benjamini, Y. C Chai, O. C Chamisha, Y. C Anglister, N. S King R. C Horowitz, I. C Aizenberg, I. C and Shamir, HM. PI (2013). Taenia multiceps coenurus brain cyst removal in two wild Nubian ibex capra nubianas. J. Zoo Wildl. Med. 45: ;104/138;0. 8. Chamisha, Y. PI Shamir, HM. C Merble, Y. C and Chai, O. PI (2014). Reversible paralysis and loss of deep pain sensation after direct intrathecal morphine administration. Vet. Surg. 44: ;37/138 (Veterinary Sciences);0. 9. Chai, O. PI Milgram, J. C Shamir, HM. C and Brenner, O PI (2015). Polioencephalomyelopathy in a mixed breed dog resembling Leigh's disease. Can. Vet. J. 56: ;90/138 (Veterinary Sciences); Espadas, I. PI Chai, I. C Lindley, S. C and Wessmann, A. PI (2015). Caudal lumbar disc disease presenting as praying position -like posture and gait. Veterinary Record Case Reports. 3;e (Does not have an impact factor). 11. Rapoport, K. PI Shamir, HM. C Bibring, U. C Barnoon, I. C Shipov, A. C and Chai, O. PI (2016). Spinal empyema secondary to vertebral osteomyelitis in a cat. Israel Journal of Veterinary Medicine. 71: ; 117/138 (Veterinary Sciences); Rosenzweig Büeler, A. PI Merbl, Y. C Kushnir,Y. C Chai, O. C, Aizenberg, I. C Horowitz, I. C Matalon, E. T Tam, D. T and Shamir, HM. PI (2016). Dorsal laminectomy to relieve spinal cord compression in a captive Syrian bear (URSUS ARCTOS SYRIACUS). J Zoo Wildl Med Dec;47(4): (0.421;104/138) (Veterinary Sciences). 6. Participation in Scientific Conferences, Lectures, and Other Activity: 6

7 6.1 Invited lectures: Romanian Veterinary Orthopedic Congress. Sinaia,Romania. Three lectures: "How to make the correct localization in the nervous system? Video cases (parts 1 and 2)" (2 hours). "Central nervous system Vs. neuromuscular disorders. How can we tell?" (1 hour). 6.2 Oral and poster presentation at international meetings: The 15 th Annual Symposium of European Society of Veterinary Neurology (Philadelphia, USA). "Postanesthetic cerebellar dysfunction in cats. Abstract The 18 th Annual Symposium of European Society of Veterinary Neurology: Nervous System Regeneration (Munich, Germany). Bite wounds to the spine (7 cases) Poster The 20 th Annual Symposium of European Society of Veterinary Neurology: Infectious and Inflammatory Diseases of the Nervous System in Animals (Bern, Switzerland). Spinal intramedullary spirocercosis in dogs a diagnostic challenge. Abstract The 34 th Symposium of Veterinary Medicine (Beit Dagan, Israel). "Neuromuscular diseases". Lecture 6.3 Awards 2002 John Presthus Award for best presentation, ECVN annual meeting, Philadelphia USA. 7. Patents: 7

8 Orit Chai, 2017 SCIENTIFIC BIOGRAPHY After completing my DVM studies at the Koret School of Veterinary Medicine and a one-year rotating internship in small animal medicine and surgery at the Veterinary teaching hospital, I pursued my interest in neurology and entered a three-year residency program. The training in veterinary neurology and neurosurgery provided me with unique hands-on clinical experience as well as exposure to a wide range of research opportunities and facilities. The faculty has facilitated my professional growth in veterinary medicine and, specifically, in neurology and served as the perfect learning environment preparing for the neurology boards. Soon after successfully completing the board exams, I joined the Neurological Department headed by Prof. Merav Shamir and took a clinical instructor position at the Veterinary Teaching Hospital. As a clinician in the field of neurology, my scientific interest and work can be divided into two main fields: 1) Identification of clinical conditions and development of new methods for the diagnosis and treatment of challenging neurological and neurosurgical conditions, and 2) the use of different imagining modalities for diagnosis, screening and prognosis of neurological diseases. 1. Identification of clinical conditions and development of new methods for the diagnosis and treatment of challenging neurological and neurosurgical conditions Over the years, I have identified and described new clinical conditions and diseases in dogs and other species. These include post-anesthetic cerebellar degeneration in cats (RA#1), bite wounds involving the spine (RA#2), MRI findings in intra-spinal aberrant migration of Spirocerca lupi (CR#3), spinal empyema secondary to vertebral osteomyelitis in a cat (CR#11), polioencephalomyelopathy in a mixed breed dog resembling Leigh's disease (CR#9) and reversible paralysis after direct intrathecal morphine administration.(cr#8). I have also searched for a treatment for meningoencephalitis of unknown etiology in dogs, which is the most common inflammatory disease of the canine central nervous system (CNS). I investigated the possibility of treating these dogs with mycophenolate mofetil, in addition to steroids, and proved it beneficial in a large proportion of cases (RA#9). Another project has provided new insights into mechanisms of epilepsy, which is a common and well-described disorder in dogs and humans with around 30% of the patients refractory to antiepileptic drugs. I have collaborated with the Lily Safra Center for Brain Sciences of the Hebrew university to examine the role of the cholinergic system in the CNS of dogs with naturally occurring seizures. For that, we measured the activity of acetyl choline esterase (AChE) and its read-through isoform AChE-R in the cerebrospinal fluid (CSF) of dogs after seizure and in control groups (RA#6). A following study focused on the CNS inflammatory response in epileptic dogs by measuring the concentrations of tumor necrosis factor-α and interleukin-6 in the CSF following seizure (RA#7). Other important studies were related to spinal cord injuries. In veterinary medicine, permanent paralysis often results in euthanasia. Hence, giving the correct prognosis in cases of sever spinal cord injury is essential. In collaboration with Prof. 8

9 Shamir, we used acute intervertebral disc herniation in dogs as a model of naturally occurring spinal cord injury. We found that in these dogs, the ratio between macrophages and monocytes in the CSF samples may be an accurate prognostic indicator for regaining ambulatory status (RA#5). We then conducted a second stage of that study, in which we looked specifically at dogs that had the most severe degree of spinal cord injury, namely lost nociception sensation (RA#8), and tested the validity of our recent prognostic factor in this challenging group of dogs. In a study of Pekingese dogs suffering from intervertebral disk herniation, I showed that disc calcification on plain radiographs is a major risk factor for the occurrence of the condition (RA#10). The results of that study have established the rationale for the use of spine radiographs as a breeding screening tool to reduce the incidence of disk herniation in Pekingese dogs Lastly, I have collaborated as senior clinician in the development and establishment of several particularly challenging neurosurgical procedures in animals we have encountered during our routine work at the department. Among these, we have established a new method for intervertebral space distraction prior to stabilization combined with complete ventral slot for the treatment of disc-associated wobbler syndrome in dogs (RA#3). We described for the first time a surgical procedure, sub-occipital craniectomy, which can save captive lions affected by calvarial hyperostosis (CR#2), brain surgery and rehabilitation protocol of wild Nubian ibex that was successfully released back to nature, Taenia multiceps coenurus brain cyst removal in two wild Nubian ibex (CR#7) and, lastly, a dorsal laminectomy to relieve spinal cord compression in a captive Syrian bear (CR#12), which was the first surgery of that kind in the world. 2. Application of different imaging modalities in neurological diseases Over the years, I have developed an increased interest in neuroimaging, aiming to improve our understanding of diseases processes through advanced use of imaging techniques. I have investigated different sequences and modalities of MR images in dogs with aberrant intra-spinal migration of Spirocerca lupi. I characterized the imaging findings in these cases, thereby improving the ability to make antemortem diagnosis of the disease (CR#3). This project is now followed by a retrospective and prospective study of changes in the muscles surrounding the vertebral column that, together with the typical changes in the spinal cord, will provide exclusive imagine patterns for early diagnosis of this disease. Lately, I have examined the use of CT to evaluate head trauma patients, with aim to utilize the obtained information to determine prognosis. Based on the recorded data, I have established a unique and novel prognostic CT-based scoring index for head trauma in dogs termed Koret CT score (RA#11). I am now performing the second stage of this project, in which I plan to test this score in a double-blind prospective study. As I look into the future, my current areas of research interest are: 1. To establish the CT scoring index as an objective prognostic tool in both dogs and cats following head trauma and to further develop the score to combine both CT and clinical findings. 2. To combine MRI findings with specific CSF bio-markers and tests their specificity and sensitivity in the diagnosis of intra-spinal Spirocerca lupi. 9

10 3. To investigate the patterns of intervertebral disk calcification in Pekingese dogs with aim to determine the correlation to disk herniation and to examine the hereditability of disk calcification in this breed. My ultimate goal is to develop a selective breeding strategy based on spinal radiographs obtained at a young age. 10