A happy pet has a forever home.

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1 A happy pet has a forever home. Calm Your Pet s Soul

2 The #1 reason dogs are surrendered 1 to animal shelters is bad behavior. Anxiety, fear, and stress play major roles in a majority of canine and feline behavioral disorders. 2 Fear and anxiety disorders affect an estimated 23 million dogs in the U.S. 3 Over Grooming Hiding & Escaping Hypersalivation Trembling & Panting DOG Fear and Anxiety Signs Elimination Destruction Excessive Barking Hiding Panting CAT Fear and Anxiety Signs Elimination Outside Litterbox Spraying Inter-cat Aggression In pet cats, behavior problems are still the most common cause of euthanasia. 4 Up to 54% of pet owners whose pets have behavioral issues have NOT consulted a veterinarian. 5 Pet owners are more likely to consult free help options such as: the internet, trainers, breeders, and friends. 5 Veterinarians lose up to 15% of their client base each year due to unresolved behavioral issues. 6

3 DIAGRAMS ARE REPRESENTATIVE L-theanine blocks excitatory glutamate receptors at the synapse while also stimulating the production of alpha brain waves throughout the brain. 11,12 Magnolia and Phellodendron extracts contain compounds which enhance the release of stabilizing GABA while blocking the release of glutamate at the synapse. 9,10,14,15 Whey protein concentrate supplements amino acid precursors required to synthesize serotonin and glutathione. 13,16

4 contains multiple active ingredients all in one chewable supplement. is for dogs and cats to help support normal behavior and facilitate a calming effect. L-theanine Magnolia/ Phellodendron An amino acid found naturally in green tea. It directly stimulates the production of alpha brain waves, which create a state of deep relaxation, wakefulness, and mental awareness. 12 The combination of Magnolia and Phellodendron extracts appear to be synergistic, with the combination controlling stress and anxiety more effectively than either compound used alone. 14 Contains NMXSLQ05 a trademarked high quality protein source which supplements essential amino acids including the precursors of glutathione and serotonin. 13,16 Whey Protein Concentrate

5 At the first sign of client complaint, veterinarians should initiate management. Ask direct questions. Are you having any trouble with 7 destructiveness or house soiling? is formulated to help facilitate contentment during periods of adjustment in a pet s daily routine. Common causes of anxiety Fireworks Being Home Alone Thunderstorms Traveling/ Unfamiliar People Unfamiliar Pets Crating Moving Transportation New Smells Kenneling Loud Noises Environmental Changes Car Rides Multi-Cat Aging Household A COMPREHENSIVE APPROACH FOR BEHAVIORAL DISORDERS: Avoidance of Fear Behavioral Modification/ Conditioning Anxiolytics Alternative Modalities Nutritional Supplement Pharmaceuticals The specific cause of a pet s anxiety may be difficult to isolate, and many anxiety issues occur in combination. 8 The proper approach should be multi-modal.

6 I encourage clients to administer a behavioral nutritional supplement for at least 4-6 weeks. While some benefits are apparent immediately, the full effect may be more noticeable in the second month of continuous administration. Theresa L. DePorter, DVM, MRCVS, DECAWBM, DACVB Relaxation without sedation Intended for daily use Tasty chewables For Small Dogs and Cats Under 8 lbs 60 count Soft Chews 1 chew For Small to Medium Dogs and Large Cats 8 30 lbs 75 count Soft Chews 8 15 lbs: 1 chew lbs: 2 chews For Medium to Large Dogs Over 30 lbs 45 count Chewable Tablets lbs: ½ tablet lbs: 1 tablet To learn more about Solliquin, contact your Nutramax Laboratories Veterinary Sciences, Inc. sales representative. Our customer service and technical advisors are available Monday thru Friday 8:30 am to 5:00 pm eastern time at Miller DD, Staats SR, Partlo C, et al. Factors associated with the decision to surrender a pet to an animal shelter. Journal of the American Veterinary Medical Association 1996;209: Landsberg GM, Hunthausen WL, Ackerman LJ. Fears, phobias, and anxiety disorders. Behavior Problems of the Dog and Cat. Edinburgh: Saunders/Elsevier, 2013; Landsberg GM, Blizzard P, De Rivera C. Prevalence of fearful and anxious behaviors in dogs in the United States. STVV-ESVCE-ECAVBM Practitioners AAoF. Feline Behavior Guidelines, Shore ER, Burdsal C, Douglas DK. Pet owners views of pet behavior problems and willingness to consult experts for assistance. Journal of Applied Animal Welfare Science 2008;11: Patronek GJ, Dodman NH. Attitudes, procedures, and delivery of behavior services by veterinarians in small animal practice. Journal of the American Veterinary Medical Association 1999;215: Sherman BL. Separation anxiety in dogs. Compendium on Continuing Education for Practicing Veterinarian 2008; 30: Overall KL, Dunham AE, Frank D. Frequency of nonspecific clinical signs in dogs with separation anxiety, thunderstorm phobia, and noise phobia, alone or in combination. Journal of the American Veterinary Medical Association 2001;219: Patocka J, Jakl J, Strunecka A. Expectations of biologically active compounds of the genus Magnolia in biomedicine. Journal of Applied Biomedicine 2006;4: Alexeev M, Grosenbaugh DK, Mott DD, et al. The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors. Neuropharmacology 2012;62: Nathan PJ, Lu K, Gray M, et al. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. Journal of Herbal Pharmacotherapy 2006;6: Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition 2008;17: Markus CR. Dietary amino acids and brain serotonin function; Implications for stress-related affective changes. Neuromolecular Medicine 2008;10: Li JM, Kong LD, Wang YM, et al. Behavioral and biochemical studies on chronic mild stress models in rats treated with a Chinese traditional prescription of banxia-houpu decoction. Life Sciences 2003;74: Lin T-Y, Lin T-Y, Lu C-W, et al. Berberine inhibits the release of glutamate in nerve terminals from rat cerebral cortex. PLoS ONE 2013;8:e Yalcin AS. Emerging therapeutic potential of whey proteins and peptides. Current Pharmaceutical Design 2006;12: DATA ON FILE. SOLLIQUIN.COM Enroll now in the Nutramax Laboratories Veterinary Sciences, Inc. Loyalty Program: nutramaxlabs.com/loyalty

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