Antibiotics A Multidisciplinary Approach

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Antibiotics A Multidisciplinary Approach"

Transcription

1 Antibiotics A Multidisciplinary Approach

2 Antibiolies A Multidisciplinary Approach Giancarlo Lancini Marion Merrell Dow Research Institute (MMDRI) Lepetit Research Center Gerenzano (Varese), Italy Francesco Parenti Marion Merrell Dow Europe AG Horgen, Switzerland and Gian Gualberto Gallo Formerly of Marion Merrell Dow Research Institute (MMDRI) Lepetit Research Center Gerenzano (Varese), Italy Springer Science+Business Media, LLC

3 Llbrary of Congress Catalog1ng-1n-Pub11cat1on Data Lanclni, Giancarlo. Anti biotlcs a multidlscipllnary approach I Giancarlo Lanclni, Francesco Parenti, and Gian Gualberto Gallo. p. cm. Includes bibllographlcal references and Index. ISBN ISBN (ebook) DOI / Antlbiotics. I. Parenti, Francesco. II. Gallo, Gian Cualberto. III. T i t l ~. [DNLM: 1. Antibiotics--pharmacology. 2. Antibiotics--metabolism. 3. Structure-Actlvity Relationship. 4. Drug Resistance, Microbial. av 350 L249a RM267.L '.329--dc20 DNLM/DLC for Llbrary of Congress CIP Publication history First edition: Biochimica e Biologie degli Antibiotici, G. C. Lancini and F. Parenti, ISEDI, Milan, Italy (1977) First edition-english translation: Antibiolies-An Integrated View, G. C. Lancini and F. Parenti, Springer-Verlag, New York (1982) First edition-russian translation: Antibiotiki, G. C. Lancini and F. Parenti, MIR Moscow, USSR (1985) Second edition: Biochimica e Biologia delgi Antibiotici, G. C. Lancini, F. Parenti, and G. G. Gallo, Salerno, ltaly (1993) ISBN Springer Science+Business Media New York Originally published by Plenum Press, New York in 1995 Softcover reprint of the bardeover 1st edition All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher

4 Preface Fifty years after the introduction of penicillin into therapeutic use, antibiotics are among the most widely used drugs, not only in the treatment of human ailments but also in veterinary practice, in agriculture, andin animal husbandry. Furthermore, they areessential tools for research in genetics, microbiology, and molecular biology. Production of antibiotics involves a diverse group of professionals: the microbiologist, the fermentation technologist, the bioengineer, and the chemist. Research and development of a new antibiotic requires the collaboration among experts in even more numerous disciplines: genetics, molecular biology, industrial microbiology, medical microbiology, chemistry of natural products, and analytical chemistry. In teaching undergraduate and postgraduate courses, it became apparent that a book did not exist presenting the facts and the basic concepts of this broad and varied subject. During many years of experience in an industrial laboratory dedicated to the research of new a n t i b i o t i c s ~ we realized that our young colleagues, specialized in one discipline, often had a poor knowledge of the general aspects of the research in which they were involved and of the problems brought about by the development and the use of antibiotics. This book was born eighteen years ago to fulfill, at least in part, this V

5 vi Preface need. Same years later, updated translations in English and in Russian were published, and, to celebrate the fiftieth anniversary of the introduction of penicillin into medical use, a new ltalian edition, completely revised in content and format, was published in The present version, which is essentially based on the last ltalian edition, has been greatly modified from the first English edition, so that it is practically a new book. We would like to believe that reading this book may also interest medical doctors, who, either in laboratories or clinics, use antibiotics and are curious to know more about the mental and practical processes that Iead from the isolation of a microorganism from a soil sample to a tablet or a vial ready to use. The understanding of the broader "biology of antibiotics" may also be of help in the proper use of these drugs. Many research colleagues in both the industrial and the academic worlds have helped conceive and realize this book. We thank them and acknowledge their contribution and the greater merit for its potential usefulness. We are particularly indebted to Dr. Mark Fisher, St. George's Hospital, London, and Stefano Donadio, of our Laboratories, for their criticisms and suggestions, and to Ms. Suzanne Ress, who patiently revised the English style. As for the first edition, we wish to dedicate this book to Piero Sensi, discoverer of rifamycins, teacher, and friend. G. C. Lancini, F. Parenti, and G. G. Gallo

6 Contents 1. The Antibiotics: An Overview Definition Chemical Nature Producing Microorganisms Biosynthesis Activity and Resistance Mechanism of Action Chemotherapy Chemical Modifications Principal Classes of Antibiotics The Activity of Antibiotics Definition Determination of the Activity Determination of the Concentration of Antibiotics (Assay) Miniaturization and Automation vii

7 viii Contents 3. The Mechanism of Action of Antibiotics General Aspects Methods of Study Inhibitors of Cell Wall Synthesis Inhibitors of Replication and Transcription of Nucleic Acid Inhibitors of Protein Synthesis Inhibitors of Cell Membrane Functions Antimetabolites Selectivity of Antibiotic Action Resistance of Microorganisms to Antibiotics General Aspects Biochemical Bases of Resistance Genehe Aspects Interesting Examples of Bacterial Resistance Activity of Antibiotics in Relation to Their Structure Introducbon ß-Lactam Antibiotics Tetracyclines Aminoglycosides (Aminocyclitols) Macrolides Ansamycins Peptide Antibiotics Glycopeptide Antibiotics (Dalbaheptides) Antitumor Antibiotics Miscellaneous Antibiotics Biosynthesis and Genetics of Antibiotic Production Methods of Study Biosynthetic Reactions and Pathways Transformation of Primary Metabolites into Antibiotics or Antibiotic Moieties Antibiotics Derived from Polyketide Synthesis Antibiotics Derived from Polymerization of Amino Acids Isoprenoid Antibiotics Oligosaccharide Antibiotics Genetics of Antibiotic Production

8 Contents ix 7. The Search for and Development of New Antibiotics The Search for New Antibiotics Development of an Antibiotic from the Labaratory to the Clinic Development of an Antibiotic from the Labaratory to the Manufacturing Process The Use of Antibiotics Chemotherapy of Infectious Diseases Uses Other Than Human Pharmacology Antibiotics as Research Tools Antibiotics and Producer Organisms Classes of Antibiotics and Taxonomie Position of Producing Organisms Paradox: How to Avoid Suicide Hypothesis about the Functions of Antibiotics in Producing Organisms Further Reading Index

Parasites and their vectors

Parasites and their vectors Parasites and their vectors ThiS is a FM Blank Page Yvonne Ai Lian Lim Indra Vythilingam Editors Parasites and their vectors A special focus on Southeast Asia Editors Yvonne Ai Lian Lim Indra Vythilingam

More information

Chapter 12. Antimicrobial Therapy. Antibiotics 3/31/2010. Spectrum of antibiotics and targets

Chapter 12. Antimicrobial Therapy. Antibiotics 3/31/2010. Spectrum of antibiotics and targets Chapter 12 Topics: - Antimicrobial Therapy - Selective Toxicity - Survey of Antimicrobial Drug - Microbial Drug Resistance - Drug and Host Interaction Antimicrobial Therapy Ehrlich (1900 s) compound 606

More information

Antibacterial susceptibility testing

Antibacterial susceptibility testing Antibiotics: Antil susceptibility testing are natural chemical substances produced by certain groups of microorganisms (fungi, ) that inhibit the growth of or kill the other that cause infection. Several

More information

Atlas of Experimental Toxicological Pathology

Atlas of Experimental Toxicological Pathology Atlas of Experimental Toxicological Pathology To Cora P. Cherry for sharing with us her wealth of experience in the field of toxicological pathology Current Histopathology Consultant Editor Professor G.

More information

Antibiotic Resistance in Bacteria

Antibiotic Resistance in Bacteria Antibiotic Resistance in Bacteria Electron Micrograph of E. Coli Diseases Caused by Bacteria 1928 1 2 Fleming 3 discovers penicillin the first antibiotic. Some Clinically Important Antibiotics Antibiotic

More information

مادة االدوية المرحلة الثالثة م. غدير حاتم محمد

مادة االدوية المرحلة الثالثة م. غدير حاتم محمد م. مادة االدوية المرحلة الثالثة م. غدير حاتم محمد 2017-2016 ANTIMICROBIAL DRUGS Antimicrobial drugs Lecture 1 Antimicrobial Drugs Chemotherapy: The use of drugs to treat a disease. Antimicrobial drugs:

More information

Burton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents

Burton's Microbiology for the Health Sciences. Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Burton's Microbiology for the Health Sciences Chapter 9. Controlling Microbial Growth in Vivo Using Antimicrobial Agents Chapter 9 Outline Introduction Characteristics of an Ideal Antimicrobial Agent How

More information

Antimicrobial Therapy

Antimicrobial Therapy Chapter 12 The Elements of Chemotherapy Topics - Antimicrobial Therapy - Selective Toxicity - Survey of Antimicrobial Drug - Microbial Drug Resistance - Drug and Host Interaction Antimicrobial Therapy

More information

Use of Quinolones in Travel Medicine

Use of Quinolones in Travel Medicine Herbert L. DuPont (Ed.) Use of Quinolones in Travel Medicine Second Conference on International Travel Medicine Proceedings of the Ciprofioxacin Satellite Symposium "Use of Quinolones in Travel Medicine"

More information

MID 23. Antimicrobial Resistance. Consequences of Antimicrobial Resistant Bacteria. Molecular Genetics of Antimicrobial Resistance

MID 23. Antimicrobial Resistance. Consequences of Antimicrobial Resistant Bacteria. Molecular Genetics of Antimicrobial Resistance Antimicrobial Resistance Molecular Genetics of Antimicrobial Resistance Micro evolutionary change - point mutations Beta-lactamase mutation extends spectrum of the enzyme rpob gene (RNA polymerase) mutation

More information

Human Food Safety of Veterinary Drugs. Bettye K. Walters, DVM

Human Food Safety of Veterinary Drugs. Bettye K. Walters, DVM Human Food Safety of Veterinary Drugs Bettye K. Walters, DVM Bettye.walters@fda.hhs.gov Pertinent International Resources Organization for Economic Co-Operation and Development (OECD) Understanding the

More information

ANTIBIOTICS IN AQUACULTURE: A (FISH) VETERINARIAN S PERSPECTIVE

ANTIBIOTICS IN AQUACULTURE: A (FISH) VETERINARIAN S PERSPECTIVE ANTIBIOTICS IN AQUACULTURE: A (FISH) VETERINARIAN S PERSPECTIVE HUGH MITCHELL, MS, D.V.M. AQUATACTICS FISH HEALTH KIRKLAND, WA HUGHM@AQUATACTICS.COM MISSION STATEMENT OF A FOODFISH VET PRACTICE: To assist

More information

Bobbie Kalman & Amanda Bishop Crabtree Publishing Company

Bobbie Kalman & Amanda Bishop Crabtree Publishing Company The Life Cycle of a Bobbie Kalman & Amanda Bishop Company www.crabtreebooks.com The Life Cycle Series A Bobbie Kalman Book Dedicated by Amanda Bishop For Mummu and Grampsie, whose pride has always meant

More information

BIOLACTAM. Product Description. An innovative in vitro diagnostic for the rapid quantitative determination of ß-lactamase activity

BIOLACTAM. Product Description.  An innovative in vitro diagnostic for the rapid quantitative determination of ß-lactamase activity BIOLACTAM www.biolactam.eu An innovative in vitro diagnostic for the rapid quantitative determination of ß-lactamase activity 1.5-3h 20 Copyright 2014 VL-Diagnostics GmbH. All rights reserved. Product

More information

DRUG-RESISTANT ACINETOBACTER BAUMANNII A GROWING SUPERBUG POPULATION. Cara Wilder Ph.D. Technical Writer March 13 th 2014

DRUG-RESISTANT ACINETOBACTER BAUMANNII A GROWING SUPERBUG POPULATION. Cara Wilder Ph.D. Technical Writer March 13 th 2014 DRUG-RESISTANT ACINETOBACTER BAUMANNII A GROWING SUPERBUG POPULATION Cara Wilder Ph.D. Technical Writer March 13 th 2014 ATCC Founded in 1925, ATCC is a non-profit organization with headquarters in Manassas,

More information

Antibiotics. Antimicrobial Drugs. Alexander Fleming 10/18/2017

Antibiotics. Antimicrobial Drugs. Alexander Fleming 10/18/2017 Antibiotics Antimicrobial Drugs Chapter 20 BIO 220 Antibiotics are compounds produced by fungi or bacteria that inhibit or kill competing microbial species Antimicrobial drugs must display selective toxicity,

More information

FINAL REPORT DESIGNING BEJAJO MALEM MAGAZINE AS TOURIST GUIDANCE TO PROMOTE NIGHT CULINARY PLACES IN PALEMBANG

FINAL REPORT DESIGNING BEJAJO MALEM MAGAZINE AS TOURIST GUIDANCE TO PROMOTE NIGHT CULINARY PLACES IN PALEMBANG FINAL REPORT DESIGNING BEJAJO MALEM MAGAZINE AS TOURIST GUIDANCE TO PROMOTE NIGHT CULINARY PLACES IN PALEMBANG This report is written to fulfill the requirement for subject of final report subject at State

More information

European Regional Verification Commission for Measles and Rubella Elimination (RVC) TERMS OF REFERENCE. 6 December 2011

European Regional Verification Commission for Measles and Rubella Elimination (RVC) TERMS OF REFERENCE. 6 December 2011 European Regional Verification Commission for Measles and Rubella Elimination (RVC) TERMS OF REFERENCE 6 December 2011 Address requests about publications of the WHO Regional Office for Europe to: Publications

More information

Introduction to Antimicrobials. Lecture Aim: To provide a brief introduction to antibiotics. Future lectures will go into more detail.

Introduction to Antimicrobials. Lecture Aim: To provide a brief introduction to antibiotics. Future lectures will go into more detail. Introduction to Antimicrobials Rachel J. Gordon, MD, MPH Lecture Aim: To provide a brief introduction to antibiotics. Future lectures will go into more detail. Major Learning Objectives: 1) Learn the different

More information

WHY IS THIS IMPORTANT?

WHY IS THIS IMPORTANT? CHAPTER 20 ANTIBIOTIC RESISTANCE WHY IS THIS IMPORTANT? The most important problem associated with infectious disease today is the rapid development of resistance to antibiotics It will force us to change

More information

Karen Pryor. Getting Started: Clicker Book. with Your Rabbit. Joan Orr and Teresa Lewin

Karen Pryor. Getting Started: Clicker Book. with Your Rabbit. Joan Orr and Teresa Lewin A Karen Pryor Getting Started: Clicker Book with Your Rabbit Joan Orr and Teresa Lewin Photo credits: B.U.N.S, Bunnies Urgently Needing Shelter, Santa Clara Humane Society, California: 1, 3, 7, 11, 15,

More information

ESEVT Indicators. European Association of Establishments for Veterinary Education

ESEVT Indicators. European Association of Establishments for Veterinary Education European Association of Establishments for Veterinary Education Association Europe enne des Etablissements d'enseignement Ve te rinaire Introduction ESEVT Indicators 1. Indicators are to be used in a non-prescriptive

More information

Brief reports. Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae

Brief reports. Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae Journal of Antimicrobial Chemotherapy (1997) 40, 105 108 Brief reports JAC Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae Andreas Pikis a *, Jacob A. Donkersloot

More information

Impact of Antimicrobial Stewardship Program

Impact of Antimicrobial Stewardship Program Impact of Antimicrobial Stewardship Program Ripal Joshi, Pharm.D. AAHIVP Tampa General Hospital January 28, 2016 Objectives Provide an overview on antimicrobial stewardship programs (ASP) Describe the

More information

Course Curriculum for Master Degree in Internal Medicine/ Faculty of Veterinary Medicine

Course Curriculum for Master Degree in Internal Medicine/ Faculty of Veterinary Medicine Course Curriculum for Master Degree in Internal Medicine/ Faculty of Veterinary Medicine The Master Degree in Internal Medicine/Faculty of Veterinary Medicine is awarded by the Faculty of Graduate Studies

More information

The OIE Manual of Diagnostic Tests and Vaccines for Terrestrial & Aquatic Animals

The OIE Manual of Diagnostic Tests and Vaccines for Terrestrial & Aquatic Animals The OIE Manual of Diagnostic Tests and Vaccines for Terrestrial & Aquatic Animals Regional seminar for OIE National Focal Points for Veterinary Products, Tokyo, Japan, 3-5 December 2014 Barbara Freischem,

More information

European Medicines Agency role and experience on antimicrobial resistance

European Medicines Agency role and experience on antimicrobial resistance European Medicines Agency role and experience on antimicrobial resistance Regional Training Workshop on Antimicrobial Resistance (AMR) Responding to the global challenge of AMR threats: toward a one health

More information

Is erythromycin bactericidal

Is erythromycin bactericidal Is erythromycin bactericidal Search Comparison of erythromycin, clarithromycin, azithromycin, telithromycin, roxithromycin: mechanism of action, spectrum of activity, side effects, drug interactions. Erythromycin

More information

Title: Record Keeping for Regulated Animals at Oklahoma State University

Title: Record Keeping for Regulated Animals at Oklahoma State University Title: Record Keeping for Regulated Animals at Oklahoma State University Policy No. IACUC-013 Effective Date: 2/09/15 1. Reference(s): USDA Animal and Plant Health Inspection Service (APHIS) Animal Care

More information

By Heather Adamson

By Heather Adamson Free ebooks ==> By Heather Adamson Free ebooks ==> Community Helpers at Work A Day in the Life of a Veterinarian by Heather Adamson Consultant: Daniel F. Simpson, DVM West Bay Animal Hospital Warwick,

More information

GENETIC CALCULATOR (INDIAN RINGNECK PARROT) Help File K Yorke

GENETIC CALCULATOR (INDIAN RINGNECK PARROT) Help File K Yorke GENETIC CALCULATOR (INDIAN RINGNECK PARROT) Help File GENETIC CALCULATOR (INDIAN RINGNECK PARROT) Help File All rights reserved. No parts of this work may be reproduced in any form or by any means - graphic,

More information

Caring for Your Dog. Jill Foran. Weigl Publishers Inc.

Caring for Your Dog. Jill Foran. Weigl Publishers Inc. Caring for Your Dog Jill Foran Weigl Publishers Inc. Project Coordinator Diana Marshall Design and Layout Warren Clark Katherine Phillips Copy Editor Jennifer Nault Photo Research Gayle Murdoff Published

More information

Animal and Veterinary Sciences Information Access Policy Clemson University Libraries

Animal and Veterinary Sciences Information Access Policy Clemson University Libraries Animal and Veterinary Sciences Information Access Policy Clemson University Libraries Animal and Veterinary Sciences Reference Librarian: Lois Sill Written Fall, 1999; revised by L. Sill, August, 2004;

More information

EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment

EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment EurEau s Contribution to the European Commission s Strategic Approach on Veterinary Pharmaceuticals in the Environment Summary Globally, pharmaceutical products are regularly administered to both livestock

More information

An#bio#cs and challenges in the wake of superbugs

An#bio#cs and challenges in the wake of superbugs An#bio#cs and challenges in the wake of superbugs www.biochemj.org/bj/330/0581/bj3300581.htm ciss.blog.olemiss.edu Dr. Vassie Ware Bioscience in the 21 st Century November 14, 2014 Who said this and what

More information

National Action Plan development support tools

National Action Plan development support tools National Action Plan development support tools Sample Checklist This checklist was developed to be used by multidisciplinary teams in countries to assist with the development of their national action plan

More information

Service Delivery and Safety Department World Health Organization, Headquarters

Service Delivery and Safety Department World Health Organization, Headquarters Service Delivery and Safety Department World Health Organization, Headquarters WHO global (laboratory-based) survey on multidrug-resistant organisms (MDROs) in health care PROJECT SUMMARY Given the important

More information

Chemotherapeutic Agents

Chemotherapeutic Agents Chemotherapeutic Agents The cell is the basic structure of all living organisms. The cell membrane features specifi c receptor sites that allow interaction with various chemicals, histocompatibility proteins

More information

Aminocyclitol Antibiotics: An Introduction

Aminocyclitol Antibiotics: An Introduction 1 Aminocyclitol Antibiotics: An Introduction KENNETH L. RINEHART, JR. and LOIS S. SHIELD Roger Adams Laboratory, University of Illinois, Urbana, IL 61801 Aminocyclitol antibiotics constitute an important

More information

BY I MMACULA A. RHODES

BY I MMACULA A. RHODES BY I MMACULA A. RHODES NEW YORK TORONTO LONDON AUCKLAND SYDNEY MEXICO CITY NEW DELHI HONG KONG BUENOS AIRES To all who teach, especially my former and fellow teachers and those who teach my children. A

More information

Workshop On Veterinary Microbiology And Immunology / Praktikum Po Veterinarnoy Mikrobiologii I Immunologii

Workshop On Veterinary Microbiology And Immunology / Praktikum Po Veterinarnoy Mikrobiologii I Immunologii Workshop On Veterinary Microbiology And Immunology / Praktikum Po Veterinarnoy Mikrobiologii I Immunologii VetAgenda - veterinary events calender: Europe, - Improve your professional qualifications in

More information

Bobbie Kalman. Crabtree Publishing Company.

Bobbie Kalman. Crabtree Publishing Company. Bobbie Kalman Company www.crabtreebooks.com Created by Bobbie Kalman For Bonnie Elizabeth Crabtree We await you, our first granddaughter, with much love. Author and Editor-in-Chief Bobbie Kalman Editor

More information

BS ANIMAL SCIENCE. Program Learning Objectives. Degree Requirements and Curriculum. BS Animal Science 1. Biochemistry/Chemistry

BS ANIMAL SCIENCE. Program Learning Objectives. Degree Requirements and Curriculum. BS Animal Science 1. Biochemistry/Chemistry BS Animal Science BS ANIMAL SCIENCE Program Learning Objectives. Demonstrate problem solving skills. 2. Demonstrate a proficiency in working as a leader and as a part of a team to achieve common goals.

More information

BIOTRANSFORMATION, A NEW APPROACH TO AMINOGLYCOSIDE BIOSYNTHESIS : II GENTAMICIN. R.T. TESTA and B.C. TILLEY

BIOTRANSFORMATION, A NEW APPROACH TO AMINOGLYCOSIDE BIOSYNTHESIS : II GENTAMICIN. R.T. TESTA and B.C. TILLEY 140 THE JOURNAL OF ANTIBIOTICS FEB. 1976 BIOTRANSFORMATION, A NEW APPROACH TO AMINOGLYCOSIDE BIOSYNTHESIS : II GENTAMICIN R.T. TESTA and B.C. TILLEY Schering Corporation, Bloomfield, New Jersey 07003,

More information

General Approach to Infectious Diseases

General Approach to Infectious Diseases General Approach to Infectious Diseases 2 The pharmacotherapy of infectious diseases is unique. To treat most diseases with drugs, we give drugs that have some desired pharmacologic action at some receptor

More information

Summary of the latest data on antibiotic consumption in the European Union

Summary of the latest data on antibiotic consumption in the European Union Summary of the latest data on antibiotic consumption in the European Union ESAC-Net surveillance data November 2016 Provision of reliable and comparable national antimicrobial consumption data is a prerequisite

More information

Veterinary Education in Europe 2009 and beyond

Veterinary Education in Europe 2009 and beyond Bulletin UASVM, Veterinary Medicine 66(2)/2009 ISSN 1843-5270; Electronic ISSN 1843-5378 Veterinary Education in Europe 2009 and beyond Marcel WANNER, Robin OAKLEY Veterinarians have a special responsibility

More information

Characteristics of the Text Genre Fantasy Text Structure Simple fi rst-person narrative, with story carried by pictures Content

Characteristics of the Text Genre Fantasy Text Structure Simple fi rst-person narrative, with story carried by pictures Content LESSON 5 TEACHER S GUIDE by Stephanie Richardson Fountas-Pinnell Level A Fantasy Selection Summary The narrator s dog pulls an increasing number of children Each load of passengers sleds down. Finally,

More information

Hormones and Reproduction in Fishes, Amphibians, and Reptiles

Hormones and Reproduction in Fishes, Amphibians, and Reptiles Hormones and Reproduction in Fishes, Amphibians, and Reptiles Hormones and Reproduction in Fishes, Amphibians, and Reptiles Edited by David O. Norris and Richard E. Jones University of Colorado Boulder,

More information

Doctor of Veterinary Medicine Curriculum Academic Year Revised June 15, 2017

Doctor of Veterinary Medicine Curriculum Academic Year Revised June 15, 2017 Doctor of Veterinary Medicine Curriculum Academic Year 2017-2018 Revised June 15, 2017 Fall Semester FIRST YEAR VM 603 Veterinary Science: Research and Methods 1 VM 606 Veterinary Immunology 3 VM 610 Foundations

More information

Course Coordinators. Course Objectives. Target Audience

Course Coordinators. Course Objectives. Target Audience Course Coordinators Maria Alexandrou, Limassol, Cyprus George Daikos, Athens, Greece George Petrikkos, Athens, Greece Course Objectives To increase awareness of infectious diseases endemic in the Mediterranean

More information

Action and Experience of Containment of AMR in Veterinary Sector JAPAN

Action and Experience of Containment of AMR in Veterinary Sector JAPAN Action and Experience of Containment of AMR in Veterinary Sector JAPAN AMR Symposium - Side event of the 1 st G7 Chief Veterinary Officers Forum - 24 November 2016 Tokyo, Japan Tatsuro Sekiya Animal Products

More information

This article reprinted from: Jansky, C. and C. Knox Nasonia vitripennis: A Drosophila alternative. Pages , in

This article reprinted from: Jansky, C. and C. Knox Nasonia vitripennis: A Drosophila alternative. Pages , in This article reprinted from: Jansky, C. and C. Knox. 2007. Nasonia vitripennis: A Drosophila alternative. Pages 319-324, in Tested Studies for Laboratory Teaching, Volume 28 (M.A. O'Donnell, Editor). Proceedings

More information

GENERAL ACADEMIC QUALIFICATIONS. Name: Ahmed Zaki Saad Ahmed Zaki Date of Birth: 11/12/1965 Place of Birth: Khartoum, Sudan Nationality: Sudanese

GENERAL ACADEMIC QUALIFICATIONS. Name: Ahmed Zaki Saad Ahmed Zaki Date of Birth: 11/12/1965 Place of Birth: Khartoum, Sudan Nationality: Sudanese GENERAL Name: Ahmed Zaki Saad Ahmed Zaki Date of Birth: 11/12/1965 Place of Birth: Khartoum, Sudan Nationality: Sudanese Sex: Male Marital status Married, 3 children Postition held: Assistant Professor

More information

LEVOFLOXACIN RESIDUES IN CHICKEN MEAT AND GIBLETS

LEVOFLOXACIN RESIDUES IN CHICKEN MEAT AND GIBLETS Bulgarian Journal of Veterinary Medicine (2013), 16, Suppl. 1, 216 219 LEVOFLOXACIN RESIDUES IN CHICKEN MEAT AND GIBLETS R. KYUCHUKOVA 1, V. URUMOVA 2, M. LYUTSKANOV 2, V. PETROV 2 & A. PAVLOV 1 1 Department

More information

Course Curriculum for Master Degree in Poultry Diseases/Veterinary Medicine

Course Curriculum for Master Degree in Poultry Diseases/Veterinary Medicine Course Curriculum for Master Degree in Poultry Diseases/Veterinary Medicine The Master Degree in Poultry Diseases /Veterinary Medicine, is awarded by the Faculty of Graduate Studies at Jordan University

More information

Animal Welfare VOLUME 4. Series Editor. Titles published in this series:

Animal Welfare VOLUME 4. Series Editor. Titles published in this series: THE WELFARE OF DOGS Animal Welfare VOLUME 4 Series Editor Clive Phillips, Professor of Animal Welfare, Centre for Animal Welfare and Ethics, School of Veterinary Science, University of Queensland, Australia

More information

Foundation in Pharmacology - 2 (Year 3 Semester 1)

Foundation in Pharmacology - 2 (Year 3 Semester 1) Foundation in - 2 (Year 3 Semester 1) Credits: 0.5 Foundation in - 2 (Credits: 2.0 Foundation in 1) Duration: 3 weeks (15 days) Topic & Concepts Objectives Time Dept. T/L activity Comments At the end of

More information

ESISTONO LE HCAP? Francesco Blasi. Sezione Medicina Respiratoria Dipartimento Toraco Polmonare e Cardiocircolatorio Università degli Studi di Milano

ESISTONO LE HCAP? Francesco Blasi. Sezione Medicina Respiratoria Dipartimento Toraco Polmonare e Cardiocircolatorio Università degli Studi di Milano ESISTONO LE HCAP? Francesco Blasi Sezione Medicina Respiratoria Dipartimento Toraco Polmonare e Cardiocircolatorio Università degli Studi di Milano Community-acquired pneumonia (CAP): Management issues

More information

Concise Antibiogram Toolkit Background

Concise Antibiogram Toolkit Background Background This toolkit is designed to guide nursing homes in creating their own antibiograms, an important tool for guiding empiric antimicrobial therapy. Information about antibiograms and instructions

More information

Mechanism of antibiotic resistance

Mechanism of antibiotic resistance Mechanism of antibiotic resistance Dr.Siriwoot Sookkhee Ph.D (Biopharmaceutics) Department of Microbiology Faculty of Medicine, Chiang Mai University Antibiotic resistance Cross-resistance : resistance

More information

CO-ACTION. Prof.dr. J.W. Mouton. Note : some technical and all results slides were removed. JPIAMR JWM Paris JWM Paris 2017

CO-ACTION. Prof.dr. J.W. Mouton. Note : some technical and all results slides were removed. JPIAMR JWM Paris JWM Paris 2017 CO-ACTION Prof.dr. J.W. Mouton Note : some technical and all results slides were removed JPIAMR 1 Clinical Development of (old drug) combinations : essentials Potency of combination CoAction PK profiling

More information

Public Assessment Report. Scientific discussion. Xiflodrop 5 mg/ml eye drops, solution. Moxifloxacin hydrochloride DK/H/2221/001/DC

Public Assessment Report. Scientific discussion. Xiflodrop 5 mg/ml eye drops, solution. Moxifloxacin hydrochloride DK/H/2221/001/DC Public Assessment Report Scientific discussion Xiflodrop 5 mg/ml eye drops, solution Moxifloxacin hydrochloride DK/H/2221/001/DC This module reflects the scientific discussion for the approval of Xiflodrop.

More information

Jonathan and Angie Scott assert their moral right to be identified as the authors of this work.

Jonathan and Angie Scott assert their moral right to be identified as the authors of this work. Big Cat Babies Published by Collins An imprint of HarperCollinsPublishers 77 85 Fulham Palace Road Hammersmith London W6 8JB Browse the complete Collins catalogue at www.collinseducation.com Text and photographs

More information

Curriculum Vitae. Tarek Soliman Shety DVM, M.VSc., Dr. Med. Vet.

Curriculum Vitae. Tarek Soliman Shety DVM, M.VSc., Dr. Med. Vet. Curriculum Vitae Tarek Soliman Shety DVM, M.VSc., Dr. Med. Vet. Current: Doctoral student at Klinik für Pferd, Freie Universität Berlin, Germany Previous: Assistant lecturer, Animal Medicine Department,

More information

OIE List of Antimicrobial Agents of Veterinary Importance and OIE Standards and Activities

OIE List of Antimicrobial Agents of Veterinary Importance and OIE Standards and Activities Veterinary Importance and OIE Standards and Activities Consultation meeting with stakeholders - Request from the European Commission for advice on the impact on public and animal health of the use of antibiotics

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research  ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Antibiotic Susceptibility Pattern of Pseudomonas Aeruginosa Isolated From Various Clinical

More information

Antimicrobial Use and Antimicrobial Resistance in Relation to the Canadian Pork Sector Presented by Jorge Correa Pork Committee Banff May 2013

Antimicrobial Use and Antimicrobial Resistance in Relation to the Canadian Pork Sector Presented by Jorge Correa Pork Committee Banff May 2013 Antimicrobial Use and Antimicrobial Resistance in Relation to the Canadian Pork Sector Presented by Jorge Correa Pork Committee Banff May 2013 Part of the Slides were extracted from a Paul Dick presentation

More information

Medical University of Warsaw Faculty of Pharmacy

Medical University of Warsaw Faculty of Pharmacy Medical University of Warsaw Faculty of Pharmacy Faculty Authorities (in academic years: 2012/2013 2015/2016) Dean - Prof. Piotr Wroczyński PharD Vice Dean for Educationals and Student s Affairs - Agnieszka

More information

Antoni Torres, Catia Cillóniz. Clinical Management of Bacterial Pneumonia

Antoni Torres, Catia Cillóniz. Clinical Management of Bacterial Pneumonia Antoni Torres, Catia Cillóniz Clinical Management of Bacterial Pneumonia Antoni Torres, Catia Cillóniz Clinical Management of Bacterial Pneumonia Authors Professor Antoni Torres MD, PhD, FERS Director

More information

Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST)

Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) Towards Rational International Antibiotic Breakpoints: Actions from the European Committee on Antimicrobial Susceptibility Testing (EUCAST) A report to ISC presented by Paul M. Tulkens representative of

More information

EXTENSION PROGRAMMES

EXTENSION PROGRAMMES EXTENSION PROGRAMMES DEDICATED TO THE ACTIVITIES OF THE VETERINARY SERVICES G. Khoury International Consultant 1 Original: English Summary: Extension programmes could be defined as the dissemination of

More information

Detection of antimicrobial drug residues in milk marketed at different areas of Sindh province

Detection of antimicrobial drug residues in milk marketed at different areas of Sindh province IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS) e-issn: 2319-2380, p-issn: 2319-2372. Volume 7, Issue 5 Ver. IV (May. 2014), PP 65-69 Detection of antimicrobial drug residues in milk marketed

More information

Federal Service for Veterinary and Phytosanitary Surveillance

Federal Service for Veterinary and Phytosanitary Surveillance Federal Service for Veterinary and Phytosanitary Surveillance Food safety Safety standards Laboratory control of production process Veterinary sanitary expertise (VSE) of slaughter products Food safety

More information

3rd International Symposium on Veterinary Pharmacovigilance Berlin, 13-14th December 2010

3rd International Symposium on Veterinary Pharmacovigilance Berlin, 13-14th December 2010 Veterinary Pharmacovigilance Centres: the French experience 3rd International Symposium on Veterinary Pharmacovigilance Berlin, 13-14th December 2010 Xavier Pineau*, Florence Roque*, Stéphane Queffélec*,

More information

January 2014 Vol. 34 No. 1

January 2014 Vol. 34 No. 1 January 2014 Vol. 34 No. 1. and Minimum Inhibitory Concentration (MIC) Interpretive Standards for Testing Conditions Medium: diffusion: Mueller-Hinton agar (MHA) Broth dilution: cation-adjusted Mueller-Hinton

More information

Anglia ESOL International Examinations. Elementary Level (A2) Paper BBPractice115. For Examiner s Use Only

Anglia ESOL International Examinations. Elementary Level (A2) Paper BBPractice115. For Examiner s Use Only Please stick your candidate label here Anglia ESOL International Examinations Elementary Level (A2) W R Paper BBPractice115 CANDIDATE INSTRUCTIONS: Time allowed TWO hours. Make sure you have the correct

More information

Veterinary Medical School Admission Requirements By Association of American Veterinary Medic

Veterinary Medical School Admission Requirements By Association of American Veterinary Medic Veterinary Medical School Admission Requirements By Association of American Veterinary Medic Prerequisites - Texas A&M College of Veterinary - Students preparing for admission to the professional veterinary

More information

Perfect Pet. The. by Samantha Bell. Samantha Bell

Perfect Pet. The. by Samantha Bell. Samantha Bell by Samantha Bell After begging for a pet, a child s mother finally says yes. But which animal will be the best pet? Using animal classification and habitat needs, the child narrows it down from Kingdom

More information

The Veterinary Epidemiology and Risk Analysis Unit (VERAU)

The Veterinary Epidemiology and Risk Analysis Unit (VERAU) Dr G. Yehia OIE Regional Representative for the Middle East The Veterinary Epidemiology and Risk Analysis Unit (VERAU) 12 th Conference of the OIE Regional Commission for the Middle East Amman, Jordan,

More information

An analysis of the incidence of Antibiotic Resistant Infections in the state of New Hampshire

An analysis of the incidence of Antibiotic Resistant Infections in the state of New Hampshire University of New Hampshire University of New Hampshire Scholars' Repository Honors Theses and Capstones Student Scholarship Fall 2012 An analysis of the incidence of Antibiotic Resistant Infections in

More information

Q1. (a) Clostridium difficile is a bacterium that is present in the gut of up to 3% of healthy adults and 66% of healthy infants.

Q1. (a) Clostridium difficile is a bacterium that is present in the gut of up to 3% of healthy adults and 66% of healthy infants. Q1. (a) Clostridium difficile is a bacterium that is present in the gut of up to 3% of healthy adults and 66% of healthy infants. C. difficile rarely causes problems, either in healthy adults or in infants.

More information

GENETIC CALCULATOR (BUDGERIGAR) Help File K Yorke

GENETIC CALCULATOR (BUDGERIGAR) Help File K Yorke GENETIC CALCULATOR (BUDGERIGAR) Help File GENETIC CALCULATOR (BUDGERIGAR) Help File All rights reserved. No parts of this work may be reproduced in any form or by any means - graphic, electronic, or mechanical,

More information

Chapter 2 Mechanisms of Antimicrobial Resistance

Chapter 2 Mechanisms of Antimicrobial Resistance Chapter 2 Mechanisms of Antimicrobial Resistance Denis K. Byarugaba Abstract There is no doubt that antimicrobial agents have saved the human race from a lot of suffering due to infectious disease burden.

More information

Topical Antimicrobials Testing And Evaluation, Second Edition By Daryl S. Paulson

Topical Antimicrobials Testing And Evaluation, Second Edition By Daryl S. Paulson Topical Antimicrobials Testing And Evaluation, Second Edition By Daryl S. Paulson If you are looking for the ebook by Daryl S. Paulson Topical Antimicrobials Testing and Evaluation, Second Edition in pdf

More information

Antimicrobial stewardship

Antimicrobial stewardship Antimicrobial stewardship Magali Dodemont, Pharm. with the support of Wallonie-Bruxelles International WHY IMPLEMENT ANTIMICROBIAL STEWARDSHIP IN HOSPITALS? Optimization of antimicrobial use To limit the

More information

Antibiotics 1. Lecture 8

Antibiotics 1. Lecture 8 Antibiotics 1 Lecture 8 Overview of antibiotics What am I treating? Viral, bacterial, fungal, mycobacterial, etc. Who am I treating? Host factors: age, genetic factors, co-morbidities (renal and liver

More information

See Important Reminder at the end of this policy for important regulatory and legal information.

See Important Reminder at the end of this policy for important regulatory and legal information. Clinical Policy: Doxycycline Hyclate (Acticlate, Doryx), Doxycline (Oracea), Minocycline (Solodyn, Ximino) Reference Number: CP.CPA.120 Effective Date: 11.16.16 Last Review Date: 11.17 Line of Business:

More information

Quelle politique antibiotique pour l Europe? Dominique L. Monnet

Quelle politique antibiotique pour l Europe? Dominique L. Monnet Quelle politique antibiotique pour l Europe? Dominique L. Monnet National Center for Antimicrobials & Infection Control Statens Serum Institut, Copenhagen, Denmark Opinion of the Section for Protection

More information

Bacterial Resistance of Respiratory Pathogens. John C. Rotschafer, Pharm.D. University of Minnesota

Bacterial Resistance of Respiratory Pathogens. John C. Rotschafer, Pharm.D. University of Minnesota Bacterial Resistance of Respiratory Pathogens John C. Rotschafer, Pharm.D. University of Minnesota Antibiotic Misuse ~150 million courses of antibiotic prescribed by office based prescribers Estimated

More information

Reflection paper on promotion of pharmacovigilance reporting

Reflection paper on promotion of pharmacovigilance reporting 13 July 2017 EMA/CVMP/PhVWP/390033/2014-Rev.1 Committee for Medicinal Products for Veterinary Use (CVMP) Reflection paper on promotion of pharmacovigilance reporting Draft agreed by CVMP Pharmacovigilance

More information

Veterinary Science Preparatory Training for the Veterinary Assistant. Floron C. Faries, Jr., DVM, MS

Veterinary Science Preparatory Training for the Veterinary Assistant. Floron C. Faries, Jr., DVM, MS Veterinary Science Preparatory Training for the Veterinary Assistant Floron C. Faries, Jr., DVM, MS The Profession of Veterinary Medicine Floron C. Faries, Jr., DVM, MS Objectives Define veterinary medicine

More information

Level: DRA: Genre: Strategy: Skill: Word Count: Online Leveled Books HOUGHTON MIFFLIN

Level: DRA: Genre: Strategy: Skill: Word Count: Online Leveled Books HOUGHTON MIFFLIN HOUGHTON MIFFLIN by Rob Arego illustrated by Suzanne Beaky Copyright by Houghton Mifflin Harcourt Publishing Company All rights reserved. No part of this work may be reproduced or transmitted in any form

More information

National Surveillance of Antimicrobial Resistance

National Surveillance of Antimicrobial Resistance National Surveillance of Antimicrobial Resistance Report to Ministry of Health by Sri Lanka College of Microbiologists SLCM ARSP & NLBSA Technical Committees December 2014 National Surveillance of Antimicrobial

More information

Antimicrobial Stewardship Strategy:

Antimicrobial Stewardship Strategy: Antimicrobial Stewardship Strategy: Prospective audit with intervention and feedback Formal assessment of antimicrobial therapy by trained individuals, who make recommendations to the prescribing service

More information

Quality Control Testing with the Disk Antibiotic Susceptibility Test of Bauer-Kirby-Sherris-Turck

Quality Control Testing with the Disk Antibiotic Susceptibility Test of Bauer-Kirby-Sherris-Turck Quality Control Testing with the Disk Antibiotic Susceptibility Test of Bauer-Kirby-Sherris-Turck DONNA J. BLAZEVIC, M.P.H., MARILYN H. KOEPCKE, B.S., A JOHN M. MATSEN, M.D. Departments of Laboratory Medicine

More information

Short Report. R Boot. Keywords: Bacteria, antimicrobial susceptibility testing, quality, diagnostic laboratories, proficiency testing

Short Report. R Boot. Keywords: Bacteria, antimicrobial susceptibility testing, quality, diagnostic laboratories, proficiency testing Short Report Frequent major errors in antimicrobial susceptibility testing of bacterial strains distributed under the Deutsches Krebsforschungszentrum Quality Assurance Program R Boot Former Section of

More information

Antimicrobial prescribing pattern in acute tonsillitis: A hospital based study in Ajman, UAE

Antimicrobial prescribing pattern in acute tonsillitis: A hospital based study in Ajman, UAE Antimicrobial prescribing pattern in acute tonsillitis: A hospital based study in Ajman, UAE Lisha Jenny John 1*, Meenu Cherian 2, Jayadevan Sreedharan 3, Tambi Cherian 2 1 Department of Pharmacology,

More information