Key words : penicillin-resistant Streptococcus pneumoniae,

Transcription

1 Key words : penicillin-resistant Streptococcus pneumoniae, respiratory infections

2 Table 1 Subject Table 2 Clinical diagnosis of Streptococcus pneumoniae infections

3 Table 3 Undelying disase of Streptococcus pneumoniae infections Table 4 Antibiotics for the tratment of cases on Streptococcus pneumoniae infections Table 5 Theraputic result of Streptococcus pneumoniae infections

4 penicillin in a pneumococci type 1. Acta Pathol Microbiol Scand 1945 ; 22 : ) Kislak JW, Razavi LMB, Daly AK, Finland M : Susceptibility of pneumococci to nine antibi- Am Med Sci 1965 ; 250 : otics ) Hansman D, Glasgow H, Sturt J, Devitt L, Douglas R : Increased resistance to penicillin of pneumococci isolated from man. N Engl J Med 1971 ; 284 ; ) Hansman D : Type distribution and antibiotic sensitivity of pneumococci from carriers in Kiriwana, Trobriand islands (New Guinea). Med J Aust 1972 ; 2 : ) Appelbaum PC, Bhamjee A, Scragg JN, Hallett AF, Bowen AJ, Cooper RC: Streptococcus pneumoniae resistant to penicillin and chloramphenicol. Lancer 1977 ; 2 : ) Kabins NS : Relapsing pneumococcal menigitis : Isolation of an organism with decreased susceptibility to penicilling. J Pediatr 1974 ; 85 : ) Caputo GM, Appelbaum PC, Liu HH : Infections due to Penicillin-Resistant Pneumococci. Arch Intern Med 1993 ; 153 : ) Beam TR : Vancomycin therapy of experimental pneumococcal meningitis caused by a penicillinsencitive and resistant strains. J Antimicrob Chemother 1981 ; 7 : ) Viladrich P, Gudiol F, Linares J, Rufi G, Ariza J, Pallares R : Characteristics and antibiotic therapy of adult menigitis due to penicillinresistant pneumococci. Am J Med 1988 ; 84 : ) Klugman KP : Pneumococcal resistance to antibiotics. Clin Microbiol Rev 1990 ; 3 : ) Alfred J : Saah, joseph, relative resis-tance to penicillin in the pneumococcus. JAMA 1980 ; 243 : ) Feldman C, Kallenbach JM, Miller SD, Thor- JR, Koornhof HJ : burn Community-acquired pneumonia due to penicilln-resistabt pneumococci. N Engl J Med 1985 ; 313 : ) Eriksen KR : Studies on induced resistance to

5 Clinical Study on Penicillin Insusceptible/Resistant Streptococcus pneumoniae in the Elderly Patients Kenichiro TAKAHIRA, Hideki KATAOKA, Yoshishige MASUDA, Makiko FUKAYAMA, Tsutomu HATAKEYA, Yumiko ISHIHAMA & Takashi INAMATSU Tokyo Metropolitan Geriatric Medical Center Clinical features of respiratory infection in the elderly with penicillin insusceptible (31 cases) and resistant (7 cases) Streptococcus pneumonia (PSSP/PRSP) are compared to those with penicillin sensitive S. pneumoniae (PSSP) (29 cases). Incidence of bacteremia and pneumonia was higher in the PSSP group. PISP/PRSP tend to be isolated from patients with bronchitis underlaid with chronic pulmonary disease without statistic significance. Efficacy of the penicillins and 1st and 2nd generation cephem was satisfactory except in only one case of pneumonia with PISP which needed an alternative choice to the 3rd generation cephem. Now a day the degree of resistance is not so high and the available antibiotics are sufficient for the treatment of pneumococcal infection in the elderly patients. However, the wide use of oral cephems and certain new quinolones which do not have enough activity against Streptococcus pneumoniae may increase resistance. In which case, continuous surveillance and clinical caution against this resistant strain is necessary.