PILGRIM CONCORD JOINT SYMPOSIUM

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1 Two EU funded projects present... ff research results ff practical recommendations...in the fight against MRSA BRUSSELS November 2011

Welcome We kindly invite you to the PILGRIM - CONCORD Joint Symposium to obtain the latest information on current research on MRSA and its impact on

Invited keynote speakers from a wide variety of stakeholder groups will share their expertise, experience and views with you.

2 Welcome We kindly invite you to the PILGRIM - CONCORD Joint Symposium to obtain the latest information on current research on MRSA and its impact on society, animal production and public health. Invited keynote speakers from a wide variety of stakeholder groups will share their expertise, experience and views with you. A warm welcome to the PILGRIM - CONCORD Joint Symposium Prof Katharina Stärk, PILGRIM Coordinator, Professor of Veterinary Public Health, The Royal Veterinary College London (RVC) Prof Ad Fluit, CONCORD Coordinator, Associate Professor, University Medical Center Utrecht 1

3 Introduction On day one, we would like to introduce you to our MRSA-related research activities by presenting our latest results on MRSA epidemiology, generated in the PILGRIM and CONCORD projects. On day two, we will focus on the research in diagnostic molecular tools, modelling and fundamental research and colonisation as well as host specificity. These topics will be followed by presentations demonstrating the practical outcome from both projects and development of suitable interventions against MRSA. A press conference and presentations of key stakeholders from both animal and healthcare settings, as well as policy-makers and industrial and international organisations will present different perspectives on MRSA-related problems. Several organisations and projects related to MRSA will display their activities parallel to the official programme. This will provide a unique opportunity to all participants for further discussion, exchange and collaboration. PROGRAMME Day 1: Monday, 28 November 2011 Registration, 13:00 Opening 13:30 MRSA media scare or true risk, Katharina Stärk / Ad Fluit 13:45 EFSA s activities supporting the EU strategy on AMR, Marta Hugas MRSA - State-of-the-art 14:15 The history of MRSA until 2007 including CA-MRSA, Robert Skov 14:45 LA-MRSA: Just another S. aureus for animals, Jaap Wagenaar 15:15 Coffee break Epidemiology 15:45 The spread of LA-MRSA among animals and humans, Els Broens / Brigitte van Cleef 16:15 Population Structure of CA-MRSA and LA-MRSA in Europe, Herminia de Lencastre / Lina Cavaco 16:45 Pig trade and antibiotic use as possible factors enhancing the spread of LA-MRSA in pig production, Luca Guardabassi 17:15 End of day 1 2

4 Day 2: Tuesday, 29 November 2011 Welcome coffee, 8:30 PILGRIM CONCORD Diagnostic molecular tools 09:00 Microarrays and PCR understanding host-pathogen interaction and development of rapid diagnostics, Jodi Lindsay / Floyd Wittink Modelling 09:30 Nosocomial transmission of Community-associated Methicillin-resistant Staphylococcus aureus, David Hetem 10:00 Modelling the spread of LA-MRSA: Who will catch it and where? Mariano Ciccolini / Katharina Stärk / Thibaud Porphyre 10:30 Coffee break Fundamental research 10:45 Community- and Livestock-associated MRSA from a whole genome perspective, Ad Fluit 11:15 Transcriptome analysis of CA/FA-MRSA isolates, Nicole ten Broeke-Smits / Floyd Wittink 11:45 Virulence factors from CA- and LA-MRSA, Gerard Lina / Sergey Konstantinov 12:15 Resistance genes in LA-MRSA, Frank M. Aarestrup / Jesper Larsen 12:45 Lunch / Colonisation and host specificity 13:30 Studies in vivo of acquisition and persistence of colonisation of pigs with MRSA, David Lloyd 14:00 A human colonization study with ST398, Bibi Slingerland / Willem van Wamel 14:30 In vitro and in vivo experiments on S. aureus host specificity, Arshnee Moodley Interventions 12:45 MRSA press conference 15:00 Bacteriophage control of MRSA in pigs on the farm, Birgitta Duim / John Hardcastle 15:30 Development and validation of a technology testing platform for MRSA decontamination, Stathis Giotis 16:00 Coffee break Impact and conclusions by stakeholders 16:15 Consortia recommendations 16:25 MRSA position of European veterinarians, Jan Bernardy 16:40 Political consequences. Examples from the EurSafety project, Alex Friedrich 16:55 Future research needs, Marc Bonten 17:10 Opportunities for industry, tbd 17:25 EU policy and support, Anna Lönnroth 3

Speakers and Chairs PILGRIM The EU funded

College, London, United Kingdom Dr Robert

Denmark Dr Jodi Lindsay, Centre for Infection

Nijmegen, Dr Els Broens, National Institute

Dr Brigitte van Cleef, National Institute

Universitet, Copenhagen, Denmark Prof David

van Wamel, Erasmus University Medical Center,

University Medical Center, Rotterdam, Dr

Disease, University of Copenhagen, Denmark

Agrochemical Research Centre, VAR-CODA-CERVA,

5 Speakers and Chairs PILGRIM The EU funded project PILGRIM has investigated MRSA for nearly three years. Its partners will present their research results and practical recommendations concerning MRSA in livestock and in the public health sector. Prof Katharina Stärk, The Royal Veterinary College, London, United Kingdom Dr Robert Skov, Statens Serum Institute, Copenhagen, Denmark Dr Jodi Lindsay, Centre for Infection Cellular and Molecular Medicine, St George s University of London, United Kingdom Dr Jesper Larsen, Statens Serum Institute, Copenhagen, Denmark Prof Andreas Voss, Radboud University Nijmegen Medical Center, Nijmegen, Dr Els Broens, National Institute Public Health and the Environment, Bilthoven, Dr Brigitte van Cleef, National Institute Public Health and the Environment, Bilthoven, Prof Luca Guardabassi, Kobenhavns Universitet, Copenhagen, Denmark Prof David Lloyd, The Royal Veterinary College, University of London, United Kingdom Dr Willem van Wamel, Erasmus University Medical Center, Rotterdam, Ms Bibi Slingerland, Erasmus University Medical Center, Rotterdam, Dr Arshnee Moodley, Department of Veterinary Disease, University of Copenhagen, Denmark Prof Patrick Butaye, Veterinary and Agrochemical Research Centre, VAR-CODA-CERVA, Brussels, Belgium Dr Efstathios Giotis, The Royal Veterinary College, London, United Kingdom 4

CONCORD The EU funded project CONCORD has explored

Project participants present their results on

modelling as well as effective strategies against

Prof Ad Fluit, University Medical Center Utrecht,

Cavaco, National Food Institute, Technical

de Lencastre, Instituto de Tecnologia Quimica e

Wittink, University of Amsterdam, Nicole ten

Gerard Lina, Laboratoire de Bacteriologie,

University Medical Center Utrecht, Prof Frank M.

University of Denmark, Lyngby, Denmark Dr Birgitta

University Medical Center Utrecht, John Hardcastle,

Mariano Ciccolini, Centre for Infectious Diseases,

speakers Prof Alex Friedrich, Lead Partner of

Groningen, Prof Jan Bernardy, University of

Republic Prof Marc Bonten, Professor of Molecular

Medical Center Utrecht, 5 Dr Anna Lönnroth,

6 CONCORD The EU funded project CONCORD has explored the adaptation of MRSA to the community and farms. Project participants present their results on fundamental research, experiments and mathematical modelling as well as effective strategies against CA- and FA-MRSA. Prof Ad Fluit, University Medical Center Utrecht, Dr Jaap Wagenaar, University Utrecht, Dr Lina Cavaco, National Food Institute, Technical University of Denmark, Lyngby, Denmark Dr Herminia de Lencastre, Instituto de Tecnologia Quimica e Biologica (ITQB), Oeiras, Portugal Dr Floyd Wittink, University of Amsterdam, Nicole ten Broeke-Smits, University Medical Center Utrecht, Dr Gerard Lina, Laboratoire de Bacteriologie, Université de Lyon, France Dr Sergey Konstantinov, University Medical Center Utrecht, Prof Frank M. Aarestrup, National Food Institute, Technical University of Denmark, Lyngby, Denmark Dr Birgitta Duim, University Utrecht, Dr David Hetem, University Medical Center Utrecht, John Hardcastle, Novolytics Limited, Warrington, United Kingdom Dr Mariano Ciccolini, Centre for Infectious Diseases, University of Edinburgh, United Kingdom Key note speakers Prof Alex Friedrich, Lead Partner of EurSafety Health-Net, Universitair Medisch Centrum Groningen, Prof Jan Bernardy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic Prof Marc Bonten, Professor of Molecular Epidemiology of Infectious Diseases, University Medical Center Utrecht, 5 Dr Anna Lönnroth, European Commission, Research DG, Health Research, Infectious Diseases, Brussels, Belgium Dr Marta Hugas, Head of Unit of Biological Hazards, European Food Safety Authority (EFSA), Parma, Italy

7 Location The PILGRIM - CONCORD Joint Symposium takes place at the Auditorium The Arc of the meeting centre SQUARE in Brussels. SQUARE - Brussels Meeting Centre Glass Entrance rue Mont des Arts B-1000 Brussels Directions SQUARE is located close to Brussels Central railway station. Inside the station, there are exit signs to Mont des Arts SQUARE. International trains arrive at Brussels Midi. From there, it is a two-minute train journey to Brussels Central. There are direct trains from Brussels International Airport (Zaventem) to Brussels Central. The train journey takes 17 minutes. For more detailed directions please visit Accommodation Accommodation needs to be arranged by participants individually. You can find several hotels close to the SQUARE, e.g. on Date Monday, 28 November, 13:00-17:30 h Tuesday, 29 November, 09:00-18:00 h More information is available on 6

8 Organisation This event is organised by partners of the PILGRIM and CONCORD projects. Registration Please register online on until 30 September Participation in the PILGRIM - CONCORD Joint Symposium is free. Places are limited. Contact For questions regarding local facilities (SQUARE), please contact: Dr Cristina Garcia-Graells Université Libre de Bruxelles-Hôpital Erasme Brussels, Belgium cgarciag@ulb.ac.be For organisational questions, please contact: Mr Michael Messerli accelopment AG, Switzerland mmesserli@accelopment.com 7

NEWSLETTER 1 MARCH Produced by CSO-MOH IL

NEWSLETTER 1 MARCH Produced by CSO-MOH IL Produced by CSO-MOH IL Contact: The JPIAMR secretariat is hosted by the Swedish Research Council in Stockholm, Sweden and currently involves the following staff: Ana Beramendi Jenny Fernebro Anna Vallstedt