LABRADOR RETRIEVER. Welcome to the Embark family!

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1 OWNER S NAME: Judy Marlene Carr DOG S NAME: Prince Silver of Tender Oak Ranch TEST DATE: December 22nd, 2017 This certifies the authenticity of Prince Silver of Tender Oak Ranch s canine genetic background as determined following careful analysis of more than 200,000 genetic markers. LABRADOR RETRIEVER Welcome to the Embark family! WOLFINESS 0.6% LOW MATERNAL HAPLOTYPE PATERNAL HAPLOTYPE A17 Hc.10 Adam Boyko, Ph.D. CHIEF SCIENCE OFFICER Ryan Boyko CHIEF EXECUTIVE OFFICER

2 GENETIC STATS Wolfiness: 0.6 % LOW Predicted adult weight: 60 lbs Genetic age: 29 human years TEST DETAILS Kit number: EM Swab number:

3 LABRADOR RETRIEVER The Labrador Retriever has been the most popular AKC breed in the United States every year for the past 25 years. Their origins have been traced to the St. John s dog, named for the capital city of the Canadian province Newfoundland and Labrador. The St. John s was developed from imported European dogs for fishing and hunting on the island of Newfoundland in the 18th century. During the 19th century St John s were bred in England and developed into the Labradors we know and love. Labradors were recognized as a breed by the British Kennel Club in 1903 and by the AKC in With their friendly dispositions and weatherproof build, they are terrific family dogs and outdoor companions. Most Labradors are very active with an appetite to match, and need plenty of exercise. Labradors often love to swim. Their double-coated weather-resistant fur can cause heavy shedding. Great hunting dogs and popular household companions, Labrador Retrievers are also employed as guide dogs and search-and-rescue dogs. Fun Fact We re pretty sure Labradors came from the island of Newfoundland, and many experts believe that the Newfoundland breed was developed in neighboring Labrador! By our calculations, there are 10 times as many Labradors in North America than there are people living in Labrador and Newfoundland. RELATED BREEDS Flat-Coated Retriever Sibling breed Golden Retriever Sibling breed Chesapeake Bay Retriever Cousin breed Newfoundland Cousin breed

4 MATERNAL LINE Through Prince Silver of Tender Oak Ranch s mitochondrial DNA we can trace his mother s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map. HAPLOGROUP: A1a A1a is the most common maternal lineage among Western dogs. This lineage traveled from the site of dog domestication in Central Asia to Europe along with an early dog expansion perhaps 10,000 years ago. It hung around in European village dogs for many millennia. Then, about 300 years ago, some of the prized females in the line were chosen as the founding dogs for several dog breeds. That set in motion a huge expansion of this lineage. It's now the maternal lineage of the overwhelming majority of Mastiffs, Labrador Retrievers and Gordon Setters. About half of Boxers and less than half of Shar- Pei dogs descend from the A1a line. It is also common across the world among village dogs, a legacy of European colonialism. HAPLOTYPE: A17 Part of the large A1a haplogroup, this common haplotype is found in village dogs across the globe. Among breed dogs, we find it most frequently in Labrador Retrievers, Boxers, and Mastiffs.

5 PATERNAL LINE Through Prince Silver of Tender Oak Ranch s Y chromosome we can trace his father s ancestry back to where dogs and people first became friends. This map helps you visualize the routes that his ancestors took to your home. Their story is described below the map. HAPLOGROUP: A2b A2b appears to have split a few times in succession, which means that some of the Central Asian male ancestors of this lineage went their separate ways before their respective Y chromosomes made their rounds. There is not much diversity in this lineage, meaning that it has only begun to take off recently. Two iconic breeds, the Dachshund and Bloodhound, represent this lineage well. Over half of Rottweilers are A2b, as are the majority of Labrador Retrievers and Cavalier King Charles Spaniels. While A2a is restricted mostly to East Asia, this paternal line is also found among European breeds. HAPLOTYPE: Hc.10 Part of the A2b haplogroup, this haplotype occurs most commonly in Labrador Retrievers, Rottweilers, Curly-Coated Retrievers, Dandie Dinmont Terriers, and village dogs throughout the world.

6 TRAITS Coat Color E Locus (Mask, Grizzle, Recessive Red) K Locus (Dominant Black) A Locus (Agouti, Sable) D Locus (Dilute, Blue, Fawn) B Locus (Brown, Chocolate, Liver, Red) ee B K k a a DD BB y t t Other Coat Traits Other Body Features Furnishings / Improper Coat (RSPO2) II Brachycephaly (BMP3) CC Long Haircoat (FGF5) GG Natural Bobtail (T) CC Shedding (MC5R) CT Hind Dewclaws (LMBR1) CC Curly Coat (KRT71) CC Performance Body Size Altitude Adaptation (EPAS1) GG Body Size - IGF1 NI Body Size - IGF1R GG Body Size - STC2 TA Body Size - GHR (E195K) GG Body Size - GHR (P177L) CC Genetic Diversity Inbreeding Coefficient 19% MHC Class II - DLA DRB1 High Diversity MHC Class II - DLA DQA1 and DQB1 High Diversity

7 CLINICAL TRAITS These clinical genetic traits can inform clinical decisions and diagnoses. These traits do not predict a disease state or increased risk for disease. We currently assess one clinical trait: Alanine Aminotransferase Activity. Alanine Aminotransferase Activity result: Normal Prince Silver of Tender Oak Ranch has two normal alleles at ALT. More information on Alanine Aminotransferase Activity: Known to be highly expressed in liver cells, activity levels of alanine aminotransferase, or ALT, is a common value on most blood chemistry panels and is known to be a sensitive measure of liver health. Dogs with two ancestral G alleles show "normal" activity. Dogs that have one or two copies of the derived A allele may have lower resting levels of ALT activity, known as "low normal". If your dog's result is "low normal" then when a blood chemistry panel is being interpreted the values that you and your veterinarian consider "normal" may need to be adjusted. Please note that neither a "normal" nor a "low normal" result for this predicts a disease state or increased risk for liver disease. Moreover, this mutation does not associate with increased levels of ALT: If your dog has high ALT levels, please consult your veterinarian.

8 HEALTH Good news! Prince Silver of Tender Oak Ranch did not test positive for any of the genetic diseases that Embark screens for. 0 AT RISK 0 CARRIER

9 OTHER CONDITIONS Good news! Prince Silver of Tender Oak Ranch tested clear for 18 genetic conditions that are common in his breed. Congenital Macrothrombocytopenia (TUBB1 Exon 1, Cavalier King Charles Spaniel Variant) Pyruvate Kinase Deficiency (PKLR Exon 7 Labrador Variant) Golden Retriever Progressive Retinal Atrophy 2 (TTC8) Achromatopsia (CNGA3 Exon 7 Labrador Retriever Variant) Degenerative Myelopathy (SOD1A) Centronuclear Myopathy (PTPLA) Myotubular Myopathy 1, X-linked Myotubular Myopathy (MTM1) Congenital Myasthenic Syndrome (COLQ) Oculoskeletal Dysplasia 1, Dwarfism-Retinal Dysplasia 1 - drd1 (COL9A3, Labrador Retriever) Canine Elliptocytosis (SPTB Exon 30) Progressive Retinal Atrophy - prcd Progressive rod-cone degeneration (PRCD Exon 1) Progressive Retinal Atrophy - crd4/cord1 (RPGRIP1) Macular Corneal Dystrophy (MCD) (CHST6) Narcolepsy (HCRTR2 Intron 6) Exercise-Induced Collapse (DNM1) Malignant Hyperthermia (RYR1) Hereditary Nasal Parakeratosis (SUV39H2) Skeletal Dysplasia 2 (COL11A2)

10 FULL TEST PANEL To help ensure healthy breeds, every test includes analysis of our full panel of over 160 genetic diseases. Prince Silver of Tender Oak Ranch is also clear of 147 other genetic diseases that Embark tests for.