FOOD DIAGNOSTICS Drug Residue Screening Reduce labour, increase productivity and decrease costs
Drug Residue Testing With nearly 30 years experience in the market and a dedicated research and development team, Randox Food Diagnostics are committed to the development and manufacturing of high quality and accurate drug residue testing solutions.this unique multi-analyte testing platform will reduce labour costs, increase throughput and guarantee overall productivity improvement. Reduce labour costs, increase throughput and guarantee overall productivity improvement Randox Food Diagnostics Products Drug residues are causing concern increasingly worldwide. Most drugs are introduced to improve animal health; however, the abuse of drugs is becoming increasingly widespread. The legitimate treatment of disease with drugs such as antibiotics (in clinical doses) reduces mortality in livestock while other growth promoting agents are misused to improve meat production. Global racing authorities are reliant upon drug residue screening solutions to maintain the integrity of the racing industry by testing for illegal performance altering drugs. An increasing number of compounds are being screened to protect the safety of animals and to ensure races are won on the animals natural ability. As a consequence of the abuse of drugs within the food production and animal racing industries, the practice of using high doses of antibiotics, growth promoters and Drugs of Abuse is strictly regulated. ELISA Kits - For screening animal and food samples for drug residues - For monitoring show and competition animals for performance enhancing drugs - Applicable to multiple matrices Immunoaffinity Columns - For sample purification prior to analyte assessment - To complement Randox ELISA and Biochip Array Technology Multiple Residue Screening - For multi-analyte screening of a comprehensive range of drug residues - Massive cost savings - Higher throughput - Applicable to multiple matrices
ELISA Tests for Drug Residue Analysis Randox Food Diagnostics ELISA kits allow screening of drug residues in various matrices. Randox ELISA kits show favourable comparison with confirmatory methods. Randox ELISA Kit Benefits: Easy to use, highly specific, cost effective screening method Measurement of drug residues in various matrices in urine, serum/plasma, tissue, muscle, feed, milk, honey, feather, bile, hair, egg and retina Intra and inter assay precision typically <10% CV Fast up to 80 samples can be analysed in two to three hours with ELISA Lower set-up costs as no expensive equipment required Randox ELISA tests can be fully automated Drug Residue ELISA Kits Available Drug Class Cat. No. Drug Residue Anabolic Steroids Anti-microbial b-agonists TB2106 NT2105 BD2382 SW2418 SQ2145 SZ2147 SM2146 SZ3471 CN1469 BL3448 BL1371 QL3454 FQ3460 NF3465 NF3462 NF3463 NF3461 STP3468 N/A CB1418 SU2148 RT3451 Trenbolone 19-Nortestosterone/Trenbolone Boldenone Stanozolol Sulphaquinoxaline Sulphadiazine Sulphamethazine Sulphamethoxazole Chloramphenicol b-lactams b-lactams standard accessory kit Quinolones Flumequine AOZ AMOZ AHD SEM Streptomycin/Dihydrostreptomycin Tetracyclines* (generic) Clenbuterol/brombuterol b-agonists (clenbuterol, salbutamol, mabuterol, brombuterol, mapenterol, terbutaline, pirbuterol, methylclenbuterol, carbuterol, mabuterol, bromochlorbuterol, cimbuterol, clenpenterol hydrochloride) Ractopamine Drugs of Abuse KT3459 Ketamine (specific for norketamine) Tri-phenylmethane dyes LMG3466 Leucomalachite Green (Leucomalachite Green, Malachite Green, Leucocrystal Violet) Non Steroidal Anti-inflammatory Oestrogenic DM2156 PB3456 FL3458 SJ2152 ZR2421 Urine controls CB3449 Clenbuterol * Currently in development Corticosteroids (dexamethasone, flumethasone, betamethasone) Phenylbutazone Flunixin Stilbenes (diethylstilbestrol, hexestrol, dienestrol) Zeranol Easy to use and cost effective ELISA screening solutions
Immunoaffinity Columns for Sample Purification Sample clean up is an essential part of drug residue testing, whether it is performed by ELISA, LC-MS or any other technique. To complement this range of ELISAs for measuring drug residues, Randox Food Diagnostics offers a wide range of Immunoaffinity Columns for sample purification. Randox Immunoaffinity Column Benefits: Very efficient and highly specific Multi-analyte testing allowing simultaneous sample clean up Higher analyte recovery Improved safety and reduced waste and disposal costs Faster due to fewer purification steps Can be automated Convenient available in packs of five with buffers for equilibration and storage Cost-effective each column can be used up to 10 times Long shelf life two years from date of manufacture The principle of sample purification by Immunoaffinity Columns Addition of crude sample Removal of interferents by washing step Elution of bound analyte KEY Analyte Antibody specific for analyte Interferent Purified sample ready for further analysis Immunoaffinity Columns Available Catalogue No. Product Description Pack Size GP1821 Growth Promoters - multi-analyte column 5 columns CB2184 Clenbuterol/b-agonists 5 columns (Clenbuterol, salbutamol, mabuterol, mapenterol, terbutaline, cimaterol, perbuterol, carbuterol, brombuterol, methylclenbuterol) DM2185 Corticosteroids (Dexamethasone, betamethasone, flumethasone) 5 columns TB2186 Trenbolone and 19-nortestosterone 5 columns SJ2154 Stilbenes (Diethylstilbestrol, hexestrol, dienestrol) 5 columns ZR2420 Zeranol 5 columns Cost Effective Immunoaffinity Columns
Biochip Array Technology for Multi-Analyte Testing Randox Food Diagnostics present the world s only multi-analyte semi-quantitative Drug Residue analyser. The use of the Evidence Investigator allows simultaneous detection of multiple analytes from a single sample, using our patented Biochip Array Technology. This unique platform consolidates testing, reduces labour costs and improves overall productivity. Consolidates testing, reduces labour costs and improves overall productivity Biochip Array Technology Benefits: Cost savings and minimal consumable costs Less labour (Minimal labour costs could be reduced by at least five fold) Faster Turnaround Time Higher Throughput (45 samples or 675 tests in under two hours) Faster Adaptability to new regulations (up to 65 new antibodies at the R+D stage) Applicable To Multiple Matrices Honey Feed Milk Urine Tissue Ideal for Drug Screening Laboratories Mutliplex screening for Veterinary Drug Residues Consolidation of testing to provide multiple test results from a single sample No requirement for deuterated standards Requires minimal technical expertise Extensive menu of drug residue tests developed Same sample preparation method can be applied across a number of our arrays. Multiplex Screening for Veterinary Drug Residues
Randox Veterinary Drug Residue Test Menu ANTIMICROBIAL ARRAYS ANTHELMINTICS ARRAY (EV3770) Amino Benzimidazoles Avermectins (generic) Benzimidazoles Levamisole Moxidectin Thiabendazole Triclabendazole ANTIMICROBIAL ARRAY I PLUS (EV3775) Sulphachlorpyridazine Sulphadiazine Sulphadimethoxine Sulphadoxine Sulphamerazine Sulphamethazine Sulphamethizole Sulphamethoxazole Sulphamethoxypyridazine Sulphamonomethoxine Sulphapyridine Sulphaquinoxaline Sulphathiazole Sulphisoxazole Trimethoprim ANTIMICROBIAL ARRAY II (EV3524) Ceftiofur Florphenicol/ Thiamphenicol Quinolones (generic) Streptomycin/Dihydrostreptomycin Tetracyclines (generic) Tylosin/ Tilmicosin ANTIMICROBIAL ARRAY III (EV3695) AHD AMOZ AOZ SEM Chloramphenicol Chloramphenicol Glucuronide ANTIMICROBIAL ARRAY III CHLORAMPHENICOL ONLY (EV3738) Chloramphenicol Chloramphenicol Glucuronide DRUGS OF ABUSE ARRAYS DRUGS OF ABUSE ARRAY I ( EV3512 - URINE EV3618 - WHOLE BLOOD EV3619 - ORAL FLUID EV3617 - URINE SQ) Amphetamine Barbiturates Benzodiazepine 1 Benzodiazepine 2 Cannabinoids Cocaine Methadone Methamphetamine Opiates Phencyclidine DRUGS OF ABUSE ARRAY I PLUS ( EV3746 - URINE EV3751 - WHOLE BLOOD) Amphetamine Barbiturates Benzodiazepine 1 Benzodiazepine 2 Buprenorphine Cannabinoids Cocaine MDMA Methadone Methamphetamine Opiates Phencyclidine Tricyclic Antidepressants (TCAs, generic) DRUGS OF ABUSE ARRAY II ( EV3662 - URINE EV3681 - WHOLE BLOOD) Buprenorphine Fentanyl Generic Opioids Ketamine LSD MDMA Methaqualone Oxycodone 1 Oxycodone 2 Propoxyphene GROWTH PROMOTERS ARRAYS GROWTH PROMOTER RAPID URINE SCREEN (EV3521) b -Agonists Boldenone Corticosteroids Ractopamine Stanozolol Trenbolone Zeranol GROWTH PROMOTER MULTIPLE MATRIX SCREEN (EV3726) b - Agonists Boldenone Corticosteroids Nandrolone Ractopamine Stanozolol Stilbenes Trenbolone Zeranol SYNTHETIC STEROIDS ARRAY (EV3694) 17b - Clostebol Ethinylestradiol Gestagens (generic) Methandriol Methyltestosterone FUTURE DEVELOPMENTS Anti-Inflammatory Drugs Array b-agonists Array Coccidiostats Array Drugs of Abuse Array III Drugs of Abuse Array IV For further information please visit www.randoxfooddiagnostics.com
Publications Examples using Randox Food Diagnostics Testing products Sterk S.S., Ohlrich D., Christensen, F., Le, N.B., Blokland, M.H., Schwillens, P.L.W.J., van Ginkel, L.A., and Stephany, R.W. Screening and confirmation of real-life urine samples for trenbolone-false positive or false negative? That s the question! Proceedings EuroResidue IV, 2000, 1035-1041. Stenhouse, A.M., Keledjian J., Vadasz, A., Dunstan, A.J., Suann, C.J., McKinney, A.R. Feed contamination leading to the detection of ractopamine in post race urine samples. Proceedings of the 16 th International Conference of Racing Analysts and Veterinarians, 2006, 138-144. Ponniah, J., Muhammad K., Abdullah, S., Ganapathy, K.K., bt Sheikh Abdul Hamid, N. Validation of ELISA test kits for detection of beta-agonist residues in meat. Southeast Asian J. Trop. Med. Public Health, 2004, 35(2): 481-487. FitzGerald, S.P., O Loan, N., McConnell, R.I., Benchikh, E.O., Kane, N.E. Stable Competitive Enzyme-Linked Immunosorbent Assay Kit for Rapid Measurement of 11 Active Beta-Lactams in Milk, Tissue, Urine and Serum. Journal of AOAC International. 2007, 90(1): 334-342. Example Randox Poster Presentations Development of a generic direct competitive ELISA for the rapid screening of quinolones in raw milk and food animal edible tissue. Lowry A.P., Benchikh E.O., O Loan N., Fitzgerald S.P., McConnell R.I., Bryson D. Fifth International Symposium on Hormone and Veterinary Drug Residue Analysis, Antwerp Belgium, 2006 Development of a competitive ELISA for the detection of malachite green and leucomalachite green. Benchikh E.O., Lowry A.P., FitzGerald S.P., McConnell R.I., Kane E.N., Bryson D. Fifth International Symposium on Hormone and Veterinary Drug Residue Analysis, Antwerp Belgium, 2006 Evidence Biochip Array Technology as a multi-analytical tool for the screening of residues in different food matrices. Tohill A., McAleer D., McConnell R.I., FitzGerald S.P. RAFA, 2009 Application of Biochip Array Technology to multi-analyte screening of sulphonamides in different matrices. Tohill A., McAleer D., Acheson R., Bell B., McConnell R.I., FitzGerald S.P. EuroResidue VI, Netherlands, 2008 Simultaneous detection of four nitrofuran metabolites in honey using multiplexing biochip screening assay. O Mahony, et al. Biosens Bioelectron. 2011, 26(10): 4076-4081. Multiplex screening for Veterinary Drug Residues The ultimate cost saving Drug Residue Screening solution
Fast track your workload Screening test menu includes Sulphonamides Chloramphenicol Tetracyclines Nitrofurans Aminoglycosides Macrolides Quinolones Beta Lactam Anthelmintics Gestagens/Androgens/ Estrogens Corticosteroids Beta Agonist Clenbuterol Ractopamine Boldenone Stanozolol Trenbolone Nandrolone FOOD DIAGNOSTICS Randox Food Diagnostics provides a unique multi-analyte testing platform that will improve the speed of throughput of your food testing laboratory. Multiplex Testing Benefits: Fast sample turnaround time Reduce labour costs Overall productivity improvements Consolidates testing Simple sample preparation Quality reassurance Matrices available: Tissue Honey Feed Urine Milk Zeranol Randox Food Diagnostics Limited, 30 Cherryvalley Road, Crumlin, County Antrim, United Kingdom, BT29 4QN T +44 (0) 28 9445 9702 F +44 (0) 28 9442 3859 E enquiries@randoxfooddiagnostics.com I www.randoxfooddiagnostics.com Information correct at time of print. All Randox Food Diagnostics products are made in the UK. Randox Food Diagnostics Limited is a company registered within Northern Ireland with Company Number NI069074. VAT Number GB 973 0927 96. Product availability may vary from country to country. Please contact your local Randox Food Diagnostics representative for information. LT015RFD OCT11