Introduction to the Antimicrobial Resistance Global Action Plan

Similar documents
Global Action Plan on AMR and Follow up

Appendix C: Religious restrictions index scores by region

Pew forum on religion & public life

Chart showing the average height of males and females in various world countries.

WHO global and regional activities on AMR and collaboration with partner organisations

One Health Collaboration to combat Antimicrobial resistance

Antimicrobial Resistance at human-animal interface in the Asia-Pacific Region

The European AMR Challenge - strategic views from the human perspective -

MESSAGE TELECOMMUNICATIONS SERVICE

Surcharge for Declared Value for each CZK or any part thereof on top of basic price: without V.A.T.

WHO efforts to reduce the impact on public and animal health of antibiotic use in animals. Dr Danilo Lo Fo Wong Senior Adviser AMR

RULES & REGULATIONS EUKANUBA WORLD CHALLENGE 2019 Birmingham March 7th

National Action Plan development support tools

Global response to antibiotic access and resistance: Stuart B. Levy, M.D. Tufts University School of Medicine Alliance for Prudent Use of Antibiotics

European poultry industry trends

Control of. Antimicrobial. Agri Food Sector. Jeffrey LeJeune, DVM, PhD

One Health tripartite initiatives Updates from WHO perspective to address zoonoses and AMR issues

GHSA Prevent-1 (AMR) road map: Progress and implementation plan Dr. Anders Tegnell, Ministry of Health and Social Affairs, Sweden

The challenge of growing resistance

The UK strategy for antimicrobial resistance (AMR) and its implications for research and development

ANTIMICROBIAL RESISTANCE: GLOBAL BURDEN

Global efforts to combat Antimicrobial Resistance

Sky Mobile Tariff Guide

Appendix F. The Test-Curriculum Matching Analysis Mathematics TIMSS 2011 INTERNATIONAL RESULTS IN MATHEMATICS APPENDIX F 465

SESSION 3: RABIES SITUATION IN THE ASIA-PACIFIC

Dr Nata Menabde Executive Director World Health Organization Office at the United Nations Global action plan on antimicrobial resistance

Global action plan to combat antimicrobial resistance (AMR)

Marine Mammal Protection Act Import Rule. Office of International Affairs and Seafood Inspection [IASI]

The APUA Global Chapter Network:

Antimicrobial Resistance, yes we care! The European Joint Action

Good governance and the evaluation of Veterinary Services

Sky Mobile Tariff Guide

Resistance and New Rules on Antibiotic Use in Agriculture

Resolution adopted by the General Assembly on 5 October [without reference to a Main Committee (A/71/L.2)]

WHO laboratory-based global survey on multidrug-resistant organisms (MDROs) in health care interim analysis

Appendix F: The Test-Curriculum Matching Analysis

Sky Mobile Tariff Guide

EU Health Priorities. Jurate Svarcaite Secretary General PGEU

COMMISSION ON GENETIC RESOURCES

Sky Mobile Tariff Guide

Summary of the latest data on antibiotic consumption in the European Union

Managing AMR at the Human-Animal Interface. OIE Contributions to the AMR Global Action Plan

International approach for veterinary medicinal products: OIE and Codex alimentarius

Sky Mobile Tariff Guide

Sky Mobile Tariff Guide

Sky Mobile Tariff Guide

Sky Mobile Tariff Guide

OECD WORK ON AMR: TACKLING THE NEGATIVE CONSEQUENCES OF ANTIBIOTIC RESISTANCE ON HUMAN HEALTH. Michele Cecchini OECD Health Division

Progress of Rabies Control from OIE perspective

REPORT ON THE ANTIMICROBIAL RESISTANCE (AMR) SUMMIT

Dr Stuart A. Slorach

OIE AMR Strategy, One Health concept and Tripartite activities

OIE mission in the framework of One Health Focus on antimicrobial resistance (AMR)

A web-based interactive tool to explore antibiotic resistance and consumption via maps and charts

Summary of the latest data on antibiotic consumption in the European Union

Promoting One Health : the international perspective OIE

Council of the European Union Brussels, 13 June 2016 (OR. en)

WHO s first global report on antibiotic resistance reveals serious, worldwide threat to public health

Prof. Otto Cars. We are overconsuming a global resource. It is a collective responsibility by governments, supranational organisatons

Antimicrobial resistance: the challenges for animal health

First OIE regional workshop on dog population management- Identifying the source of the problem and monitoring the stray dog population

OIE Resolution and activities related to the Global Action Plan. Regional Seminar for OIE National Focal Points for Veterinary Products 4 th Cycle

Global Strategies to Address AMR Carmem Lúcia Pessoa-Silva, MD, PhD Antimicrobial Resistance Secretariat

Dr Elisabeth Erlacher Vindel Head of Science and New Technologies Departement OIE AMR strategy and activities related to animal health

Dr Liz Tayler Antimicrobial Resistance Secretariat Global action plan on antimicrobial resistance

OIE Strategy on Antimicrobial Resistance and the Prudent Use of Antimicrobials in Animals Part I

Antibiotics and resistance in the WHO Regional Office for Europe. Dr Nienke van de Sande On behalf of the AMR Working Group

Antibiotic resistance: the rise of the superbugs

Consumption of antibiotics in hospitals. Antimicrobial stewardship.

Perspective on AnA Global timicrobial Resistance

Monitoring gonococcal antimicrobial susceptibility

The role of FAO in AMR

World Health Organization Emerging and other Communicable Diseases, Surveillance and Control

Draft global action plan on antimicrobial resistance

FSSC at Nestlé: A global solution with a local approach

Global Action Plan on Antimicrobial resistance

Antimicrobial Resistance in the South-East Asia Region

Regional Analysis of the OIE PVS Missions in South-East Asia with a focus on APFS

Fifth GF-TADs for Europe Steering Committee meeting (RSC5) FAO assistance to prevent and control brucellosis

What is the problem? Latest data on antibiotic resistance

European Medicines Agency role and experience on antimicrobial resistance

ANTIMICROBIAL RESISTANCE and causes of non-prudent use of antibiotics in human medicine in the EU

WHO's View on IVDs for Addressing AMR

Quality of veterinary medicines

The OIE-PVS: a tool for good Governance of Veterinary Services

International Activities In Antimicrobial Resistance

Quelle politique antibiotique pour l Europe? Dominique L. Monnet

RSPCA International- Europe, Turkey and Central Asia. Alexandra Hammond Seaman

Dr Marc Sprenger Director Antimicrobial Resistance Secretariat Global action plan on antimicrobial resistance

Food & Veterinary Office

Private Sector Perspectives IFAH (worldwide)

OIE 12, rue de Prony Paris France Tel.: 33 (0) Fax: 33 (0)

Combat Antimicrobial Resistance

First-year experiences in implementing Thailand s National Strategic Plan on AMR

Recommendations of the 3 rd OIE Global Conference on Animal Welfare

Actions for combatting Antimicrobial Resistance (AMR)

2016/LSIF/FOR/004 Policies to Promote Patient Access to Innovative Treatments and Combat Antimicrobial Resistance

WORLD ORGANIZATION FOR ANIMAL HEALTH /OIE/- ENGAGEMENT WITH ANIMAL WELFARE AND THE VETERINARY PROFFESSION

OIE Activities for the Containment of Antimicrobial Resistance. Dr Elisabeth Erlacher-Vindel, Deputy Head of the Scientific and Technical Department

Antimicrobial resistance (EARS-Net)

Transcription:

Introduction to the Antimicrobial Resistance Global Action Plan Gyanendra Gongal Scientist Health Security and Emergency Response WHO Regional Office for South East Asia

Outline AMR as a global public health crisis Global Action Plan on AMR Sample of actions requested by the Global Action Plan Surveillance of AMR AMR containment strategies and approaches in the Asia-Pacific Region Take home message

Fuel & Potable Ethanol COMPLEXITY OF ANTIMICROBIAL RESISTANCE Fuel Ethanol Producers AQUACULTURE Sea / Lakes Drinking Water Swimming Distillers Grain By- Products Land Fill Farm Effluents and Manure Spreading Drinking water Rivers and Streams SOIL Sewage Industrial & Household Antibacterial Chemicals Rendering Animal Feeds Re-mix COMPANION ANIMALS SHEEP VEAL CALVES Dead stock SWINE FOOD ANIMALS OTHER FARMED LIVESTOCK CATTLE POULTRY Offal WILDLIFE Commercial Abattoirs / Processing Plants Meat Vegetation, Seed Crops, Fruit Handling Preparation Consumption HOSPITALIZED EXTENDED CARE FACILITIES HUMAN COMMUNITY - URBAN -RURAL TRAVELLERS Direct Contact After Linton AH (1977), modified by Irwin RJ - 2012 version IMPORTS

Antibiotics: precious but diminishing resource Bringing a new antibiotic in market: Cost USD 1 billion, Time:12-14 years: Life:??

Alexander Fleming's Nobel Prize Lecture It is not difficult to make microbes resistant to penicillin. The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily under-dose himself and by exposing his microbes to nonlethal quantities of the drug make them resistant.

Estimates of Burden of Antibacterial Resistance Global information is insufficient to show complete disease burden impacts and costs

Published on April 29, 2015

Overall Key Findings The survey was completed by 133 countries in 2013-2014. Few countries (34 out of 133) have a comprehensive national plan to fight resistance to antibiotics and other antimicrobial medicines. Monitoring is key for controlling antibiotic resistance, but it is infrequent. In many countries, poor laboratory capacity, infrastructure and data management are preventing effective surveillance, which can reveal patterns of resistance and identify trends and outbreaks.

Overall Key Findings $ Sales of antibiotics and other antimicrobial medicines without prescription remain widespread, with many countries lacking standard treatment guidelines, increasing the potential for overuse of antimicrobial medicines by the public and medical professionals. Lack of programmes to prevent and control hospital-acquired infections remains a major problem. Public awareness of the issue is low in all regions, with many people still believing that antibiotics are effective against viral infections.

Key Findings by Region WHO African Region WHO Region of the Americas WHO Eastern Mediterranean Region WHO European Region WHO South East Asian Region WHO Western Pacific Region

WHO Africa Region 8 out of 47 Member States in the region participated in the survey. Poor-quality medicines are a general problem, further contributing to the challenge. All8countries in the region state that resistance to treatments for malaria and TB are their greatest challenges. The data in this region are incomplete due to lack of information, however the results suggest that antimicrobial resistance is a growing problem. Countries who participated in the survey: Burkina Faso, Central African Republic, Gambia, Ghana, South Sudan, United Republic of Tanzania, Uganda and Zambia

WHO Region of the Americas 26 out of 35 Member States in the region participated in the survey. Antibiotics and other antimicrobial medicines are available over the counter without a prescription in 18 countries. Only3countries in the region report having a national plan to address antimicrobial resistance. Poor quality medicines are a problem, particularly in Latin America. Only10 countries have standard treatment guidelines. Few countries produced a report on surveillance of antimicrobial resistance in humans. Countries who participated in the survey: Antigua and Barbuda, Argentina, Barbados, Belize, Bolivia (Plurinational State of), Brazil, Canada, Chile, Colombia, Costa Rica, Cuba, Dominica, Dominican Republic, Ecuador, El Salvador, Guatemala, Guyana, Honduras, Jamaica, Mexico, Nicaragua, Paraguay, Peru, Saint Kitts and Nevis, Suriname, Uruguay

WHO Eastern Mediterranean Region 13 out of 21 Member States in the region participated in the survey. None of the countries report having a national action plan for antimicrobial resistance. 3 countries have conducted a public information campaign in the previous 2 years. Antibiotics and other antimicrobial medicines are available without a prescription in 9 countries. Countries who participated in the survey: Afghanistan, Bahrain, Egypt, Iran (Islamic Republic of), Jordan, Lebanon, Morocco, Oman, Pakistan, Saudi Arabia, Sudan, Syrian Arab Republic, United Arab Emirates Poor awareness and understanding in all public sectors. Many gaps were found in addressing the issue. This is not surprising, given the other emergencies in the region, including natural disasters and conflicts.

WHO Europe Region 49 out of 53 Member States in the region participated in the survey. 40% of countries report having comprehensive plans and strategies to address antimicrobial resistance. About50% of countries have a national Infection Prevention and Control (IPC) programme. Public information campaigns are common, however about half the population believe that antibiotics are effective against viruses. All EU countries undertake surveillance of resistant bacteria through the European Antimicrobial Resistance Surveillance Network (EARS- Net), which is facilitated by the European Centre for Disease Prevention and Control. Countries who participated in the survey: Albania, Armenia, Austria, Azerbaijan, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, France, Georgia, Germany, Greece, Hungary, Iceland, Ireland, Israel, Italy, Kazakhstan, Kyrgyzstan, Latvia, Lithuania, Luxembourg, Malta, Montenegro, Netherlands, Norway, Poland, Portugal, Republic of Moldova, Romania, Russian Federation, Serbia, Slovakia, Slovenia, Spain, Sweden, Switzerland, Tajikistan, The former Yugoslav Republic of Macedonia, Turkey, Turkmenistan, Ukraine, United Kingdom, Uzbekistan

WHO South-East Asia Region All11 Member States in the region participated in the survey. Public awareness in the region is growing 5 countries report conducting awareness-raising activities in the previous 2 years. 5 of 11countries have national plans to address antimicrobial resistance. 9 of 11countries have a national IPC programme and a national regulatory agency responsible for ensuring quality of medicines. Countries report that health workers comply poorly with prescribing guidelines. Monitoring use of antibiotics and other antimicrobial medicines is limited, and medicines are available without a prescription in more than half the countries. Health ministers expressed their commitment to prevent and control antimicrobial resistance through the Jaipur Declaration in 2011. Countries who participated in the survey: Bangladesh, Bhutan, Democratic People s Republic of Korea, India, Indonesia, Maldives, Myanmar, Nepal, Sri Lanka, Thailand, Timor-Leste

WHO Western Pacific Region 26 out of 27 Member States in the region participated. Only4of the reporting countries have a national action plan. 2/3of the countries report having an IPC programme. There is weak enforcement of regulations on the sale of antibiotics and other antimicrobial medicines without prescription and of quality standards. Nearly70%of countries report surveillance for antimicrobial resistance in bacteria; this proportion may increase following introduction of the Western Pacific Antimicrobial Resistance Surveillance system in the near future. Countries who participated in the survey: Australia, Brunei Darussalam, Cambodia, China, Cook Islands, Fiji, Japan, Kiribati, Lao People's Democratic Republic, Malaysia, Marshall Islands, Micronesia (Federated States of), Mongolia, New Zealand, Niue, Palau, Papua New Guinea, Philippines, Republic of Korea, Samoa, Singapore, Solomon Islands, Tonga, Tuvalu, Vanuatu, Viet Nam

Perspective on the GAP for AMR The impact on health, & implications for health care are the core fundamental concerns However, solutions require engagement beyond health sector alone Broad range of global / intersectoral stakeholders beyond health Overlapping but also differing concerns & perspectives Stakeholder involvement is currently insufficient Consensus & synergy building requires process

Timeline: Consultations on Draft GAP for AMR Strengthened tripartite collaboration (FAO, OIE, WHO) Worked together on development of global action plan Shared actions for the collaboration Web based call for contributions: July-August 2014 Consultation with Member States 16 October 2014 WHO Strategic Technical Advisory Group (STAG) on AMR convened Member State consultations Human, animal, agriculture (The Hague, June 2014) Optimizing use of medicines (Oslo, November 2014) Global surveillance (Stockholm, December 2014) Research needs (Brasilia, March 2015)

WHO Executive Board Meeting January 2015 Strong support to take plan to World Health Assembly 39 country statements, plus 5 NGOs Some requests for modification WHO FAO OIE tripartite meeting 10 Feb 2015 Meeting with Geneva Permanent Missions 20 Feb 2015 WHO Advisory Group meeting 24-25 Feb 2015 Re-submitted to World Health Assembly March 2015 EB web site at http://apps.who.int/gb/e/e_eb136.html It is listed as document EB136/20. Available in 6 languages. Supplementary material is available on our AMR webpages at http://www.who.int/drugresistance/global_action_plan/en/

Global action plan on antimicrobial resistance SCOPE

Scope Differences, but also many commonalities Common biological paths Common drivers Common actors

Scope The global action plan covers antibiotic resistance in more detail than other antimicrobials. Establishes links to existing action plans where appropriate, for viral, parasitic and bacterial diseases, including HIV/AIDS, malaria and tuberculosis.

Global action plan on antimicrobial resistance PRINCIPLES

Principles Whole-of-society engagement, including a one-health approach: the issue affects all, so can only be tackled with participation of the entire society Prevention first > good sanitation, hygiene and IPC Access > preserve ability to prevent and treat infections Sustainability > all countries to have a national plan with defined budget within 2 years of the endorsement Incremental targets for implementation > different stages for different countries

World Health Day April 7, 2011 WHA 67. 25 2014 Antimicrobial resistance

Global action plan on antimicrobial resistance STRATEGIC OBJECTIVES & FRAMEWORK FOR ACTION

Global Action Plan Strategic Objectives 1. Improve awareness and understanding of AMR through effective communication, education and training. 2. Strengthen the knowledge and evidence base through research and surveillance. 3. Reduce the incidence of infection through effective hygiene and infection prevention measures. 4. Optimize the use of antimicrobial medicines in human and animal health. 5. Develop the economic case for sustainable investment that takes account of the needs of all countries, as well as the case for investment in new medicines, diagnostic tools, vaccines and other interventions. 6. Commitment to report progress

Framework for action Actions defined for each strategic objective for: Member States WHO Secretariat International and national partners Central aspect: DEVELOPMENT OF NATIONAL PLANS Alignment with global action plan Alignment with standards defined by intergovernmental bodies (e.g., Codex Alimentarius, OIE, FAO)

Sample framework for action from global action plan Strategic objective 1: Improve awareness and understanding Member State WHO Promote awareness raising Develop global communications strategy AMR to be a core component of professional education Develop OIE FAO WHO core communications Establish & support coalitions Maintain AMR as priority among MS Strategic objective 2: Strengthen the knowledge and evidence base Member State WHO Develop national surveillance system Develop global surveillance system Promote surveillance in animal health Work with OIE FAO on integrated surveillance Participate in global & regional surveillance Report on AMR and antimicrobial use regularly

Sample framework for action from global action plan Strategic objective 3: Reduce the incidence of infection Member State Strengthen animal health and agricultural practices through OIE codes and FAO/WHO Codex Alimentarius WHO Work with FAO and OIE, within the tripartite collaboration, to develop recommendations for the use of vaccines in food-producing animals Strategic objective 4: Optimize the use of antimicrobials Member State Develop policies on use of antimicrobial agents in terrestrial and aquatic animals and agriculture Regulate licensing, distribution, use and quality assurance of antimicrobial medicines in human and animal health WHO Strengthen and align, within the tripartite collaboration with FAO and OIE, the concepts of critically important antibiotics for human and animal health Develop standards and guidance for the presence of antimicrobial agents and their residues in the environment, especially in water, wastewater and food

Sample framework for action from global action plan Strategic objective 5: Develop the economic case for sustainable investment Member State WHO Work with the World Bank and with FAO and OIE, within the tripartite collaboration, to assess the economic impact of antimicrobial resistance and of implementation of the action plan in animal health and agriculture.

Example of activities under the Global action plan on antimicrobial resistance NATIONAL PLANS

AMR National plans National action plans: 34 out of 133 countries that responded to the survey.

Development of National Action Plans Governance Assessment & Analysis Planning National Action Plan Identify/Designate National Focal Point Establish National Steering Committee Collect/Compile Available Data on Burden due to AMR Generate Data on Practices, Behaviour Detailed Info on Policies, Rules, Regulations and Structures Set Targets Identify Activities Assign Responsible Persons/Institutions Identify Costs and Resources Required Identify Technical Assistance Needs

Development of National Action Plans National plans will provide the basis for the assessment of resources needs. WHO Secretariat will facilitate through: supporting countries to develop, implement and monitor national plans; leading and coordinating support to countries for assessment and implementation of investment needs monitoring development and implementation of action plans by Member States and other partners publishing biennial progress reports

Example of activities under the Global action plan on antimicrobial resistance DEVELOPMENT OF A GLOBAL SURVEILLANCE SYSTEM

Development of a global surveillance system for common bacteria Targets To assess impact and trends of antimicrobial resistance Episode of infection, instead of (only) laboratory isolates What has been done? Surveillance standards defined Surveillance manual being developed (WHO) Country enrolment in global surveillance to start in 2015

What has WHO been doing in the Asia-Pacific Region?

South-East Asia Region: Commitment Goal: To minimise the morbidity and mortality due to antimicrobial resistant infection and to preserve the effectiveness of antimicrobial agents in the treatment and prevention of microbial infections. (simplified version of global strategy)

AMR- Flagship Priority Area To work closely with Member States in development of their respective National Action Plans in alignment with, and as articulated in the Global Action Plan Following a systematic approach, based on deliverables and result-based management, to accelerate the progress being already made by our Member States

Action Agenda for Antimicrobial Resistance in the Western Pacific Region Three Priority Actions: 1) Develop/ implement comprehensive national plans to contain antimicrobial resistance and raise awareness. 2) Improve surveillance of antimicrobial resistance and monitoring of antimicrobial use. 3) Strengthen health system's capacity to contain antimicrobial resistance.

Regional Action Agenda - Ongoing Work Development of National Action Plans on AMR with multisectoral collaboration Australia : First National Antimicrobial Resistance Strategy for 2015 2019 launched in June 2015 Cambodia National AMR Plan launched 2015 national multisectoral committee set up Viet Nam 2013 + multisectoral Aide Memoire - June 2015 Philippines Presidential order on national AMR Plan and establishment of inter-agency committee 2014 Lao Peoples Democratic Republic (development of a road map for national map ongoing ) Republic of Korea Draft Action Plan on AMR by KCDC waiting for approval

Key health system strategies to contain and prevent AMR Educational strategies Public awareness campaigns has been shown to reduce antibiotic consumption Regulatory strategies Regulatory restrictions on use of antibiotics in human and animals have been demonstrated to achieve reduction of resistance Managerial strategies Antimicrobial stewardship program shown to be effective changing decision-making and prescribing practices Economic strategies Financial incentives to institutions, providers and patients in combination with actions on pricing structure, the price setting and the reimbursement mechanism reduced unnecessary consumption

Take home message.. Antimicrobial resistance is a complex problem at the human-animal interface that requires a multi-sectoral, "One Health" approach Global Action Plan on AMR galvanizes partners around common goals WHO, FAO, OIE and other high level fora (G7, GHSA) have prioritized addressing antimicrobial resistance For the first time, the governing bodies of FAO, WHO and OIE have adopted resolutions on AMR in the same year, and all three resolutions have stressed the importance of the "One Health "collaboration to combat AMR The momentum is high.so are expectations!

World Antibiotic Awareness Week Antibiotics: handle with care 16-22 November 2015