Capnocytophaga canimorsus infection caused by dog/cat-bites/scratches Michio SUZUKI C. canimorsus Capnocytophaga canimorsus 200 C. canimorsus 30 C. canimorsus Capnocytophaga canimorsus 30 200 2 90 470 80 6,000 6,300 2 5 957 3 2 Pasteurella P. multocida 2, 3 Staphylococcus 062-8640 -23- Laboratory of Reservoir Control of Zoonoses, Department of Veterinary Science, National Institute of Infectious Diseases (-23- Toyama, Shinjuku-ku, Tokyo)
Streptococcus Fusobacterium 4 Bartonella 5 C. canimorsus Capnocytophaga canimorsus C. canimorsus C. canimorsus 976 6 976 30 200 7, 8 2, 9 2 0, 9 3 Capnocytophaga Capnocytophaga Capnocytophaga 979 4 7 C. ochracea 5 5 Capnocytophaga 6, 7 C. canimorsus C. cynodegmi 2 DF-2Dysgonic Fermenter-2 DF-2-like 989 8 canimorsus cynodegmi 9 2 2 C. canimorsus C. cynodegmi C. canimorsus Capnocytophaga 2 Capnocytophaga 5 2 8 C. canimorsus C. cynodegmi Capnocytophaga C. ochracea C. gingivalis C. sputigena C. haemolytica C. granulosa C. canimorsus C. cynodegmi DIC
C. canimorsus C. canimorsus 35 37 5CO2 HK 5 C. canimorsus C. cynodegmi PCR 20, 26 300 400 22 C. canimorsus C. cynodegmi 2004 2007 C. canimorsus 74 57 C. cynodegmi 86 842 92 86 20 C. canimorsus C. canimorsus 200 7, 8 C. canimorsus immunocompromised host 7, 0, 7, 9, 23. Capnocytophaga C. canimorsus C. cynodegmi C. ca andor C. cy C. canimorsus C. cynodegmi C. ca andor C. cy 74 86 92 2. Capnocytophaga 57 84 86 C. ca : C. canimorsus, C. cy : C. cynodegmi
0 99 40 7, 9 90 7, 9 7, 2 DIC 30 7, 0 2 3 5 24 C. canimorsus 25 C. canimorsus 2002 95 26 5 4 3, 23, 26 34 44 95 4 65 27 C. canimorsus. n98 2. n70 3. n99 4. n8 57 6 8 7 29 7 7 6 5 4 2 65 34 68 4 4 2 9 3, 23, 26 34 2 7 ICU ICU 28, C. canimorsus 35 58 6 8 7 4 0 0 9 7 6 7 66 34 84 5 5 2
C. canimorsus No. 90 26 60 29 40 30 70 60 DIC 32 3 70 50 60 50 40 70 70 70 DIC DIC DIC DIC 34 28 27 23 50 DIC 3 35 immunocompromised host C. canimorsus C. canimorsus 4 8 20 C. canimorsus 36 C. canimorsus 23, 27, 28 PCR 20, 23 PCR 20, 26 6S rrna 23 C. canimorsus C. canimorsus C. canimorsus
C. canimorsus ST B SXT DDDDDDDDDDDDDDDDDDDDDDDDDDDDD C. canimorsus Tel : 03-5285- 2622, Fax : 03-5285-79 E-mail : michios@nih.go.jp DDDDDDDDDDDDDDDDDDDDDDDDDDDDD Centers for Disease Control and PreventionCDC: Nonfatal dog bite-related injuries treated in hospital emergency departments--united States, 200. MMWR Morb. Mortal. Wkly. Rep. 26: 605-60. 2003. 2,., : 65-70, 2009. 3 Holst E., Rollof J., Larsson L., et al.: Characterization and distribution of Pasteurella species recovered from infected humans. J. Clin. Microbiol. : 2984-2987. 992. 4 Talan D.A., Citron D.M., Abrahamian F.M., et al.: Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group. N. Engl. J. Med. 2: 85-92. 999. 5. 9: 203-2, 2004. 6 Bobo R.A. and Newton E.J.: A previously undescribed Gram-negative bacillus causing septicemia and meningitis. Am. J. Clin. Pathol. : 564-569, 976. 7 Gaastra W. and Lipman. L.J.A.: Capnocytophaga canimorsus. Vet. Microbiol. : 9-346, 200. 8 Macrea M.M., McNamee M., Martin T.J.: Acute onset of fever, chills, and lethargy in a 36-year-old woman. Chest : 505-507, 2008. 9 Janda J.M., Graves M.H., Lindquist D., et al.: Diagnosing Capnocytophaga canimorsus infections. Emerg. Infect. Dis. : 340-342, 2006. 0Lion C., Escande F., Burdin J.C.: Capnocytophaga canimorsus infections in human: review of the literature and cases report. Eur. J. Epidemiol. 5: 52-5, 996. Pers C., Gahrn-Hansen B., Frederiksen W.: Capnocytophaga canimorsus septicemia in Denmark, 982-995 : review of 39 cases. Clin. Infect. Dis. : 7-75, 996. 2Valtonen M., Lauhio A., Carlson P., et al.: Capnocytophaga canimorsus septicemia: fifth report of a cat-associated infection and five other cases. Eur. J. Clin. Microbiol. Infect Dis. 6: 520-523, 995. 3 Capnocytophaga canimorsus. : 554, 2007. 4Leadbetter E.R., Holt S.C.,Socransky S.S.: Capnocytophaga : new genus of gram-negative gliding bacteria. I. General characteristics, taxonomic considerations and significance. Arch. Microbiol. : 9-6, 979. 5.. p48, 2007. 6Buu-Hoi A.Y., Joundy S., Acar J.F.: Endocarditis caused by Capnocytophaga ochracea. J. Clin. Microbiol. 5: 06-062, 988. 7Desai S.S., Harrison R.A., Murphy M.D.: Capnocytophaga ochracea causing severe sepsis and purpura fulminans in an immunocompetent patient. J. Infect. 2: e07-09, 2007.
8Brenner D.J., Hollis D.G., Fannning, G.R., et al.: Capnocytophaga canimorsus sp. nov.formerly CDC Group DF- 2, a cause of localized wound infection following dog bite. J. Clin. Microbiol. : 23-235, 989. 9Blanche P., Bloch E., Sicard D.: Capnocytophaga canimorsus in the oral flora of dogs and cats. J. Infect. : 34, 998. 20Suzuki M., Kimura M., Imaoka K., et al : Prevalence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs and cats determined by using a newly established species-specific PCR. Vet. Microbiol. doi0.06 j.vetmic.200.0.00, 200. 2Westwell A.J., Kerr K., Spencer M.B., et al.: DF-2 infection. BMJ, 6666: 6-7, 989. 22 http:www.petfood.or.jpdatachart2008 23,, Capnocytophaga canimorsus. 4: 48, 2009. 24Moal G.L., Landron C., Grollier G., et al.: Meningitis due to Capnocytophaga canimorsus after receipt of a dog bite : case report and review of the literature. Clin. Infect. Dis. 3: e42-46, 2003. 25de Smet M.D., Chan C.C., Nussenblatt R.B., et al.: Capnocytophaga canimorsus as the cause of a chronic corneal infection. Am. J. Ophthalmol. 2: 240-242, 990. 26 Capnocytophaga canimorsus. : 9-4, 2005. 27. 2: 67, 2009. 28,, Capnocytophaga canimorsus., : 66-664, 2009 29 Capnocytophaga canimorsus. : S263, 2005. 30 Canocytophaga canimorsus HPVB9 HPS. 8: 90, 2005. 3 Capnocytophaga canimorsus. : 290, 2009. 32 Capnocytophaga canimorsus. : 226-23, 2009. Capnocytophaga canimorsus 4. 4: 48, 2008. 34 Capnocytophaga canimorsus. : S47, 2008. 35Morgan M. and Palmer J.: Dog bites. BMJ. 7590: 43-47. 2007. 36 Capnocytophaga canimorsus. JVM3: 27-28. 200.