Apivar. Effective tool specially designed for Varroa Mite management in honeybee colonies

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2 Apivar Effective tool specially designed for Varroa Mite management in honeybee colonies Controlled-release strips formulated with 3.3% Amitraz (0.5g active per 15g strip)

3 Apivar : a new toolto relyon Continuously released amitraz in the colony over a six-week treatment, ensuring healthy and productive colonies Kills up to 99% of mites in one application Proven safe and effective for more than 15 years Leaves no significant residues in hive products Convenient and easy to use

4 Amitraz : Miticidewell-known for its effectiveness AMITRAZ Contact DEATH DUE TO STARVATION DROP FROM BEE BACK MOVEMENT DIFFICULTIES PARALYSIS No immediate knock-down. Gradual reduction of mites over extended period

5 Continuously-released in the colony over a six-week period Contact action only = no vaporization into the atmosphere of the hives. High importance of positioning into the colony for a high level of efficacy

6 Apivar interrupts the mite reproduction cycle Apivar kills the phoreticmites, as well as successive generations, leaving the bees mite-free. A fertilized female Varroa mite enters the cell. The young bee leaves the cell carrying two fertilized female mites. The cell is sealed and the fertilized Varroa mite enclosed feeds on haemolymph from the bee larva. The female mite continues to lay eggs. When the female offspring reach sexual maturity, they are fertilized by the one male mite in the cell. The female mite lays an egg every 30 hours. The first offspring is a male; the subsequent offspring are all female.

7 Advantage of long release technology Theoretical modeling of the effects of 2 types of treatments Repeated short-acting treatment or single-shot controlled-released treatment

8 Kills up to 99% of mites in one application

9 Effective to control Varroa mite infestation High level of effectiveness of amitraz + High quality standard of amitraz + Long release technology More than 15 years of effectiveness of Apivar Many effectiveness studies performed in numerous countries under different environmental conditions (France, New-Zealand, Canada, USA, Japan, Turkey )

10 Field effectiveness study USA Compared to control colonies, Apivar reduced mite loads significantly (P < 0,0001) Jeff Pettis, Denis vanengelsdorp 2009

11 Field effectiveness trial USA Spring2012 Controlling Varroa destructor with APIVAR Eischen et al, Honey bee research Unit, USDA-ARS, Weslaco, TX APIVAR = 52-fold drop in mite population against untreated control Threshold for efficacy = 10-fold difference between the negative control mite level and experimental treatment

12 Effectiveness study Canada Fall2008 EFFICACY OF APIVAR ON THE VARROA MITE, VARROA DESTRUCTOR, IN ALBERTA,CANADA Fall2008, Nasret al Source : Nasr et al, Efficacy of Apivar on the Varroa Mite, Varroa destructor in Alberta, Canada Canadian Pest Surveillance Branch, Research and Innovation Division, Agriculture and Rural Development.

13 2012 US Field trial Apivar effectiveness (20 hives treated with Apivar in 3 apiaries, Autumn 2012) Varroa infestation rate after 6 weeks of Apivar treatment (# Varroa / 300 bees) 22,15 4,60 Before treatment Mean After treatment

14 2012 US Field trial Apivar effectiveness in Florida 3 apiaries-spring Mite population before and after Apivar treatment in comparison with untreated control 7 6 # Mites per 100 bees ,99 0,62 4,64 4,12 - Apivar (n=30) Control (n=30) Before treatment After treatment Source: Gary D Van Cleef, Apiary Inspection Supervisor Region I, Division of Plant Industry, Florida Department of Agriculture and Consumer Services.

15 Proven safe for more than 15 years Perfectly safe for bees and beekeepers No significant residues in hive products

16 Safefor beesand queens Harmlessto beesand queensatup to 5 times recommendeddose The product had no effect on bee mortality, size of the brood-comb, hive activity, hive weight or the size of the honey harvest when used at twice the indicated dose. 10 strips per [Dadant] hive would not cause side effects Apivar product therefore has a considerable safety margin particularly if we consider its very low risk in the case of overdose Source: m_residue_limits_-_report/2009/11/wc pdf Source: T.M. Trower et al, amitraz residues in honeyand beewax, 2002

17 High level of safety in comparison with illegal treatment No direct contact with the active No vaporization in the hive atmosphere Wearing of chemical-resistant gloves is recommended Controlled-released disposal Residues in hive products, and particularly in honey, are insignificant regardless of when the product is used 1. Refer to instruction for use on the label as US Sect 18 authorization adds restrictions for the timing of use. No excipients introduced that may interact or potentialize other stressors 1: Martel et al, Acaricideresidues in honey and wax after treatment of honey bee colonies with Apivar or Asuntol 50, Apidologie 38 (2007)

18 Lowlevelof residues CHEMO-CHEMICAL PROPERTIES of AMITRAZ Highly unstable in acidic environments and highly sensitivity to hydrolysis CONSEQUENCES Quick degradation in honey = No accumulation in honey Ex: No residuesof amitrazin honey-10 weeksof treatmentwithapivar RESIDUES Very low level residues of active substance and components Not expected to exceed 0.2ppm in honey and 9ppm in honeycomb beeswax Sources: 1/ Acaricide residues in honey and wax after treatment of honey bee colonies with Apivar and Asuntol 50 Martel et al, /EMA, committee for veterinary medicinal products amitraz (bees) summary report

19 New-Zealandresiduesstudy Distribution of amitraz and its components in honey (2 Apivar stripsper broodchamber 6 weekstreatment. n= 12 Honeysupers addedatthe removalof the strips) 100% % of hives where residues are detectable 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Maximum residues allowed in EU in honey Equivalent to the tolerance threshold for Sect 18 0,00 0,01 0,02 0,03 0,04 0,05 0,06 0,07 0,08 0,09 0,10 0,11 0,12 0,13 0,14 0,15 0,16 0,17 0,18 0,19 0,20 Detected Dose (µg/g) No residues (amitraz and components) detected in more than 65% of the hives 100%hives show residues dramatically bellow the authorized threshold.

20 Lowlevelof residues US Section 18 status ADDITIONAL PRECAUTIONS TO SECURE THE QUALITY OF PRODUCTION Maximum of 2 treatments per year (spring and fall treatment) May not be used when honey supers are present Honey super cannot be installed until 14 days after strip removal

21 Instructions for use

22 Easyto use

23 Instructions for use 1-Use 2 Apivar stripsper broodchamber Separate the double rigid strips. 2-Use the strip's die-cut triangle as a hanging hook, or insert a toothpick or hook in the hole provided. 3-Hang each strip between two comb frames inside the brood area or the bee cluster, with a minimum distance of two frames between strips.

24 Instructions for use

25 Instructions for use Insertions of Strips End of treatment Insert honey supers 6 weeks = one full treatment 2 weeks after treatment 2 strips per brood chamber Inside the brood area Treat all colonies at the same time Wear protective gloves Remove after a maximum of 56 days Do not re-use the strips If the bee cluster moves away from the strips, reposition the strips into the bee cluster, and leave them in place for 14 more days before removal.

26 Timing recommendations 2 applications per year are possible (if required) Goal: lowerthe infestation rate to secure honey yield Goal: lowerthe infestation rate to secure wintering

27 Practical information #1 Treatment effectiveness depends of the position of the strips Mode of action: The distribution of amitraz in the colony results from the bees coming into contact with the strips. Recommended positioning: Place the strips in the brood area (2 strips per brood chamber) to ensure the highest frequency of contact of the bees with the strips

28 Practical information #2 Treatment effectiveness can be increased by feeding bees Feeding bees stimulates the colony, which increases the activity of the honey bees. Advice : feeding bees while the Apivar strips are installed will improve the colony s health by: Enhancing contact with Apivar strips, thereby improving distribution of the active ingredient inside the colony Stimulating new brood development with fewer mites.

29 Practical information #3 Treatment effectiveness can be increased by treating all the colonies of the apiary at the same time In the colony: Adult varroa are present on the back of the foragers High frequency of robbing and drifting Many exchanges between honeybees and colonies including parasitic ones! Varroa treatment : If all colonies are not treated at the same time, there is high risk of re-infestation after the removal of the strips in the treated hives.

30 Practical information #4 Treatment effectiveness can be increased by repositioning the strips In the colony Frequent movements of the brood inside the hive --> Strips no longer in the area of high activity --> Less effective distribution of amitraz in the colony Recommendation for Apivar treatment: Check the position of the strips during the treatment or at the end. In case of movement of bees inside the beehive away from the strips, reposition the strips into the bee cluster and leave in place for 14 days.

31 Apivar : a new toolto relyon CONVENIENT ONLY 1 TREATMENT REQUIRED FOR 6 WEEKS OF PROTECTION USABLE INSPRINGAND IN FALL PROVEN EFFECTIVENESS UP TO 99% REDUCTION IN MITES IN BROOD SAFE RESIDUES LEVELS VERY LOW AND CONTROLLED NO ACCUMULATION OF RESIDUES IN BEESWAX SAFE FORYOUR BEES, BROOD, QUEENS...

32 CAUTION Apivar has been approved under Section 18 emergency use exemptions in select states. Apivar does not have Section 18 approval in all states. Prior to using this product, contact your local Department of Agriculture or your Apivar distributor to determine the status of Section 18 authorization in your state.

33 Company presentation

34 Honey bee orientated company History Formed in 2000 after the purchase of Apivar SA shares by Nutritomen. Part of ArystaHealth and Nutrition Science Based in France 100% dedicated to beekeeping industry by the development and marketing of medicines and healthcare products for honeybees and beekeeping industry BEEING A KEE PLAYER FOR THE DEVELOPMENT OF BEEKEEPING INDUSTRY

35 Our vision GIVING WORTH TO HONEYBEES AND BEEKEEPERS Our mission : Using our expertise and dynamism to serve the beekeeping industry worldwide by developing healthcare products for colonies and supporting added-value bee products. To be a key-player of beekeeping industry, we focus our development on the three pillars of health : DIAGNOSIS PREVENTION TREATMENT The involvement of Arysta HNS into pharmaceutical, nutraceutical and cosmeceutical industries gives us the expertise to provide the best solutions for the beekeeping industry.

36 Our DNA HONEYBEE PASSION Our team shares a common motivation: to bring to market innovative solutions to support the beekeeping industry. TEAM ORIENTED The team spirit is not only evident among our staff, but also among beekeepers, whose burdens we try to ease with our products. HIGH QUALITY STANDARDS Quality is central to our accorder products as a result of our role as a veterinary pharmaceutical lab. All products developed by our qualified team are tested in the field to offer efficacy andsafety to colonies and beekeepers.

37 A company of Arysta Health& Nutrition Science Animal Health HONEYBEE HEALTH: Development and production of medicine and healthcare products and add value to bee products. Pharma / cosmetics Sourcing, distribution and formulation of API for cosmeceuticalsand pharmaceuticals companies Plant nutrition PETS AND LIVESTOCK: Development and manufacturing of medicines, dietary supplement and healthcare products on behalf of our customers ACTIVES: Distribution of Actives for animal health companies (vitamins, colistin, ) LONG ACTING FERTILIZER For more information: