Programme MONDAY, MARCH 19
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1 Challenges and new concepts in antibiotics research March 19 21, 2018 Institut Pasteur Conference Center (C. I. S.) Programme MONDAY, MARCH 19 12h00 18h00 Registration 15h00 15h25 15h25 16h00 16h05 16h40 16h45-17h15 17h15 19h15 17h15 17h40 17h45 17h57 18h00 18h25 Welcome addresses and opening Philippe Glaser, Institut Pasteur, Paris France Stewart Cole, General Director, Institut Pasteur, Paris France Philippe Sansonetti, LabEx IBEID, Institut Pasteur, France Introductory lecture Chair: Philippe Glaser Marc Sprenger, Director, Antimicrobial Resistance Secretariat, WHO The AMR Crisis: a WHO perspective Sharon Peacock (London School of Hygiene and Tropical Medicine, UK) Are bacterial pathogens isolated from animals a common cause of drug-resistant infection in humans? Antibiotic resistance a one health context Chair: Kathleen Victoir & Arnaud Fontanet Kamini Walia (Indian Council of Medical Research, India) AMR in India: understanding drivers and opportunities for action Philip Supply (Institut Pasteur de Lille, FR) Deep amplicon sequencing for surveillance and diagnostics of drug resistant tuberculosis directly from primary specimens" Frank Møller Aarestrup (Technical University of Denmark, Lyngby, DK) Global surveillance of antimicrobial resistance
2 18h30 18h42 18h45 19H10 19h15 Niyaz Ahmed (ICDDRB, Dhaka, BG) Comparative genomics and molecular epidemiology of multiple drug resistant bacteria in India and Bangladesh Tim Walsh (Cardiff University, Cardiff, UK) One health approach to AMR in LMICs: reality or fantasy? Welcome Reception at Institut Pasteur TUESDAY, MARCH 20 8h45 10h30 8h45 9h10 9H15 9h27 9h30 9h42 9h45 10h10 10h15 10h27 10h30 11h00 11h00 12h30 11H00 11H25 11h30 11H42 11h45 12h10 12h15 12h27 Resistance and virulence Chair: Lulla Opatowski and Jan Maarten van Dijl Sophie Helaine (Imperial College London, UK) Salmonella persisters during infection Lejla Imamovic (Technical University of Denmark, Lyngby,DK) Phenotypic convergence in response to drug exposure supports collateral sensitivity to counter drug resistance Tim Stinear (University of Melbourne, AU) Increasing tolerance of hospital Enterococcus faecium to handwash alcohols Nassos Typas (EMBL, Heidelberg, DE) Drugs & Bugs: unexplored relationships Meriem El Karoui (University of Edinburgh, UK) DNA repair and antibiotic tolerance in Escherichia coli" Antibiotics, microbes and models Chair: Carmen Buchrieser and Bruno Coignard Sebastian Bonhoeffer (ETH Zürick, CH) An old challenge and some new concepts: a dynamical perspective on antibiotic resistance evolution Alan Mcnally (University of Birmingham, UK) Signatures of selection in colonisation factors and the evolution of a multi-drug resistant lineage of Escherichia coli" Martin Blaser (NYU School of Medicine, New York, US) "The antibiotic paradox" Audrey Duval (Université Versailles Saint-Quentin, FR) Between-human proximity networks support transmission of ESBL-producing Klebsiella pneumoniae but not Escherichia coli
3 12h30 15h00 Lunch Poster Session Cafe and dessert 15h00 16h30 Dissemination of antibiotic resistance Chair: Eliora Ron and Didier Mazel 15h00 15h25 Marie-Cécile Ploy (INSERM, Limoges, FR) "Antibiotic resistance: the necessary balance between expression and acquisition?" 15h30 15h42 Arnaud Gutierrez (U1001, INSERM, Paris, FR) Antibiotic activity, the environment matters. High-throughput killing assay for screening antibiotic lethality" 15h45 16h10 Dan Andersson (Uppsala University, SE) Unstable antibiotic resistance 16h15 16h27 Birge Ozel Duygan (University of Lausanne, CH) Microbial degradation of antibiotics: the necessity for micromolar concentration studies 16h30-17h00 17h00 19h10 Developing new drugs: academic and industrial innovations Chair: Laura Marin and George Griffin 17h00-17h35 Stewart Cole (Institut Pasteur, Paris FR & EPFL, Lausanne, CH) "Towards a new combination therapy for tuberculosis" 17h40 19h10 Round table: Public private partnership for New Antibiotics Manica Balasegaram (GARDP, Geneva, CH) Laurent Fraisse (SANOFI, Lyon, Fr) Marc Lemonnier (Antabio, Toulouse, Fr) Laura Marin (JPI AMR, Stockholm, SW) Sarah Paulin (WHO, Geneva, CH) Kim Lewis (Northeastern University, Boston, US) 20h00 Conference Diner at Maison des Polytechniciens WEDNESDAY MARCH 21 8h45 10h30 8h45 9h10 9h15 9h27 Mechanisms of resistance Chair: Anne-Brit KOLSTØ and Frédéric Barras Jean-Marc Ghigo (Institut Pasteur, Paris, FR) Biofilm tolerance to antibiotics Magdalena Bielecka (University of Southampton, UK)
4 Developing a novel 3-dimensional cell culture platform for studying antimicrobial resistance 9h30 9h42 9h45 10h10 10h15 10h27 10h30-11h00 11h00 12h50 11h00 11h25 11h30 11h55 12h30 12h50 12h50 15h05 Frederic Béquet (Bioaster, Paris, FR) Met-SAMoA : an automated metabolic screening platform for the prediction of new antimicrobials mechanism of action. Nathalie Balaban (The Hebrew University; Jerusalem, IL) "Evolution under intermittent antibiotic exposure: interplay between tolerance and resistance" Kristin Baker (RUSVM, St. Kitts and UCPH, DK) Peptidomimetics induce azithromycin and rifampicin susceptibility against multidrug resistant Gram-negative pathogens" Molecular machines and new targets Chair: Nathalie Balaban and Ivo Boneca Nora Vazquez-Laslop (University of Illinois, Chicago, US) "Context specific mode of action of ribosomal antibiotics" Michel Arthur (INSERM, Paris, FR) Non-conventional strategies to fight ß-lactam-resistant bacteria Breakthrough session - Poster talks (5 ) Maya Nadimpalli (Institut Pasteur, Paris, FR) Damien Thiry (Liège University, BE) Ana Elena Perez Cobas (Institut Pasteur, Paris, FR) Romain Guerillot (University of Melbourne, AU) Agnes Jousset (Université Paris-Sud, Bicêtre, FR) Richard Allen (ETH Zürich) Petra Eva Szili (Hungarian Academy of Sciences, HU) André Mateus (EMBL, Heidelberg, DE) Benoit Marteyn (Institut Pasteur, Paris, FR) Lunch at Institut Pasteur Poster session Cafe and dessert 15h05 16h30 15h05 15h40 Finding new antibiotics Chair: Ariel Blocker and Thierry Naas Kim Lewis (Northeastern University, Boston, US) The Antibiotic Discovery Challenge
5 15h45 15h57 16h00 16h25 16h30-17h00 17h00 19h00 17h00 17h25 17h30 17h42 17h45 18h10 18h15 18h40 18h45 18h57 19h00 Brice Felden (U1230 Inserm, Rennes, FR) New antibiotics active on multi-resistant bacteria" Pei Zhou (Duke University, Durham, US) Novel Antibiotics Targeting Lipid A Biosynthesis in Gramnegative Pathogens Conventional and non-conventional strategies to fight resistant bacteria Chair: Hilde de Reuse and Nassos Typas Priscile Brodin (Institut Pasteur, Lille, Fr) Phenotypic screenings for the discovery of first-in-class smallmolecules against tuberculosis Bruno Gonzalez-Zorn (Universidad Complutense de Madrid, SP) Reversion of intrinsic antibiotic resistance through aerial interbacterial communication mediated by H2S David Bikard (Institut Pasteur, Paris, FR) CRISPR tools to study and fight pathogenic bacteria Roy Kishony (TECHNION, Haifa, IL) Predicting antibiotic resistance" Laurent Debarbieux (Institut Pasteur, Paris, FR) Driving the success of phage therapy with insights into host immune responses " Closing remarks Pascale Cossart, LabEx IBEID, Institut Pasteur, France Closing Cocktail
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