AUGMENTIN. Proceedings of the European Symposium Scheveningen, The Netherlands June, Excerpta Medica
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1 AUGMENTIN clavulanate-potentiated amoxycillin c Proceedings of the European Symposium Scheveningen, The Netherlands June, 1982 Editors: E.A.P. Croydon and M.F. Michel UNIVERSITATS- BIBLIOTHEK 1983 Excerpta Medica
2 Introduction E.A.P. Croydon andm.f. Michel Welcoming address E.A.P. Croydon Session I: Microbiology The history and background of Augmentin 5 G.N. Rolinson Augmentin and (3-lactamases: inactivation of (3-lactamase by clavulanic acid 11 R. Labia andj. Peduzzi Antibacterial activity of amoxycillin/clavulanic acid (Augmentin) in vitro 21 A.R. White, RJ. Boon, P.J. Masters andr. Sutherland Antimicrobial activity of Augmentin in vitro 42 L. Verbist In-vitro antibacterial activity of clavulanic acid-potentiated amoxycillin 47 G. Peters and G. Pulverer Efficacy of amoxycillin/clavulanic acid against experimental infections 53 RJ. Boon, A.S. Beale, C. V. Pierce andr. Sutherland Microbiological testing of the action of Augmentin 63 H. W. Van Landuyt and A. Lambert Microcalorimetric and turbidimetric investigations of the actions of amoxycillin, 68 clavulanic acid and Augmentin on amoxycillin-resistant strains of Escherichia coli, Klebsiella and Staphylococcus aureus E. Semenitz and P. A. Casey General discussion 77 Session II: Clinical pharmacology Absorption, pharmacokinetic and metabolic studies with Augmentin 83 D. Jackson, D.L. Cooper, R. Horton, P.F. Langley, D.S. Staniforth andaj. Sutton Comparative pharmacokinetics of amoxycillin, clavulanic acid and their combi- 102 nation G. Hqffken, G. Witkowski, H. Lode and P. Koeppe VIII
3 Pharmacokinetics of the association amoxycillin and clavulanic acid in renal 109 insufficiency and during haemodialysis F. Dalet, E. Cabrera, T. Donate and G. Del Rio General discussion 121 The effect of amoxycillin and amoxycillin plus clavulanic acid on human bowel 125 flora H. W. Mittermayer A prospective study of the evolution of bacterial resistance to Augmentin 134 R. Labia, R. Beguin-Billecoq and P. Baron General discussion 143 Session III: Genito-urinary tract infections A clinical trial of Augmentin in urinary tract infections 147 P. Van Erps, P. Nowe and L.J. Denis Augmentin in the treatment of urinary tract infections due to amoxycillin- 153 resistant bacteria B. Leng Oral Augmentin in the treatment of urinary tract infections 161 G. Umbach, N. Lang andh. Werner Augmentin therapy of urinary tract infections in patients with neurogenic 169 disorders of micturition secondary to spinal injury E. Reiner The protective role of clavulanic acid in urinary tract infections 178 F.W. Goldstein, M.D. KitzisandJ.F. Acar Clinical experience with 3 dosage regimens of oral Augmentin in patients with 183 urinary tract infections /. Derluyn Clinical evaluation of Augmentin treatment of urinary tract infections, with a 192 study of Augmentin's serum bacteriostatic and bactericidal activity F. Crokaert.M.P. Van der Linden and E. Yourassowsky / General discussion 202 Augmentin in the treatment of urinary tract infection in pregnant women and 207 pelvic inflammatory disease H.O. Mayer, H. Jeschek and A. Kowatsch Augmentin in the treatment of gonorrhoea caused by penicillinase-producing 218 gonococci D. Tio, G.A.J. de Koning, M.C. Ansink-Schipper andr.a. Coutinho IX
4 General discussion 222 Session IV: Skin and soft-tissue infections The penetration of Augmentin into ischaemic ulcers of the leg 227 M.D. Kitzis, Y. Juillet, J.N. Feissinger, E. Housset andj.f. Acar Augmentin in the treatment of skin infections 234 J.P. Garrel,J.M. Sonneck.A. ThabautandJ.B. Leaute A trial of orally administered Augmentin in the treatment of post-traumatic bone 241 and joint infections D. Lippert Protection of amoxycillin by clavulanic acid from inactivation by staphylococcal 252 (3-lactamase in vivo, R. Sutherland General discussion 256 Session V: Respiratory tract infections The penetration of Augmentin into the pleural fluid 261 M.D. Kitzis, M.B. Kitzis, C. Yvelin, J.F. Acar andb. Andreassian Experience with Augmentin in the treatment of chronic bronchitis and broncho- 267 pneumonia K. Aigner, H. W. Mittermayer andr. Schindl The use of Augmentin in general practice 278 G. Kynast A comparative study of amoxycillin and Augmentin in the treatment of broncho- 282 pulmonary infections Y. Benard, J. Lemenager and C. Morel A therapeutic study of Augmentin in a chest clinic 291 G. Kapetanakis, F. W. Hulla andd. Keratzopoulos Therapy of bronchopulmonary infections due to (3-lactamase-positive micro- 298 organisms isolated by transtracheal puncture G. Ninane Evaluation of Augmentin in patients with lower respiratory tract infections and 303 severe underlying disease CD. Schwigon andf. W. Hulla General discussion 312 X
5 Session VI: Paediatric infections Pharmacokinetics of Augmentin in children 319 P. Begue, F. Quiniou, N. Nocquet, C. Gaillard and C. Safran A trial of orally administered Augmentin in the treatment of urinary tract 325 infection and lower respiratory tract infection in a children's hospital M. Fink and W. Swoboda Effectiveness of Augmentin in the treatment of urinary tract infections in children 334 C. Kattamis, V. Syriopoulou, M. Papagregoriou-Theodoridou, G. Mostrou- Antonellou and G. Tzanetou Clinical experience with oral Augmentin in the treatment of ear, nose and throat 341 infections in children R. Wielemans andj.p. Gline Experience with Augmentin in the treatment of infections in children 347 H. DebrayandA. Galland The use of Augmentin syrup for the treatment of paediatric infections in general 354 practice. An interim report A.J. Rose General discussion 360 Concluding remarks 363 E.A.P. Croydon Index of authors 366 XI
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