Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Nairobi 2

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1 Bull. Anim. Hlth. Prod. Afr (2012) THE EFFICACY OF ALBENDAZOLE AND MOXIDECTIN IN THE CONTROL OF NEMATODE INFECTION IN DAIRY CATTLE 1 *, Kitala P M 1, Gitau G K 2, Maingi N Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Nairobi 2 Department of Clinical Studies, Faculty of Veterinary Medicine, University of Nairobi 3 Department of Veterinary Pathology, Microbiology and Pathology, Faculty of Veterinary Medicine, University of Nairobi 4 Centre for Veterinary Epidemiologic Research, Department of Health Management, Atlantic Abstract Key Words: District. L EFFICACITE DE L ALBENDAZOLE ET DE LA MOXIDECTINE DANS LE CONTROLE DE L INFECTION AUX NEMATODES CHEZ LES BOVINS LAITIERS Résumé L objectif de cet essai contrôlé randomisé sur site était de déterminer et de comparer les des cultures larvaires ont été réalisées sur des échantillons groupés pour chaque exploitation,

2 394 Kabaka W M, Kitala P M, Gitau G K, Maingi N and VanLeeuwen J A Mots-clés : Introduction Material and Methods The use of anthelmintics in cattle has reduced the impacts of gastrointestinal nematodes Study area use and under-dosing have contributed to the emergence of nematode populations resistant assist veterinarians and farmers in decisions on Dairy farming is an important enterprise in et al. the Great Rift Valley. Dairy farmers in the Studies carried out in Nyahururu District of al., et Study design A total of 419 head of cattle on 128 level using a sampling frame of the dairy farms project comparing smallholder dairy farms et al., 2012a; Dohoo Kenya. larger, and therefore on farms that had large randomly selected, such that no more than 10

3 395 16th June 2010 and 30th August On the nematode eggs at the parasitology laboratory at the Faculty of Veterinary Medicine, University the treatment groups of the animals. Results and mean FECs of the 3 treatment groups the prevalence of GIN infections in the study demonstrating an effective random allocation process. Haemonchus, Trichostrongylus and Oesophagostomum pour-on placebos On the second visit, 2 of the 419 enrolled along the dorsal midline of the animal, and an oral placebo. treated animals had a numerically but not placebo. Discussion sample s group status. Data handling and Statistical Analysis treatment for each of the anthelmintic et al., 100. The formula uses the post-treatment FECs assuming that the pre-treatment FECs are the same due to the random allocation of animals opposed to geometric mean, as the geometric on trematodes.

4 396 Kabaka W M, Kitala P M, Gitau G K, Maingi N and VanLeeuwen J A Table 1. Number of cattle allocated to the anthelmintic treatment, the mean epg count 14 days Treatment Group Number Sampled Mean FEC [95% CI] 1 [95% CI] Placebo [6.5, 20.1] - Moxidectin [0, 3.2] [0, 7.9] Veterinary Congress Foundation. Mr. R. Otieno because it has been in use for a long time as the drug of choice for dairy farmers in Kenya, for their contribution in processing the samples, assisting in sample and data collection. References another study carried out on goats in Kenya by et al. among goats in Kenya than among cattle. counter under many varying brand names by Kenyan smallholder dairy farms. Global Public Health journal. In Press. J A, 2012b. Pilot study on the impacts of biogas Kenyan smallholder dairy farms. Journal of Environtal Public Health. In Press. contributed to resistance over time. Conclusions Moxidectin had a very good GIN should be encouraged to use a variety of anthelmintic drugs, in rotation, including moxidectin, to ensure proper GIN control, in providers. Acknowledgement production in Nova Scotia dairy herds. Preventive Veterinary Medicine Manual. Veterinary naturally acquired nematode infections in cattle in the Mexican tropics. Veterinary Parasitology, 134: Helping Farmers, a Canadian non-governmental and levamisole in nematodes parasites of sheep in Nyandarua Districts of Kenya, Acta Tropica, 69:

5 397 Maingi N, Gichigi M N, Njoroge G K, Gastrointestinal nematode infections in sheep central Kenya. Bulletin of Animal Health and Production in Africa, 49: Michel J F, Strategy for the use of anthelmintics of drug resistance. Parasitology, 90: helminths in small ruminant production in tropical Africa. The Kenyan Veterinarian, gastrointestinal nematode infections in goats. Indian Journal of Animal Sciences District Veterinary Annual Report. Nyeri Ministry of Planning and National Development, Nyeri District Strategic Plan of Argentina. Veterinary Parasitology, 144, for the Advancement of Veterinary Parasitology Veterinary Parasitology The Constitution of Kenya, Republic of Kenya, government printers, Nairobi. First Schedule: Article

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