Efficacy of Moxidectin 6-Month Injectable and Milbemycin Oxime/Lufenuron Tablets Against Naturally Acquired Toxocara canis Infections in Dogs*
|
|
- Emil Palmer
- 5 years ago
- Views:
Transcription
1 Efficacy of Moxidectin 6-Month Injectable and Milbemycin Oxime/Lufenuron Tablets Against Naturally Acquired Toxocara canis Infections in Dogs* Dwight D. Bowman, MS, PhD a Walter Legg, DVM b David G. Stansfield, BVSc, MRCVS b a CHK-R &D Polk Road Stanwood, MI b Novartis Animal Health P.O. Box Greensboro, NC ABSTRACT The efficacy of moxidectin injection (Pro- Heart 6 Sustained Release Injectable for Dogs, Fort Dodge Animal Health) against naturally acquired infections of Toxocara canis was compared with that of milbemycin oxime/ lufenuron tablets (Sentinel Flavor Tabs, Novartis Animal Health). Eighteen dogs with naturally acquired infections of T. canis were ranked by egg counts and randomly assigned to treatment with moxidectin (170 µg/kg), milbemycin (500 µg/kg)/lufenuron (10 mg/kg), or to an untreated control group (six dogs per treatment). Dogs were euthanized 7 days after treatment for recovery, identification, and enumeration of parasites by species. There was no apparent efficacy for moxidectin against T. canis. Conversely, milbemycin oxime/lufenuron was 91.5% effective against naturally occurring infections of this canine parasite. *Funding for this study was provided by Novartis Animal Health, Greensboro, North Carolina INTRODUCTION Milbemycin oxime/lufenuron in a tablet formulation (Sentinel Flavor Tabs, Novartis Animal Health) to be given monthly is approved for prevention of heartworm infections (Dirofilaria immitis), treatment and control of intestinal infections with whipworms (Trichuris vulpis) and ascarids (Toxocara canis and Toxascaris leonina), and control of hookworms (Ancylostoma caninum). Lufenuron, an insect development inhibitor, has activity against flea eggs produced by female fleas feeding on treated dogs. The product is given monthly at a dose calculated to provide 500 µg milbemycin and 10 mg lufenuron/kg body weight. A commercial formulation of moxidectin (Proheart 6 Sustained Release Injectable for Dogs, Fort Dodge Animal Health) is administered to dogs for the prevention of canine heartworm infections and for the treatment of existing larval and adult canine hookworm infections (A. caninum and Uncinaria steno- 281
2 Veterinary Therapeutics Vol. 3, No. 3, Fall 2002 cephla). The product is given by subcutaneous injection every 6 months at a dose calculated to deliver 170 µg moxidectin/kg. Although this injectable canine formulation does not have a claim of efficacy against canine ascarids (T. canis and T. leonina), an injectable formulation of moxidectin designed for use in cattle (Cydectin Injectable, Fort Dodge Animal Health) has been shown to be efficacious against T. canis when injected subcutaneously to dogs at 200 µg moxidectin/kg body weight. 1 Additionally, an oral paste formulation of moxidectin (Quest, Fort Dodge Animal Health) is effective against several species of equine parasites, including the large ascarid, Parascaris equorum. 2 The present study examined the efficacy of moxidectin given by subcutaneous injection at the dosage rate recommended for heartworm and hookworm control in dogs against naturally acquired adult T. canis infections. Efficacy of moxidectin was compared with that for a group that received no treatment and a group treated with milbemycin/lufenuron. MATERIALS AND METHODS Animals Eighteen random-source adult dogs (15 males and three females) of various breeds, harboring patent, natural parasite infections (as determined by fecal flotation), were acquired from sources that typically supply animals to the research facility. Except for natural parasite infections, all dogs were determined to be healthy by physical examination before dosing and were negative for heartworm microfilariae. Because a sufficient number of naturally infected dogs could not be identified at one time, the study was performed in two replicate groups of nine dogs, with three dogs per treatment in each replicate. In both replicates, dogs were individually housed in cages or runs from the time of treatment until necropsy. Housing, handling, and routine care conformed to standards established at the facility. Each animal was identified by a collar with an attached medallion bearing a unique identification number, and each cage was marked with the corresponding animal identification number. Except for the day of dosing, dogs were provided nutritious, palatable food ad libitum throughout the day, and food was removed in the evening for fasting overnight. Water was available ad libitum. Allocation and Treatments Fecal samples were collected for fecal egg counts on two occasions during the 7-day acclimation period (treatment day = Day 0). A mean fecal egg (T. canis) count was calculated for each dog from these two samplings and dogs within each replicate were ranked by these egg counts and randomly allocated to three groups of three dogs each. Treatments (moxidectin injectable, milbemycin oxime/ lufenuron, untreated control) were randomly allocated to each group thus formed. Moxidectin was provided as the commercially available injectable formulation designed for heartworm prevention in dogs. The product was given according to label recommendations at a dose that provided a minimum of 170 µg moxidectin/kg (Table 1). Milbemycin oxime/ lufenuron combination also was obtained from commercial sources and administered orally at a dose calculated to deliver 500 µg milbemycin oxime and 10 mg lufenuron/kg body weight. The control groups did not receive any treatment for parasites. Dogs of each replicate were individually weighed on their respective Day 1. On the morning of Day 0, a staff member experienced in injection techniques administered moxidectin according to label instructions to dogs assigned to that treatment. Dogs assigned to treatment with milbemycin oxime/lufenuron were fasted 282
3 TABLE 1. Dog Identification, Treatments, and Adult Toxocara canis Recovered at Necropsy Mean Pretreatment Treatment T. canis T. canis Group Egg Counts* Dog ID Sex Weight (kg) Dose Recovered Control Male 28.4 Untreated 10 Replicate Male 18.8 Untreated Male 31.0 Untreated Female 14.2 Untreated 6 Replicate Female 13.7 Untreated Male 26.7 Untreated 15 Geometric Grand Mean 7.1 Moxidectin Injection Male mg 49 Replicate Male mg Male mg Female mg 88 Replicate Male mg Male mg 7 Geometric Grand Mean (% Efficacy) 13.1 (0%) Milbemycin Oxime/Lufenuron Tablets Male lb tablet 2 Replicate Male lb tablet E2355 Male lb tablet E2490 Male lb tablet 0 Replicate Male lb tablet Male lb tablet 0 Geometric Grand Mean (% Efficacy) 0.6 (91.5%) *Eggs per gram of feces. overnight before dosing. On the morning of Day 0, whole milbemycin/lufenuron tablets hidden in food balls were administered orally by staff members experienced in oral dosing techniques. After dosing, dogs in this group were offered half of their usual morning ration. All dogs were observed approximately every hour for 3 hours after dosing with milbemycin/lufenuron for evidence of vomiting. Necropsy and Parasite Counts Seven days after treatment, all dogs in a replicate were euthanized and the intestinal tract was opened and thoroughly searched for 283
4 Veterinary Therapeutics Vol. 3, No. 3, Fall 2002 remaining T. canis using standard parasite recovery techniques. Contents from the lumen of the intestinal tract were washed through a 40-mesh sieve, and all worms encountered were recovered, enumerated, and identified according to stage and species. Other parasite species were present in some dogs; however, counts are presented only for T. canis. Analysis Efficacy of the two treatments was based on the percent reduction for T. canis as compared with the worm count for the control group. Parasite counts were transformed to the natural logarithm of (count + 1) for analysis and for calculation of geometric means. Efficacy of each treatment was calculated as follows: Percent efficacy = ([X c X t ]]/X c ) 100 where X c = geometric mean number of T. canis recovered in the control group and X t = geometric mean number of T. canis recovered in the treatment group. RESULTS All dogs remained healthy and completed the study. No vomiting occurred in any dog after oral administration of milbemycin oxime/ lufenuron tablets. A mean of 5.8 T. canis was recovered from the control group in Replicate 1 and a mean of 8.6 T. canis was recovered from controls in Replicate 2. The grand mean number of T. canis recovered from the control group was 7.1 (Table 1). All dogs treated with moxidectin injection had T. canis present at necropsy. A mean of 16.7 was recovered from dogs in Replicate 1 and a mean of 10.3 was recovered from dogs in Replicate 2. The geometric grand mean T. canis recovered from dogs treated with moxidectin was 13.1 (0% efficacy). Only three of the six dogs treated with milbemycin oxime/lufenuron had live T. canis present at necropsy. A mean of 0.8 worms was recovered from dogs in Replicate 1 and a mean of 0.4 worms was recovered from this group in Replicate 2. The geometric grand mean T. canis remaining at necropsy after treatment with milbemycin oxime/lufenuron was 0.6 (91.5% efficacy). DISCUSSION Moxidectin in the formulation and dosage used for prevention of heartworm and hookworm infection in dogs was ineffective against T. canis infections within 7 days after treatment in this study. In contrast, milbemycin oxime/lufenuron was highly effective, removing more than 90% of the worms present. The lack of efficacy for moxidectin against this parasite species is possibly related to the administration of the drug by the subcutaneous route. The subcutaneous route of administration might possibly minimize the direct effect of the compound on the unattached worms within the intestine. Early work with milbemycin oxime against T. canis has shown that the majority of worms are shed within the first 2 days after treatment and that all affected worms are passed within 5 days after treatment. 3 However, no information was found on the rate of worm kill with the administration of moxidectin. Thus, it is conceivable that the pharmacokinetics of the injectable moxidectin formulation could provide for achievement of peak levels in the intestines several days after treatment. If this does occur, a higher rate of efficacy might have been observed by performing necropsies on dogs treated with injectable moxidectin 3 to 7 days later than they were done in this study. Currently, milbemycin oxime is available in two formulations for prevention of canine heartworm disease (Interceptor and Sentinel Flavor Tabs ). In addition to heartworm prevention, both milbemycin formulations are effective 284
5 against canine ascarids and whipworms and provide control of canine hookworms. The latter of the two formulations also contains lufenuron, which provides control of flea populations by inhibition of egg development. CONCLUSION Moxidectin, given by injection at the dosage recommended for control of canine heartworms and hookworms, had virtually no effect on the number of adult T. canis in this study. In contrast, milbemycin oxime/lufenuron, given orally at the dosage rate recommended for control of heartworm and certain intestinal parasites of dogs, demonstrated excellent efficacy against the canine ascarid, T. canis. Additionally, this combination provides excellent efficacy against T. vulpis and A. caninum infections in dogs. REFERENCES 1. Martinez-Labat P, Garrido-Alcala Y, Vizzuett-Resendiz B: Prueba critica a la moxidectina como antinematodico alternativo en caninos. Vet Argentina 13: , Costa AJ, Barbosa OF, Moraes FR, et al: Comparative efficacy evaluation of moxidectin gel and ivermectin paste against internal parasites of equines in Brazil. Vet Parasitol 80:29 36, Bowman DD, Parsons JC, Grieve RB, et al: Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection. Am J Vet Res 49: ,
Dwight D. Bowman, MS, PhD a Tracey Rock, DVM b Kathleen Heaney, DVM b Norwood R. Neumann, DVM, PhD a Michael Ulrich, BS a Deborah Amodie, BS b
Veterinary Therapeutics Vol. 4, No. 3, Fall 2003 Persistent Efficacy of Moxidectin Canine Sustained- Release Injectable Against Experimental Infections of Ancylostoma caninum and Uncinaria stenocephala
More informationPARASITE TREATMENTS PROVEN PROTECTION FOR DOGS AND CATS
PARASITE TREATMENTS PROVEN PROTECTION FOR DOGS AND CATS THIS IS WHY For pets and the families who love them Now, more than ever, pets are considered part of the family. But when parasites are involved,
More informationRx, For use by or on the order of a licensed veterinarian.
A. General Information NADA Number: 140-915 Sponsor: Generic Name of Drug: Trade Name: Marketing Status: Novartis Animal Health Post Office Box 18300 Greensboro, NC 27419 Milbemycin Oxime INTERCEPTOR Flavor
More informationSHE SINGS ALONG TO EVERY SONG...
Prevention. Protection. SHE SINGS ALONG TO EVERY SONG... Protect your best friend with the 5-IN-1 HEARTWORM MEDICINE THAT USES LUFENURON TO STOP FLEAS BEFORE THEY START. Prevention. Protection. POWERED
More informationTHE VETERINARIAN'S CHOICE. Compendium clinical Trials. Introducing new MILPRO. from Virbac. Go pro. Go MILPRO..
THE VETERINARIAN'S CHOICE. Introducing new MILPRO from Virbac. Compendium clinical Trials Go pro. Go MILPRO.. milbemycin/praziquantel Content INTRODUCTION 05 I. EFFICACY STUDIES IN CATS 06 I.I. Efficacy
More informationNEW. paralysis ticks fleas heartworm intestinal worms
NEW paralysis ticks fleas heartworm intestinal worms Dog owners are confused With so many different products to choose from, many owners are unsure what parasites their dogs are currently protected against.
More information*Adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina), and adult whipworm (Trichuris vulpis)
Main Message Trifexis (spinosad+milbemycin oxime) provides 3-in-1 parasite protection against heartworm, fleas and intestinal parasites. * *adult hookworm, roundworm and whipworm infections Description
More informationEFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR CANINES
VICH GL19 (ANTHELMINTICS: CANINE) June 2001 For implementation at Step 7 - Draft 1 EFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR CANINES Recommended for Implementation on June 2001 by the VICH
More informationCAZITEL FLAVORED ALLWORMER FOR DOGS
CAZITEL FLAVORED ALLWORMER FOR DOGS For use in dogs only. Do not use on cats or rabbits. For use on puppies and dogs from 2 weeks of age. INDICATION Multi spectrum intestinal wormers for puppies and adult
More informationVICH Topic GL19 EFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR CANINES
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology CVMP/VICH/835/99-FINAL London, 30 July 2001 VICH Topic GL19 Step 7 EFFICACY OF ANTHELMINTICS:
More informationVICH Topic GL20 EFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR FELINE
The European Agency for the Evaluation of Medicinal Products Veterinary Medicines and Information Technology CVMP/VICH/545/00-FINAL London, 30 July 2001 VICH Topic GL20 Step 7 EFFICACY OF ANTHELMINTICS:
More informationDear Doctor: Our sincerest thanks, Stephen A. Connell, DVM Director, Technical, Academic and Consumer Services Elanco Companion Animal Health
Dear Doctor: As a trained professional, you understand the loss of a pet is incredibly difficult. Every pet owner responds differently as they grieve. We believe the recent negative media coverage of Trifexis
More informationPush flea protection forward
Push flea protection forward Advantage Multi (imidacloprid + moxidectin) pushes protection forward The imidacloprid in prescription-only Advantage Multi starts working through contact fleas don t have
More informationyour dog Protect UP TO $50 AND SAVE COME SEE US TO [City, ST ZIP] [Street Address] [First Name Last Name] [Phone Number] [City, ST ZIP]
[City, ST ZIP] COME SEE US TO Protect your dog [First Name Last Name] [City, ST ZIP] AND SAVE UP TO $50 [Customer Name], [Dog Name deserves/your dogs deserve] powerful parasite protection. We recommend
More informationHEARTWORM DISEASE AND THE DAMAGE DONE
HEARTWORM DISEASE AND THE DAMAGE DONE Stephen Jones, DVM There are now more months of the year where environmental conditions favor mosquito survival and reproduction. Warmer temperatures Indoor environments
More informationIn a tasty bone shape.
Drontal Plus Taste Tabs the worms enemy, the dog s friend Easy to administer Can help increase owner compliance Effective against the most common types of intestinal worms found in dogs The most comprehensive
More informationTRUST. Easy to give. Protection to live.
TRUST in Easy to give. Protection to live. HEARTGARD (ivermectin) BEGAN AS AN IDEA an idea that if we could make preventing heartworm disease easier, more convenient* and lower risk**, then more dogs would
More informationGuard against intestinal worms with Palatable All-wormer
Guard against intestinal worms with Palatable All-wormer WHIPWORMS HOOKWORMS TAPEWORMS ROUNDWORMS Palatable All-wormer, for superior, flexible protection of dogs and cats. GENTLE ON PETS, TOUGH ON WORMS.
More informationLabel (2 tab) - front panel Issue Date: Page: 1 of 14 The information above this line is not included in the label FOR ANIMAL TREATMENT ONLY
Label (2 tab) - front panel Issue Date: 30-8-00 Page: 1 of 14 FOR ANIMAL TREATMENT ONLY Bay-o-Pet DRONTAL Allwormer FOR LARGE DOGS Infopest Verified Controls all 11 gastrointestinal worms Active Constituents:
More informationIn 2013 The FDA Approved The Use Of Advantage Multi For The Prevention Of Heartworms And Fleas On Us Ferrets Too!
In 2013 The FDA Approved The Use Of Advantage Multi For The Prevention Of Heartworms And Fleas On Us Ferrets Too! Because our hearts are so small, when we contract heartworms, it only takes one or two
More informationCOMMON INTESTINAL WORMS IN DOGS AND CATS W. JEAN DODDS, DVM :: HEMOPET/NUTRISCAN :: SALINAZ AVENUE :: GARDEN GROVE, CALIF.
The following is a quick reference guide for pet caregivers about intestinal worms found in dogs and cats. At the end, I have provided my thoughts on treatment options. Roundworms Intestinal Parasite Most
More informationSUMMARY of PRODUCT CHARACTERISTICS
SUMMARY of PRODUCT CHARACTERISTICS 1. Name of the veterinary medicinal product HELM-EX Flavour Tablets 2. Qualitative and quantitative composition Each tablet contains: Active ubstances Praziquantel 50.0
More informationIntroducing the Elanco Pet Reach Program
Introducing the Elanco Pet Reach Program reach your clients with this free marketing program A NEW WAY TO KEEP YOUR CLIENTS COMING BACK The Elanco Pet Reach Program makes it easy to connect with your clients.
More informationMOXIDECTIN SPOT-ON SOLUTION FOR KITTENS AND SMALL CATS. 280 mg/ml FLURALANER 14 mg/ml MOXIDECTIN Also contains: 339 mg/ml DIMETHYLACETAMIDE (solvent)
Product Name: BRAVECTO PLUS FLEA, TICK AND WORM 112.5 MG FLURALANER AND 5.6 MG MOXIDECTIN SPOT-ON SOLUTION FOR KITTENS AND SMALL CATS APVMA Approval No: 85418/113229 Label Name: BRAVECTO PLUS FLEA, TICK
More informationEfficacies of fenbendazole and albendazole in the treatment of commercial turkeys artificially infected with Ascaridia dissimilis
Efficacies of fenbendazole and albendazole in the treatment of commercial turkeys artificially infected with Ascaridia dissimilis Jessica Perkins, Thomas Yazwinski, Chris Tucker Abstract The goal of this
More informationSUMMARY of PRODUCT CHARACTERISTICS (SPC)
1. Name of the veterinary medicinal product Cestal Plus flavour tablets ad us. vet. active substances: praziquantel pyrantel pamoate fenbendazole SUMMARY of PRODUCT CHARACTERISTICS (SPC) 2. Qualitative
More informationTablet. A light-brown to brown, meat flavoured, bone shaped tablet scored on both sides that can be divided into halves.
1 NAME OF THE VETERINARY MEDICINAL PRODUCT Drontal Dog Tasty Bone 150/144/50 mg tablets 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active Substances: 150 mg Febantel 50 mg Pyrantel
More informationMosquitoes & Diseases. Maxwell Lea, Jr. DVM State Veterinarian Louisiana Dept. of Agriculture and Forestry Department of Animal Health Services
Mosquitoes & Diseases Maxwell Lea, Jr. DVM State Veterinarian Louisiana Dept. of Agriculture and Forestry Department of Animal Health Services Canine Heartworm Disease Eastern Equine Encephalomyelitis
More informationEfficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis in dogs
The Author(s) Parasites & Vectors 2017, 10(Suppl 2):482 DOI 10.1186/s13071-017-2429-5 RESEARCH Open Access Efficacy of oral moxidectin against susceptible and resistant isolates of Dirofilaria immitis
More informationFederal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian.
BAYER HEALTHCARE LLC Animal Health Division P.O. BOX 390, SHAWNEE MISSION, KS, 66201-0390 Customer Service Tel.: 800-633-3796 Customer Service Fax: 800-344-4219 Website: www.bayer-ah.com USA Product Label
More informationVetoquinol/DOLPAC Small dogs/european Renewal June 2011 SUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Austria Belgium Cyprus Malta Czech Republic Netherlands Greece Portugal Slovakia Hungary Slovenia Germany Finland France Luxembourg
More informationFOR ANIMAL TREATMENT ONLY
Hangsell card front panel (2 chew) Issue Date: 5/4/2011 Page: 1 of 11 FOR ANIMAL TREATMENT ONLY Each chew contains: 175 mg PRAZIQUANTEL 174.4 mg PYRANTEL as PYRANTEL EMBONATE 875 mg FEBANTEL Controls all
More informationPrescription Label. Patient Name: Species: Drug Name & Strength: Directions (amount to give how often & for how long):
Prescription Label Patient Name: Species: Drug Name & Strength: Directions (amount to give how often & for how long): Prescribing Veterinarian's Name & Contact Information: Refills: [Content to be provided
More informationProHeart 6 Safety Assessment by Fort Dodge Animal Health
ProHeart 6 Safety Assessment by Fort Dodge Animal Health January 31, 2005 Rami Cobb, BVSc (Hons.) MACVSc Vice President Pharmaceutical Research & Development Fort Dodge Animal Health ProHeart 6 Introduction
More informationSummary of Product Characteristics
Summary of Product Characteristics 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Prazitel Plus XL Tablets For Dogs 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active substances: Praziquantel
More informationApril is National Heartworm Awareness month, a
Peer Reviewed Parasite Protocols Parasite Protocols For Your Practice Comprehensive Advice on Parasite Control A Broad Spectrum Approach to Controlling Parasites of Dogs and Cats Recommendations from the
More informationTO ENSURE ADEQUATE ABSORPTION, ALWAYS ADMINISTER PROGRAM FLAVOR TABS IN CONJUNCTION WITH A NORMAL MEAL.
NOVARTIS ANIMAL HEALTH US, INC. USA Product Label http://www.vetdepot.com 3200 NORTHLINE AVE. SUITE 300, GREENSBORO, NC, 27408 Customer Service: 800 332 2761 Professional Services: 800 637 0281 Fax: 336
More informationDiagnosing intestinal parasites. Clinical reference guide for Fecal Dx antigen testing
Diagnosing intestinal parasites Clinical reference guide for Fecal Dx antigen testing Screen every dog at least twice a year The Companion Animal Parasite Council (CAPC) guidelines recommend including
More informationFREEDOM OF INFORMATION SUMMARY
Date of Approval: FREEDOM OF INFORMATION SUMMARY ORIGINAL NEW ANIMAL DRUG APPLICATION LONGRANGE (eprinomectin) Extended-Release Injectable Parasiticide for the treatment and control of internal and external
More informationTreatment of mixed infections by nematodes and cestodes of the following species:
1 NAME OF THE VETERINARY MEDICINAL PRODUCT Drontal Tasty Bone Multi-worm XL 525/504/175 mg tablets 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active Substances 525 mg febantel 175
More informationDiagnosing intestinal parasites. Clinical reference guide for Fecal Dx antigen testing
Diagnosing intestinal parasites Clinical reference guide for Fecal Dx antigen testing Screen every dog at least twice a year The Companion Animal Parasite Council (CAPC) guidelines recommend including
More informationDoug Carithers 1 William Russell Everett 2 Sheila Gross 3 Jordan Crawford 1
Comparative Efficacy of fipronil/(s)-methoprene-pyriproxyfen (FRONTLINE Gold) and Sarolaner (Simparica ) Against Induced Infestations of Ixodes scapularis on Dogs Doug Carithers 1 William Russell Everett
More informationComparison of Lufenuron and Nitenpyram Versus Imidacloprid for Integrated Flea Control*
P. F. Miller, B. A. Peters, and C. A. Hort Comparison of Lufenuron and Nitenpyram Versus Imidacloprid for Integrated Flea Control* Peter F. Miller, MSc, PhD a Bryce A. Peters, B. App Sc a Colin A. Hort,
More informationGuidelines for Veterinarians: Prevention of Zoonotic Transmission of Ascarids and Hookworms of Dogs and Cats
Guidelines for Veterinarians: Prevention of Zoonotic Transmission of Ascarids and Hookworms of Dogs and Cats Alphabetical Listing Travel Guidelines for Veterinarians: Prevention of Zoonotic Transmission
More informationSummary of Product Characteristics
Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT ZANTEL 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Active substances: Per tablet Praziquantel 50.0 mg Fenbendazole 500.0 mg
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Prinovox 250 mg + 62.5 mg spot-on solution for large dogs 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each 2.5 ml pipette
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Drontal Plus XL Flavour Tablets for Dogs 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Febantel Pyrantel
More informationIntroduction. Materials and methods. Procox
Parasitol Res (2011) 109:S21 S28 DOI 10.1007/s00436-011-2399-z Procox Field Evaluations of the Efficacy and Safety of Emodepside plus Toltrazuril (Procox Oral Suspension for Dogs) against Naturally Acquired
More informationSUMMARY: The Food and Drug Administration (FDA or we) is amending the animal drug
This document is scheduled to be published in the Federal Register on 12/13/2017 and available online at https://federalregister.gov/d/2017-26753, and on FDsys.gov 4164-01-P DEPARTMENT OF HEALTH AND HUMAN
More informationRepeat Dose Tolerance of a Combination of Milbemycin Oxime and Praziquantel in Breeding and Lactating Queens
Repeat Dose Tolerance of a Combination of Milbemycin Oxime and Praziquantel in Breeding and Lactating Queens Rudolf Schenker, PhD 1 Robert Cody, M. Agr. Sc. H. Dip. Tox 1 Günther Strehlau, Dr. rer.nat
More informationModern Parasitology For The Cat:
Modern Parasitology For The Cat: Fleas, Mites, and Worms, Oh My! Annette Litster BVSc PhD FACVSc (Feline Medicine) MMedSci (Clinical Epidemiology) Senior Veterinary Specialist, Zoetis Chris Adolph DVM,
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT NEXGARD SPECTRA 9 mg / 2 mg chewable tablets for dogs 2 3.5 kg NEXGARD SPECTRA 19 mg / 4 mg chewable tablets for
More informationHeartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States
Bowman Parasites & Vectors 2012, 5:138 REVIEW Heartworms, macrocyclic lactones, and the specter of resistance to prevention in the United States Dwight D Bowman * Open Access Abstract In order to provide
More informationIDEXX PetChek IP A new approach to intestinal parasites in veterinary medicine
IDEXX PetChek IP A new approach to intestinal parasites in veterinary medicine Making next-generation testing a part of parasite control programmes Introduction Veterinary practices routinely implement
More informationSummary of Product Characteristics
Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Prazitel Plus XL Tablets For Dogs 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active substances: Praziquantel
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS AN: 01695/2015 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Milbemax Tablets for small dogs and puppies 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Active substances:
More informationSUMMARY OF PRODUCT CHARACTERISTICS. Milprazon 2.5 mg/25 mg Tablets for Small Dogs and Puppies Weighing At Least 0.5 kg
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Milprazon 2.5 mg/25 mg Tablets for Small Dogs and Puppies Weighing At Least 0.5 kg 2. QUALITATIVE AND QUANTITATIVE COMPOSITION
More informationFREEDOM OF INFORMATION SUMMARY. Rx: U.S. Federal law restricts this drug to use by or on the order of a licen
Page 1 of 47 FREEDOM OF INFORMATION SUMMARY I. GENERAL INFORMATION NADA Number: 141-152 Sponsor: Generic Name: Trade Name: Marketing Status: II. INDICATIONS FOR USE Pfizer Inc. 235 East 42nd St. New York,
More information1.3.1 Milbemycin oxime + Praziquantel SPC, Labeling and Package Leaflet GB
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS SmPCPIL095728_1 04.07.2017 Updated: 04.07.2017 Page 1 of 17 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Milquantel 2.5 mg/25 mg tablets for small dogs and puppies
More informationScience and Art of Flea and Tick Control:
Science and Art of Flea and Tick Control: Michael W. Dryden, DVM, Ph.D. Professor of Veterinary Parasitology Department of Diagnostic Medicine/Pathobiology College of Veterinary Medicine, Kansas State
More informationFrom 15th American Heartworm Society Triennial Symposium New Orleans, LA, USA. September 11-13, 2016
The Author(s) Parasites & Vectors 2017, 10(Suppl 2):485 DOI 10.1186/s13071-017-2430-z RESEARCH Microfilarial reduction following ProHeart 6 and ProHeart SR-12 treatment in dogs experimentally inoculated
More informationUnited Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS DECENTRALISED PROCEDURE
United Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS DECENTRALISED PROCEDURE PUBLICLY AVAILABLE ASSESSMENT REPORT FOR A VETERINARY MEDICINAL PRODUCT Milbactor
More informationRecommended for Implementation at Step 7 of the VICH Process on 21 November 2000 by the VICH Steering Committee
VICH GL7 (ANTHELMINTICS GENERAL) November 2000 For implementation at Step 7 EFFICACY OF ANTHELMINTICS: GENERAL REQUIREMENTS Recommended for Implementation at Step 7 of the VICH Process on 21 November 2000
More informationA statistical approach for evaluating the effectiveness of heartworm preventive drugs: what does 100% efficacy really mean?
The Author(s) Parasites & Vectors 2017, 10(Suppl 2):516 DOI 10.1186/s13071-017-2440-x RESEARCH Open Access A statistical approach for evaluating the effectiveness of heartworm preventive drugs: what does
More informationUS Federal law restricts this drug to use by or on the order of a licensed veterinarian.
PFIZER INC. PFIZER ANIMAL HEALTH USA Product Label http://www.vetdepot.com 235 E. 42ND ST., NEW YORK, NY, 10017 Telephone: 269 833 4000 Customer Service: 800 733 5500 and 800 793 0596 Veterinary Medical
More informationVeterinary Parasitology 112 (2003)
Veterinary Parasitology 112 (2003) 249 254 Comparative speed of kill between nitenpyram, fipronil, imidacloprid, selamectin and cythioate against adult Ctenocephalides felis (Bouché) on cats and dogs R.
More informationFor the treatment and prevention of infections caused by:
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT CYDECTIN 0.1 % W/V ORAL SOLUTION for sheep 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml contains Active substance Moxidectin
More informationDetermining the Most Prevalent Parasitic Worms Found in Canines Surrounding the Bryan/College Station Area
Determining the Most Prevalent Parasitic Worms Found in Canines Surrounding the Bryan/College Station Area Yineli Carreon, Katie Freeman, Jesus Garcia, Cierra Briggs, Koren Dunn, Morgan De Shields, and
More informationCardiac blood samples were collected in EDTA tubes as described in Chapter 2, and
48 Cardiac blood samples were collected in EDTA tubes as described in Chapter 2, and stored in a refrigerator for processing later. Following euthanasia, adhesive tape swabs were collected from each dog
More informationSUMMARY OF PRODUCT CHARACTERISTICS. Equest Oral Gel, 18,92 mg/g, Oral Gel for Horses and Ponies
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Equest Oral Gel, 18,92 mg/g, Oral Gel for Horses and Ponies (Sweden: Cydectin Vet) 2. QUALITATIVE AND QUANTITATIVE COMPOSITION
More informationMany veterinarians and veterinary technicians
Peer reviewed Today s Technician Safe & Humane Handling of Small mammal PatientS Valarie V. Tynes, DVM, Diplomate ACVB Many veterinarians and veterinary technicians are filled with trepidation when small
More informationSummary of Product Characteristics
Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Prazical Plus XL Tablets For Dogs 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active substances: Praziquantel
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Veloxa Forte Chewable Tablets for Dogs (in Greece and Hungary) Veloxa 175/504/525 mg Chewable Tablets for Dogs (in Denmark,
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS 1. NAME OF THE VETERINARY MEDICINAL PRODUCT CESTEM Flavoured tablets for large dogs [UK, IT, DE, AT, BE, NL, LU, ES, PL, BG, CY, CZ, EE, EL, HU, LT, LV, PT, RO, SK, SI]
More informationSUMMARY OF PRODUCT CHARACTERISTICS
SUMMARY OF PRODUCT CHARACTERISTICS Revised: May 2016 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Milpro 12.5 mg/125 mg film-coated tablets for dogs Milpro Vet. 12.5 mg/125 mg film-coated tablets for dogs
More informationSummary of Product Characteristics
Summary of Product Characteristics 1 NAME OF THE VETERINARY MEDICINAL PRODUCT Zantel Cat and Dog Tablets 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Active substances (per tablet): Praziquantel Fenbendazole
More informationParasite Prevention Strategies for Bison.
Parasite Prevention Strategies for Bison Donald H. Bliss, Ph.D. Veterinary Parasitologist MidAmerica Ag Research Verona, WI drbliss@chorus.net www.midamericaagresearch.net Parasite Control is Paramount
More informationComponents of Modified Kramer System
Components of Modified Kramer System 1. Previous Experience (-1, 0,+1) 2. Alternative Etiologic Candidate (-1, 0, +2) 3. Timing (-2, 0, +1) 4. Overdose (0, +1) 5. Dechallenge (-1, 0, +1) 6. Rechallenge
More informationHookworms in Dogs & Cats Blood-Sucking Parasites in our Pets
Hookworms in Dogs & Cats Blood-Sucking Parasites in our Pets Recently I came across a news story of a couple who visited the Dominican Republic. While in the tropical paradise, they became infected with
More informationLarge Animal Topics in Parasitology for the Veterinary Technician Jason Roberts, DVM This presentation is designed to review the value veterinary
Large Animal Topics in Parasitology for the Veterinary Technician Jason Roberts, DVM This presentation is designed to review the value veterinary technicians can add to mixed or large animal practices
More informationFREEDOM OF INFORMATION SUMMARY
Date of Approval: June 30, 2004 FREEDOM OF INFORMATION SUMMARY SUPPLEMENTAL NEW ANIMAL DRUG APPLICATION NADA 141-095 (doramectin) To extend the period of persistent effect for Cooperia oncophora and Dictyocaulus
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationMcKeever Dermatology Clinics
McKeever Dermatology Clinics Cassidy Schuff, DVM candidate 2017 Nicole Heinrich DVM DACVD www.mckeevervetderm.com 952-946-0035 NexGard (Merial) Treats and prevents flea infestation. Treats and controls
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Trifexis 270 mg/4.5 mg chewable tablets for dogs (3.9 6.0 kg) Trifexis 425 mg/7.1 mg chewable tablets for dogs (6.1
More informationEffects of an Ivermectin Otic Suspension on Egg Hatching of the Cat Ear Mite, Otodectes cynotis, in Vitro*
D. D. Bowman, S. Kato, and E. A. Fogarty Effects of an Ivermectin Otic Suspension on Egg Hatching of the Cat Ear Mite, Otodectes cynotis, in Vitro* Dwight D. Bowman, PhD Satomi Kato, DVM, MS Elizabeth
More informationChapter 7. Anthelmintic efficacy of oxibendazole against some important nematodes in dogs and cats
Chapter 7 Anthelmintic efficacy of oxibendazole against some important nematodes in dogs and cats P.A.M. Overgaauw 1 and J.H. Boersema 2 1 Virbac Nederland B.V, P.O. Box 313, 3770 AH Barneveld, the Netherlands
More informationTherapeutic efficacy of a mixture of ivermectin and closantel against gastrointestinal parasites in draft horses
( - ) ( ) % 88.0 19 %15.75 Oxyuris equi % 1.58 Strongylus spp..% 42.10 / 0.05.% 10.52 Parascaris equorum Parascaris equorum % 100 14 Strongylus spp. % 99.42 Oxyuris equi.gastrophilus nasalis Therapeutic
More informationHeartworm Disease in Dogs
Customer Name, Street Address, City, State, Zip code Phone number, Alt. phone number, Fax number, e-mail address, web site Heartworm Disease in Dogs Basics OVERVIEW Disease caused by infestation with heartworms
More informationFederal law (U.S.A.) restricts this drug to use by or on the order of a licensed veterinarian.
BAYER HEALTHCARE LLC Animal Health Division USA Product Label http://www.vetdepot.com P.O. BOX 390, SHAWNEE MISSION, KS, 66201-0390 Customer Service Tel.: 800-633-3796 Customer Service Fax: 800-344-4219
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Advocate 40 mg + 4 mg spot-on solution for small cats and ferrets Advocate 80 mg + 8 mg spot-on solution for large
More informationUnited Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS (Reference Member State) MUTUAL RECOGNITION PROCEDURE
United Kingdom Veterinary Medicines Directorate Woodham Lane New Haw Addlestone Surrey KT15 3LS (Reference Member State) MUTUAL RECOGNITION PROCEDURE PUBLICLY AVAILABLE ASSESSMENT REPORT FOR A VETERINARY
More informationDetermination of the Anthelmintic Efficacy of Albendazole in the Treatment of Chickens Naturally Infected with Gastrointestinal Helminths
2007 Poultry Science Association, Inc. Determination of the Anthelmintic Efficacy of Albendazole in the Treatment of Chickens Naturally Infected with Gastrointestinal Helminths C. A. Tucker, T. A. Yazwinski,
More informationA revolution in the parasite control for cats. Dr Anne Bollart Merial Technical & Marketing Manager - Pets Business
A revolution in the parasite control for cats Dr Anne Bollart Merial Technical & Marketing Manager - Pets Business Jelgava 11/09/2014 AGENDA The cat endectocide market & Results of an epidemiological survey
More informationSummary of Product Characteristics
Summary of Product Characteristics 1. NAME OF THE VETERINARY MEDICINAL PRODUCT MILBEMAX Film-coated tablets for cats 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains: Active substances:
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Trifexis 270 mg/4.5 mg chewable tablets for dogs Trifexis 425 mg/7.1 mg chewable tablets for dogs Trifexis 665 mg/11.1
More informationEFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR PORCINES
VICH GL16 (ANTHELMINTICS: PORCINE) June 2001 For implementation at Step 7 - Draft 1 EFFICACY OF ANTHELMINTICS: SPECIFIC RECOMMENDATIONS FOR PORCINES Recommended for Implementation on June 2001 by the VICH
More informationCydectin. Fort Dodge PRODUCT DESCRIPTION
Cydectin Fort Dodge moxidectin Injectable Solution for Beef and Nonlactating Dairy Cattle Antiparasitic Contains 10 mg moxidectin/ml Not for use in female dairy cattle of breeding age, veal calves, and
More informationANNEX I SUMMARY OF PRODUCT CHARACTERISTICS
ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS 1 1. NAME OF THE VETERINARY MEDICINAL PRODUCT Advocate 40 mg + 4 mg spot-on solution for small cats and ferrets Advocate 80 mg + 8 mg spot-on solution for large
More informationFEEDLOT PERFORMANCE, HEALTH, AND CARCASS CHARACTERISTICS OF BEEF HEIFERS TREATED WITH CYDECTIN OR DECTOMAX AT PROCESSING
Beef Cattle Research 2005 FEEDLOT PERFORMANCE, HEALTH, AND CARCASS CHARACTERISTICS OF BEEF HEIFERS TREATED WITH CYDECTIN OR DECTOMAX AT PROCESSING R. L. Hale, D. Gray 1, and R. Armendariz 2 Summary Two
More informationTales from the Hood. Chemo safety and administration
Get Smart Tales from the Hood Chemo safety and administration by Kathi L. Smith, RVT, VTS (Oncology) An increasing number of clients are choosing to treat their pets that have been diagnosed with cancer.
More information