Primary Lens Luxation
|
|
- Jordan Knight
- 5 years ago
- Views:
Transcription
1 Primary Lens Luxation Cathryn Mellersh Animal Health Trust February, 2009
2 Collaboration & Acknowledgements David Sargan (University of Cambridge) David Gould (Davies Veterinary Specialists) AHT Ophthalmologists & BVA Eye Panelists Owners and breeders who have donated DNA samples from their dogs Kennel Club Charitable Trust, American Kennel Club Canine Health Foundation, Breed Clubs & individuals.
3 Talk Layout Brief overview of Primary Lens Luxation. DNA what it is, what it does, and how mutations in DNA cause inherited disease. How a mutation progresses through a pedigree. How a mutation is tracked down PLL mutation and DNA test what the results mean mutation frequency in the population general advice Vitreal leakage
4 Primary Lens Luxation Zonules In the normal eye the lens is held in place by numerous fibres, called zonules. Lens luxation occurs when all of these fibres are broken and the lens becomes loose within the eye, where it can move forwards or (less commonly) backwards in the eye.
5 PLL Primary Lens Luxation is a well-recognised, painful & potentially blinding condition known to affect many terrier and terrier-type breeds. Believed to be inherited as an autosomal recessive condition in all breeds studied. Difficult to eliminate from at risk breeds because: Clinically unaffected carriers can pass mutation on to offspring Condition is mid-late onset, so affected dogs often bred with prior to onset of clinical signs DNA test required
6 DNA DNA is a very long molecule & is found in virtually every cell of the body. The canine genome consists of approximately 2,500,000,000 nucleotides of DNA If each nucleotide was 1mm long the canine genome would stretch from Land s End to John O Groats and back. ALL the DNA is copied every time a cell divides DNA is responsible for every aspect of you and your dog that is not controlled by the environment.
7 Coding DNA DNA C G A T G T C A A T G C A C C G C T A C A G T T A C G T G G Transcription mrna G C U A C A G U U A C G U G G Translation Protein A T V T W
8 DNA DNA is a code/blueprint for every physical characteristic of a dog that is not determined by the environment. The code is determined by the order of nucleotides along the DNA. ALL 2,500,000,000 nucleotides are copied every time a cell divides. Mistakes that arise are called MUTATIONS. Most mutations that arise are repaired whereas a tiny minority persist. Most mutations have no effect, whereas some can be advantageous. Some mutations have a deleterious effect & cause inherited disease. *
9 Chromosomes Egg Sperm fertilization 38 autosomes & 1 X chromosome 38 autosomes & 1 X or Y chromosome X Y 38 pairs of autosomes & 1 pair sex chromosomes
10 Spontaneous Mutation X
11 Recombination X
12 Propagation X
13 Inheritance of Mutation Down a Pedigree Parents G-Parents G G-Parents G G G-Parents
14 Affected Shared Region of DNA
15 Mutation Identification Affected Unaffected
16 PLL research Research to identify mutation responsible for PLL initiated ~ 10 years ago. DNA from affected & unaffected dogs was analysed to identify region of the genome that was homozygous in all affected dogs, and different in the unaffected dogs. MBTS 40 cases & 11 controls LHs 22 cases & 18 controls X breeds 5 cases to cut a very long story short we identified the mutation responsible for PLL in Miniature Bull Terriers & Lancashire Heelers in summer It is a single nucleotide substitution. *
17 Breeds carrying PLL mutation Miniature Bull Terrier Lancashire Heeler Jack Russell Terrier Parson Russell Terrier Jagd Terrier Volpino Italiano Australian Cattle Dog Yorkshire Terrier Patterdale Terrier Sealyham Terrier Chinese Crested Dog Tibetan Terrier
18 Between Breeds
19 DNA Test Results DNA test developed and made available October 19th, Clear Carrier Genetically Affected
20 PLL DNA Test Kits for taking cheek swabs are available by phoning +44 (0) or via to Further information
21 PLL DNA Test Results CLEAR: these dogs have two normal copies of DNA. Our research has demonstrated clear dogs will not develop PLL as a result of the mutation we are testing for, although we cannot exclude the possibility they might develop PLL due to other causes, such as trauma or the effects of other, unidentified mutations. GENETICALLY AFFECTED: these dogs have two copies of the mutation and will almost certainly develop PLL during their lifetime. We advise that all genetically affected dogs have their eyes examined by a veterinary ophthalmologist every 6 months, from the age of 18 months, so the clinical signs of PLL are detected as early as possible.
22 Carriers CARRIER: these dogs have one copy of the mutation and one normal copy of DNA. Our research has demonstrated that carriers have a very low risk of developing PLL. The majority of carriers do not develop PLL during their lives but a small percentage do. We currently estimate that between 2% 20% of carriers will develop the condition, although we believe the true percentage is nearer to 2% than 20%. We do not currently know why some carriers develop the condition whereas the majority do not, and we advise that all carriers have their eyes examined by a veterinary ophthalmologist every 6-12 months, from the age of 2, throughout their entire lives. Current best estimate = 2.5% *
23 Mutation Frequency We collected DNA from random LHs to estimate the mutation frequency Samples from 98 dogs collected We removed all full & half-siblings left with 46 dogs that didn t share a sire or a dam Clear 28 (61%) Carrier 17 (37%) Affected 1 (2%)
24 LHs Tested Country Dogs tested Clear % Carrier % Affected % Finland % 28 50% 1 2% Netherlands % 0 0% 0 0% Norway % 3 60% 0% Sweden % 29 28% 0% UK % 33 38% 3 3% TOTALS % 93 36% 4 2%
25 TTs Tested (January 10) Country Dogs Tested Clear Clear % Carrier Carrier % Affected Affected % Australia % 0 0% 0 0% Belgium % 2 29% 0 0% Denmark % 0 0% 0 0% Eire % 2 18% 0 0% Finland % 5 23% 0 0% Germany % 48 17% 5 2% Holland % 4 67% 0 0% Ireland % 3 38% 0 0% Italy % 0 0% 0 0% Netherlands % 3 21% 0 0% Norway % 16 24% 0 0% Sweden % 3 60% 0 0% UK % 99 32% 7 2% USA % 3 30% 0 0% TOTALS % % 12 2%
26 PRTS Tested (February 2010) Country Dogs tested Clear % Carrier % Affected % Austria % 0 0% 0 0% Belgium % 0 0% 0 0% Czech Republic % 0 0% 0 0% Finland % 58 16% 7 2% Germany % 22 21% 1 1% Netherlands % 1 33% 0 0% Norway % 3 20% 0 0% Portugal % 3 75% 0 0% Slovakia % 1 50% 0 0% Sweden % 5 26% 0 0% Switzerland % 1 17% 0 0% UK % 30 28% 1 1% USA % 1 50% 0 0% TOTALS % % 9 1%
27 Advice Normally for recessive conditions we advise breeders to mate their carriers to tested, clear dogs. Puppies don t have to be DNA tested unless they will be bred with. NOT all the same advice for PLL. Owners DO need to breed with their carriers, because the mutation frequency is so high. But all puppies that are the offspring of at least one carrier parent should be DNA tested. Dogs carrying the mutation need to be clinically monitored throughout their lives. *
28 30% Carriers Males
29 30% Carriers Females
30 Breeding Outcomes Clear Clear x Clear 100% Carrier Genetically Affected Clear x Carrier 50% 50% Carrier x Carrier 25% 50% 25% Clear x Genetically Affected 100% Carrier x Genetically Affected 50% 50% Genetically Affected x Genetically Affected 100%
31 Vitreal Leakage As zonules rupture vitreous can leak into the anterior chamber of the eye vitreal leakage. In some countries evidence of vitreal leak age is sufficient for a dog to fail an eye examination and be classed as PLL affected We have analysed DNA from several dogs now, mainly Lancashire Heelers, that have clinical evidence of vitreal leakage but that are clear of the PLL mutation. Vitreal leakage might be a distinct condition from PLL in some dogs, and be caused by different mutation(s). Vitreal leakage alone is not diagnostic of PLL, although many dogs with vitreal leakage will progress to develop LL. Perhaps LL can be secondary to vitreal leakage????
32 LHs that Don t Fit Some dogs with clinical lens luxation are only carriers of PLL mutation explained by fact that small minority of carriers develop clinical PLL Some dogs with vitreal leakage (subluxation code 0) do not carry the PLL mutation - explained by fact that vitreal leakage might be a distinct condition from PLL in some dogs Some dogs with lens luxation are clear of the PLL mutation explanations include the possibility that LL can occur secondary to vitreal leakage OR there is another genetic form of PLL in the Lancashire Heeler. * Keep in mind that there are very few discrepancies of any breed
33 Samples for Future Research To help us understand the affected carrier phenomenon and vitreal leakage we need samples from from: carriers that develop PLL carriers that reach the age of 10 yo without developing PLL dogs diagnosed with vitreal leakage that reach 10 yo without developing PLL clear dogs with clinical LL All samples MUST be accompanied by full eye examination history
34 Thank You to all the owners who have provided DNA from their dogs and supplied us with information. to everybody who has made a financial donation to the research. We couldn t have done it without you.
Lens luxation when the lens gets wobbly
Lens luxation when the lens gets wobbly Introduction The lens what is it there for? The lens - anatomy Lens luxation What does that mean? Lens luxation - what to look out for? Lens luxation How can it
More informationThis AHT Information Sheet contains details on late-onset PRA in three breeds: Gordon Setters, Irish Setters and Tibetan Terriers.
This AHT Information Sheet contains details on late-onset PRA in three breeds: Gordon Setters, Irish Setters and Tibetan Terriers. Late-Onset Progressive Retinal Atrophy in the Gordon Setter A mutation
More informationADAMTS17 mutation associated with primary lens luxation is widespread among breeds
Veterinary Ophthalmology (2011) 14, 6, 378 384 DOI:10.1111/j.1463-5224.2011.00892.x associated with primary lens luxation is widespread among breeds David Gould,* Louise Pettitt, Bryan McLaughlin, Nigel
More informationPPPA Health and Research Committee Report to the Club April 1, 2017
PPPA Health and Research Committee Report to the Club April 1, 2017 We have had a very busy last 8 months with the discovery of several Genetic Markers in the breed. This was an unexpected benefit of the
More informationThe Genetics of Canine Glaucoma James Oliver
The Genetics of Canine Glaucoma James Oliver Head of Ophthalmology at AHT RCVS & European Specialist in Veterinary Ophthalmology BVA/KC/ISDS Eye Scheme Panellist PhD Student in Genetics of Canine Glaucoma
More information+ Karyotypes. Does it look like this in the cell?
+ Human Heredity + Karyotypes A genome is the full set of genetic information that an organism carries in its DNA. Karyotype: Shows the complete diploid set of chromosomes grouped together in pairs, arranged
More informationFive year report. March December 2013
Five year report March 2009 - December 2013 2 Introduction Inherited disease within purebred dogs has become headline news in recent years. Strong selection for desired characteristics, and the fact that
More informationInheritance of Livershunt in Irish Wolfhounds By Maura Lyons PhD
Inheritance of Livershunt in Irish Wolfhounds By Maura Lyons PhD Glossary Gene = A piece of DNA that provides the 'recipe' for an enzyme or a protein. Gene locus = The position of a gene on a chromosome.
More informationInformation Guide. Breeding for Health.
Information Guide Breeding for Health www.thekennelclub.org.uk www.thekennelclub.org.uk Breeding for Health Dog breeders today have a number of different considerations to make when choosing which dogs
More informationDO NOT WRITE ON THIS TEST Unit 6 Assessment Genetics Objective 3.2.2
DO NOT WRITE ON THIS TEST Unit 6 Assessment Objective 3.2.2 Vocabulary Matching + 1 point each 1. dominant 2. recessive 3. genotype 4. phenotype 5. heterozygous 6. homozygous 7. incomplete dominance 8.
More informationFrench Bulldog Club of England Health Improvement Strategy 2012,
French Bulldog Club of England Health Improvement Strategy 2012, Owners & Breeders Continue to promote and encourage owners and breeders to participate in the French Bulldog Health Scheme, DNA testing
More informationMiniature Schnauzer Annual Breed Health Report 2016
Miniature Schnauzer Annual Breed Health Report 2016 This form should be completed by your Breed Health Co-ordinator and submitted via email to the Kennel Club s Health Team (email address tbc). Section
More informationShetland Sheepdog Health Day
Shetland Sheepdog Health Day Friday 25 th January 2019 Animal Health Trust The Animal Health Trust is a registered charity that works to reduce the impact disease and injury have on the welfare of companion
More informationPart One: Introduction to Pedigree teaches students how to use Pedigree tools to create and analyze pedigrees.
Genetics Monohybrid Teacher s Guide 1.0 Summary The Monohybrid activity is the fifth core activity to be completed after Mutations. This activity contains four sections and the suggested time to complete
More information8.2- Human Inheritance
8.2- Human Inheritance Sex Linked Traits Traits controlled by genes on the sex chromosome. Recessive X-linked traits are always shown in males. Males only have one X chromosome Females must inherit two
More informationNATIONAL ROTTWEILER COUNCIL (AUSTRALIA)
NATIONAL ROTTWEILER COUNCIL (AUSTRALIA) JLPP (Juvenile Laryngeal Paralysis Polyneuropathy) SCHEME 1 P a g e Brief out line of JLPP: What is Juvenile Laryngeal Paralysis & Polyneuropathy? The brain controls
More informationEssayOnDeclawingCatsForStudents
EssayOnDeclawingCatsForStudents In the 1960s many people in America started keeping their cats strictly indoors because the world outside was becoming more dangerous. The only problem was that cats need
More informationMucopolysaccharidosis type IIIB (MPSIIIB) in Schipperkes and DNA Testing
Mucopolysaccharidosis type IIIB (MPSIIIB) in Schipperkes and DNA Testing Ten years ago we identified a genetic disease that is present in Schipperkes and in humans. When a dog is affected it is ultimately
More informationComments on the Ridge Gene, by Clayton Heathcock; February 15, 2008
Comments on the Ridge Gene, by Clayton Heathcock; February 15, 2008 Note: This article originally appeared in the March 2008 issue of "The Ridgeback", the official publication of the Rhodesian Ridgeback
More informationMolecular characterization of CMO. A canine model of the Caffey syndrome, a human rare bone disease
Molecular characterization of CMO A canine model of the Caffey syndrome, a human rare bone disease (Report summarised by Dr P. Bamas) Abstract Dog CMO disease (Cranio Mandibular Osteopathy) is a clinical
More informationPractice Study Guide Genetics:
Name: Period: Date: Practice Study Guide Genetics: Solve the following questions: Problem 1: a. What is the most likely mode of inheritance for this pedigree? Why? Problem 2: Assume that the individual
More informationNext Wednesday declaration of invasive species due I will have Rubric posted tonight Paper is due in turnitin beginning of class 5/14/1
Next Wednesday declaration of invasive species due I will have Rubric posted tonight Paper is due in turnitin beginning of class 5/14/1 4/13. Warm-up What is the difference between mrna and trna: mrna
More informationLesson Overview. Human Chromosomes. Lesson Overview Human Chromosomes
Lesson Overview 14.1 Karyotypes To find what makes us uniquely human, we have to explore the human genome. A genome is the full set of genetic information that an organism carries in its DNA. A study of
More informationEuropean poultry industry trends
European poultry industry trends November 5 th 2014, County Monaghan Dr. Aline Veauthier & Prof. Dr. H.-W. Windhorst (WING, University of Vechta) 1 Agenda The European Chicken Meat Market - The global
More informationGenetics Since Mendel. At dog and cat shows, an animal s owner may be asked to show its pedigree. What do you think a pedigree shows?
chapter 35 Heredity section 2 Genetics Since Mendel Before You Read At dog and cat shows, an animal s owner may be asked to show its pedigree. What do you think a pedigree shows? What You ll Learn how
More informationEU Health Priorities. Jurate Svarcaite Secretary General PGEU
EU Health Priorities Jurate Svarcaite Secretary General PGEU Members: Professional Bodies & Pharmacists Associations 2016: 33 Countries Austria Belgium Bulgaria Croatia Cyprus Czech Rep Denmark Estonia
More informationLesson Overview. Human Chromosomes. Lesson Overview Human Chromosomes
Lesson Overview 14.1 Genome a full set of all the genetic information that an organism carries in its DNA. Karyotypes Karyotype a picture that shows the complete diploid set of human chromosomes, They
More informationThe Genetics of Color In Labradors
By Amy Frost Dahl, Ph.D. Oak Hill Kennel First published in The Retriever Journal, June/July 1998 Seeing that two of the dogs I brought in for CERF exams were black Labs, the vet's assistant started telling
More informationGenetics Assignment. Name:
Genetics Assignment Name: 1. An organism is heterozygous for two pairs of genes. The number of different combinations of alleles that can form for these two genes in the organism s gametes is A. 1 B.
More informationSEX LINKED INHERITANCE & PEDIGREES
SEX LINKED INHERITANCE & PEDIGREES A DAY: 5/17 B DAY: 5/18 ONLY 2 MORE CLASSES WITH NEW CONTENT RETEACH AND RETAKE DURING FRESHMEN SEMINAR TODAY I WILL RETEACH THE MATERIAL ON THE QUIZ FROM LAST CLASS
More informationPage 1 of 7. Name: A. Preliminary Assessment #3. You may need a calculator for numbers 2&3.
Page 1 of 7 Name: 03-121-A Preliminary Assessment #3 You may need a calculator for numbers 2&3. You may bring one 3 inch by 5 inch card or paper with anything handwritten on it (front and back). You have
More informationChart showing the average height of males and females in various world countries.
Chart showing the average height of males and females in various world countries. Country/Region Average male height Average female height Sampled Age Range Albania 174.0 cm (5 ft 8 1/2 in) 161.8 cm (5
More informationMendelian Genetics 1
Mendelian Genetics 1 Genetic Terminology Trait - any characteristic that can be passed from parent to offspring Heredity - passing of traits from parent to offspring Genetics - study of heredity 2 Gregor
More informationPutting Science into Animal Science Projects. Area: Using Genetics (advanced members) Activity: Eradicate Scrapie in Sheep through Genetic Selection
Putting Science into Animal Science Projects Area: Using Genetics (advanced members) Activity: Eradicate Scrapie in Sheep through Genetic Selection Goal: Provide advanced members with the information and
More informationIn the first half of the 20th century, Dr. Guido Fanconi published detailed clinical descriptions of several heritable human diseases.
In the first half of the 20th century, Dr. Guido Fanconi published detailed clinical descriptions of several heritable human diseases. Two disease syndromes were named after him: Fanconi Anemia and Fanconi
More informationTested Sex Result Date Age Brigburn Kit Carson Dog 0 31/07/ years, 4 months Brigburn Murray Dog 0 03/12/ year, 2 months
Brigburn Kit Carson Health Test Results - Progeny Comparison BVA/KC Elbow Dysplasia Scheme Brigburn Kit Carson Dog 0 31/07/2014 2 years, 4 months Brigburn Murray Dog 0 03/12/2015 1 year, 2 months BVA/KC
More informationVirtual Lab: Sex-Linked Traits Worksheet. 1. Please make sure you have read through all of the information in the
Virtual Lab: Sex-Linked Traits Worksheet 1. Please make sure you have read through all of the information in the Questions and Information areas. If you come upon terms that are unfamiliar to you, please
More informationJerry and I am a NGS addict
Introduction Identification and Management of Loss of Function Alleles Impacting Fertility L1 Dominette 01449 Jerry and I am a NGS addict Jerry Taylor taylorjerr@missouri.edu University of Missouri 2014
More informationGenetics Problem Set
AP Biology - Unit 6: Patterns of Inheritance Name: Genetics Problem Set Independent Assortment Problems 1. One gene has alleles A and a. Another has alleles B and b. For each genotype listed, what type(s)
More informationBreeding Rules and Registration Regulations
Breeding Rules and Registration Regulations CONTENTS 1. General provisions 1.1. Breeding 1.2. Health and responsibility 1.3. Processing forms true copies 1.4. Administrative costs 1.5. The puppy buyer
More informationQUEEN S CORGI OFF AT RISK LIST FOR FIRST TIME IN ALMOST A DECADE
QUEEN S CORGI OFF AT RISK LIST FOR FIRST TIME IN ALMOST A DECADE But Save Forgotten Dog Breeds campaign launched as other British breeds tumble to record lows Pembroke Welsh Corgi comes off Kennel Club
More informationGenetics of Arrhythmogenic Right Ventricular Cardiomyopathy in Boxer dogs: a cautionary tale for molecular geneticists.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy in Boxer dogs: a cautionary tale for molecular geneticists.
More informationAnimal Law in Europe Progress and Challenges. Prof. Dr. Marita Giménez-Candela Master in Animal Law and Society Director
Animal Law in Europe Progress and Challenges Prof. Dr. Marita Giménez-Candela Master in Animal Law and Society Director TREATY OF LISBON (TFEU), Art. 13 In formulating and implementing the Union s agriculture,
More informationKaryotypes Pedigrees Sex-Linked Traits Genetic Disorders
Karyotypes Pedigrees Sex-Linked Traits Genetic Disorders Consists of 23 pairs of chromosomes. Images are taken from diploid cells during mitosis. Chromosomes 1 through 22 are called autosomes. The X and
More informationPatterns of Inheritance. What are the different ways traits can be inherited?
Patterns of Inheritance What are the different ways traits can be inherited? Review: Patterns of Inheritance we know already 1. Autosomal dominant: If an individual is heterozygous, only one allele is
More informationBioSci 110, Fall 08 Exam 2
1. is the cell division process that results in the production of a. mitosis; 2 gametes b. meiosis; 2 gametes c. meiosis; 2 somatic (body) cells d. mitosis; 4 somatic (body) cells e. *meiosis; 4 gametes
More informationBVA/KC/ISDS Primary Glaucoma
BVA/KC/ISDS Primary Glaucoma What is primary glaucoma? Primary glaucoma is a painful and blinding disease associated with high intraocular pressure (high pressure inside the eye). It is an inherited condition
More informationBi156 Lecture 1/13/12. Dog Genetics
Bi156 Lecture 1/13/12 Dog Genetics The radiation of the family Canidae occurred about 100 million years ago. Dogs are most closely related to wolves, from which they diverged through domestication about
More informationFOR INCLUSION WITH ANNUAL RETURNS 2012
ENGLISH SPRINGER SPANIEL BREED CLUBS HEALTH REPORT 2011/12 *on behalf of: The English Springer Spaniel Club The English Springer Spaniel Club of Scotland The English Springer Spaniel Club of Wales The
More informationSCIENTIFIC REPORT. Analysis of the baseline survey on the prevalence of Salmonella in turkey flocks, in the EU,
The EFSA Journal / EFSA Scientific Report (28) 198, 1-224 SCIENTIFIC REPORT Analysis of the baseline survey on the prevalence of Salmonella in turkey flocks, in the EU, 26-27 Part B: factors related to
More informationThe issue of kinked tail in Syrian hamster
By Marta Jesariew (Podrik Hamstery, Poland), Christina Linde (Lindes Hamsteri, Denmark) and Tomasz Piasecki (Doctor of Veterinary Medicine, Poland) Our last observations clearly show that among hamster
More informationHealth Service Executive Parkgate St. Business Centre, Dublin 8 Tel:
Health Service Executive Parkgate St. Business Centre, Dublin 8 Tel: 01 635 2500 www.hse.ie Health Service Executive Oak House, Millennium Park, Naas, Co. Kildare Tel: 045 880 400 www.hse.ie The prevention
More informationLAB : PAPER PET GENETICS. male (hat) female (hair bow) Skin color green or orange Eyes round or square Nose triangle or oval Teeth pointed or square
Period Date LAB : PAPER PET GENETICS 1. Given the list of characteristics below, you will create an imaginary pet and then breed it to review the concepts of genetics. Your pet will have the following
More informationAppendix F: The Test-Curriculum Matching Analysis
Appendix F: The Test-Curriculum Matching Analysis TIMSS went to great lengths to ensure that comparisons of student achievement across countries would be as fair and equitable as possible. The TIMSS 2015
More informationOnline Heredity Lab. 5. Explain how a trait can disappear and then reappear in later generations.
Name: Online Heredity Lab Period Mendel and his Peas Mendel Animation 1. What fundamental questions did Mendel try to answer? 2. What does Homozygous mean? 3. What is a Gamete? 4. What is a Phenotype?
More informationEjner B rsting, Chief Geneticist, Danish Fur Breeders Association, 60 Langagervej, DK-2600 Glostrup Denmark
F U R B R E E D I N G Ejner B rsting, Chief Geneticist, Danish Fur Breeders Association, 60 Langagervej, DK-2600 Glostrup Denmark S U M M A R Y. The fur industry is a young partner in animal production.
More informationHeredity B Station 1. Examine the following karyotype.
Heredity B Station 1 Examine the following karyotype. 1. What gender is this individual? a. male b. female c. indeterminate d. you cannot tell from this type of diagram 3. Which is true about this karyotype?
More informationUnderstanding Heredity one example
204 Understanding Heredity one example We ve learned that DNA affects how our bodies work, and we have learned how DNA is passed from generation to generation. Now we ll see how small DNA differences,
More informationMRSA in the United Kingdom status quo and future developments
MRSA in the United Kingdom status quo and future developments Dietrich Mack Chair of Medical Microbiology and Infectious Diseases The School of Medicine - University of Wales Swansea P R I F Y S G O L
More informationCytogenetic Investigation of Canine Soft Tissue Sarcomas. and Histiocytic Malignancies INFORMED CONSENT FOR PARTICIPANTS GOLDEN RETRIEVER
Cytogenetic Investigation of Canine Soft Tissue Sarcomas and Histiocytic Malignancies Matthew Breen PhD., FSB. - Principal Investigator NCSU College of Veterinary Medicine INFORMED CONSENT FOR PARTICIPANTS
More informationUnit 5 Guided Notes Genetics
Gregor Mendel Modern genetics began in the mid-1800s in an abbey garden, where a monk named documented inheritance in peas Medel s Work What is inheritance: used good experimental design used analysis
More informationAntibiotic resistance: the rise of the superbugs
Antibiotic resistance: the rise of the superbugs Allen Cheng Associate Professor of Infectious Diseases Epidemiology, Alfred Health; Monash University About me Specialist in infectious diseases Head, Infection
More informationLOOF statistics - BALINESE MANDARIN ORIENTAL SIAMESE. Kitten/litters statistics
Number of registrations per year LOOF statistics - BALINESE MANDARIN ORIENTAL SIAMESE Kitten/litters statistics (years refer to the pedigree number or to the RF registration certificate, the kittens who
More informationAppendix F. The Test-Curriculum Matching Analysis Mathematics TIMSS 2011 INTERNATIONAL RESULTS IN MATHEMATICS APPENDIX F 465
Appendix F The Test-Curriculum Matching Analysis Mathematics TIMSS 2011 INTERNATIONAL RESULTS IN MATHEMATICS APPENDIX F 465 TIMSS went to great lengths to ensure that comparisons of student achievement
More informationCAVALIER KING CHARLES SPANIEL POPULATION SURVEY
CAVALIER KING CHARLES SPANIEL POPULATION SURVEY 27 Arnold JACQUES www.of-maesllyn.be BELGIUM Cavalier King Charles Spaniel population survey 27 page 1 INTRODUCTION The purpose of this survey was to make
More informationIMPORT HEALTH STANDARD FOR THE IMPORTATION INTO NEW ZEALAND OF RABBIT MEAT FOR HUMAN CONSUMPTION FROM THE EUROPEAN COMMUNITY
IMPORT HEALTH STANDARD FOR THE IMPORTATION INTO NEW ZEALAND OF RABBIT MEAT FOR HUMAN CONSUMPTION FROM THE EUROPEAN COMMUNITY ANNEX A ASSIGNED NUMBERS (AN): 4C.2, 4D.1, 5C.2, 5D.1, 6C.1, 6D.2, Issued pursuant
More informationWHO global and regional activities on AMR and collaboration with partner organisations
WHO global and regional activities on AMR and collaboration with partner organisations Dr Danilo Lo Fo Wong Programme Manager for Control of Antimicrobial Resistance Building the AMR momentum 2011 WHO/Europe
More informationSpanish Water Dog Club. Annual Health Report 2017
Spanish Water Dog Club Annual Health Report 2017 Content Questions following 2017 - Health Seminar Health Report 2017 (highlights) Introduction CHG and NAD Eye Testing / Gonioscopy (update) Free Resources
More informationIncomplete Dominance, Co-Dominance, and Sex-linked dominance NON-MENDELIAN GENETICS
Incomplete Dominance, Co-Dominance, and Sex-linked dominance NON-MENDELIAN GENETICS INCOMPLETE DOMINANCE INCOMPLETE DOMINANCE Two alleles dominant and recessive Genotypes are the same as simple Mendelian
More informationDEN TALK VOLUME 1, ISSUE 4 UPCOMING PLAYDAYS. Oct 1, September 29 10am-2pm Erwin Park, McKinney, Texas. Letter from the President,
VOLUME 1, ISSUE 4 DEN TALK Oct 1, 2007 UPCOMING PLAYDAYS September 29 10am-2pm Erwin Park, McKinney, Texas November 24 10am ~2pm Erwin Park, McKinney Texas SWJRTN Trial Trial Chairs: Mitzi Day and Kay
More informationTHE DEVELOPMENT OF A RISK BASED MEAT INSPECTION SYSTEM SANCO / 4403 / 2000
FEDERATION OF VETERINARIANS OF EUROPE FVE/01/034 Final THE DEVELOPMENT OF A RISK BASED MEAT INSPECTION SYSTEM SANCO / 4403 / 2000 Members FVE COMMENTS Austria Belgium Croatia Cyprus Czech Republic Denmark
More informationCoat Colour. Lakeland Terrier
A Discussion of Coat Colour Genetics in the Lakeland Terrier Chapter 8 Liver By Ron Punter Liver/Chocolate/Brown - the bb gene A recessive Red homozygous for Liver gene will have a liver nose. The first
More information1 - Black 2 Gold (Light) 3 - Gold. 4 - Gold (Rich Red) 5 - Black and Tan (Light gold) 6 - Black and Tan
1 - Black 2 Gold (Light) 3 - Gold 4 - Gold (Rich Red) 5 - Black and Tan (Light gold) 6 - Black and Tan 7 - Black and Tan (Rich Red) 8 - Blue/Grey 9 - Blue/Grey and Tan 10 - Chocolate/Brown 11 - Chocolate/Brown
More informationMiniature Schnauzer Breed: Health & Avian Tuberculosis (MAC) Montgomery Dog Show Urs Giger Keijiro Mizukami
Miniature Schnauzer Breed: Health & Avian Tuberculosis (MAC) AMSC @ Montgomery Dog Show 2016 Urs Giger Keijiro Mizukami Section of Medical Genetics School of Veterinary Medicine University of Pennsylvania
More informationGENETIC DRIFT Carol Beuchat PhD ( 2013)
GENETIC DRIFT Carol Beuchat PhD ( 2013) By now you should be very comfortable with the notion that for every gene location - a locus - an animal has two alleles, one that came from the sire and one from
More informationPreserve genetic analysis for the swedish Vallhund
Preserve genetic analysis for the swedish Vallhund Mija Jansson (translated by Isabell Skarhall, 2017) 2015-01-12 In the wild it is of great importance that a species has a genetic variation in order for
More informationEuropean Medicines Agency role and experience on antimicrobial resistance
European Medicines Agency role and experience on antimicrobial resistance Regional Training Workshop on Antimicrobial Resistance (AMR) Responding to the global challenge of AMR threats: toward a one health
More informationQuestions About the PLN Research
Questions About the PLN Research Dr. Meryl Littman and Dr. Paula Henthorn, University of Pennsylvania School of Veterinary Medicine very kindly answered these questions for us. We want to thank them for
More informationGenetics Intervention
Genetics Intervention Vocabulary: Define the following terms on a separate piece of paper. allele autosome chromosome codominance dihybrid diploid dominant gene gamete haploid heterozygous homozygous incomplete
More informationMendelian Genetics SI
Name Mendelian Genetics SI Date 1. In sheep, eye color is controlled by a single gene with two alleles. When a homozygous brown-eyed sheep is crossed with a homozygous green-eyed sheep, blue-eyed offspring
More information3) DEFINITIONS: multiple alleles: polygenic traits: codominance: incomplete dominance: gene: allele: homozygous: heterozygous: autosomal: sex-linked:
WLHS / Biology / Unit 6 Genetics / Monson Name Date Per 1) Compare the processes of MITOSIS and MEIOSIS: How many daughter cells are produced? If the parent cell has 22 chromosomes, how many chromosomes
More informationSummary of the latest data on antibiotic consumption in the European Union
Summary of the latest data on antibiotic consumption in the European Union November 2012 Highlights on antibiotic consumption Antibiotic use is one of the main factors responsible for the development and
More informationAntimicrobial resistance (EARS-Net)
SURVEILLANCE REPORT Annual Epidemiological Report for 2014 Antimicrobial resistance (EARS-Net) Key facts Over the last four years (2011 to 2014), the percentages of Klebsiella pneumoniae resistant to fluoroquinolones,
More informationBiology 3201 Sex Linked Review Mr.Gillam Name:
Biology 3201 Sex Linked Review Mr.Gillam Name: A female has the chromosomes XX, while a male has the chromosomes XY. In sex-linked inheritance the genes are carried on the chromosome and as a rule and
More informationSimple Genetics Quiz
Simple Genetics Quiz Matching: Match the terms below to their correct definition. (1 point each) 1. heterozygous 2. homozygous 3. dominant 4. recessive 5. phenotype 6. Cystic Fibrosis 7. Sickle Cell Anemia
More informationSeed color is either. that Studies Heredity. = Any Characteristic that can be passed from parents to offspring
Class Notes Genetic Definitions Trait = Any Characteristic that can be passed from parents to offspring Heredity The passing of traits from parent to offspring - Blood Type - Color of our Hair - Round
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationAre Bull Terriers on their way to extinction?
Are Bull Terriers on their way to extinction? According to The Kennel Club Bull Terriers have an effective breed population of only 41.9 which means that it is at high risk of suffering detrimental effects
More informationGuide Dogs UK Breeding Programme. Rachel Moxon Canine Reproduction Research Associate
Guide Dogs UK Breeding Programme Rachel Moxon Canine Reproduction Research Associate www.guidedogs.org.uk History 1931 - first 4 British guide dogs trained 1959 - first brood bitch, a German shepherd named
More informationPre-AP Biology Tuesday February 20. Introduction to Pedigrees
Pre-AP Biology Tuesday February 20 Introduction to Pedigrees If you were absent: 1. See slides 3 7 for review question/answers 2. See slides 9 11 for background on how to read pedigrees 3. Try practice
More informationTOPIC 8: PUNNETT SQUARES
Page 1 TOPIC 8: PUNNETT SQUARES PUNNETT SQUARES 8.1: Definition A Punnett square is a device to help you predict the possible genotypes of the offspring if you know the genotypes of the parents. Because
More informationAKC Canine Health Foundation Grant Updates: Research Currently Being Sponsored By The Vizsla Club of America Welfare Foundation
AKC Canine Health Foundation Grant Updates: Research Currently Being Sponsored By The Vizsla Club of America Welfare Foundation GRANT PROGRESS REPORT REVIEW Grant: 00748: SNP Association Mapping for Canine
More informationThis document is a preview generated by EVS
EESTI STANDARD EVS-EN 13532:2002 Üldnõuded in vitro diagnostilistele enesekontrolli meditsiiniseadmetele General requirements for in vitro diagnostic medical devices for self-testing EESTI STANDARDIKESKUS
More informationHeredity and Genetics Noteguide (Spring Semester)
Heredity and Genetics Noteguide (Spring Semester) **Your test over this unit will include all in this packet and the one from last semester.** Multiple Alleles- A set of control a trait. Example: Blood
More informationSpaniel (Cocker) Varieties
Spaniel (Cocker) The breed's name comes from its original function, as he was used to hunt woodcock. The breed was not recognised as a separate variety until 1893 and until that time all the spaniels,
More informationTE 408: Three-day Lesson Plan
TE 408: Three-day Lesson Plan Partner: Anthony Machniak School: Okemos High School Date: 3/17/2014 Name: Theodore Baker Mentor Teacher: Danielle Tandoc Class and grade level: 9-10th grade Biology Part
More informationFCI World Championship in Heelwork to Music on June 2010 in the MCH MESSECENTER HERNING, Vardevej 1, DK-7400 Herning
FCI World Championship in Heelwork to Music on 25-27 June 2010 in the MCH MESSECENTER HERNING, Vardevej 1, DK-7400 Herning Wednesday, 02 June 2010 Dear HTM & Freestyle World Championship participant. Thank
More informationBell Ringer. Which features do you have that match your mother? Your father? Which of the following features do you have?
Bell Ringer Which features do you have that match your mother? Your father? Which of the following features do you have? Widow s Peak? Ability to roll your tongue? Attached earlobes? Simple Genetics Exploring
More informationOECD WORK ON AMR: TACKLING THE NEGATIVE CONSEQUENCES OF ANTIBIOTIC RESISTANCE ON HUMAN HEALTH. Michele Cecchini OECD Health Division
OECD WORK ON AMR: TACKLING THE NEGATIVE CONSEQUENCES OF ANTIBIOTIC RESISTANCE ON HUMAN HEALTH Michele Cecchini OECD Health Division Antimicrobial Resistance is a Global Threat Modern medicine and surgery
More informationCow Exercise 1 Answer Key
Name Cow Exercise 1 Key Goal In this exercise, you will use StarGenetics, a software tool that simulates mating experiments, to analyze the nature and mode of inheritance of specific genetic traits. Learning
More information