CURRICULUM VITAE. Associate Professor and Chair of Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade

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1 CURRICULUM VITAE Biographical information Name: Sasa M Trailovic Date of birth: January 28, 1963 Birthplace: Negotin, Serbia Citizenship: Serbian Current position: Business address: Associate Professor and Chair of Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade Bulevar oslobodjenja 18, Belgrade 11000, Serbia Phone: /355 sasa@vet.bg.ac.yu Home address: Pedje Milosavljevica 82/21, Belgrade Foreign languages: English Academic degrees and professional qualifications Post doctorate studies, College of Veterinary Medicine, Iowa State University, Iowa, USA 2001 Ph.D. Thesis in Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Serbia Thesis: Study of mechanisms of Ivermectine neurotoxic effects 1994 Master s Scientific Degree in Veterinary Medicine, Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Serbia Thesis: Investigations of furazolidone toxicity in rats 1989 DMV: Faculty of Veterinary Medicine, Belgrade, Yugoslavia 1981 High school, Negotin, Yugoslavia 1

2 Professional experience Present, Chair of Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Serbia Present, Chairman, Serbian Committee for Pharmacovigilance for Veterinary drugs, Medicines and Medical Devices Agency of Serbia Present, member and co-chair of the National Committee for Marketing Authorization of Veterinary Drugs, Medicines and Medical Devices Agency of Serbia Assistant Professor Dept. of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Serbia full time position Post doctorate research position, Iowa State University, College of Veterinary Medicine, Department of Biomedical Sciences (Professor Dr Richard Martin lab.) Training Instructor (100% appointment), Dept. of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Yugoslavia Teaching Instructor (100% appointment), Dept. of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Yugoslavia Teaching assistant (100% appointment), Dept. of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Yugoslavia 1989 Mixed veterinary practice, Veterinary Clinic Negotin, Serbia Professional affiliations -Serbian Association of Pharmacologist and Toxicologist -Serbian Veterinary Society -EUROTOX, European Societies of Toxicology Experience in the Marketing Authorization of Veterinary Drugs In accordance with a previously Low on medical products (Sl. list SRJ No 18/93), Dr Sasa Trailovic was author of more then 50 Pharmacological Experts Reports ( ) 2

3 and leader of more then 120 Reports of Acute Toxicology Testing ( ) in process of investigation and market authorization of the veterinary drugs. Research interests and ongoing projects -Investigations of pharmacological properties of nicotine and GABA receptors in mammalians and parasitic nematodes. -Investigation of physiology and pharmacology of neurotransmission in parasitic trematodes (F.magna) -Evaluation of field antiparasitic resistance in various food-production animal species (pigs, ruminants) in Serbia -Pharmacovigilance in veterinary medicine in Serbia and EU, harmonization and improvement -Improvement in teaching process and new curriculum according European Directive N 78/1027/EEC in Faculty of Veterinary Medicine, University of Belgrade (TEMPUS Project EC JEP : Serbia: reform at FVMB according to EU directive No: 78/1027/EEC) 01/05-01/10 PI - Sasa M. Trailovic, Ministry of Sciences Republic of Serbia, National Grant No : INVESTIGATIONS OF MECHANISMS OF RESISTANCE AND TOXICITY OF ANTHELMINTICS-GABA AND NICOTINIC AGONISTS 13,000 euros per year 04/08-04/09 - Sasa M. Trailovic, Ministry of Sciences Republic of Serbia, Technology Development Project of 20,119: DEVELOPMENT OF SOFTWARE REGULATED SYSTEM FOR INVESTIGATION ON ISOLATED ORGANS MD Thesis in Veterinary Pharmacology and Toxicology Investigation of furazolidone toxicity in rats, Faculty of Veterinary Medicine, University of Belgrade, Yugoslavia, PhD Thesis in Veterinary Pharmacology and Toxicology Study of mechanisms of Ivermectine neurotoxic effects Major-Professor: Professor Dr Vladislav M Varagic, Department of Pharmacology and Toxicology, School of Medicine, University of Belgrade. 3

4 Teaching experience Practical classes in Veterinary Pharmacology and Toxicology for 3rd year veterinary students (V and VI semester) 1. Drug Prescription in Veterinary Medicine [practical classes for students (n=10-30), 3 hours/week, 4 week training course] -Guidance on prescribing; Pharmacopoeia Yug Ed IV; Incompatibility; 3 hours/week, Student training (n=20-30) -Classification of veterinary drugs; 3 hours/week. Student training (n=20-30). -Prescription, writing; Official and Non-official preparations; Pharmaceutical formulations licensed in Serbia; 3 hours/2 weeks. Student training (n=20-30). 1. Training in Experimental Pharmacology and Toxicology [practical classes for students (n=10-20), 3 hours in laboratory/week, 15 weeks] -The influences of routes of drug administration on its effect in organism; 3 hours laboratory/week; Student evaluations (n=10-15) -Biological variations and the effects of drugs; 3 hours in laboratory/week; Student evaluations (n=10-15) -Dose-response relationship; 3 hours in laboratory/week; Student evaluations (n=10-15) -Drug interactions-synergism of drugs; 3 hours in laboratory/week; Student evaluations (n=10-15) -Drug interactions-antagonism of drugs; 3 hours in laboratory/week; Student evaluations (n=10-15) -Analgesics; 3 hours in laboratory/week; Student evaluations (n=10-15) -Local anesthesia; 3 hours in laboratory/week; Student evaluations (n=10-15) -General anesthesia; 3 hours in laboratory/week; Student evaluations (n=10-15) -Pharmacology of autonomic nervous system I - Adrenergic drugs; 3 hours in laboratory/week; Student evaluations (n=10-15) -Pharmacology of autonomic nervous system II - Cholinergic drugs; 3 hours in laboratory/week; Student evaluations (n=10-15) -Mechanisms of the antidote effects (examples); 3 hours in laboratory/week; Student evaluations (n=10-15) -Chemical-toxicological analysis; 3 hours in laboratory/week; Student evaluations (n=10-15) -Regulation in pesticides market; 1 hour's training/week; Student evaluations (n=10-15) 1998/2002 Practical classes in Experimental Pharmacology and Toxicology for postgraduate students 4

5 Course for postgraduate DVM students: Methods in Experimental Pharmacology -Isolated guinea-pig ileum -Isolated phrenic nerve-diaphragm preparation of the rat -Procedure on Rota-Rod -Barbiturate sleeping time -Convulsion models; anticonvulsant drugs -Direct recording of blood pressure in various experimental animals -Isolated Ascaris neuro-muscle preparation -Isolated Fasciola neuro-muscle preparation Course for postgraduate DVM students: Methods in experimental Toxicology -Acute Toxicity Tests Various Routes and Rates Statistical Analysis of Studies -Prolonged Toxicity Test -Chronic Toxicity Tests -Reproduction Tests -Skin and Eye Tests -Behavioral Tests Present Lectures in Pharmacology and Toxicology for 3rd year veterinary students (V and VI semester) Present, Lectures in course for postgraduate MD students (School of Medicine, University of Belgrade): Experimental Methodology in Medical Research Present, Lectures in course for postgraduate VMD students: Experimental animals and experimental models. 5

6 Refereed publications 1. Trailovic S.M., Ivanovic S.R., Varagić V.M.: Ivermectin effects on motor coordination and contractions of isolated rat diaphragm, Res Vet Sci., [Epub ahead of print], Trailovic M.S., Robertson P.A. and Nedeljkovic-Trailovic J.: INHIBITORY EFFECT OF EUGENOL ON RAT ILEAL MOTILITY IN VITRO, Acta Veterinaria (Beograd), Vol. 59, No. 2-3, , Sasa M. Trailovic, Saurabh Verma, Cheryl L. Clark, Alan P. Robertson, and Richard J. Martin: Effects of the muscarinic agonist, 5-methylfurmethiodide, on contraction and electrophysiology of Ascaris suum muscle, International Journal of Parasitology, 38(8-9): , Trailovic S.M., Varagic V.M.: The Effect of Ivermectin on Convulsions in Rats Produced by Lidocaine and Strychnine, Vet Res Commun. 31, , S.M. Trailovic, Milanka B. Jezdimirovic, V. Krstic: Pharmacotherapy of stomach diseases in dogs, Veterinarski glasnik, Vol 59, (1-2), pp , S.M. Trailovic, A. P. Robertson, C. L. Clark and R. J. Martin: BRIEF APPLICATION OF AF2 PRODUCES LONG LASTING POTENTIATION OF nachr RESPONSES IN ASCARIS SUUM, Molecular and Biochemical Parasitology, 139 (1): 51-64, Ivanovic S.. Milanka Jezdimirovic, Trailovic S.M.. Milovanovic Mirjana and Pejcic Zorica: Investigation of influence of active herbal ingredijent Eugenol on rat inestinale passage, Veterinary Journal of Republic of Srpska, Vol V, No 1-2, pp 71-75, Trailovic S.M., Jezdimirovic Milanka, Ivanovic S.: Investigation of Eugenol effects on isolated rat ileum, Veterinary Journal of Republic of Srpska, Vol V, No 1-2, pp 76-80, R. J. Martin, C. L. Clark, S. M. Trailovic and A. P. Robertson: Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol, 34(9): , Sasa M. Trailovic, Alan P. Robertson, Cheryl L. Clark & Richard J. Martin: Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest CaM kinase and tyrosine kinase regulate sensitivity to levamisole, J Exp Biol 205, , Alan P. Robertson, Cheryl L. Clark, Teresa Burns, David P. Thompson, Timothy G. Geary, Sasa M. Trailovic and Richard J. Martin: Praherqamide and 2-Deoxy- 6

7 paraherqamide distinguish cholinergic receptor subtypes in Ascaris muscle, Journal of Pharmacology and Experimental Therapeutics, Vol 302, No 3, , Jezdimirovic M., Cupic V., Trailovic S.M., Milovanovic M.: Drug therapy of gastrointestinal tract diseases in piglets, Veterinarski Glasnik, Vol 50, No 1-2, , Jezdimirovic M., Varagic V., Trailovic S.M., Zivanov D.: Rational pharmacotherapy of skin diseases in small animals. Veterinarski Glasnik, Vol 48, No 7, , Trailovic S.M., Zivanov D., Knezevic M: Effects of multiple closantel administration on body weight and red blood count of experimental animals. Veterinarski Glasnik, Vol 46, No 1, 17-20, Trailovic S.M., Knezevic M., Zivanov D.: Pathomorphologic changes in rat organs after multiple closantel application. Veterinarski Glasnik, Vol 46, No 2, , Jezdimirovic M., Zivanov D., Trailovic S.M.: Bronchodilatators in therapy of chronic obstructive pulmonary disorders (COPD) in horses, Veterinarski Glasnik, Vol 46, No 11-12, , Trailovic S.M., Zivanov D.: Closantel toxicity after prolonged repeated application. Veterinarski Glasnik, Vol 45 No 11-12, pp , Tesic M., Stankov M., Trailovic S.M., Basaric-Dinic Lj., Pejin I.: The effect of artificially reproduced voice of the boar on estrus induction and production performance in gilts. Acta Veterinaria, Vol 41 No 1, 33-40, Books Trailovic S.M., Milovanovic Mirjana, Pejcic Zorica: Veterinary Pharmacography, Faculty of Veterinary Medicine, Belgrade, Serbia and Montenegro, Trailovic S.M.: Drugs and doses in therapy of equine respiratory diseases, in Equine Respiratory Diseases, Ed: Trailovic D. Trailovic S.: Drugs and doses in therapy of equine respiratory diseases, in Equine Respiratory Diseases, Ed: Trailovic D., Faculty of Veterinary Medicine, Belgrade, Proceedings Trailovic S.M., Milanka Jezdimirovic: Pharmacotherapy of gastric diseases in dogs, Proceedings of the XVI Conference of Veterinarians of Serbia, pp 67-69, Zlatibor, September 8-10, (Invited lecture). 7

8 Trailovic S.M., Trailovic D.R.: Basic principles of pharmacotherapy in horse lameness, Proceedings of the V Symposium Clinica Veterinaria. pp , Trailović S.M.: Antibiotics in poultry production - equalization with European Regulative, Živinarstvo, No. 8-9, pp , Pejcic Zorica, Jezdimirovic Milanka, Trailovic S.M., and Milovanovic Mirjana: Differences in efficacy and toxicity between some synthetic pyrethroiodes, Proceedings of the XV Symposium: Disinfection, Disinsectization, Deratization and Decontamination in protection of life environment, pp , Tara, May 20-23, Jezdimirovic Milanka, Trailovic S.M., Milovanovic Mirjana and Pejcic Zorica: New Spasmolytics in Veterinary Practice, Proceedings of the V Symposium Clinica Veterinaria, pp , (Invited speaker, article in full text). Trailovic S.M., Jezdimirovic Milanka: Improvement in Pharmacotherapy of Endoparasitic infection in Animals, Proceedings of the V Symposium Clinica Veterinaria, pp , (Invited speaker, article in full text). Richard Martin, G. Bai, S. Trailovic, C. Clark and A. Robertson: Levamisole Receptor Phosphorylation: Effect of kinaze Antagonists in Ascaris Suum, Siggest CaM Kinase and Tyrosine Kinaze Regulates Sensityvity to Levamisole and Could Be Involved in Drug Resistance, Proceedings of The 10th International Congress of Parasitology, ICOPA X, Vancouver, Canada, August 4-9, (Invited speaker, article in full text). Trailovic S.M., Jezdimirovic Milanka: Study of Avermectines neurotoxic effects, Proceedings of the IV Symposium Clinica Veterinaria, pp , (Invited speaker, article in full text) Jezdimirovic Milanka, Cupic V., Trailovic S.M., Pejcic Zorica: Veterinary toxicology, present positions and perspectives. Proceedings of the IV Symposium Clinica Veterinaria, pp , Budva, Jun 10-14, (Invited speaker, article in full text) Jezdimirovic Milanka, Cupic V., Trailovic S.M., Milovanovic MIrjana: Interaction between drugs and pesticides, Proceedings of the XII Symposium: Disinfection, Disinsectization, Deratization and Decontamination in protection of life environment pp 39-51, Banja-Junakovic, Apatin May, 2001 (Invited speaker, article in full text) Jezdimirovic Milanka, Trailovic D., Trailovic S.M., Cupic V.: Monitoring and recordings of adverse effects of veterinary drugs, Proceedings of the II Symposium Clinica Veterinaria, pp , Budva, Jun 12-16, (Invited speaker, article in full text) Trailovic M.S., Jezdimirovic Milanka, Cupic V.: Prevention and therapy of adverse drugs effects, Proceedings of the II Symposium Clinica Veterinaria pp , Budva, Jun 12-16, (Invited speaker, article in full text) 8

9 First author abstracts and poster presentations Trailovic S.M., Jezdimirovic B. Milanka, Djurdjevic D: Influence of ivermectine on tiopentone sleeping-time and motor coordination in rat, Veterinary Pharmacology and Therapeutics, Proceedings of The European Association for Veterinary Pharmacology and Toxicology, Vol 26, Supp 1, Trailovic S.M., Jezdimirovic Milanka: Comparative protective effect of ivermectin on convulsions produced by lidocaine and strychnine, 8th International Congress of The European Association for Veterinary Pharmacology and Toxicology (EAVPT), Jerusalem, Israel, July 30- August 3, Trailoivic S.M., Jezdimirovic Milanka: Influence of Ivermectin and Flumazenil on barbiturate sleeping time in rats, 2nd European Congress of Pharmacology, Fundamental & Clinical Pharmacology, vol 13/Supp. 1, p 221,