The South African AMR strategy. 3 rd Annual Regulatory Workshop Gavin Steel Sector wide Procurement National Department of Health; South Africa
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1 The South African AMR strategy 3 rd Annual Regulatory Workshop Gavin Steel Sector wide Procurement National Department of Health; South Africa
2 Background to AMR 2
3 What is Antimicrobial stewardship and resistance? Antimicrobial stewardship (AMS) is a multi-disciplinary, systematic approach to optimising the appropriate use of all antimicrobials to improve patient outcomes and limit emergence of resistant pathogens whilst ensuring patient safety. Antibiotic: any of a large group of chemical substances, such as penicillin, having the capacity to inhibit the growth of, or to destroy bacteria and other microorganisms, used chiefly in the treatment of infectious diseases Antimicrobial: an agent such as a drug that destroys or inhibits the growth of a microorganism Antimicrobial resistance (AMR): the ability of a microorganism to withstand treatment with an antimicrobial drug
4 Background Antimicrobial resistance (AMR) is a major global public health crisis. The Global Action Plan (GAP) objectives, adopted by the 68 th World Health Assembly in May 2015 calls for the countries to put in place their own Action plans to address AMR The development and implementation of a national AMR strategy that complements international efforts is a major step towards containment of the growing threat of AMR in human and animal health. The AMR Strategy Framework has been approved The Implementation Plan that puts these strategic objectives into effect has also been developed
5 Why do we need an AMR strategy Multidrug resistant TB (MDR TB) and implementation plan? South Africa s triple burden of AMR Multidrug resistant organisms The AMR strategy and implementation plan is a template for all multidrug resistant organisms Drug resistant HIV DRHIV Multi drug resistant organisms (MDR) Bacteria and Fungi
6 How serious is AMR in SA? SAMJ situational analysis 2011 The situational analysis identified numerous multidrug resistant organism concerns and resource constraints limiting implementation of good infection control practices and antimicrobial stewardship programs
7 Key AMR organisms baselines Available surveillance data from both the public and private sectors over the period have been aggregated and combined to create the baseline results for 3 key multidrug resistant organisms. The baseline findings are that all three organismantibiotic combinations show statistically significant change over time: Staphylococcus aureus and cloxacillin significant decrease in resistance over 3 years (p<0.001) - currently resistance is at 30% Klebsiella pneumoniae and carbapenems significant increase in resistance over 3 years (p<0.001) - currently resistance is at 3,2% Escherichia coli and ciprofloxacin no change in resistance over the 3 years (p=0.83) - currently resistance is at 27% Resistance Maps generated by CDDEP using Private sector data as collected by SASCM (South Africa Society of Clinical Microbiologists) and public sector data as collected through the 21 sentinel sites by the NICD (National Institute for Communicable Diseases). 7
8 Therefore we need to implement Antimicrobial Stewardship at all levels We need to better manage our antimicrobial resistance, to limit further increases in resistant microbial infections, and improve patient outcomes. We can achieve this through: Preventing infections in the first place through good Infection Prevention & Control practices and immunisations Rational and prudent Antimicrobial use a The purpose of the AMR Strategic framework is to provide structure for managing AMR, to limit further increases in resistant microbial infections, and improve patient outcomes
9 The AMR journey that South Africa undertook 9
10 The South African AMR initiative started at the summit in October Brought together key stakeholders from government, laboratory services, clinician societies, civil societies and regulatory bodies 10
11 The summit culminated in all stakeholders signing a commitment to
12 Stakeholder committed to work collaboratively, to invest resources and implement sustainable strategies and intervention to manage AMR in South Africa 1. To collaborate as intersectoral, interdisciplinary organisations and departments to strengthen, co-ordinate and institutionalise efforts to address Antimicrobial Resistance 2. To establish a national surveillance system to track and report resistant organisms and Antimicrobial use in agriculture and human health 3. To enhance the processes, structures, resources and supplies needed for effective Infection Prevention & Control 4. To promote the appropriate use of Antimicrobials in human and animal health through antimicrobial stewardship in facilities and suitable enabling legislation and regulations 5. To build the expertise and strengthen the competency of health and veterinary professionals and improve the staffing levels of the workforce in Antimicrobial Resistance and Infection Prevention & Control 6. To increase the community awareness of Antimicrobial Resistance 7. To promote research into novel diagnostics and clinical trials in Infection Prevention & Control and Antimicrobial Resistance 12
13 Enablers Strategic objective Pillars of the South African AMR Strategy Framework Impact: Rational Antimicrobial use and improved patient outcomes Antimicrobial resistance Governance Diagnostic stewardship Enhance Surveillance Antimicrobial Stewardship Prevention including IPC and vaccination Health systems strengthening, research, education and communication
14 Objectives of the South African AMR Strategy Framework Strategic objective 1: Strengthen, coordinate and institutionalize interdisciplinary efforts through national and health establishment level governance structures 2: Optimise surveillance and early detection of antimicrobial resistances to enable reporting 3: Enhance infection prevention and control of the spread of resistant microbes to patients in healthcare settings, wide-reaching vaccination programmes and improvements in water and sanitation; and 4: Promote appropriate use of antimicrobials in human and animal health through antimicrobial stewardship. Strategic Enablers Legislative and policy reform for health systems strengthening to support the quality of antimicrobials and to enable control over prescribing of antimicrobials in the animal health sector Education of all levels of health providers in human health and agriculture in the critical concepts of antimicrobial stewardship, infection control, infectious diseases, microbiology and pharmacology Communication to educate the public, create awareness and enhance patient advocacy of the dangers of inappropriate antimicrobial use Research into novel diagnostics such as point of care testing and clinical trials of treatment duration, antimicrobial consumption plus new antimicrobials. The AMR implementation plan describes the activities needed to effect the strategy
15 Infection Prevention & Control Strategic Objective Enhance infection prevention and control of the spread of resistant microbes to patients in healthcare settings, widereaching vaccination programmes and improvements in water and sanitation 16
16 Infection Prevention & Control Strategic Objective Prevention of infection is a key step in reducing the need for antibiotic use. Therefore preventing and controlling the spread of resistant microorganisms would include a focus on: Preventing new infections through an effective immunisation campaign as part of EPI and seasonal prevention strategies Prevent and control the spread of resistant organisms at health facility level through: Improvements in basic infection control techniques such as hand hygiene and use of Personal Protective Equipment Ensuring that the Infection Prevention & Control practitioners are sufficient in number and sufficiently qualified to perform their functions according to the standards required Improvement in the availability of cleaning and IPC supplies Improved planning of health establishments infection control infrastructure needs 17
17 Infection Prevention and Control Activities in Implementation plan Output Activity Availability of IPC supplies and equipment 1 Update the list of non-negotiable IPC supplies and cleaning supplies 2 Improve the availability at Health establishment level of non negotiable IPC supplies 1 Evaluate the IPC gaps in standards to determine interventions required IPC that meets standards at Health Establishment level 2 Strengthen the implementation of the core standards for IPC through the reinforcement of the ICAT manual and Infection Prevention & Control guidelines and Quality improvement methodology 3 Improve hand hygiene through awareness days 4 Ensure staffing norms for IPC practitioners are put in place Improved immunisation uptake 1 Determine interventions to address gaps and promote appropriate immunisation uptake 2 Encourage seasonal vaccine uptake 18
18 Infection Prevention and Control Activities in Implementation plan Output Activity Recognition of IPC practitioners as a cadre of staff Collaborate with SANC to determine standard Infection Prevention & Control practitioner qualifications and recognition Clearly define the roles and responsibilities and competencies of the IPC practitioner in the Health Establishment Assess the availability and competencies of IPC practitioners at Health establishment and District level against norm 4 Develop a HRD strategy to address gaps in competency and number of IPC practitioners 5 Establish IPC practitioners in all health establishment as per norms agreed 19
19 Infection Prevention & Control Strategic Objective INFECTION PREVENTION AND CONTROL NDOH Communicable disease unit to take on role of IPC : New IPC specialist post to be motivated for a suitable candidate to Implement the IPC guidelines and policy Linkage between National IPC and the already established IPC structures at facility, district and province level needs to be determined Standardise surveillance system and reporting of infections to be developed Monitoring and evaluation systems to be put in place to determine implementation against policy and NCS 20
20 Office of Health Standards Compliance provides the regulatory support The facility level requirements for implementation of IPC is prescribed within the Norms & Standards for health facilities protect and promote the health and safety of the healthcare users and staff They place an obligation on the health facility to implement the systems and processes within their clinical units to ensure compliance to these standards and therefore provides the traction and an enforcement mechanism for the AMS policy
21 Medicines Control Council (MCC) REGULATORY SUPPORT Commodities required for AMS: Quality Antimicrobials, vaccines, diagnostics & IPC products. Expedited review of novel health technologies. Vaccination Policy Seasonal. Clinical trials Education Uninterrupted supplies 22
22 Thank you
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