Parasite control in a class of its own

Transcription

1 Cydectin (moxidectin) PourOn PourOn Parasite control in a class of its own

2 The true cost of parasites How long would it take you to notice if your cattle had a parasite infection? Chances are that by the time cattle show clinical signs, the infestation has been progressing for some time. The true cost of parasitism occurs with subclinical infection, when symptoms are not as obvious. The damage that can take place is often hidden, but it can still influence the health and performance of your cattle. Neglecting parasite control has been shown to cause as much as $190/head in economic loss in North American cattle over the lifetime of the animal. 1 The importance of strategic deworming Most parasites are found out in the pasture, beginning as eggs in the fecal deposits of cattle that are already infested. When you treat in the fall, you are only targeting the 5% of the parasite population that have infested cattle. When treating in the spring, you target the 95% of the parasite population that have already infected and are currently infecting cattle through their grazing behavior. 6 Clinical signs: Diarrhea Bottle jaw Anemia Rough hair coat Subclinical signs: Reduced milk production 2 Reduced reproductive performance 2 Reduced milk quality 3 Increased susceptibility to disease 4 Reduced growth rate 2 Reduced weaning weight 5 A strategic deworming program aims to interrupt the lifecycle of the parasite. It is recommended to deworm twice a year in most areas of the country.* In the fall when gathering or during preg checks to kill any parasites currently infecting the animal In the spring at the beginning of grass greenup, before turn out, or before branding to kill parasites that cattle ingest through their grazing behavior 5% 95% Spring deworming Targets 95% of the parasite population 6 Fall deworming Targets 5% of the parasite population 6 By minimizing parasite exposure in the fall, animals are more likely to remain healthy over the winter. Treated cattle are less likely to shed additional parasite eggs through their feces, helping keep pastures from becoming recontaminated. Deworming twice a year is essential to helping minimize the damage parasites can cause.* *Consider a third deworming in the summer in areas with a longer growing season (i.e., the Deep South).

3 Combining strategy with efficacy in a class of its own To reap the benefits of strategic deworming, it s critical to use an effective product at the most strategic times. So why should you choose Cydectin (moxidectin) PourOn? REASON # 1: Package Size #/head Convenient Cydectin PourOn is easy to use and offers multiple benefits: Zero milk/meat withdrawal allows for more flexibility in treatment timing Purple dye helps to identify treated cattle Weatherproof, oilbased formulation helps keep rain from washing away your investment Five userfriendly package sizes to fit all operations Dose = 1 ml for 22 lbs # of treatments for 1,100 lb cattle 500 ml 10 1 Liter Liter 50 REASON # 2: 5 Liter Liter 200 Unique active ingredient Cydectin is the only dewormer on the market in the milbemycin chemical class. All other dewormers are part of the avermectin chemical class. The active ingredient in Cydectin, moxidectin, has a unique molecular structure. This allows for greater distribution in the fat, which enables extended activity to kill key parasites longer. Milbemycins Cydectin (moxidectin) PourOn Macrocyclic Lactones Avermectins Ivomec (ivermectin) PourOn AgriMectin (ivermectin) PourOn/Generics Dectomax (doramectin) PourOn Eprinex (eprinomectin) PourOn

4 REASON # 3: Kills key parasites longer Cydectin (moxidectin) PourOn provides persistent activity against several key species, including the brown stomach worm (Ostertagia ostertagi), the costliest internal parasite of cattle in the United States. 7 Cydectin (moxidectin) PourOn Eprinex (eprinomectin) PourOn Brown Stomach Worm (Ostertagia ostertagi) 28 days Lungworm 42 days 21 days Nodular Worm 28 days Barberpole Worm 14 days Eprinex has no persistent activity against the brown stomach worm, 8 the parasite that causes both Type I and Type II Ostertagiasis Cydectin PourOn lasts twice as long as Ivomec Pouron against the brown stomach worm (28 days vs. 14 days) 8 Cydectin controls 37 parasite species and stages on beef and dairy cattle and offers persistent killing of internal parasites at multiple stages Increased persistency results in fewer parasite eggs shed, reduced pasture parasite levels and increased opportunities for weight gain.

5 REASON # 4: REASON # 5: Dung beetle friendly Controls lice, mange and more FPO STK $220 Dung beetles provide an estimated $380 million of economic benefit annually in the U.S. 9 Unlike other dewormers on the market today, Cydectin is the most dung beetle friendly. BENEFITS OF DUNG BEETLES Cydectin (moxidectin) PourOn controls Four species of biting and sucking lice Two species of mites: the common scab mite (Psoroptes ovis) and the chorioptic tail head mange mite (Chorioptes bovis) Two species of cattle grubs Cydectin PourOn provides Seven days of persistent activity against horn flies* Reduce cattle pests Healthy dung beetle populations have been shown to significantly reduce both horn fly and nematode populations Promote pasture productivity Through the incorporation of manure into the soil, pastures with dung beetles have been shown to have improved grass yield, equivalent to application of 200 lbs per acre of nitrogen fertilizer. 13 *For optimal control of horn flies, Cydectin should be used as part of an integrated control program utilizing other methods to provide extended control. Increase pasture access Nondegraded manure can create an area around the dung pat that cattle have been shown to avoid for up to two years. Dung beetles help raise the carrying capacity of the grazing area, so less total land is needed. 14 Cydectin is the only pouron labeled for the control of Psoroptes, which is a reportable disease requiring quarantine.

6 CYDECTIN moxidectin PourOn for Beef and Dairy Cattle Antiparasitic Contains 5 mg moxidectin/ml For Treatment of Infections and Infestations Due to Internal and External Parasites of Beef and Dairy Cattle Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism. If animals are likely to be reinfected following treatment, a strategic parasite control program should be established. Mode of Action: Moxidectin is an endectocide in the milbemycin chemical class which shares the distinctive mode of action characteristic of macrocyclic lactones. CYDECTIN (moxidectin) PourOn is specially formulated to allow moxidectin to be absorbed through the skin and distributed internally to the areas of the body affected by endo and/or ectoparasitism. Moxidectin binds selectively and with high affinity to glutamategated chloride ion channels which are critical to the function of invertebrate nerve and muscle cells. This interferes with neurotransmission resulting in paralysis and elimination of the parasite. Indications: CYDECTIN PourOn when applied at the recommended dose level of 0.5 mg/2.2 lb (0.5 mg/kg) body weight is effective in the treatment and control of the following internal [adult and fourthstage larvae (L 4 )] and external parasites of cattle: Gastrointestinal Roundworms Ostertagia ostertagi Adult and L 4 (including inhibited larvae) Haemonchus placei Adult and L 4 Trichostrongylus axei Adult and L 4 Trichostrongylus colubriformis Adult and L 4 Cooperia oncophora Adult and L 4 Cooperia pectinata Adult Cooperia punctata Adult and L 4 Cooperia spatulata Adult Cooperia surnabada Adult and L 4 Bunostomum phlebotomum Adult Nematodirus helvetianus Adult and L 4 Oesophagostomum radiatum Adult and L 4 Lungworms Dictyocaulus viviparus Adult and L 4 Cattle Grubs Hypoderma bovis Hypoderma lineatum Mites Chorioptes bovis Psoroptes ovis (Psoroptes communis var. bovis) Lice Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Bovicola (Damalinia) bovis Horn Flies Haematobia irritans Management Considerations for External Parasites: For most effective external parasite control, CYDECTIN PourOn should be applied to all cattle in the herd. Cattle entering the herd following this administration should be treated prior to introduction. Consult your veterinarian or a livestock entomologist for the most appropriate time to apply CYDECTIN PourOn in your location to effectively control horn flies and external parasites. CYDECTIN PourOn provides seven days of persistent activity against horn flies. For optimal control of horn flies, the product should be used as part of an integrated control program utilizing other methods to provide extended control. Persistent Activity: CYDECTIN PourOn has been proven to effectively control infections and protect from reinfection with Haemonchus placei for 14 days after treatment, Oesophagostomum radiatum and Ostertagia ostertagi for 28 days after treatment, and Dictyocaulus viviparus for 42 days after treatment. Efficacy below 90% was observed in some Ostertagia ostertagi persistent activity studies at 21 and 28 days posttreatment. Dosage: CYDECTIN (moxidectin) PourOn is a readytouse topical formulation intended for direct application to the hair and skin in a narrow strip extending along the top of the back from the withers to the tailhead (see Figure 1). Due to the angular topline characteristic of most dairy breeds, it is recommended that all pouron products be applied slowly to dairy cows. Apply to healthy skin avoiding any mange scabs, skin lesions, mud or manure. Treated cattle can be easily recognized by the characteristic purple color, which will remain for a short period of time after treatment. The recommended rate of administration is 1 ml for each 22 lb (10 kg) body weight which provides 0.5 mg moxidectin for each 2.2 lb (0.5 mg/kg) body weight. The table below will assist in the calculation of the appropriate volume of pouron which must be applied based on the weight of animal being treated. Body Weight Lb (kg) Dose ml Body Weight Lb (kg) Dose ml 88 (40) (150) (50) (200) (60) (250) (70) (300) (80) (350) (90) (400) (100) (450) (110) (500) (120) (550) (130) (600) (140) (650) 65 WITHERS TAILHEAD Figure 1. Where to Apply CYDECTIN PourOn Use Conditions: Varying weather conditions, including rainfall, do not affect the efficacy of CYDECTIN PourOn. Administration: CYDECTIN PourOn is available in three convenient package styles designed for ease of administration and the number of cattle to be treated. Directions for use of each container type follow: SqueezeMeasurePour System (16.91 fl oz/500 ml and fl oz/1 L Bottles) Determine the weight of the animal, calculate the recommended volume of CYDECTIN PourOn and locate the volume marker equivalent to this dose on the dosing chamber of the bottle. Remove the dosing chamber cap and squeeze the main chamber of bottle until the desired level of solution is present in the dosing chamber. Release pressure on the container to avoid further filling. Holding the dosing chamber as shown below, pour this measured volume of solution evenly along the backline of the animal from the withers to the tailhead (see Figure 1). DOSING CHAMBER VOLUME MARKER MAIN CHAMBER DOSING CHAMBER CAP Figure 2. SqueezeMeasurePour System (16.91 fl oz/500 ml and fl oz/1 L Bottles) Large Conventional Containers (84.54 fl oz/2.5 L and 169 fl oz/5 L Bottles and 338 fl oz/10 L Cubetainer) These bottles are designed for use with the CYDECTIN (moxidectin) PourOn applicators. Simply remove the transient cap and seal and replace with the vented cap. Attach the applicator feeder hose to the vented cap. Invert the container prior to use (2.5 L and 5 L containers only). Apply the recommended volume of CYDECTIN PourOn evenly along the backline of the animal from the withers to the tailhead (see Figure 1). APPLICATOR GUN FEEDER HOSE 2.5 L BOTTLE OF CYDECTIN SHOULDER STRAP VENTED CAP Figure 3. Large Conventional Containers (84.54 fl oz/2.5 L and 169 fl oz/5 L Bottles) APPLICATOR GUN FEEDER HOSE 10 L BOTTLE OF CYDECTIN VENTED CAP Figure 4. Large Conventional Container (338 fl oz/10 L Cubetainer) Animal Safety: Tolerance and toxicity studies have demonstrated an adequate margin of safety to allow treatment of cattle of all ages with CYDECTIN PourOn. No toxic signs were seen in cattle given up to 25 times the recommended dose level. Newborn calves similarly showed no toxic signs when treated with up to three times the recommended dose level within 12 hours of birth and nursing from cows concurrently treated with the recommended dose level of CYDECTIN PourOn. In breeding animals (bulls and cows in estrous and during early, mid and late pregnancy), treatment with three times the recommended dose level had no effect on breeding performance. Warning: Not For Use In Humans. Keep this and all drugs out of the reach of children. This product can cause irritation to skin, eyes, or mucous membranes. In case of accidental skin contact and/or clothing contamination, wash skin thoroughly with soap and water and launder clothing with detergent. In case of accidental eye contact, flush eyes with copious amounts of water. When direct inhalation occurs, cleanse lungs and respiratory passages with fresh air. In case of ingestion do not induce vomiting and seek medical attention immediately. If irritation or any other symptom attributable to exposure to this product persists, consult your physician. To obtain a copy of the material safety data sheet (MSDS) which provides more detailed occupational safety information or to report adverse reactions attributable to exposure to this product, call Residue Warning: When used according to label directions, neither a preslaughter drug withdrawal period nor a milk discard time are required. Meat and milk from cattle treated with CYDECTIN (moxidectin) PourOn may be used for human consumption at any time following treatment. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. Precautions: For external use only. Do not apply to areas of skin with mange scabs, skin lesions, mud or manure. CYDECTIN PourOn is not recommended for use in species other than cattle. This product has been formulated specifically for topical use in cattle and should not be used in other animal species or by other routes of administration as adverse reactions may occur. CYDECTIN PourOn is effective against the migrating stage of cattle grubs (Hypoderma larvae). Treatment with CYDECTIN PourOn during the period when grubs are migrating through vital areas may cause undesirable hostparasite reactions. Killing H. lineatum when they are located in periesophageal tissues may cause bloat. Killing H. bovis when they are in the vertebral canal may cause staggering or hindlimb paralysis. Cattle should be treated as soon as possible after heel fly (warble fly) season to avoid this potential problem. Cattle treated with CYDECTIN PourOn at the end of fly season can be retreated during the winter without danger of grubrelated reactions. Consult your veterinarian for more information regarding these secondary grub reactions and the correct time to treat with CYDECTIN PourOn. Environmental Safety: Studies indicate that when moxidectin comes in contact with the soil it readily and tightly binds to the soil and becomes inactive. Free moxidectin may adversely affect fish and certain aquatic organisms. Do not contaminate water by direct application or by improper disposal of drug containers. Storage: Store product at or below room temperature. Avoid prolonged exposure above 25 C (77 F). If product becomes frozen, thaw completely and shake well prior to use. Disposal: Dispose of containers in an approved landfill or by incineration. Package Information: CYDECTIN PourOn is available in five convenient container sizes. The fl oz/500 ml and fl oz/1 L are packaged in speciallydesigned squeezemeasurepour polyethylene bottles. When treating larger numbers of cattle, fl oz/2.5 L, 169 fl oz/5 L, or 338 fl oz/10 L conventional polyethylene containers are available for use with most commerciallyavailable topical applicators. U.S. Patent No. 6,514,951 Bayer HealthCare, LLC, Animal Health Division, Shawnee Mission, Kansas Made in Italy Bayer, the Bayer Cross and Cydectin are registered trademarks of Bayer Bayer Restricted Drug (CA) Use Only As Directed NADA , Approved by FDA February, 2017 LV1702

7 Cydectin (moxidectin) PourOn is the #1selling pouron cattle dewormer 15 Has a unique active ingredient not found in other dewormers Provides 28 days of persistent activity against brown stomach worm (Ostertagia ostertagi) Approved for zero slaughter withdrawal Approved for zero milk discard Features a highly visible purple marker dye Weatherproof Nonflammable Most dung beetle friendly Milbemycin Cydectin PourOn Ivomec PourOn AgriMectin PourOn/ Generics Avermectin Dectomax PourOn Eprinex PourOn Learn more at BayerLivestock.com For further technical information, please call Bayer Veterinary Technical Services at For customer service, please call Lawrence JD, Ibarburu MA. (2007). Economic analysis of pharmaceutical technologies in modern beef production. In: Proceedings of the NCCC134 Conference on Applied Commodity Price Analysis, Forecasting, and Market Risk Management; April 1617; Chicago, IL. Available at: Accessed April 19, Gadberry S, Powell J. Internal parasites in beef and dairy cattle. University of Arkansas Division of Agriculture Cooperative Extension Service website. Available at: Accessed April 4, Taylor MA, Coop RL, Wall RL. (2007). Veterinary Parasitology. 3 rd ed. Oxford, UK: Blackwell Publshing Ltd; Smith RA, Rogers KC, Huse S, et al. (2000). Pasture deworming and (or) subsequent feedlot deworming with fenbendazole. I. Effects on grazing performance, feedlot performance and carcass traits of yearling steers. Bovine Practitioner. 34(2): Stromberg BE, Vatthauer RJ, Schlotthauer JC, et al. (1997). Production responses following strategic parasite control in a beef cow/calf herd. Vet Parasitol. 68(4): Stromberg BE, Averbeck GA. (1998). What s new for parasite control in cattle. University of Minnesota Digital Conservancy website. Available at: edu/bitstream/handle/11299/117341/stromberg.pdf?sequence=1. Accessed May 15, Elsener J, Villeneuve A, DesCôteaux L. (2001). Evaluation of a strategic deworming program in dairy heifers in Quebec based on the use of moxidectin, an endectocide with a long persistency. Can Vet J. 42(1): Based upon comparisons of FDAapproved label indications. 9 Losey J, Vaughan M. (2006). The economic value of ecological services provided by insects. BioScience. 56(4): Bornemissza GF. (1970). Insectary studies on the control of dung breeding flies by the activity of the dung beetle, Onthophagus gazella F. (Coleoptera: Scarabaeinae). Aust Entomol. 9(1): Fincher GT. (1975). Effects of dung beetle activity on the number of nematode parasites acquired by grazing cattle. J Parasitol. 61(4): Fincher GT. (1973). Dung beetles as biological control agents for gastrointestinal parasites of livestock. J Parasitol. 59(2): Fincher GT, Monson WG, Burton GW. (1981). Effects of cattle feces rapidly buried by dung beetles on yield and quality of coastal bermudagrass. Agron J. 73(5): Anderson JR, Merritt RW, Loomis EC. (1984). The insectfree cattle dropping and its relationship to increasing dung fouling of rangeland pastures. J Econ Entomol. 77(1): Sales data as of from independent thirdparty market research. Keep out of reach of children Bayer, Shawnee Mission, KS Bayer, the Bayer Cross and Cydectin are registered trademarks of Bayer. AgriMectin is a registered trademark of Agri Laboratories Ltd. Dectomax is a registered trademark of Zoetis Inc., its affiliates and/or its licensors. Eprinex and Ivomec are registered trademarks of Merial. CY17166 IMPORTANT SAFETY INFORMATION: When used according to label directions, neither a preslaughter withdrawal period nor a milk discard time is required. Do not use in calves to be processed for veal. For external use only. Do not apply to areas of skin with mange scabs, skin lesions, mud or manure. Cydectin PourOn is not recommended for use in species other than cattle.