Impact of the «One Health» approach in public health Example of the EJP on Foodborne Zoonoses

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1 Impact of the «One Health» approach in public health Example of the EJP on Foodborne Zoonoses By CORDEVANT Christophe ANSES Strategy and Programme Department Research and Reference Division Biorisk Meeting, Anses, Maisons-Alfort 22 May 2018 This meeting is part of the European Joint Programme One Health EJP. This project has received funding from the European Union s Horizon 2020 research and innovation programme under Grant Agreement No

2 The concept of One health No single definition of One Heath; scope can be very large Broad sense: Eco-Health, Global Health, Planetary Health In the narrow sense (FAO) A collaborative, international, cross-sectoral, multidisciplinary mechanism to address threats and reduce risks of detrimental infectious diseases at the animal-human-ecosystem interface. Interface between human and animal Med Vet approach Source: OIE - 2

3 One Health EJP EU cofund initiative HORIZON Work Programme Area : Food security, sustainable agriculture and forestry, marine and maritime and inland water research and the bioeconomy healthy and safe foods and diets for all Call SFS : "One Health" (zoonoses emerging threats) Publication date: 14 October 2015 Deadline: 14 February 2017 Type of action: European Joint Programme - EJP Duration : 5 years Selected in Cofund: 90 M October Partnership: 41 partners /19 Members States

4 OH EJP Kick off meeting Jan 2018 "One Health EJP started on January 2018 Launch meeting - 30 & 31 January at ANSES 40 partners from 19 Member States 140 participants: project partners, Ministries of Health, Agriculture, Research, EFSA, ECDC, DG Agri & Health and REA 4

5 One Health EJP Concept - Following a One Health approach Med-Vet Partnership - The EJP aims to create a sustainable European One Health framework - By alignment and integration of medical, veterinary and food institutes strategies and expertise - Through joint programming of national research agendas and by funding research projects - Matching the needs of European and national policy makers and stakeholders 5

6 One Health EJP scope Vector borne Direct (Air, Contact) Environment Food 6

7 One Health EJP scope Food Borne Zoonose (FBZ) Bacteria Viruses Prions Parasites One Health Zoonoses Antimicrobial Resistance (AMR) Transmission by food or not (2/3) (1/3) 85% Emerging threats (ET) Zoonotic potential suspected NFBZ FBZ 15% 7

8 One Health EJP consortium A European network of public research institutes on food safety EJP FP6 Network of Excellence 7 Med + 7 Vet/Food = 14p Foodborne zoonoses Association (Loi 1901) A self-sustained Network 20 Research institutes Foodborne zoonoses Cofund EJP H2020 Network 40 Research institutes Foodborne zoonoses 8 A Pre-existing network looking for a long term sustainability plan

9 One Health EJP consortium Austria Belgium Bulgaria Czech Republic Denmark Estonia France Germany Hungary Ireland Italy Netherlands Norway Poland Portugal Romania Spain Sweden United Kingdom 9

10 One Health EJP The criteria to select a partner MS have been established by the consortium and in agreement with the EC 1. Mandates of reference 2. Scientific production in zoonoses 3. Networking activities in that field IRELAND VET2 IRELAND VET ESTONIA VET2 ESTONIA VET1 ESTONIA MED consortium ROMANIA VET ROMANIA MED IRELAND MED Portugal MED 5 Portugal VET CZECH 4 CZECH 3 GREECE MED1 2 GREECE MED2 1 0 GREECE VET BULGARIA BULGARIA SWEDEN MED BULGARIA VET AUSTRIA CROATIA MED ISRAEL VET CROATIA VET SERBIA VET REFERENCE SCIENCE NETWORK Country Programme manager Med AT BE WIV-ISP AGES CODA-CERVA BG NCIPD NDVRI Stefan Angeloff Ins (LTP) CZ SZU/NIPH VRI DE RKI BfR FLI DK SSI DTU EE University of Tartu VFL ES ISCIII INIA UCM (VISAVET) EU FR GB MVNA PHE APHA Surrey Univ ANSP (LTP) ANSES Institut Pasteur de Paris INRA HU NCE IVMR IE NUIG TEAGASC IT NL ISS IZS AM Teramo IZS LER Brescia RIVM WR NCOH (LTP) NO FHI/NIPH NVI PL NIZP-PZH/NIPH-NIH PIWET/NVRI PT INSA INIAV RO CNIR IISPV SE PHAS NFA SVA 19 countries + 1 association Programme manager Vet 43 Full Members Partners LTP + MedVetNet Association 10

11 One Health EJP governance EC REA Programme Managers Committee (PMC) Directors/CEO Scientific Steering Board (SSB) Scientific Directors / Head of Dpts Programme Owners Committee ( POC ) (Ministry of authority) External Scientific Advisory Board (ESAB) Stakeholders Committee Support Team (ST) Project Management Team (PMT) Coordinator + WP leaders Ethics Advisors National Mirror Groups (NMG) 11

12 EJP Kick off meeting participants 14/41 Programme Managers Committee (PMC) 15/44 Committee ( POC ) (Ministry of authority) EC REA Directors/CEO Scientific Steering Board (SSB) Scientific Directors / Head of Dpts 38/41 External Scientific Advisory Board (ESAB) Stakeholders Committee Support Team (ST) Project Management Team (PMT) Coordinator + WP leaders 13/13 Ethics Advisors 12 National Mirror Groups (NMG)

13 One Health EJP structure Arjen van de Giessen Hein Imberechts Ann Lindberg Roberto La Ragione Annemarie Kaesbohrer Andre Jestin Luca Busani 13

14 One Health EJP dynamics 14

15 EJP preparation - SRA & 1 st Internal Call WP2 Integrative SRA Strategic Research Agenda (SRA) and the priority topics in the three domains identified: foodborne zoonoses, antimicrobial resistance and emerging threats Foodborne zoonoses Antimicrobial resistance Emerging threats analytical Isabel Cuesta ISCIII Jean-Yves Madec ^ ANSES Dan Horton Surrey 6 MED methods Stefano Morabito > ISS Dik Mevius CVI Steven van Borm CODA-CERVA 6 VET Nadine Botteldoorn WIV-ISP Ana Alastruey ISCIII Ralitsa Popova-Ilinkina NDRVMI Jeffrey Hoorfar DTU Henrik Hasman SSI Barry Rockx RIVM host-microbe Karen Krogfelt ^ SSI Bruno González-Zorn > VISAVET-UCM Zoltán Zádori VMRI 4 MED interaction Karsten Nöckler BfR Didier Mazel IPP Miguel Angel Jiménez INIA 8 VET Artur Rzezutka PIWet Ákos Tóth NCE Philippe Velge INRA Cecilia Jernberg PHA Lynda Gun UCD Heinrich Neubauer FLI epidemiology Henriette de Valk InVS Dariusz Wasyl > Piwet Joke van der Giessen ^ RIVM 8 MED Paolo Calistri IZSAM Akke Vellinga NUI Simon Cauchemez IPP 4 VET Klaus Stark RKI Annalisa Pantosti ISS Jenny Frössling SVA Solveig Jore FHI Alex Cook Surrey Line Vold FHI risk assessment Renata Karpíšková VRI Aleksander Masny NIZP-PZH Sarah Welby CODA-CERVA 6 MED Maarten Nauta > DTU Neil Woodford PHE Barbora Macková NIPH 6 VET Stayanka Stoitsova SAIM-BAS Bernd-Alois Tenhagen BfR Dilys Morgan PHE Jakob Ottoson NFA Dearbhaile Morris NUI Pascal Hendrikx ANSES intervention Merete Hofshagen NVI Klemens Fuchs AGES Enikő Bán NCE 5 MED Rob Davies APHA Mardjan Arvand RKI Marianne Elvander > SVA 7 VET Christian Kornschober AGES Chris Teale APHA Giorgio Varisco IZSLER Iva Christova NCIPD Giovanni Alborali IZSLER Katarzyna Pancer NIZP-PZH 11 MED - 9 VET 10 MED - 10 VET 8 MED - 12 VET 60 scientific experts gathered over 2 days to produce the research topics Priority setting of research topics using Multi-Criteria Decision Analysis (MCDA) 15

16 EJP preparation - SRA & 1 st Internal Call Experts meeting Anses, May 3& Domain-theme-area secretaries 16 MRESI grant funding Experts consultation

17 Selected priority topics first call DOMAINES THEMES Food Borne Zoonoses (FBZ) AntiMicrobial resistance (AMR) Emerging threats (ET) Analytical methods NGS based methods Phenotypic methods Non-NGS based methods Host-microbe interaction Epidemiology Imp.surveillance Source Attribution Epi - AMR Risk assessment RA - AMR Intervention Biosecurity Joint integrative priority topics: Interpretation of surveillance data Common reporting and signalling procedures 17

18 Call 1: Selection of projects March April May June July August September October November December January February Task 1. Define guidelines for identification of candidate coordinators and selection of activities to be funded Define procedures (Task HI) Task 2. Collect Letters of Intent, perform eligibility check and send them to EJP Coordinator Launch invitation to propose research activities (Task AJ): 9 June 9 Preparation of Letters of Intent Deadline submission Letters of Intent: 8 July Letter of Intent 8 Collect Letters of Intent (Task AJ) Invitation to submit full proposal (Task AJ): 15 July 15 Task 3. Collect Full Proposals, perform eligibility check and organize evaluation by external experts Identify and contact External Experts (Tasks HI + Task leader) Propose uniform evaluation form with criteria (Task HI) Preparation of Full Proposals Full Proposal Deadline submission Full Proposals: 18 September 18 Collect Full Proposals (Tasks HI, AL, RL) Send full proposals to External Experts (Task HI, AL, RL) Evaluation of Full Proposals Evaluation Deadline evaluation: 6 November 6 Rank proposals and send them to Mgt Team (Task HI, AL, RL) Task 4. Propose research activities to be funded; final validation by SSB Send proposals to SSB and PMC for validation (Task AJ/HI): 10 November 10 Validation by SSB in meeting: 24 November 24 Invitation to prepare institutional letter (agreement for funding) (Task AJ): 6 November 6 Preparation of Letter of Commitment Deadline Institutional letter 18 December Let. of Commitment 18 Inform research activity coordinators about the outcome: before Xmas (Task AJ or Adm Board) Include the outcome in the 1Y and 5Y work plan (Task AJ): start 1 December Document of Work Submission of DoW Med-Vet EJP: 14 February 2017 (Task AJ) 14 Task 5. Follow up of JRP, JIP & PhD during the 5 year duration of the Med-Vet EJP Define KPI for follow up of research activities (Task HI + Task leader) 18

19 OH EJP project proposals DOMAINES THEMES Food Borne Zoonoses (FBZ) AntiMicrobial resistance (AMR) Emerging threats (ET) Analytical methods METASTAVA LISTADAPT IMPART MAD-VIR TOX-Detect Host-microbe interaction Epidemiology NOVA ARDIG MedVetKlebs Risk assessment RaDAR Intervention AIR-SAMPLE MoMIR-PPC Joint integrative projects: COHESIVE ORION 19

20 Joint Research & Integrative Projects Topic ref coord MS coord Org Projects Acronyme Projects Title IA-1 DE BfR ORION One health surrveillance Initiative on harmonization of data collection and interpretation IA-2 NL RIVM COHESIVE One Health Structure In Europe AMR-1 NL CVI IMPART IMproving Phenotypic Antimicrobial Resistance Testing AMR-2 GB APHA ARDIG Antibiotic Resistance Dynamics: the influence of geographic origin and management systems on resistance gene flows within humans, animals and the environment AMR-3 NL RIVM RADAR Risk and Disease burden of Antimicrobial Resistance ET-1 FR Anses TOXdetect Development and harmonization of innovative methods for comprehensive analysis of food-borne toxigenic bacteria, ie. Staphylococci, Bacillus cereus and Clostridium perfringens ET-1 DK SSI MAD-VIR Metagenomic Array Detection of emerging Virus in EU FBZ-1 SE SVA NOVA Novel approaches for design and evaluation of cost-effective surveillance across the food chain FBZ-2 FR Anses LISTADAPT Adaptive traits of Listeria monocytogenes to its diverse ecological niches FBZ-2 BE CODA- CERVA METASTAVA Standardisation and validation of metagenomics methods for the detection of foodborne zoonoses, antimicrobial resistance and emerging threats. FBZ-3 DK DTU AIR-SAMPLE A Low-Cost Screening Tool in Biosecured Broiler Production FBZ-3 FR INRA MoMIR-PPC Monitoring the gut microbiota and immune response to predict, prevent and control zoonoses in humans and livestock in order to minimize the use of antimicrobials FBZ-4 FR IP MedVetKlebs Klebsiella pneumoniae: from ecology to source attribution and transmission control projects selected and associated with WP3 & WP4

21 Two rounds of calls 2016 WP2: Strategic Research Agenda (1) Identification of teams 2017 Submission & selection Start of first round of Research & Integrative Projects 11 Research Projects 2 Integrative Projects WP2: Strategy Research Agenda (2) Identification of teams Start of second round of Research & Integrative Projects 10 Research Projects 3 Integrative Projects 21

22 Budget Total budget = 90 M EC (50%) = 45 M Institutional = 45 M Allocation of the resources = 90 M Overarching = 09 M Joint Research Projects = 50 M Joint Integrative Projects = 27 M Training Education = 04 M 22

23 Conclusion A pilot experience A cofund exercice Ministry of authority providing Mandates A consortium with majority of full partners One Health, restriction to «Med-Vet» Narrow scope «FOOD» Internal calls, in kind Policy-driven 23

24 This meeting is part of the European Joint Programme One Health EJP. This project has received funding from the European Union s Horizon 2020 research and innovation programme under Grant Agreement No Thank for your attention André JESTIN - EJP Coordinator ANSES Strategy and Programme Department Research and Reference Division andre.jestin@anses.fr