SIMAGCHEM CORPORATION

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SIMAGCHEM CORPORATION Corporation SIMAGCHEM was established in 1996. We are a dynamic and innovative chemical supplier company based in China.

2 SIMAGCHEM CORPORATION Corporation SIMAGCHEM was established in We are a dynamic and innovative chemical supplier company based in China. In term of our teamwork and EPR -BDL database, we are professional and successful in association with our principal partners providing our market intelligence to evaluate best suitable sources and JIT quick response system. The company vision is to be a bridge between East-West trades Service As a reliable partner in China, we are specialized in pharma chemicals. Consolidating sourcing, marketing, sales distribution and quality-control sections, we provide our partners with a full service of sourcing evaluation, regulation affair support, custom synthesis/contract manufacture for outsourcing, investment solution and suitable partnership establishment in China. SOURCING CUSTOM MANUFACTURE QUALITY CONTROL REGULATION COMPLIANCE

3 APIs Product Name Application Documents Penicillin G Procaine Antibacterial COS/CGMP Ampicillin Trihydrate Antibacterial CGMP Spectinomycin sulfate tetrahydrate Antibacterial CGMP/FDA Trimethoprim Antibacterial COS Rifampicin Antibacterial COS Neomycin sulphate Antibacterial COS Norfloxacin Antibacterial COS Povidone Nominal K-value 30 Antibacterial COS Metronidazole Antibacterial COS Azithromycin dihydrate Antibacterial COS/CGMP Amoxicillin Trihydrate Antibacterial COS/CGMP Phenoxymethylpenicillin Potassium Antibacterial COS Tetracycline hydrochloride Antibacterial COS Dihydrostreptomycin sulphate Antibacterial COS Lincomycin hydrochloride Antibacterial COS Spectinomycin dihydrochloride pentahydrate Antibacterial COS/CGMP Clarithromycin Antibacterial COS/CGMP Erythromycin Antibacterial COS/CGMP Clindamycin hydrochloride Antibacterial COS/CGMP/EDMF Clindamycin phosphate Antibacterial COS/CGMP/EDMF Sulfamethoxazole Antibacterial COS Streptomycin sulphate Antibacterial COS Ticlopidine hydrochloride Anticoagulant COS Glipizide Antidiabetic COS Acarbose Antidiabetic COS Glimepiride Antidiabetic COS Benzocaine Anesthesia COS Tetracaine HCL Anesthesia EDMF

4 APIs Product Name Application Documents Cinnarizine Antiepileptic COS Bimatoprost Antiglaucoma HOUSE STANDARD Fenofibrate Antilipemic COS Chondroitin sulphate sodium terrestrial origin Antilipemic COS Pravastatin Sodium Antilipemic COS/CGMP Atorvastatin Calcium Antilipemic DMF Rosuvastatin Calcium Antilipemic COS Hydroxychloroquine Sulfate Antimalarial USP Epirubicin HCl Antineoplastic COS/CGMP/DMF Gemcitabine hydrochloride Antineoplastic COS Etoposide Antineoplastic COS Fluorouracil Antineoplastic COS Methotrexate Antineoplastic COS Bleomycin Sulphate Antineoplastic COS Oxaliplatin Antineoplastic COS Cyclophosphamide Antineoplastic COS Paclitaxel Isolated from natural sources Antineoplastic COS Doxorubicin HCl Antineoplastic COS /DMF Mitomycin Antineoplastic COS/CGMP/DMF Leucovorin calcium Antineoplastic DMF Epothilone B Antineoplastic HOUSE STANDARD Clavulanate Potassium+ Microcrystalline cellulose(1:1) Antibacterial DMF Diclofenac sodium Antipyretic analgesics COS Phenylbutazone Antipyretic analgesics COS Ibuprofen Antipyretic analgesics COS Metamizole sodium Antipyretic analgesics COS Naproxen Antipyretic analgesics COS/EDMF

5 APIs Product Name Application Documents Meloxicam Antipyretic analgesic HOUSE STANDARD Paracetamol Antipyretic analgesics COS/DMF Antipyrine Antipyretic analgesics COS Ciprofloxacin hydrochloride hydrate Antiinfection COS/DMF Topiramate Antiepileptic HOUSE STANDARD Nevirapine Antivirus CGMP/EDMF/USDMF ciclovir Antivirus COS Fludarabine phosphate Antivirus COS Acyclovir sodium Antivirus DMF Valsartan Cardiovascular CGMP/EDMF/USDMF Irbesartan Cardiovascular CGMP/EDMF/USDMF Doxazosin mesilate Cardiovascular COS Captopril Cardiovascular COS Lovastatin Cardiovascular COS Sotalol hydrochloride Cardiovascular COS Iohexol Cardiovascular COS Diatrizoic acid dihydrate Cardiovascula HOUSE STANDARD Levetiracetam Central nervous system CGMP/EDMF/USDMF Primidone Central nervous system COS Sulpiride Central nervous system COS Phenobarbital Central nervous system COS Mirtazapine Central nervous system COS Citicoline sodium Central nervous system DMF Granisetron hydrochloride Digestive system COS Ranitidine hydrochloride Digestive system COS Omeprazole Digestive system COS Spironolactone Diuretics COS Torasemide, anhydrous Diuretics COS

6 APIs Product Name Application Documents Allopurinol Diuretics COS Furosemide Diuretics HOUSE STANDARD Gelatin Limed Bone Gelatin Excipients COS Polyvinylpyrrolidone PVP K30 Excipients HOUSE STANDARD Prednisolone Hormones COS Progesterone Hormones COS Mycophenolate mofetil Immunosuppressant COS Azathioprine Immunosuppressant COS Tranexamic acid Procoagulant COS Spiramycin Respiratory system COS Theophylline-ethylenediamine anhydrous Respiratory system COS Potassium guaiacolsulfonate hemihydrate Respiratory system DMF Sulfadiazine Sulfonamide COS Ampicillin sodium Penicillin HOUSE STANDARD

7 Animal health Product Name Application Documents Levamisole Hydrochloride Anthelmintic COS Flubendazole Polymorph B Anthelmintic COS Albendazole Anthelmintic COS Oxfendazole For Veterinary Use Anthelmintic COS Sulfadimidine Anthelmintic COS Fenbendazole Anthelmintic COS/DMF/EDMF Avermectin Anthelmintic FDA Diclazuril Anthelmintic HOUSE STANDARD Maduramycin 1% Anthelmintic HOUSE STANDARD Nitazoxanide Anthelmintic HOUSE STANDARD Salinomycin 12% 24% Anthelmintic HOUSE STANDARD Monensin sodium USP 40% 20% Anthelmintic USP Avermectin Anthelmintic FDA Ivermectin Anti parasitic COS Mebendazole Polymorph C Anti parasitic COS Tinidazole Anti parasitic COS/ DMF Amprolium HCl Anti parasitic HOUSE STANDARD Oxytetracycline dihydrate Antibacterial COS Nifuroxazide Antibacterial COS Doxycycline hyclate Antibacterial COS Oxytetracycline hydrochloride Antibacterial COS/CGMP Florfenicol Antibacterial DMF Flavomycin 4% 8% Antibacterial HOUSE STANDARD Erythromycin Thiocyanate Antibacterial CGMP Colistin Sulfate Antibacterial COS Tiamulin Fumarate USP Antibacterial USP

8 Animal health Product Name Application Documents Tylosin tartrate for veterinary use Antibacterial COS N-Methylglucamine Antibacterial USP Spectinnomysin sulfate tetrahydrate Antibacterial CGMP/FDA Ceftiofur Crystalline Free Acid Antibacterial HOUSE STANDAR Ceftiofur Hcl Antibacterial HOUSE STANDARD Ceftiofur Sodium Antibacterial HOUSE STANDARD Enrofloxacin Antibacterial HOUSE STANDARD Tylosin Antibacterial HOUSE STANDARD Cholesterol Feed additive USP Choline Chloride Feed additive HOUSE STANDARD

9 Plant extract Product Name Melatonin Leonurine Hydrochloride Lentinan Capsaicin Chenodeoxycholicacid Application Medicines and Health Products With blood stasis, diuresis detumescence Immunostimulants Drug treatment of soft tissue injury For the prevention and treatment of cholesterol gallstones L-Epicatechin Arbutin Oleanic acid Cyanidin A drug used as elevated white blood cell Diuretics, anti-infective urinary system Reduce liver injury Can be used as food coloring, cosmetic raw materials, etc. Beta-Sitosterol Bilberry Extract Scopine Hydrochloride Soy protein isolate Used as lipid-lowering drugs Nutrition Dietary Supplements Pharmaceutical intermediates Nutritional additives

10 Bio chemical Product Name Dicyclohexylcarbodiimide(DCC) Application Biochemical reagents and synthetic organic dehydrating condensation agent Diisopropylcarbodiimide (DIC) Dehydrating agent of Amikacin, glutathione and other drugs Di-tert-butyl dicarbonate(diboc) 9-Fluorene methanol (FMOC-OH) Amino protective agent Preparation in process of peptide synthesis protecting amino -9-9-fluorenylmethyl chloroformate Fmoc-Osu TBTU N-Methylglucamine Polysucrose 400 Triphenylmethyl Chloride N-(Benzyloxycarbonyloxy)succinimide (+)-Di-1,4-toluoyl-D-tartaric acid ( DDTTA ) Anhydrous Glucose Tris(2-cyanoethyl)phosphine (-)-Di-p-toluoyl-L-tartaric acid Calcium gluconate Amino protective agent Coupling reagent in synthesis of solid phase peptide Diagnostic agent, cosolvent, surfactant contrast agent Cell separation Reducing agent of sartan products. As peptide reagent Used for chiral separation of amines Nutritive sweeteners Protein transfer agent Used for chiral separation of amines For calcium enhancer, buffer, curing agent, chelating agent Orotic acid Biological research

11 Amino acid Product Names L-Valine L-Nitroarginine (NNA) L-Aspartic Acid Beta- Alanine Application Infusion of amino acids, food additives Amino acid derivatives Electrolyte Supplement drug is used amino acid infusion Synthesis of Pantothenate, also used in electroplating inhibitors and biochemical reagents Dl-Alanine Food flavoring agents, nutritional supplements of vitamins B6 intermediates, feed additives L-Carnitine,Base or Complex L-Alanine L-Lysine Hcl Dl-Methionine L-Cysteine Hcl,Mono Glycine L-Asparagine,Mono or Anhydrous L-Leucine L-Phenylalanine L-Threonone D-Tryptophan L-Methionine L-Glutamic Acid L-Grginine hcl L-Tyrosine L-Proline L-Isoleucine Food fortifier Food additives, feed, pharmaceutical intermediates Pharmaceutical, food, cosmetic additives Medicine, feed and food additives Pharmaceutical raw materials and food additives Nutrition Enhancer Nutrition enhancer Nutritional additives

12 Amino acid Product Names Application L-Histidine L-Glutamine L-Cysteine, flavoring flavoring agent Widely used in pharmaceutical, food and cosmetics industries L-Hydroxyproline Dl-Phenylalanine L-Arginine,Base N-Acetyl Cysteine Hcl Flavor enhancers; nutrition fortifier., beverage additives For pharmaceutical raw materials and food additives Dissolving phlegm medicine, also used for biochemical Studies BCAA Sarcosine Maximises Lean Muscle Gowth,Optimises post-workout recovey Amino acid type surfactants, health drugs fatigue recovery agent

13 Food additive Product Names Inositol Application For food fortifier, health care products, aquatic feed Additive L-Tartaric acid DL-Tartaric Acid D-Tartaric acid Methylparaben Ethylparaben Propylparaben Butylparaben Calcium gluconate Food acidulant Food acidulant Pharmaceutical resolving agent, food additives Antiseptic Antiseptic Antiseptic Antiseptic As calcium enhancer, buffering agents, curing agents, chelating agents D-Biotin Xanthan Gum Used in the food industry as processing aids. Stabilizer, thickeners, emulsifier, suspending agent, foam enhancers D-Glucono-delta-Lactone Used as a protein coagulant, sour agents, leavening agent, preservative agent and in cosmetics, toothpaste production DL-malic acid As sour agent, color retention agents, preservatives and egg yolk emulsion stabilizer in food industry Ferrius fumarate Dextrin Creatine Monohydrate Ferrous Bisglycinate beta-carotene Kappa Carrageenan Food iron enhancer As emulsion stabilizers and thickeners Used in food, beverage, and some additives. New iron supplement Edible orange coloring and nutrition fortifier. Used in food, medicine, daily chemical industries. Also in biochemistry, architectural coatings

14 Food additive Product Names Application L-Carnitine-L-tartrate D-(+)-Trehalose Used in medicine and health products, food additives Used in the food industry, including beverages, chocolate and confectionery, baked goods and

15 Sweetener Product Name Erythritol Maltitol Mannitol Aspartame Isomalt D-Sorbitol Application Low-calorie sweeteners Low-calorie sweeteners Low-calorie sweeteners Food additives, nutritive sweeteners Functional sugar alcohols With a special moisturizing sweetener in toothpaste production and pharmaceutical industries D-xylose L-Arabinose Xylitol Acesulfame K Sucralose Anhydrous Glucose Lactose Anhydrous Lactose Monohydrate D-Glucose monohydrate Acarbose No-calorie sweetener, also used for making xylitol Food additive, also used in medicine and for medium Food sweet taste agent Food Sweeteners Food Sweeteners Nutritive sweeteners Nutritive sweeteners Nutritive sweeteners Nutritional medicine can be used for glucose injection For insulin-dependent and non-insulin-dependent diabetes D-Tryptophan Nutritional additives

16 Vitamin Product Name Application Vitamin A Acetate For vitamin A deficiency Vitamine A Palmitate Additives of food, medicines, nutritional supplements, cosmetics and feed Vitamin B1 (Thiamine HCL/Mono). Vitamin B1 involved in carbohydrate metabolism in the body Vitamin B2 (Riboflavin) Vitamin B3 (Niacinamide) Vitamin B5 (Calcium D-Pantothenate) Nutrition fortifier and food additives Nutrition fortifier, food and feed additives Food and feed additives.for the treatment of vitamin B deficiency, peripheral neuritis and post-operative colic. Vitamin B6 (Pyridoxin HCL) Mainly as medicine, or further synthesis for pyridoxal phosphate andpyritinol hydrochloricde.also used as feed and food additives Vitamin B9 (Folic Acid) Anti-anemia drugs. For anemia of symptomatic or nutritional giant cell Vitamin B12 (Cyanocobalamin) (DMF) Primarily for the treatment of megaloblastic anemia, malnutrition, post-hemorrhagic anemia, neuralgia and obstructive disorders Vitamin C For the prevention and treatment of scurvy, also for a variety of acute and chronic infectious diseases and purpura Vitamine D3 Mainly to promote the absorption and deposition for Ca phosphorus. Used in the treatment of rickets and osteomalacia Vitamin E Acetate,50%,98% USP Used as medicines,nourishment,cosmetic and feed additives Vitamin E Succinate Senior health food additives and advanced cosmetic's raw material

17 Vitamin Product Name Application Vitamin K1 Food supplements. For the deficiency of vitamin K1, thrombin low disease Vitamin K3 R-(+)-alpha-Lipoic acid Procoagulant drugs For the treatment of chronic hepatitis, psoriasis and lupus erythematosus Vitamin PP(Nicotinic Acid) For the anti-pellagra, can also be used as blood vasodilators, as food and feed additives, pharmaceutical intermediates. Coenzyme Q10 10%/20%/40% Food Grade Important antioxidant and immune enhancer ;Nano-Emulsion 10%.

Customer Service Lines: Tel: 0086 592 2680277 / 275 / 654 / 279 Fax:0086 592 2680237 E-mail: sale@simagchem.

18 Customer Service Lines: Tel: / 275 / 654 / 279 Fax: sale@simagchem.com China Headquarter SIMAGCHEM Corporation Commercial Centre: 21/F Hulong Office Buliding, No.6 Hubin East Road, Xiamen,China HongKong Office SIMAG Holdings LTD Unit 1001 Fourseas, Building Nathan Road,Kowloon, Hongkong Application of our products The products of the SIMAGCHEM corporation are produced and/or distributed in accordance with the existing legal requirements. However, it is the sole responsibility of the user of our products to make sure that the application of the products is done in accordance with the applicable laws.

SIMAGCHEM CORPORATION

SIMAGCHEM CORPORATION Corporation SIMAGCHEM was established in 1996. We are a dynamic and innovative chemical supplier company based in China. In term of our teamwork and EPR -BDL database, we are professional