Current EU Antibiotic Maximum Residue Limits

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1 R-Biopharm Rhône Current EU Antibiotic Maximum Residue Limits March 2011

2 R-Biopharm Rhône Current EU Antibiotic Limits 2

3 Contents Antibiotics in Food Aminoglycosides...4 Ansamycins...4 Beta-lactams...5 Beta-lactams continued...6 Fluoroquinolones...6 Fluoroquinolones continued...7 Macrolides...8 Nitrofurans...9 Phenicol...9 Pleuromutilin...9 Polypeptides...10 Sulfonamides...10 Tetracyclines References

4 Aminoglycosides Dihydrostreptomycin / Streptomycin All ruminants, pigs, Muscle rabbits Dihydrostreptomycin / Streptomycin All ruminants Gentamicin (Sum of C1, C1a, C2 and C2a) Cattle, pigs Muscle 7 Gentamicin (Sum of C1, C1a, C2 and C2a) Cattle Kanamycin A All food Muscle 2, 1 Neomycin B All food Muscle 5,000 ppb 1, Spectinomycin Sheep Muscle 2,000 ppb 5,000 ppb Spectinomycin All other food Muscle 5,000 ppb Streptomycin All ruminants, pigs, Muscle rabbits Ansamycins Rifaximin Cattle 60 ppb R-Biopharm Rhône Current EU Antibiotic Limits 4

5 Beta-lactams Amoxicillin All food Muscle 4 ppb Ampicillin All food Muscle 4 ppb Cefacetrile Cattle 125 ppb Cefalexin Cattle Muscle Cefalonium Cattle 20 ppb Sum of cefapirin and Cattle Muscle desacetylcephapirin 60 ppb Cefazolin Cattle, sheep, goats Cefoperazone Cattle Cefquinome Cattle, pigs, horse family Muscle Cefquinome Cattle 20 ppb Ceftiofur All mammalian food Muscle 2,000 ppb 2,000 ppb 6,000 ppb Cloxacillin All food Muscle 30 ppb Dicloxacillin All food Muscle 30 ppb Nafcillin All ruminants Muscle 30 ppb 5

6 Beta-lactams continued Oxacillin All food Muscle 30 ppb Benzylpenicillin All mammalian food Muscle 4 ppb Phenoxymethylpenicillin Pigs Muscle 25 ppb 25 ppb 25 ppb Phenoxymethylpenicillin Poultry Muscle 25 ppb Skin 25 ppb 25 ppb 25 ppb 25 ppb Fluoroquinolones Danofloxacin Cattle, sheep, goats, Muscle poultry 400 ppb 400 ppb Danofloxacin All other food Muscle Danofloxacin Cattle, sheep, goats 30 ppb Difloxacin Cattle, sheep, goats Muscle 400 ppb 1,400 ppb 800 ppb Difloxacin Pigs Muscle 400 ppb 800 ppb 800 ppb Difloxacin Poultry Muscle 400 ppb 1,900 ppb R-Biopharm Rhône Current EU Antibiotic Limits 6

7 Fluoroquinolones continued Difloxacin All other food Muscle 800 ppb Sum of enrofloxacin and ciprofloxacin Cattle, sheep, goats Muscle Sum of enrofloxacin and ciprofloxacin Pigs, rabbits Muscle Sum of enrofloxacin and ciprofloxacin Poultry Muscle Sum of enrofloxacin and ciprofloxacin All other food Muscle Flumequine Cattle, sheep, goats, pigs Muscle 1, Flumequine Cattle, sheep, goats Flumequine Poultry Muscle 400 ppb ppb Flumequine Fin fish Muscle and skin Flumequine All other food Muscle 2 Marbofloxacin Cattle, pigs Muscle Marbofloxacin Cattle 75 ppb 7

8 Macrolides Erythromycin A All food Muscle 40 ppb 1 Lincomycin All food Muscle 1, 1 Novobiocin Cattle Pirlimycin Cattle Muscle 400 ppb Sum of spiramycin and neospiramycin Cattle Muscle Sum of spiramycin and neospiramycin Chicken Muscle 400 ppb Tilmicosin Poultry Muscle 75 ppb 75 ppb 2 Tilmicosin All other food Muscle Tylosin A All food Muscle R-Biopharm Rhône Current EU Antibiotic Limits 8

9 Nitrofurans MRPL Nitrofurans (AHD, SEM, AOZ, AMOZ) Poultry Muscle 0 ppb 1 ppb Nitrofurans (AHD, SEM, AOZ, AMOZ) All food Aquaculture products 0 ppb 1 ppb Phenicol MRPL Chloramphenicol All food Muscle 0 ppb 0.3 ppb 0 ppb 0.3 ppb 0 ppb 0.3 ppb Urine 0 ppb 0.3 ppb Aquaculture products 0 ppb 0.3 ppb Honey 0 ppb 0.3 ppb Pleuromutilin Tiamulin (Sum of metabolites that may be hydrolysed to 8-α-hydroxymutilin) Tiamulin (Sum of metabolites that may be hydrolysed to 8-α-hydroxymutilin) Pigs, rabbits Muscle Chicken Muscle Skin Tiamulin (Sum of metabolites Turkey Muscle that may be hydrolysed to Skin 8-α-hydroxymutilin) Tiamulin Poultry MRPL: Maximum Residue Performance Limit 9

10 Polypeptides Colistin All food Muscle Bacitracin Cattle Bacitracin Rabbits Muscle Sulfonamides Sulfonamides All food Muscle Sulfonamides Cattle, sheep, goats R-Biopharm Rhône Current EU Antibiotic Limits 10

11 Tetracyclines Chlortetracycline (Sum of parent drug and its 4 epimers) Doxycycline (Sum of parent drug and its 4 epimers) Doxycycline (Sum of parent drug and its 4 epimers) Oxytetracycline (Sum of parent drug and its 4 epimers) Tetracycline (Sum of parent drug and its 4 epimers) All food Muscle Cattle Muscle Pigs, poultry Muscle All food Muscle All food Muscle References Commission Regulation (EU) No. 37/2010. Commission Decision 2003/

12 R-Biopharm Rhône Ltd Block 10 Todd Campus West of Scotland Science Park Acre Road, Glasgow G20 0XA Phone: +44 (0) Fax: +44 (0)

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