DIRECTIONS. (developing or ganization: Joint- - Khrustalny, Vladimir Region) I. GENERAL PROVISIONS

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1 SEEN AND APPROVED BY Deputy Director of the Federal Service for Veterinary and Phytosanitary Surveillance E. Nepoklonov on April 28 th, 2012 DIRECTIONS for the use of CREOLIN-X for the prevention and treatment of arachnoentomosis of animals (developing or ganization: Joint- - Khrustalny, Vladimir Region) I. GENERAL PROVISIONS 1. Trade name of the drug preparation: Creolin-X (Kreolin-X). International non-proprietary name: cypermethrin. 2. Creolin-X contains cypermethrin - 2.5% or 5% as the active ingredient and Bituminous coal creolin without phenol - up to 100% as the auxiliary ingredient. Externally Creolin-X is a homogeneous oily liquid, transparent in a thin layer, with coal oil odor, from dark brown to black and brown. With water it forms a milky white or milky gray emulsion. Creolin-X is released packaged in glass bottles, vials and jars or plastic bottles, vials with plastic stoppers; in steel or plastic cans. 3. Provided the storage conditions are observed, the shelf life of Creolin-X is 2 years from the date of release. Do not use the drug preparation after the expiration date. 4. Creolin-X is stored in sealed original packaging in a dry place protected from direct 5. Creolin-. 6. Drug preparation remains are detoxified with a 5% solution of caustic alkali or of slaked aqueous suspension or of chlorine (1:3). The ware contaminated with Creolin-X is detoxified by filling it with a 3.5% solution of soda for 5-6 hours and then washed with running water. Working emulsions, drainage effluents and waste waters resulting from the cleaning and detoxifying of premises, vehicles, ware, equipment and overalls, are collected in a concrete tank and processed with bleach (500 g per 10 l of waste water.) II. PHARMACOLOGICAL PROPERTIES 7. Pharmacotherapeutic group: insectoacaricide agent. Cypermethrin, which is part of Creolin-X, belongs to second generation pyrethroids, has a wide range of insectoacaricide effects, is active against sarcoptidae, ixodic ticks and insects. The mechanism of the insectoacaricide effect is based on the violation of cell membrane permeability and blocking of sodium channels in the nerve system of arthropods which leads to their death. By degree of exposure, Creolin-X belongs to moderately hazardous substances (hazard class 3 according to All-Union State Standard ); in recommended doses and concentrations, has no local irritative or sensibilizing effect. Toxic to fish and bees. III. USAGE PROCEDURE 8. Creolin-X is externally applied to animals: - For the treatment and prevention of psoroptes in sheep, as well as psoroptes, chorioptic, sarcoptic mange, siphunculatosis, lesion with ixodic ticks in great cattle;

2 - For the treatment of pigs with sarcoptic mange and gematopinosis; - For the treatment of poultry against chicken, Persian mites, bed bugs and plumage lice and disinsection and disacaridization of poultry-breeding premises; - For the treatment and prevention of sarcoptic, notoendric and otodectic mange in foxes, raccoon dogs and other fur-bearing animals, and of notoendric mange and psoroptes in rabbits; - against bloodsucking dipterans (mosquitoes, black flies, biting midges, horseflies) and pasture flies in the quantities causing concern, disruption of normal grazing or rest and reducing the productivity of animals, or creating a risk of the spread of infectious and parasitic diseases. 9. Increased individual sensitivity of the animal to the agent is a contraindication to the use of Creolin-X. 10. Before mass treatment, each series of Creolin-X is tested on heads of animals. If within one day after the treatment the animals show no signs of toxicity, the treatment of the entire livestock is further started. Working emulsions of Creolin-X are prepared immediately before use, taking into account the presence of the active ingredient in Creolin-X, under the supervision of a veterinarian or a paramedic. The volume of the working emulsion necessary for the treatment and the amount of Creolin-X required for its preparation are thereby determined (see Table 1). Table 1 Ratio of Creolin-X and water in the preparation of 0.005% dipping emulsion Bath volume (l) Creolin- l) Water (l) 2,5 % emulsion concentrate ,0 5 % emulsion concentrate 50 0, , Sheep with psoroptes are dipped in a swim-bath, using a 0.005% aqueous emulsion of Creolin-X, twice with an interval of days for therapeutic purposes, once for prophylactic purposes. The required amount of Creolin-X is thoroughly mixed with 2-3 volumes of warm water (28- C) and then poured into a water-filled swim-bath, adding water up to the required volume with constant stirring. dipping emulsion of seconds. Prior to the treatment, the sheep are kept fasted for 10 hours. 2 hours before the treatment, the animals need to be watered. After shearing, the sheep must be dipped no earlier than in 3 days. Lambs aged less than 1 month are dipped separately from adult animals. After leaving the bath, the sheep are left at a special site for minutes in order for the emulsion to run off, and then driven into the pen. Refilling of the bath is carried out after the treatment of unshorn or shorn sheep by adding 4 l of 2.5% or 2 l of 5% Creolin-X to every 1000 l of new water in the bath with constant stirring. After the treatment of 1000 sheep, the used emulsion is poured into mud sumps to prevent environmental pollution; the bath is cleaned from dirt and filled with the newly prepared dipping emulsion. Great cattle with psoroptes, chorioptic mange, siphunculatosis, lesion with ixodic ticks are treated with a 0.005% aqueous emulsion of Creolin-X. The animals are sprayed by wetting the entire body, treating lesion locations and spots around the ears, limbs, abdomen and tail with particular care. The consumption rate of the working Creolin-X emulsion, depending on the weight of the animal is l.

3 Repeated treatment of great cattle with enthomosis and lesion with ixodic ticks in the season of their parasitizing is carried out according to the indications, of those with sarcoptic mange - twice with an interval of 7-10 days. Pigs with sarcoptic mange and gematopinosis are sprayed with 0.025% aqueous emulsion of Creolin-X with a consumption rate of ml per animal. For example, to prepare 100 ml of a 0.025% aqueous emulsion, one needs 1 l of 2.5% Creolin-X and 99 l of water or 0.5 l of 5% Creolin-X and 99.5 l of water. Animal treatment is carried out twice with an interval of 7-10 days. Ears are treated with Creolin-X with particular care. In the farms disadvantaged by sarcoptic mange, disacaridisation of premises is carried out simultaneously with animal treatment by using a 0.005% aqueous emulsion of Creolin-X with a consumption rate of ml / m2 of the processed surface. Spraying of premises is carried out in the absence of animals, with preliminary removal of remains of feed, water and milk equipment; milking equipment is covered with plastic wrap hours after the processing, the premises are aerated for at least 1 hour, the processed surfaces are thoroughly washed with water, feeders and waterers are thoroughly washed with a 3% sodium carbonate solution. They are rinsed with water, after which the animals are placed in the premises. The treatment of poultry against plumage lice, chicken and Persian mites, bed bugs is carried out with Creolin-X by small-drop spraying of the birds with directed sprays of a 0.005% aqueous emulsion (by cypermethrin). The treatment is carried out after the collection of eggs at a dose of ml per bird twice with an interval of 8-10 days. Disinsection and disacaridisation of the premises of poultry factories, poultry farms, and farms is carried out in the absence of birds during a technological break period. Before the processing, the poultry house is subjected to a parasitological examination to determine the species composition of parasites. Disinsection and disacaridisation are carried out with a 0.005% aqueous emulsion of Creolin-X (by cypermethrin) twice taking into account the development cycle of ectoparasites and the air temperature in the poultry house during the technological break: - for the extermination of chicken mites at an air temperature of 15- processing is days, at a temperature of C days; - for the extermination of bed bugs and Persian ticks, the interval between the processing is days at an air temperature of days at a temperature of C and above. The first processing of poultry houses for the extermination of the bulk of ectoparasites and prevention of their spread or transfer to other objects is carried out before the mechanical cleaning of the premises immediately after removing the poultry. The consumption rate of the working emulsion is ml / m2 of the processed surface. The second processing is carried out after a sanitary preparation (cleaning, repair and whitewash) of the poultry house with the consumption rate of the working emulsion being ml / m2 of the processed surface. The processing exposure lasts for 24 hours. After the exposure, the premises are aerated for at least 1 hour, the exterminated ectoparasites are swept and destroyed, the processed surfaces are washed with water, feeders and waterers are thoroughly washed with a 3% sodium carbonate solution and rinsed with water; the birds are further placed in the premises. To exterminate zoophilous flies in closed industrial premises (poultry houses) spraying is carried out with a 0.005% aqueous emulsion of Creolin-X with a consumption rate of ml / m2 of the processed surface. Repeated processing is carried out on entomological grounds. In cases of sarcoptic, notoendric and otodectic mange in foxes, foxes, racoon dogs and other furbearing animals, as well as notoendric mange and psoroptes in rabbits, Creolin-X is used for therapeutic and prophylactic purposes with a concentration of 0.005% by cypermethrin (see Table 1). Fur-bearing animals and rabbits are dipped in the bath, placed in heated premises, twice with an interval of 7-8 days for therapeutic purposes, once for prophylactic purposes.

4 emulsion being minutes. Prior to the treatment, to avoid bites of the fixed with a tape loop and the animals are dipped in the dipping emulsion. In order for the acaricide liquid to reach the surface of the skin, during the dipping, the hair of the animals and rabbits is massaged by stroking it in the direction from tail to head and the limbs are massaged from the bottom up. During the dipping, the head of the animal is dipped for 2-3 seconds in the dipping emulsion twice, the nostrils and the mouth being clamped with a hand. After the dipping, the pelage is squeezed, letting the liquid flow back into the bath, and then the animals are placed in warm disinfected cages. After the treatment of twenty fur-bearing animals or thirty rabbits in a bath containing 50 l of the working emulsion, the treatment is stopped and the used emulsion is poured into mud sumps to prevent environmental pollution, the bath is cleaned from dirt and refilled with the prepared dipping emulsion. In the fur and rabbit farms disadvantaged by sarcoptic mange, disacaridisation of premises is carried out simultaneously with the treatment of animals using a 0.005% aqueous emulsion of Creolin-X with the consumption rate of ml / m2 of the processed surface. Spraying of premises is carried out in the absence of animals, after cleaning the remains of feed and water. The exposure of processing lasts for hours, then the premises is aerated for at least 1 hour, the processed surfaces are washed with water, feeders and waterers are thoroughly washed with a 3% sodium carbonate solution and rinsed with water, after which the animals are placed in the premises. In cases of sarcoptic, notoendric and otodectic mange in fur-bearing animals, as well as psoroptes in rabbits, a 0.005% (by cypermethrin) oil emulsion of Creolin-X is used. Paraffin or sunflower oil are used as oil solvents. Creolin-X is added into the oil pre-warmed up to 32- portions with constant stirring to obtain a homogeneous emulsion. Before the treatment of animals, the oil emulsion is heated to a temperature of 30- each ear by 1-2 ml. For a more complete treatment of the entire surface of the ear and the ear canal, the ear is folded in half lengthwise and gently massaged at the bottom. The treatment is carried out twice with a 7-10-day interval. The oil emulsion is necessarily introduced into both ears, even in case only one ear suffered a mite lesion. To combat blood-sucking insects (mosquitoes, gnats, midges, horseflies), great cattle are treated with Creolin-X by spraying with a 0.008% aqueous emulsion (by cypermethrin) with the following consumption rates: youngsters aged up to 1 year ml; those aged over 1 year ml per animal. For example, to prepare 100 l of the 0.008% aqueous emulsion, one must take 320 ml of 2.5% Creolin-X-and l of water or 160 ml of 5% Creolin-X and l of water. The time of treatment and the need for it are defined depending on the dominant ingredients of blood-sucking insects. In case of a high number of horseflies and sand flies, the treatment of animals is carried out every day after the morning milking, and at a high number of mosquitoes and midges - after the evening milking. In case of a moderate number of blood-sucking insects, the treatment is carried out once in 2-3 days and in case of an attack by pasture flies only - in 7-10 days. The spraying of great cattle is performed using a PER device, a knapsack sprayer OP-8, DUK or other sprinkling devices providing small-drop spraying. It is prohibited to treat animals with infectious diseases and malnourished animals, as well as females during the second half of pregnancy with Creolin-X. 11. No symptoms of overdose when using the preparation have been identified 12. No specific features of the effect of the drug preparation during its first use or cancellation have been identified. 13. In the case of non-compliance with the set period of repeated treatment, the use of the preparation must be resumed at the same dose in the same way. 14. As a rule, no side effects or complications when using Creolin- X in accordance with these

5 Directions are observed. In case of increased individual sensitivity of the animal to the ingredients of the preparation, individual reactions (skin irritation, lacrimation, salivation) may occur, in which case the preparation must be washed off with soap and water. 15. Do not simultaneously use insectoacaricide preparations of other groups. 16. The slaughter of sheep and rabbits for meat is allowed no earlier than in 15 days, that of great cattle and pigs - no earlier than 25 days after the last treatment with Creolin-X. The slaughter of poultry for meat is allowed no earlier than in 48 hours after the last treatment In case of a forced slaughter before the set dates, the meat can be used as feed for animals, or for the production of meat and bone meal. The eggs obtained from the hens treated with Creolin-X can be used without restrictions. The milking of cows and the use of milk is allowed 12 hours after the treatment with Creolin X. The milk obtained at an earlier date, is used in animal feed IV. PERSONAL PREVENTIVE MEASURES 17. When working with Creolin-X, one must comply with the general rules of personal hygiene and safety techniques provided for working with medical agents. Everyone who works with Creolin-X must be provided with and must use a set of overalls and personal protective equipment (gown, headgear, rubber apron, rubber boots, goggles, a respirator of the brands F-62 (HIM), -2", of the type "Lepestok-40", "Lepestok-5"). During the work, it is prohibited to drink, smoke, eat. After the work, the overalls must be taken off, the face and hands must be washed with warm water and soap, the mouth rinsed with water. 18. In case of the contact of Creolin-X with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. People with hypersensitivity to the preparation ingredients must avoid direct contact with Creolin-X. In case of allergic reactions or accidental ingestion of the preparation, one must immediately contact a medical institution (one must have the directions for the use of the preparation or a label at hand). 19. Empty drug preparation packaging must not be used for household purposes; it must be disposed of with household waste. 20. Manufacturing organization: Joint- Himzavodskaya Str., d. 2, Gus-Khrustalny, Vladimir Region, With the approval of these Directions, the Directions for the use of Creolin-X approved by the Federal Service for Veterinary and Phytosanitary Surveillance on December 29 th, 2006 become invalid. Recommended for. Registration Certificate number /00944.