This drug SHOULD NOT be used in: XXPregnant or nursing animals. XXDogs that are weak, old, or frail.

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1 Fipronil with (S)-Methoprene & Pyripoxyfen, Topical (Dogs) (fip-roe-nil with meth-oh-preen and pye-ri-proks-i-fen) Category: Topical Agent to Treat & Control Fleas, Ticks, & Lice; Insect Growth Regulator Other Names for this Medication: Frontline Gold Common Dosage Forms: Veterinary: Fipronil 9.8%, (S)-methoprene 8.8%, pyripoxyfen 0.25% liquid for topical application. Available in 4 different sizes based on dog s body weight. Human: None. This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and effectively to your animal. If you have other questions or need more information about this medication, contact your veterinarian or pharmacist. Key Information X For elimination of fleas and ticks on dogs; may also be used to treat chewing lice and sarcoptic mange. Labeled for monthly use. X Do not use on rabbits or other small mammals as this drug can be toxic to these species. X When used as directed on the label, side effects are not likely. X Dispose of empty containers and any unused product carefully. How is this medication useful? The combination of fipronil with (S)-methoprene and pyriproxyfen is licensed by the US EPA (Environmental Protection Agency) for use on dogs and puppies 8 weeks of age and older for treatment and control of fleas and ticks. It may also be used to treat sarcoptic mange mites and chewing lice. Fleas may be controlled for up to 3 months after application, but ticks and lice require monthly use. You and your veterinarian can discuss why this drug is the most appropriate choice. What should I tell my veterinarian to see if this medication can be safely given? Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions. Other drugs can cause problems when used with this product, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each. Tell your veterinarian about any conditions or diseases your pet may have now or has had in the past. If your animal has been treated for the same disease or condition in the past, tell your veterinarian about the treatment and how well it did or didn t work. If your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug. Tell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past. When should this medication not be used or be used very carefully? No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal. This drug SHOULD NOT be used in: Dogs that are allergic to it. Dogs less than 8 weeks old. Rabbits or other small mammals (eg, rodents). This drug should be used WITH CAUTION in: Pregnant or nursing animals. Dogs that are weak, old, or frail. If your dog matches any of these conditions, talk to your veterinarian about the possible risks of using the medication versus the benefits that it might have. What are the side effects of this medication? When used as directed on the label, dogs typically tolerate this drug well. Side effects that usually are not serious include: Skin irritation at the application site can occur. Vomiting, diarrhea. The product (Frontline Gold) label states: If these or other side effects occur, consult your veterinarian or call If my pet gets too much of this medication (an overdose), what should I do? If you witness or suspect an overdose either by topical application or if an animal eats the drug, contact your veterinarian or an animal poison control center for further advice. Animal poison control centers that are open 24 hours a day include: ASPCA Animal Poison Control Center ( ) and Pet Poison HELPLINE ( ); a consultation fee is charged for these services. Have the product container or label with you when calling a poison control center or doctor, or going for treatment. How should this medication be given? For this medication to work, give it exactly as your veterinarian has prescribed. It s a good idea to always check the prescription label to be sure you are giving the drug correctly. Wearing disposable gloves is not mandatory (not mentioned on label), but is recommended when applying this medication. Using the appropriate sized tube for your dog s weight: Remove one applicator from child-resistant package. Hold applicator upright, pointed away from face. Twist dispensing tip clockwise about ½ turn while pushing down to break the tube s seal. Do not remove the dispensing tip. Position the dispensing tip on the dog s back, between the shoulder blades. Use the dispensing tip of the tube to part the dog s hair so that the product will be applied at skin level. Begin squeezing out the contents of the tube to form a stripe as you move from the shoulder blades along the dog s back to the base of the tail. (Frontline Gold label)

2 Avoid contact with treated area until dry. This medication can be administered for various lengths of time, so be sure you understand how long the veterinarian wants you to continue giving it. You may need to get refills before the therapy will be complete. What should I do if I miss giving a dose of this medication? If you miss administering a dose, apply it when you remember and then wait the amount of time between doses recommended by your veterinarian before giving another dose. Do not double-up or give extra doses. How should I store this medication? Store in the original container. Do not use or store near heat or open flame. Keep away from children and other animals. Can handling this medication be hazardous to me, my family, or other pets? The product label states: Harmful if swallowed. Causes eye irritation. Avoid contact with skin, eyes, or clothing. Wash thoroughly with soap and water after handling. IF SWALLOWED: Call a poison control center or doctor immediately for treatment advice. Have person sip a glass of water if able to swallow. Do not induce vomiting unless told to do so by a poison control center or doctor. Do not give anything by mouth to an unconscious person. IF IN EYES: Flush eyes with plenty of water. Call a doctor if irritation persists. IF ON SKIN OR CLOTHING: Wash with plenty of soap and water for minutes. Get medical attention if irritation persists. HOTLINE NUMBER: Have the product container or label with you when calling a poison control center or doctor, or going for treatment. For additional information on this product, including health concerns, medical emergencies, or possible incidents, you may call Merial at , Monday-Friday 8am-8pm EST. Disposable gloves are not required (not mentioned on label), but they may be considered when applying this medication. How should I dispose of this medication if I don t use it all? If any medication remains call your local solid waste agency or CLEANUP for disposal instructions. Never place unused product down any indoor or outdoor drain. Recommend putting the empty container in a sealed plastic bag before placing in trash or offer for recycling if available. Do not save leftover medication for future use or give it to others to use. What other information is important for this medication? After applying, do not reapply for thirty (30) days unless your veterinarian specifically instructs you to do so. The product remains effective even after bathing, water immersion, or exposure to sunlight. The Frontline Gold product label states: Consult with your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Dispose of any unused product carefully. This product can be very toxic to fish and wildlife. Use of this drug may not be allowed in certain animal competitions. Check rules and regulations before entering your animal in a competition while this medication is being administered. If you have any other questions or concerns about this medication, contact your veterinarian or pharmacist.

3 Imidacloprid with Pyriproxyfen, Topical (Cats) (ih-mid-a-kloe-prid with peer-ih-prox-eh-fen) Category: Agent to Treat & Control Fleas; Insect Growth Regulator Other Names for this Medication: Advantage II for Cats Common Dosage Forms: Veterinary: Imidacloprid 9.1%, Pyriproxyfen 0.46% for topical application. Available in 3 sizes based on cat s body weight: 2-5 lbs (0.23 ml), 5-9 lbs (0.4 ml), over 9 lbs (0.8 ml). Human: None. This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and effectively to your animal. If you have other questions or need more information about this medication, contact your veterinarian or pharmacist. Key Information X For treatment and control of fleas on cats. This product does not control ticks. X When used as directed on the label, imidacloprid with pyriproxyfen is safe in most cats. X Do not let the cat lick treated area; prevent other pets and children from contact until the area has dried (about 30 minutes). X Dispose of empty containers and any unused product carefully. How is this medication useful? The topical product combining imidacloprid and pyriproxyfen (Advantage II for Cats) is licensed by the US EPA (Environmental Protection Agency) for treatment and control of flea infestations on cats 8 weeks of age and older and weighing more than 2 lb. You and your veterinarian can discuss why this drug is the most appropriate choice. What should I tell my veterinarian to see if this medication can be safely given? Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions. Other drugs can cause problems when taken with this product, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each. Tell your veterinarian about any conditions or diseases your pet may have now or has had in the past. If your animal has been treated for the same or similar condition in the past, tell your veterinarian about the treatment and how well it did or didn t work. If your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug. Tell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past. When should this medication not be used or be used very carefully? No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal. This drug SHOULD NOT be used on cats: That are allergic to imidacloprid or pyriproxyfen. That are less than 8 weeks old. This drug should be used WITH CAUTION in cats that are: Weak, frail. Old. Pregnant, or nursing. If your pet has any of these conditions, talk to your veterinarian about the potential risks versus benefits. What are the side effects of this medication? When used as directed on the label, side effects are unlikely. Side effects that usually are not serious include: Mild behavioral changes (eg, hiding, excessive grooming, pacing). Redness, itching, and discomfort at application site. You don t have to be overly concerned if you see any of these signs unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens. Side effects that may be serious or indicate a serious problem: Excessive salivation, vomiting, diarrhea. If you see any of these signs, contact your veterinarian immediately. If you see anything unusual with your cat after applying, contact your veterinarian or the manufacturer (Bayer HealthCare) at or, if it is a medical emergency call If my pet gets too much of this medication (an overdose), what should I do? If you witness or suspect an overdose either by topical application or ingestion, contact your veterinarian or an animal poison control center for further advice. Animal poison control centers that are open 24 hours a day include: ASPCA Animal Poison Control Center ( ) and Pet Poison HELPLINE ( ); a consultation fee is charged for these services. How should this medication be given? For this medication to work, apply it exactly as your veterinarian has prescribed. It s a good idea to always check the prescription label to be sure you are giving the drug correctly. Monthly treatments are required for control and prevention of fleas. Do not get this product in cat s eyes or mouth. Do not apply to irritated skin.

4 Using the appropriately sized tube for your cat s weight: Remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position. Pull the cap off the tube. Turn the cap around and place other end of the cap back on the tube. Twist the cap to break seal, then remove the cap from the tube. See the illustrations that come with product for more information. Part the hair on the neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents of the tube directly on the skin. Do not get this product in your cat s eyes or mouth. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. Treatment at the base of the head helps prevent the opportunity for the cat to lick the treated area. Under normal conditions, the product is effective for a month; however, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every 14 days for kittens or once every 7 days for small and large cats. After flea control is attained, return to a monthly retreatment schedule. What should I do if I miss giving a dose of this medication? If you miss applying a dose, apply it when you remember and then wait the amount of time between doses recommended by your veterinarian before giving another dose. Do not double-up or give extra doses unless instructed to do so by your veterinarian. How should I store this medication? Store unused product in a cool, dry place. Keep away from children and other animals. Can handling this medication be hazardous to me, my family, or other pets? The product label states: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water after handling. Keep out of reach of children. Do not contaminate feed or food. Disposable gloves are not required (not mentioned on label), but they may be considered when applying this medication. How should I dispose of this medication if I don t use it all? Dispose of this product carefully, as it is can be toxic to fish, turtles, and wildlife. Do not flush this medication down the toilet or wash it down the sink. Do not reuse empty container. Recommend you put the empty container inside a sealed baggie then place in trash or offer for recycling, if available. If partly filled: Call your local solid waste agency or for disposal instructions. Never place unused product down any indoor or outdoor drain. Do not save left over medication for future use or give it to others to use. What other information is important for this medication? This product is waterproof and remains effective following a shampoo treatment, swimming, or after exposure to rain or sunlight. If you have any other questions or concerns about this medication, contact your veterinarian or pharmacist.

5 Imidacloprid with Pyriproxyfen, Topical (Dogs) (ih-mid-a-kloe-prid with peer-ih-prox-eh-fen) Category: Agent to Treat & Control Fleas & Lice; Insect Growth Regulator Other Names for this Medication: Advantage II for Dogs Common Dosage Forms: Veterinary: Imidacloprid 9.1%, Pyriproxyfen 0.46% for topical application. Available in 4 sizes based on dog s body weight: 3-10 lbs (0.4 ml), lbs (1.0 ml), lbs (2.5 ml), over 55 lbs (4.0 ml). Human: None. Key Information X Controls fleas and chewing lice on dogs. This product does not control ticks. X When used as directed on the label, imidacloprid with pyriproxyfen is safe in most dogs. X Do not let other pets or children come into contact with the product until the area has dried. X Dispose of empty containers and any unused product carefully. How is this medication useful? The combination of imidacloprid and pyriproxyfen (Advantage II for Dogs) is licensed by the US EPA (Environmental Protection Agency) for prevention and treatment of flea and chewing lice infestations on dogs and puppies 7 weeks of age and older. You and your veterinarian can discuss why this drug is the most appropriate choice. What should I tell my veterinarian to see if this medication can be safely given? Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions. Other drugs can cause problems when taken with this product, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each. Tell your veterinarian about any conditions or diseases your pet may have now or has had in the past. If your animal has been treated for the same or similar condition in the past, tell your veterinarian about the treatment and how well it did or didn t work. If your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug. Tell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past. When should this medication not be used or be used very carefully? No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal. This drug SHOULD NOT be used on dogs: This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and effectively to your animal. If you have other questions or need more information about this medication, contact your veterinarian or pharmacist. That are allergic to imidacloprid or pyriprofyfen. That are less than 7 weeks old. This drug should be used WITH CAUTION in dogs that are: Weak, frail. Old. Pregnant or nursing. If your pet has any of these conditions or signs, talk to your veterinarian about the potential risks versus benefits. What are the side effects of this medication? When used as directed on the label side effects are unlikely. Side effects that usually are not serious include: Redness, itching, and discomfort at application site. You don t have to be overly concerned if you see any of these unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens. Side effects that may be serious or indicate a serious problem: Excessive salivation, vomiting, diarrhea. If you see any of these signs, contact your veterinarian immediately If you see anything unusual with your dog after applying contact your veterinarian or the manufacturer (Bayer HealthCare) at or if it is a medical emergency call If my pet gets too much of this medication (an overdose), what should I do? If you witness or suspect an overdose either by topical application or ingestion, contact your veterinarian or an animal poison control center for further advice. Animal poison control centers that are open 24 hours a day include: ASPCA Animal Poison Control Center ( ) and Pet Poison HELPLINE ( ); a consultation fee is charged for these services. How should this medication be given? For this medication to work, apply it exactly as your veterinarian has prescribed. It s a good idea to always check the prescription label to be sure you are giving the drug correctly. Monthly treatments are required for control and prevention of fleas. Do not get this product in dog s eyes or mouth. Do not apply to irritated skin. Using the appropriately sized tube for your dog s weight: Remove applicator tube from the package. Use scissors and peel down foil. Hold the applicator tube in an upright position. Pull the cap off the tube. Turn the cap around and place other end of the cap back on tube. Twist the cap to break the seal, then remove the cap from the tube.

6 The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 1 to 4 spots (depending on the size of the dog; see the illustrations that come with product for more information) on the top of the back from the shoulder to the base of the tail. At each spot, part the hair so the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the liquid on the skin. Do not apply an excessive amount of liquid at any one spot that could cause some of the liquid to run off. Under normal conditions, the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than 4 weeks. Do not retreat more often than once every 7 days. After flea control is obtained, return to a monthly retreatment schedule. What should I do if I miss giving a dose of this medication? If you miss applying a dose, apply it when you remember and then wait the amount of time between doses recommended by your veterinarian before giving another dose. Do not double-up or give extra doses unless instructed to do so by your veterinarian. How should I store this medication? Store unused product in a cool, dry place. Keep away from children and other animals. How should I dispose of this medication if I don t use it all? Dispose of this product carefully, as it is can be toxic to fish, turtles, and other wildlife. Do not flush this medication down the toilet or wash it down the sink. Do not reuse empty container. Recommend you put the empty container in a sealed plastic bag, then place in trash or offer for recycling, if available. If partly filled: Call your local solid waste agency or for disposal instructions. Never place unused product down any indoor or outdoor drain. Do not save left over medication for future use or give it to others to use. What other information is important for this medication? This product is waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight. If you have any other questions or concerns about this medication, contact your veterinarian or pharmacist. Can handling this medication be hazardous to me, my family, or other pets? The product label states: Harmful if swallowed. Causes moderate eye irritation. Avoid contact with eyes or clothing. Wash hands thoroughly with soap and warm water after handling. Disposable gloves are not required (not mentioned on label), but they may be considered for treatment application.

7 Imidacloprid, Permethrin, Pyriproxyfen, Topical (Dogs) (ih-mid-a-kloe-prid, per-meeth-rin, peer-ih-prox-eh-fen) Category: Agent to Treat & Control Fleas, Ticks, Mosquitoes, Biting Flies, & Lice; Insect Growth Regulator Other Names for this Medication: K9 Advantix II Common Dosage Forms: Veterinary: Imidacloprid 8.8%, Permethrin 44%, Pyriproxyfen 0.44% for topical application. Available in 4 sizes based on dog s body weight: 4-10 lbs (0.4 ml), lbs (1.0 ml), lbs (2.5 ml), over 55 lbs (4.0 ml). Human: None. Key Information X Controls fleas, ticks, mosquitoes, biting flies, and chewing lice on dogs. X Must NOT be used on cats or in households with cats. Permethrin is toxic to cats. X When used as directed on the label, this combination product is safe in most dogs. X Dispose of empty containers and any unused product carefully. How is this medication useful? The combination of imidacloprid, permethrin, and pyriproxyfen (K9 Advantix II) is licensed by the US EPA (Environmental Protection Agency) for prevention and treatment of fleas, ticks, mosquitoes, biting flies, and chewing lice for monthly use on dogs and puppies 7 weeks of age and older. You and your veterinarian can discuss why this drug is the most appropriate choice. What should I tell my veterinarian to see if this medication can be safely given? Many things might affect how well this drug will work in your animal. Be sure to discuss the following with your veterinarian so together you can make the best treatment decisions. Other drugs can cause problems when taken with this product, so be sure to tell your veterinarian and pharmacist what medications (including vitamins, supplements, or herbal therapies) you give your animal, including the amount and time you give each. Tell your veterinarian about any conditions or diseases your pet may have now or has had in the past. If your animal has been treated for the same or similar condition in the past, tell your veterinarian about the treatment and how well it did or didn t work. If your animal is pregnant or nursing, talk to your veterinarian about the risks of using this drug. Tell your veterinarian and pharmacist about any medication side effects (including allergic reactions, lack of appetite, diarrhea, itching, hair loss) your pet has developed in the past. When should this medication not be used or be used very carefully? No drug is 100% safe in all patients, but your veterinarian will discuss with you any specific concerns about using this drug in your animal. This drug SHOULD NOT be used on: This information sheet does not contain all available information for this medication. It is to help answer commonly asked questions and help you give the medication safely and effectively to your animal. If you have other questions or need more information about this medication, contact your veterinarian or pharmacist. Dogs that are allergic to imidacloprid, pyriprofyxfen, or permethrin. Cats. Permethrin is toxic to cats. Dogs less than 7 weeks old. This drug should be used WITH CAUTION in dogs that are: Weak, frail. Old. Pregnant or nursing. If your pet has any of these conditions, talk to your veterinarian about the potential risks versus benefits. What are the side effects of this medication? When used as directed on the label side effects are not likely. Side effects that usually are not serious include: Redness, itching, and discomfort at application site. You don t have to be overly concerned if you see any of these signs unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens. Side effects that may be serious or indicate a serious problem: Excessive salivation, vomiting, diarrhea. If you see any of these signs, contact your veterinarian immediately After applying, if you see anything unusual with your dog contact your veterinarian or the manufacturer (Bayer HealthCare) at or if it is a medical emergency call If my pet gets too much of this medication (an overdose), what should I do? If you witness or suspect an overdose either by topical application or ingestion, contact your veterinarian or an animal poison control center for further advice. Animal poison control centers that are open 24 hours a day include: ASPCA Animal Poison Control Center ( ) and Pet Poison HELPLINE ( ); a consultation fee is charged for these services. How should this medication be given? For this medication to work, apply it exactly as your veterinarian has prescribed. It s a good idea to always check the prescription label to be sure you are giving the drug correctly. Monthly treatments are required for control and prevention of fleas and ticks. Do not get this product in your dog s eyes or mouth. Do not apply to irritated skin. Using the appropriately sized tube for your dog s weight: Remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position. Pull the cap off the tube. Turn the cap around and place other end of cap back on tube. Twist the cap to break the seal, then remove the cap from the tube.

8 The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 2 to 6 spots (depending on the size of the dog) on the top of the back from the shoulder to the base of the tail. At each spot, part the hair until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the liquid on the skin. Do not apply an excessive amount of liquid at any one spot that could cause some of the liquid to run off the side of the dog. See the illustrations that come with product for more information. If re-treatment is necessary, do not apply more than once every week. What should I do if I miss giving a dose of this medication? If you miss applying a dose, apply it when you remember and then wait the amount of time between doses recommended by your veterinarian before giving another dose. Do not double-up or give extra doses unless instructed to do so by your veterinarian. How should I store this medication? Store unused product in a cool, dry place. Protect from freezing. Keep away from children and other animals. How should I dispose of this medication if I don t use it all? Dispose of this product carefully as it is can be toxic to fish, turtles, and other wildlife. Do not flush this medication down the toilet or wash it down the sink. Do not reuse empty container. Recommend you put it into a sealed baggie then place in trash or offer for recycling if available. If partly filled: Call your local solid waste agency or for disposal instructions. Never place unused product down any indoor or outdoor drain. Do not save left over medication for future use or give it to others to use. What other information is important for this medication? This product is waterproof and remains effective following a shampoo treatment, swimming, or after exposure to rain or sunlight. If you have any other questions or concerns about this medication, contact your veterinarian or pharmacist. Can handling this medication be hazardous to me, my family, or other pets? The product label states: Causes substantial but temporary eye injury. Do not get in eyes or on clothing. Harmful if swallowed. Avoid contact with skin or clothing. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Remove and wash contaminated clothing before reuse. Disposable gloves are not required (not mentioned on label), but they may be considered when applying this medication.

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