Vascular and Cardiothoracic Surgery Solutions

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1 Vascular and Cardiothoracic Surgery Solutions Over 50 Years of Technical and Clinical Experience in Vascular Graft Technology This document is intended to provide information to an international audience outside of the US. Effective April 2016

2 Vascular and Cardiothoracic Surgery Solutions Table of Contents Knitted vascular grafts HEMAGARD Knitted HEMAGARD Knitted Ultrathin HEMAGARD Knitted Trifurcated/Quadrifurcated Woven vascular grafts HEMASHIELD PLATINUM Woven Double Velour HEMASHIELD PLATINUM Woven Aortic Branch CARDIOROOT INTERGARD WOVEN INTERGARD WOVEN Aortic Branch INTERGARD WOVEN Thoracic Aortic Graft Antimicrobial vascular grafts INTERGARD SYNERGY INTERGARD SILVER Heparin coated vascular grafts FUSION BIOLINE INTERGARD KNITTED Heparin INTERGARD KNITTED Heparin Ultrathin eptfe grafts Hybrid vascular grafts FUSION FUSION BIOLINE Knitted patches HEMAGARD Patch Knitted HEMAGARD Carotid Patch Knitted HEMAGARD Carotid Patch Knitted Ultrathin HEMACAROTID Patch Heparin Knitted Ultrathin HEMAPATCH SILVER Knitted Ultrathin Woven patches HEMASHIELD DOUBLE VELOUR FABRIC HEMAPATCH WOVEN Tunneling solutions Tunneler Vein Graft Tunneling System (VGTS) Other products Polyester tape Graft Sizers FLIXENE Advanta SST Advanta VXT

3 HEMAGARD PATCHES HEMASHIELD DOUBLE VELOUR FABRIC CARDIOROOT FUSION HEMASHIELD PLATINUM WOVEN FLIXENE INTERGARD SYNERGY FUSION BIOLINE INTERGARD WOVEN Advanta SST HEMAGARD KNITTED Advanta VXT HEMAGARD KNITTED ULTRATHIN Tunneler 10 Refer to Instructions For Use for current indications, warnings, contraindications, and precautions.

4 Knitted Vascular Grafts

5 Knitted Vascular Grafts HEMAGARD Knitted Material: Collagen-coated polyester graft Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* HEMAGARD Knitted properties: Proprietary textile design: reverse locknit knitting technique produces burst strength, radial tensile strength and suture pull-out strength characteristics which are significantly greater than corresponding material, which utilize a tricot knit* Hemagard locknit construction designed to have a long term stability and resistance to post-operative dilatation Reverse Locknit Tricot Knit *Data on file

6 Knitted Vascular Grafts HEMAGARD Knitted Straight Diameter 6 mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK mm 20 cm HGK Diameter 6 mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK mm 40 cm HGK Diameter 12 mm 60 cm HGK mm 70 cm HGK mm 70 cm HGK mm 70 cm HGK mm 70 cm HGK mm 100 cm HGK mm 100 cm HGK mm 100 cm HGK mm 100 cm HGK Radially Supported Bifurcated Diameter Proximal/ Distal Supported Total 8 mm 40/15 cm 15 cm 70 cm HGK0008RS15 6 mm 35/15 cm 20 cm 70 cm HGK0006RS20 8 mm 35/15 cm 20 cm 70 cm HGK0008RS20 6 mm 25/15 cm 30 cm 70 cm HGK0006RS30 8 mm 25/15 cm 30 cm 70 cm HGK0008RS30 8 mm 20/20 cm 45 cm 85 cm HGK0008RS45 Axillo-Bifemoral Diameter 12 mm x 6 mm 50 cm HGK mm x 7 mm 50 cm HGK mm x 7 mm 50 cm HGK mm x 8 mm 50 cm HGK mm x 8 mm 50 cm HGK mm x 9 mm 50 cm HGK mm x 9 mm 50 cm HGK mm x 10 mm 50 cm HGK mm x 10 mm 50 cm HGK mm x 11 mm 50 cm HGK mm x 11 mm 50 cm HGK mm x 12 mm 50 cm HGK2412 Diameter Distal body/branch Supported body/branch Total body/branch 8x8 mm 100/60 cm HGKAX x10 mm 100/60 cm HGKAX1010 8x8 mm 20/35 cm 45/20 cm 85/55 cm HGKAX0808RS45/20 8x8 mm 20/25 cm 45/30 cm 85/55 cm HGKAX0808RS45/30 8x8 mm 20/25 cm 60/30 cm 100/55 cm HGKAX0808RS60/30 10x8x8 mm 25/35 cm 35/20 cm 85/55 cm HGKAX100808RS35/20 8x6x6 mm 25/35 cm 35/20 cm 85/55 cm HGKAX080606RS35/20

7 Knitted Vascular Grafts HEMAGARD Knitted Ultrathin Material: Collagen-coated polyester graft Reverse locknit knitting technique Water permeability : < 5ml/cm²/min * HEMAGARD Knitted Ultrathin properties: Proprietary ultrathin wall technology designed to improve compliance in peripheral applications Available in radially supported configuration for kink and compression resistance, including axillo-bifemoral and fem-fem crossover procedures. Ultrathin Straight Diameter 6 mm 20 cm HGKUT mm 20 cm HGKUT mm 20 cm HGKUT mm 40 cm HGKUT mm 40 cm HGKUT mm 40 cm HGKUT mm 70 cm HGKUT mm 70 cm HGKUT mm 70 cm HGKUT Ultrathin Radially Supported Straight Diameter Proximal / Distal Supported Total 8 mm 40/15 cm 15 cm 70 cm HGKUT0008RS15 6 mm 35/15 cm 20 cm 70 cm HGKUT0006RS20 7 mm 35/15 cm 20 cm 70 cm HGKUT0007RS20 8 mm 35/15 cm 20 cm 70 cm HGKUT0008RS20 6 mm 25/15 cm 30 cm 70 cm HGKUT0006RS30 7 mm 25/15 cm 30 cm 70 cm HGKUT0007RS30 8 mm 25/15 cm 30 cm 70 cm HGKUT0008RS30 *Data on file

8 Knitted Vascular Grafts HEMAGARD Knitted Trifurcated/Quadrifurcated Material: Collagen-coated polyester graft Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Trifurcated Diameter (mm) (cm) 14 x 7 20 x 35 **HGKT x 8 20 x 35 **HGKT x 9 20 x 35 **HGKT x x 35 **HGKT2010 Quadrifurcated Main Body Diameter Outside Branch Diameter / Inside Branch Diameter / 16 mm 08 mm 35 cm 07 mm 34 cm HGKQ160807/1 ** Made on request only *Data on file

9 Woven Vascular Grafts

10 Woven Vascular Grafts HEMASHIELD PLATINUM Woven Double Velour Material: Woven double velour collagen impregnated polyester graft Water permeability : < 5ml/cm²/min* Straight over 15 cm usable length: over 30 cm usable length: over 60 cm usable length: Diameter 12 mm M P0 14 mm M P0 16 mm M P0 18 mm M P0 20 mm M P0 22 mm M P0 24 mm M P0 26 mm M P0 28 mm M P0 30 mm M P0 32 mm M P0 34 mm M P0 38 mm M P0 Bifurcated over 40 cm usable length: Diameter 12 mm x 6 mm M P0 14 mm x 7 mm M P0 14 mm x 8 mm M P0 16 mm x 8 mm M P0 16 mm x 9 mm M P0 18 mm x 9 mm M P0 Diameter 6 mm M P0 7 mm M P0 8 mm M P0 10 mm M P0 12 mm M P0 14 mm M P0 16 mm M P0 18 mm M P0 20 mm M P0 22 mm M P0 24 mm M P0 26 mm M P0 28 mm M P0 30 mm M P0 32 mm M P0 34 mm M P0 38 mm M P0 Diameter 18 mm x 10 mm M P0 20 mm x 10 mm M P0 20 mm x 11 mm M P0 22 mm x 11 mm M P0 24 mm x 12 mm M P0 Diameter 6 mm M P0 7 mm M P0 8 mm M P0 10 mm M P0 20 mm M P0 22 mm M P0 24 mm M P0 26 mm M P0 28 mm M P0 30 mm M P0 32 mm M P0 34 mm M P0 38 mm M P0 *Data on file

11 Woven Vascular Grafts HEMASHIELD PLATINUM Woven Aortic Branch Material: Woven double velour collagen impregnated polyester graft Water permeability : < 5ml/cm²/min* Aortic Arch Single Branch 50 cm usable length: Thoracic Size Branch Size 20 mm x 50 cm 10 mm M P0 22 mm x 50 cm 10 mm M P0 24 mm x 50 cm 10 mm M P0 26 mm x 50 cm 10 mm M P0 28 mm x 50 cm 10 mm M P0 30 mm x 50 cm 10 mm M P0 32 mm x 50 cm 10 mm M P0 34 mm x 50 cm 10 mm M P0 Aortic Arch 4 Branch 50 cm usable length: Thoracic Size Branch Size 20 mm x 50 cm 10, 10, 8, 8 mm M P0 22 mm x 50 cm 10, 10, 8, 8 mm M P0 24 mm x 50 cm 10, 10, 8, 8 mm M P0 26 mm x 50 cm 10, 10, 8, 8 mm M P0 28 mm x 50 cm 10, 10, 8, 8 mm M P0 30 mm x 50 cm 10, 10, 8, 8 mm M P0 32 mm x 50 cm 12, 10, 10, 10 mm M P0 34 mm x 50 cm 12, 10, 10, 10 mm M P0 Angled Four Branch 50 cm usable length: Thoracic Size Branch Size 24 mm x 50 cm 12, 10, 8, 8 mm M AP0 26 mm x 50 cm 12, 10, 8, 8 mm M AP0 28 mm x 50 cm 12, 10, 8, 8 mm M AP0 30 mm x 50 cm 12, 10, 8, 8 mm M AP0 Thoraco Abdominal Aortic Graft 47 cm usable length: Thoracic Size Branch Size 26 mm x 47 cm 10, 10, 8, 8 mm *M T0 28 mm x 47 cm 10, 10, 8, 8 mm *M T0 30 mm x 47 cm 10, 10, 8, 8 mm *M T0 32 mm x 47 cm 10, 10, 8, 8 mm *M T0 * Made on request only 3 Branch Graft 30 cm usable length Thoracic Size Branch Size 12 mm x 30 cm 8 mm M P0 14 mm x 30 cm 10 mm M P0 *Data on file

12 Woven Vascular Grafts CARDIOROOT Aortic Graft Maquet CARDIOROOT Competitor A Straight Tube The proximal collar can be used for prosthetic valve sewing or trimmed/inverted for valve sparing procedures. Bore One piece-design collagen-coated CARDIOROOT graft delivers a new option for the repair or reconstruction of the ascending aorta. The design of CARDIOROOT mimics the anatomy and blood flow dynamics of the natural sinuses of Valsalva. Anatomically correct shape Unique uncrimped section that does not stretch: allows for easy sewing of valve remnants, or prosthetic valve within the tube and shortening the procedure facilitates estimation of the length required for placement of valve remnants or prosthetic valve can be precisely trimmed and shaped in case of remodeling technique procedures. 3 reference lines acting as a guide for prosthetic valve or valve remnants anastomosis. Body Bulge Collar CARDIOROOT Body Diameter Body Bulge Diameter Bulge Collar 24 mm 15 cm 32 mm 24 mm 10 mm HEWROOT mm 15 cm 34 mm 26 mm 10 mm HEWROOT mm 15 cm 36 mm 28 mm 10 mm HEWROOT mm 15 cm 38 mm 30 mm 10 mm HEWROOT mm 15 cm 40 mm 32 mm 10 mm HEWROOT mm 15 cm 42 mm 34 mm 10 mm HEWROOT0034

13 Woven Vascular Grafts INTERGARD Woven Material: Collagen-coated external-velour polyester graft Water permeability : < 5ml/cm²/min* Straight Diameter 12 mm 15 cm IGW mm 15 cm IGW mm 15 cm IGW mm 15 cm IGW mm 15 cm IGW mm 15 cm IGW mm 15 cm *IGW mm 15 cm *IGW mm 15 cm *IGW mm 15 cm *IGW mm 15 cm *IGW mm 15 cm *IGW mm 15 cm IGW * Made on request only Diameter 6 mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW mm 30 cm IGW Diameter 22 mm 60 cm IGW mm 60 cm IGW mm 60 cm IGW mm 60 cm IGW mm 60 cm IGW mm 60 cm IGW Bifurcated Diameter 12 x 6 mm 50 cm IGW x 7 mm 50 cm IGW x 8 mm 50 cm IGW x 9 mm 50 cm IGW x 10 mm 50 cm IGW x 11 mm 50 cm IGW x 12 mm 50 cm IGW2412 *Data on file

14 Woven Vascular Grafts INTERGARD Woven Aortic Branch Material: Collagen-coated external-velour polyester graft Water permeability : < 5ml/cm²/min* INTERGARD Woven Aortic Arch properties: Pre-sewn branches designed for total replacement of all diseased segments, and to allow reduced cardiac ischemic time Anatomically correct angle of branches is designed for easy suturing to the host vessels and to prevent graft kinking 30 cm length perfusion branch designed to be positioned outside of the operative field for improved control and visualization Material: Collagen-coated external-velour polyester graft Water permeability : < 5ml/cm²/min* INTERGARD HEMABRIDGE properties: Designed to allow an easier and less time consuming technique Pre-sewn perfusion branch allow for antegrade arterial perfusion, and can be used to replace the brachiocephalic artery in a partial arch replacement Aortic Arch Diameter (mm) (cm) 20x10x8x8x10 50x30x30x30x30 HEWAA /1 22x10x8x8x10 50x30x30x30x30 HEWAA /1 24x10x8x8x10 50x30x30x30x30 HEWAA /1 26x10x8x8x10 50x30x30x30x30 HEWAA /1 28x10x8x8x10 50x30x30x30x30 HEWAA /1 30x10x8x8x10 50x30x30x30x30 HEWAA /1 32x10x8x8x10 50x30x30x30x30 HEWAA /1 34x10x8x8x10 50x30x30x30x30 HEWAA /1 Hemabridge Diameter 20 mm x 10 mm 35 cm x 40 cm HEW2010BRIDGE 22 mm x 10 mm 35 cm x 40 cm HEW2210BRIDGE 24 mm x 10 mm 35 cm x 40 cm HEW2410BRIDGE 26 mm x 10 mm 35 cm x 40 cm HEW2610BRIDGE 28 mm x 10 mm 35 cm x 40 cm HEW2810BRIDGE 30 mm x 10 mm 35 cm x 40 cm HEW3010BRIDGE 32 mm x 10 mm 35 cm x 40 cm HEW3210BRIDGE 34 mm x 10 mm 35 cm x 40 cm HEW3410BRIDGE 36 mmx10mm 35 cm x 40 cm HEW3610BRIDGE *Data on file

15 Woven Vascular Grafts INTERGARD Woven Thoracic Aortic Graft Material: Collagen-coated external-velour polyester graft Water permeability : < 5ml/cm²/min* INTERGARD Woven Thoracic Aortic Graft properties: A woven graft with an uncrimped section to reconstruct or replace the thoracic ascending aorta Thoracic Aortic Graft Diameter 24 mm 15 cm **IGW NGG 26 mm 15 cm **IGW NGG 28 mm 15 cm **IGW NGG 30 mm 15 cm **IGW NGG 32 mm 15 cm **IGW NGG 34 mm 15 cm **IGW NGG ** Made on request only *Data on file

16 Antimicrobial Grafts

17 Antimicrobial Grafts INTERGARD SYNERGY Consistent with Maquet s continuous innovation policy, INTERGARD SYNERGY is the first vascular prosthesis combining two well-known antimicrobial agents: silver acetate and triclosan. While those antimicrobial agents are effective alone, their power to prevent development of infection intensifies when combined, offering increased antimicrobial properties than the existing available vascular prosthesis on the market. Material: Silver acetate/triclosan collagen-coated polyester graft Available in Knitted and Ultrathin configuration Water permeability : < 5ml/cm²/min* *Data on file

18 Antimicrobial Grafts INTERGARD SYNERGY Straight Diameter 6 mm 20 cm IGK SG 8 mm 20 cm IGK SG Diameter 6 mm 40 cm IGK SG 7 mm 40 cm IGK SG 8 mm 40 cm IGK SG 10 mm 40 cm IGK SG 12 mm 40 cm IGK SG 14 mm 40 cm IGK SG 16 mm 40 cm IGK SG 18 mm 40 cm IGK SG 20 mm 40 cm IGK SG 22 mm 40 cm IGK SG 24 mm 40 cm IGK SG Diameter 6 mm 70 cm IGK SG 7 mm 70 cm IGK SG 8 mm 70 cm IGK SG 10 mm 70 cm IGK SG Radially Supported Diameter Proximal Supported Distal Total 6 mm 35 cm 20 cm 15 cm 70 cm IGK0006RS20SG 6 mm 25 cm 30 cm 15 cm 70 cm IGK0006RS30SG 6 mm 20 cm 45 cm 20 cm 85 cm IGK0006RS45SG 8 mm 12.5 cm 15 cm 12.5 cm 40 cm IGK0008RS15-40SG 8 mm 40 cm 15 cm 15 cm 70 cm IGK0008RS15SG 8 mm 35 cm 20 cm 15 cm 70 cm IGK0008RS20SG 8 mm 25 cm 30 cm 15 cm 70 cm IGK0008RS30SG 8 mm 20 cm 45 cm 20 cm 85 cm IGK0008RS45SG 8 mm 20 cm 60 cm 20 cm 100 cm IGK0008RS60SG 10 mm 15 cm 10 cm 15 cm 40 cm IGK0010RS10-40SG Bifurcated Diameter 12x6 mm 50 cm IGK1206SG 14x7 mm 50 cm IGK1407SG 16x8 mm 50 cm IGK1608SG 18x9 mm 50 cm IGK1809SG 20x10 mm 50 cm IGK2010SG 22x11 mm 50 cm IGK2211SG 24x12 mm 50 cm IGK2412SG Axillo-Bifemoral Diameter Supported (body/branch) Total (body/branch) 8x8 mm 100x60 cm IGKAX0808SG 8x8 mm 45x20 cm 85x55 cm IGKAX0808RS45/20SG 8x8 mm 45x30 cm 85x55 cm IGKAX0808RS45/30SG 8x8 mm 60x30 cm 100x55 cm IGKAX0808RS60/30SG Ultrathin Radially Supported Diameter Proximal Supported Distal Total 6 mm 35 cm 20 cm 15 cm 70 cm IGKUT0006RS20SG 6 mm 25 cm 30 cm 15 cm 70 cm IGKUT0006RS30SG 7 mm 35 cm 20 cm 15 cm 70 cm IGKUT0007RS20SG 7 mm 25 cm 30 cm 15 cm 70 cm IGKUT0007RS30SG 8 mm 15 cm 10 cm 15 cm 40 cm IGKUT0008RS10-40SG 8 mm 12.5 cm 15 cm 12.5 cm 40 cm IGKUT0008RS15-40SG 8 mm 40 cm 15 cm 15 cm 70 cm IGKUT0008RS15SG 8 mm 35 cm 20 cm 15 cm 70 cm IGKUT0008RS20SG 8 mm 25 cm 30 cm 15 cm 70 cm IGKUT0008RS30SG Ultrathin Straight Diameter 6 mm 40 cm IGKUT SG 7 mm 40 cm IGKUT SG 8 mm 40 cm IGKUT SG 6 mm 70 cm IGKUT SG 7 mm 70 cm IGKUT SG 8 mm 70 cm IGKUT SG

19 Antimicrobial Grafts INTERGARD SILVER Material: Silver acetate collagen-coated polyester graft Available in Knitted, Woven and Ultrathin configuration Water permeability : < 5ml/cm²/min* Straight Diameter 6 mm 20 cm IGK S 8 mm 20 cm IGK S 12 mm 20 cm *IGK S 14 mm 20 cm IGK S 16 mm 20 cm IGK S 18 mm 20 cm IGK S 20 mm 20 cm IGK S 22 mm 20 cm IGK S 24 mm 20 cm *IGK S * Made on request only Diameter 6 mm 40 cm IGK S 7 mm 40 cm IGK S 8 mm 40 cm IGK S 10 mm 40 cm IGK S 12 mm 40 cm IGK S 14 mm 40 cm IGK S 16 mm 40 cm IGK S 18 mm 40 cm IGK S 20 mm 40 cm IGK S 22 mm 40 cm IGK S 24 mm 40 cm *IGK S Bifurcated Diameter 6 mm 70 cm IGK S 7 mm 70 cm IGK S 8 mm 70 cm IGK S 10 mm 70 cm IGK S Diameter 12x6 mm 50 cm IGK1206S 14x7 mm 50 cm IGK1407S 16x8 mm 50 cm IGK1608S 18x9 mm 50 cm IGK1809S 20x10 mm 50 cm IGK2010S 22x11 mm 50 cm IGK2211S 24x12 mm 50 cm IGK2412S *Data on file

20 Antimicrobial Grafts INTERGARD SILVER Radially Supported Diameter Proximal Supported Distal Total 6 mm 35 cm 20 cm 15 cm 70 cm IGK0006RS20S 6 mm 25 cm 30 cm 15 cm 70 cm IGK0006RS30S 6 mm 20 cm 45 cm 20 cm 85 cm IGK0006RS45S 8 mm 12.5 cm 15 cm 12.5 cm 40 cm IGK0008RS15-40S 8 mm 40 cm 15 cm 15 cm 70 cm IGK0008RS15S 8 mm 35 cm 20 cm 15 cm 70 cm IGK0008RS20S 8 mm 25 cm 30 cm 15 cm 70 cm IGK0008RS30S 8 mm 20 cm 45 cm 20 cm 85 cm IGK0008RS45S 8 mm 20 cm 60 cm 20 cm 100 cm IGK0008RS60S 10 mm 15 cm 10 cm 15 cm 40 cm IGK0010RS10-40S Axillo-Bifemoral Diameter Supported (body/branch) Total (body/branch) 8x8 mm 100x60 cm IGKAX0808S 8x8 mm 45x20 cm 85x55 cm IGKAX0808RS45/20S 8x8 mm 45x30 cm 85x55 cm IGKAX0808RS45/30S 8x8 mm 60x30 cm 100x55 cm IGKAX0808RS60/30S Ultrathin Radially Supported Ultrathin Diameter Proximal Supported Distal Total 6 mm 35 cm 20 cm 15 cm 70cm IGKUT0006RS20S 6 mm 25 cm 30 cm 15 cm 70cm IGKUT0006RS30S 7 mm 35 cm 20 cm 15 cm 70cm IGKUT0007RS20S 7 mm 25 cm 30 cm 15 cm 70cm IGKUT0007RS30S 8 mm 15 cm 10 cm 15 cm 40cm IGKUT0008RS10-40S 8 mm 12.5 cm 15 cm 12.5 cm 40cm IGKUT0008RS15-40S 8 mm 40 cm 15 cm 15 cm 70cm IGKUT0008RS15S 8 mm 35 cm 20 cm 15 cm 70cm IGKUT0008RS20S 8 mm 25 cm 30 cm 15 cm 70cm IGKUT0008RS30S Diameter 6 mm 40 cm IGKUT S 7 mm 40 cm IGKUT S 8 mm 40 cm IGKUT S 6 mm 70 cm IGKUT S 7 mm 70 cm IGKUT S 8 mm 70 cm IGKUT S INTERGARD SILVER Woven Straight 15 cm length: Diameter 12 mm IGW S 14 mm IGW S 16 mm IGW S 18 mm IGW S 20 mm IGW S 22 mm IGW S 24 mm IGW S 26 mm IGW S 28 mm IGW S 30 mm IGW S 32 mm IGW S 30 cm length: Diameter 8 mm IGW S 10 mm IGW S 12 mm IGW S 14 mm IGW S 16 mm IGW S 18 mm IGW S 20 mm IGW S 22 mm IGW S 24 mm IGW S 26 mm IGW S 28 mm IGW S 30 mm IGW S 32 mm IGW S Bifurcated 50 cm length: Diameter 14 mm x 7 mm IGW1407S 16 mm x 8 mm IGW1608S 18 mm x 9 mm IGW1809S 20 mm x 10 mm IGW2010S 22 mm x 11 mm IGW2211S 24 mm x 12 mm IGW2412S

21 Heparin Vascular Grafts

22 Heparin Vascular Grafts FUSION BIOLINE Dual-layer construction: eptfe and PET layers FUSION BIOLINE Vascular Graft is constructed of two layers. The inner layer is comprised of eptfe. The BIOLINE heparin coating is bonded to this inner layer with albumin, the main blood protein. The outer layer is a knit polyester textile. These two layers are fused together with a proprietary polycarbonate-urethane. By adding the benefits of heparin to the unique FUSION duallayer construction, the FUSION BIOLINE Graft sets a new standard for peripheral bypass treatment. Straight Diameter 5 mm 40 cm M B0 5 mm 80 cm M B0 6 mm 20 cm M B0 6 mm 40 cm M B0 6 mm 60 cm M B0 6 mm 80 cm M B0 7 mm 40 cm M B0 7 mm 80 cm M B0 8 mm 40 cm M B0 8 mm 60 cm M B0 8 mm 80 cm M B0 10 mm 40 cm M B0 10 mm 80 cm M B0 Helix Supported Diameter 5 mm 40 cm M B0 5 mm 80 cm M B0 6 mm 40 cm M B0 6 mm 60 cm M B0 6 mm 80 cm M B0 7 mm 40 cm M B0 7 mm 80 cm M B0 8 mm 40 cm M B0 8 mm 60 cm M B0 8 mm 80 cm M B0 10 mm 40 cm M B0 10 mm 80 cm M B0 All grafts are fully supported except 3 cm on 1 end.

23 Heparin Vascular Grafts INTERGARD Heparin Knitted Material: Collagen-coated heparin-bonded polyester graft Available in Knitted and Ultrathin configuration Water permeability : < 5ml/cm²/min* INTERGARD Heparin properties: Proprietary heparin-bonding process designed to allow the antithrombotic properties of biologically active heparin to be available locally at the graft surface Higher patency rates at three years compared to PTFE 1 Significantly lower amputation rates than PTFE 1 Validated intended use with rifampicin loading *Data on file 1. Devine C, McCollum C; North West Femoro-Popliteal Trial Participants. Heparinbonded Dacron or polytetrafluorethylene for femoropopliteal bypass: Five-year results of a prospective randomized multicenter clinical trial. J Vasc Surg Nov;40(5):

24 Heparin Vascular Grafts INTERGARD Heparin Knitted Straight Diameter 6 mm 70 cm IGK H 7 mm 70 cm IGK H 8 mm 70 cm IGK H 10 mm 70 cm IGK H Diameter 14 mm 40 cm IGK H 16 mm 40 cm IGK H 18 mm 40 cm IGK H 20 mm 40 cm IGK H 22 mm 40 cm IGK H 24 mm 40 cm IGK H Radially Supported Straight Diameter Proximal / Distal Supported Total 6 mm 35/15 cm 20 cm 70 cm IGK0006RS20H 8 mm 35/15 cm 20 cm 70 cm IGK0008RS20H 6 mm 25/15 cm 30 cm 70 cm IGK0006RS30H 8 mm 25/15 cm 30 cm 70 cm IGK0008RS30H Bifurcated Diameter 12x6 mm 50 cm IGK1206H 14x7 mm 50 cm IGK1407H 16x8 mm 50 cm IGK1608H 18x9 mm 50 cm IGK1809H 20x10 mm 50 cm IGK2010H 22x11 mm 50 cm IGK2211H Ultrathin Straight Diameter 6 mm 40 cm IGKUT H 7 mm 40 cm IGKUT H 8 mm 40 cm IGKUT H Diameter 6 mm 70 cm IGKUT H 7 mm 70 cm IGKUT H 8 mm 70 cm IGKUT H Ultrathin Radially Supported Straight Diameter Proximal / Distal Supported Total 6 mm 35/15 cm 20 cm 70 cm IGKUT0006RS20H 7 mm 35/15 cm 20 cm 70 cm IGKUT0007RS20H 8 mm 35/15 cm 20 cm 70 cm IGKUT0008RS20H 6 mm 25/15 cm 30 cm 70 cm IGKUT0006RS30H 7 mm 25/15 cm 30 cm 70 cm IGKUT0007RS30H 8 mm 25/15 cm 30 cm 70 cm IGKUT0008RS30H 6 mm 20/20 cm 45 cm 85 cm IGKUT0006RS45H 8 mm 20/20 cm 45 cm 85 cm IGKUT0008RS45H

25 eptfe Grafts

26 eptfe vascular grafts FLIXENE FLIXENE provides a durable vascular access option Durable Construction Engineered to meet clinical demands Strength and Durability FLIXENE exhibits high radial tensile strength even after simulated needle cannulations 1 Improved Suture Retention FLIXENE offers greater suture retention over Maquet s single-layer eptfe grafts 1 Published Data Successful early cannulation (24-72 hours) in select patient series 2 3 Layer eptfe graft Large pore surface layer, more receptive to tissue ingrowth Middle layer, reinforcing wrap for added durability Small pore base layer, inner graft surface porosity of nominal 20um 1. Data on file. 2. Schild AF, Schuman ES, Noicely K, et al. Early cannulation prosthetic graft (FLIXENE) for arteriovenous access. J Vasc Access Jul-Sep;12(3):

27 eptfe vascular grafts FLIXENE FLIXENE Graduated Wall Technology: FLIXENE Graduated Wall exhibits a gradual, reduced wall thickness that extends approximately 8 cm on each end. This offers surgeons improved suturability and handling over FLIXENE standard wall grafts without sacrificing the strength and durability needed for needle cannulation. Inflow Options Cannulation Zone Outflow Options GW GW Straight Diameter Wall Thickness Slider GDS 6 mm 10 cm SW mm 30 cm GW Yes mm 40 cm GW Yes mm 50 cm GW Yes mm 10 cm SW mm 30 cm GW Yes mm 40 cm GW Yes mm 50 cm GW Yes mm 50 cm SW Straight Trumpet GWT GW Taper GW TRMP Diameter Wall Thickness Slider GDS 6 mm 30 cm GW Yes mm 45 cm GW Yes mm 45 cm GW Yes mm 45 cm GWT Yes mm 35 cm GWT Yes mm 45 cm GWT Yes mm 35 cm GWT Yes Trumpet GW = Graduated Wall TRMP = Trumpet GWT = Graduated Wall Taper Tapered Diameter Wall Slider Thickness GDS 4-6 mm 35 cm GWT-GW Yes mm 45 cm GWT-GW Yes mm 35 cm GWT-GW Yes mm 45 cm GWT-GW Yes 25138

28 eptfe vascular grafts ADVANTA SST Straight Diameter Wall Thickness Helix Support Slider GDS 5 mm 80 cm TW Yes mm 50 cm TW Yes mm 70 cm TW Yes mm 10 cm TW mm 50 cm TW Yes mm 80 cm TW Yes mm 50 cm TW Yes mm 80 cm TW Yes Helix Ultra-Thin 3 Layer Reinforced Graft SST s ultra-thin wall design is Maquet s thinnest eptfe graft available, resulting in an extremely low profile graft Available with an internal helix to resist potential for kinking or compression Proprietary processing techniques allow Maquet to maintain an ultra-low profile in the SST graft design in spite of its 3 layer construction Available with Slider GDS Diameter Wall Thickness Helix Support Slider GDS 4-7 mm 80 cm TW 20 cm Yes mm 50 cm TW 30 cm Yes mm 80 cm TW 20 cm Yes mm 80 cm TW 20 cm Yes mm 80 cm TW 20 cm Yes Slider Graft Deployment System: The patented Slider Graft Deployment System (GDS) is an innovation that equips physicians with a means of surgically implanting a vascular graft, making it easy to implant with low tunnel bleeding. 1 The Slider GDS tunneling system provides fast graft attachment and insertion. The Slider GDS System makes it easy to pull any small diameter graft through the subcutaneous tissue. The low profile tunneler tip with its thin protection sleeve minimizes trauma, allows for a tight graft tunnel, and minimizes pre-wetting of the graft. 1 The Slider GDS has a double sheath system designed to minimize the risk of contaminating the graft material prior to insertion. 1. Schild AF, Baltodano NM, Alfieri K, Livingstone J, Raines JK. New Graft for Low Friction Tunneling in Vascular Access Surgery. J Vasc Access Jan-Mar;5(1):19-24.

29 eptfe vascular grafts ADVANTA VXT VXT has a large pore surface VXT has an inner surface porosity of nominal 20 µm 2-Layer Reinforced Grafts Experience Maquet s VXT graft technology in your next surgical graft placement. The 2-layer construction makes VXT a strong and durable vascular graft. Straight Diameter Wall Thickness Helix/ Ring Support Slider GDS 4 mm 10 cm SW mm 50 cm SW mm 70 cm SW mm 10 cm SW mm 40 cm SW Yes mm 50 cm SW Yes mm 70 cm SW Yes mm 10 cm SW mm 10 cm TW mm 30 cm SW mm 40 cm SW Yes mm 40 cm TW Yes mm 50 cm SW Yes mm 50 cm TW Yes mm 70 cm SW Yes mm 70 cm TW Yes mm 80 cm TW Yes mm 10 cm SW mm 50 cm SW Yes mm 50 cm TW Yes mm 70 cm SW Yes mm 70 cm TW Yes mm 10 cm SW mm 40 cm SW Yes mm 40 cm TW Yes mm 50 cm SW Yes mm 70 cm SW Yes mm 70 cm TW Yes mm 80 cm TW Yes mm 50 cm SW mm 70 cm SW Externally supported Diameter Wall Thickness Helix/ Ring Support Slider GDS 5 mm 10 cm SW Yes mm 40 cm SW Yes Yes mm 50 cm SW Yes Yes mm 80 cm SW Yes mm 10 cm SW Yes mm 40 cm SW Yes Yes mm 50 cm SW Yes Yes mm 50 cm TW Yes Yes mm 70 cm SW Yes Yes mm 70 cm TW Yes Yes mm 80 cm SW Yes Yes mm 80 cm TW Yes Yes mm 100 cm TW Yes Yes mm 50 cm SW Yes Yes mm 50 cm TW Yes Yes mm 70 cm SW Yes Yes mm 70 cm TW Yes Yes mm 80 cm SW Yes Yes mm 40 cm TW Yes Yes mm 50 cm SW Yes Yes mm 50 cm TW Yes Yes mm 70 cm SW Yes Yes mm 70 cm TW Yes Yes mm 80 cm TW Yes Yes mm 80 cm SW Yes Trumpet Diameter Wall Thickness Helix/ Ring Support Slider GDS 6 mm 40 cm SW Yes mm 60 cm TW Yes Yes mm 80 cm TW Yes Yes mm 60 cm TW Yes Yes mm 80 cm TW Yes Yes mm 80 cm TW Yes Yes Tapered Diameter Wall Thickness Helix/ Ring Support Slider GDS 4-6 mm 45 cm SW Yes mm 45 cm SW Yes mm 70 cm SW Yes mm 45 cm SW Yes mm 80 cm TW Yes Yes mm 80 cm TW Yes Yes 22267

30 Hybrid Vascular Grafts

31 Hybrid Vascular Grafts FUSION Dual-layer construction: eptfe and PET layers The FUSION vascular graft is constructed of two layers. The inner layer is comprised of eptfe. The outer layer is a knit polyester textile. These two layers are fused together with a proprietary polycarbonate-urethane. By adding the benefits of eptfe and a knit polyester textile, the FUSION graft sets a new standard for peripheral bypass treatment. Straight Diameter 5 mm 40 cm M mm 80 cm M mm 20 cm M mm 40 cm M mm 60 cm M mm 80 cm M mm 40 cm M mm 80 cm M mm 40 cm M mm 60 cm M mm 80 cm M mm 40 cm M mm 80 cm M Helix Supported Diameter 5 mm 40 cm M mm 80 cm M mm 40 cm M mm 60 cm M mm 80 cm M mm 40 cm M mm 80 cm M mm 40 cm M mm 60 cm M mm 80 cm M mm 40 cm M mm 80 cm M * Hybrid indicates a combination of materials: eptfe and PET. All grafts are fully supported except 3 cm on 1 end.

32 Patches

33 Knitted Patches HEMAGARD Patch Material: Collagen-coated polyester patch Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Knitted Dimensions 25 mm x 50 mm HGK25/50P (1) 25 mm x 75 mm HGK25/75P (1) 25 mm x 150 mm HGK25/150P (1) 25 mm x 100 mm HGK25/100P (1) 50 mm x 50 mm HGK50/50P (1) 50 mm x 75 mm HGK50/75P (1) 50 mm x 150 mm HGK50/150P (1) 75 mm x 75 mm HGK75/75P (1) 100 mm x 100 mm HGK100/100P (1) 10 mm x 140 mm HGK10/140P (1) 20 mm x 140 mm HGK20/140P (1) *Data on file

34 Knitted Patches HEMAGARD Carotid Patch Material: Collagen-coated polyester patch Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Knitted Dimensions Tapered 6 mm x 75 mm Yes HGKTP06/75CP (1) 8 mm x 75 mm Yes HGKTP08/75CP (1) 10 mm x 75 mm No HGK10/75CP (1) 12 mm x 75 mm No HGK12/75CP (1) 14 mm x 75 mm No HGK14/75CP (1) *Data on file

35 Knitted Patches HEMAGARD Carotid Patch Ultrathin Material: Collagen-coated polyester patch Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Knitted Ultrathin Dimensions Tapered 6 mm x 75 mm Yes HGKTP06/75CPUT (1) 8 mm x 75 mm Yes HGKTP08/75CPUT (1) 8 mm x 150 mm Yes HGKTP08/150CPUT (1) 10 mm x 75 mm No HGK10/75CPUT (1) 12 mm x 75 mm No HGK12/75CPUT (1) 14 mm x 75 mm No HGK14/75CPUT (1) 10 mm x 150 mm No HGK10/150CPUT (1) 25 mm x 100 mm No HGK25/100CPUT (1) 6 mm x 120 mm Yes HGKTP06/120CPUT (1) 8 mm x 120 mm Yes HGKTP08/120CPUT (1) 25 mm x 75 mm No HGK25/75CPUT (1) 25 mm x 150 mm No HGK25/150CPUT (1) *Data on file

36 Knitted Patches HEMACAROTID Patch Heparin Ultrathin Material: Collagen-coated heparin-bonded polyester patch Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Heparin Knitted Ultrathin Dimensions 6 mm x 75 mm HEK06/75CPUTH (1) 8 mm x 75 mm HEK08/75CPUTH (1) 10 mm x 75 mm HEK10/75CPUTH (1) 12 mm x 75 mm HEK12/75CPUTH (1) 14 mm x 75 mm HEK14/75CPUTH (1) *Data on file

37 Knitted Patches HEMAPATCH Silver Ultrathin 1 Silver ions bind to the phospholipid layer, penetrate and change the permeability of the bacterial cell wall 2 Silver ions bind to functional proteins and interfere with cellular respiration Bacteria 3 Silver ions bind with the bases in the bacterial DNA molecule and inhibit cell division 4 Silver ions inactivate enzymes by binding to sulfhydryl groups in the proteins Cellular lysis Material: Silver acetate collagen-coated polyester patch Reverse locknit knitting technique Water permeability : < 5ml/cm²/min* Ultrathin Dimensions 10 mm x 150 mm HEK10/150UTS (1) 14 mm x 75 mm HEK14/75UTS (1) 25 mm x 100 mm HEK25/100UTS (1) *Data on file

38 Woven Patches HEMASHIELD Double Velour Fabric Material: Woven double velour impregnated polyester fabric Water permeability : < 10ml/cm²/min* HEMASHIELD Woven Double Velour Fabric Width x (inch) Width x (cm) 1.0 x x 15.2 M x x 7.6 M x x 15.2 M *Data on file

39 Woven Patches HEMAPATCH Woven Material: Collagen-coated polyester patch Water permeability : < 5ml/cm²/min* Woven Dimensions 25 mm x 50 mm HEW25/50P (1) 25 mm x 100 mm HEW25/100P (1) 50 mm x 50 mm HEW50/50P (1) 75 mm x 75 mm HEW75/75P (1) 100 mm x 100 mm HEW100/100P (1) *Data on file

40 Tunneling Solutions

41 Tunneling Solutions Tunneler Tunneler Product Description AV/PV combination Tunneler Set with tray AV-1 Tunneler AV-2 Tunneler PV-1 Tunneler PV-2 Tunneler AV/PV combination Tunneler Case 2 AV Tunnelers, 2 PV Tunnelers, Set of 8 Tips, 2 per size: 6 mm, 7 mm, 8 mm, 10 mm 26 cm with 50º curve (Stainless Steel) 27 cm with 180º curve (Stainless Steel) 33cm with 12º curve (Stainless Steel) 58 cm with 24º curve (Stainless Steel) Low Profiling Tunneling Instrumentation Tunneling tips feature a large grasping area for easier manipulation. Creates a tighter tunnel to match graft diameter. Tunneler Tips Set of 8 Size Tips 2 per size: 6 mm, 7 mm, 8 mm, 10 mm mm Tips Set of mm Tips Set of mm Tips Set of mm Tips Set of mm Tips Set of mm Tips Set of Set of 8 Blunt Tips 2 per size: 6 mm, 7 mm, 8 mm, 10 mm mm Blunt Tips Set of mm Blunt Tips Set of mm Blunt Tips Set of mm Blunt Tips Set of Unique thumb tab provides directional control. Slider GDS The Slider GDS tunneling system provides fast graft attachment and insertion. The Slider GDS System makes it easy to pull any small diameter graft through the subcutaneous tissue. The low profile tunneler tip with its thin protection sleeve minimizes trauma, allows for a tight graft tunnel, and minimizes pre-wetting of the graft. 1 The Slider GDS has a double sheath system designed to minimize the risk of contaminating the graft material prior to insertion. Protected by the following international and U.S. Patent(s): 1. Schild AF, Baltodano NM, Alfieri K, Livingstone J, Raines JK. New Graft for Low Friction Tunneling in Vascular Access Surgery. J Vasc Access Jan-Mar;5(1):19-24.

42 Tunneling Solutions Vein Graft Tunneling System Vein Graft Tunneling System (VGTS): Quick attachment of a prepared harvested vein is made by the preattached slipknot suture. The protective outer sheath reduces trauma and stress on vein and surrounding tissue. The VGTS attaches easily to Atrium s tunneler for quick implantation. Creates a tighter, smaller tunnel compared to that of conventional sheath style tunnelers. Vein Graft Tunneling System 26050

43 Other Products

44 Other Products Polyester Tape Material: Braided polyester fabric Effective retraction: Strong, tight braided polyester fabric designed to reduce risk of tissue trauma while providing effective retraction Sterile Width x (inch) Width x (cm) 1/8 x x 45.7 M /8 x x 61.0 M /8 x x 76.2 M /16 x x 45.7 M /16 x x 61.0 M /16 x x 76.2 M /4 x x 45.7 M /4 x x 61.0 M /4 x x 76.2 M Packaged 2 strips per package. Packaged 5 per box.

45 Other Products Graft Sizers Single use plastic sizers for graft measurement prior to graft implantation. Small graft sizer Diameter (mm) Multipack units per pack M Large graft sizer Diameter (mm) Multipack units per pack M

46

47 Knowing What s Important The Surgical Academy As a communication center the MAQUET Surgical Academy offers a variety of specialist events on topics relating to medicine, health policy, and hospital management. An exhibition hall with the complete product range, two auditoria with multimedia equipment, four conference rooms as well as fully equipped and functional operating and intensive care rooms are among the infrastructure at this unique facility. In workshops, experts in small groups communicate valu able findings for everyday clinical work. Practiceoriented teaching materials supplement the offering, for example a positioning primer which explains the rudiments of surgical positioning step-by-step. Inhouse product trainings for worldwide MAQUET business partners ensure a permanent high level of knowledge and the ability of excellent customer support.

48 Local Contact Address Label Here Getinge Group P.O. Box 8861 SE Göteborg Sweden Getinge Group is a leading global provider of innovative solutions for operating rooms, intensive-care units, hospital wards, sterilization departments, elderly care and for life science companies and institutions. With a genuine passion for life we build quality and safety into every system. Our unique value proposition mirrors the continuum of care, enhancing efficiency throughout the clinical pathway. Based on our first-hand experience and close partnerships, we are able to exceed expectations from customers improving the every-day life for people, today and tomorrow. M Advanta vascular grafts, Slider graft deployment system (GDS), and FLIXENE vascular grafts are manufactured by Atrium Medical Corporation, 40 Continental Blvd., Merrimack NH M INTERGARD/HEMAGARD/HEMASHIELD vascular products, Polyester Tape and Graft Sizers are manufactured by Intervascular SAS, Z.I. Athélia 1, La Ciotat Cedex, France +33 (0) M Fusion and Fusion Bioline products are manufactured by Maquet Cardiovascular, LLC, 45 Barbour Pond Drive, Wayne, NJ (+1) Protected by the following international and U.S. patent(s): Getinge Group, Getinge, ArjoHuntleigh, Maquet and Atrium are trademarks or registered trademarks of Getinge AB, its subsidiaries or affiliates in the United States or other countries Getinge Getinge Group, ArjoHuntleigh, Maquet and Atrium are registered with the U.S. Patent and Trademark Office. Copyright 2016 Atrium Medical Corp. or its affiliates. All rights not expressly granted are reserved. Refer to Instructions for Use for current indications, warnings, contraindications, and precautions. 06/16 Part No Rev AB This document is intended to provide information to an international audience outside of the US. Certain products may not be licensed or available in certain countries or in stock. Please check with your local distributor for availability.

The only device incorporating infrarenal anchors for active fixation with proven migration prevention through 5 years of follow-up.

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