Antibiotic Resistance in the European Union Associated with Therapeutic use of Veterinary Medicines Report and Qualitative Risk Assessment by the Committee for Veterinary Medicinal Products Annex III Surveillance Programmes in the EU Regarding Antimicrobial Resistance in Animal Isolates Public EMEA 1999 1
THE EU REGARDING ANTIMICROBIAL RESISTANCE IN ANIMAL ISOLATES Austria No vet. resistance surveillance programme exists Belgium spp. Poultry breeders (healthy animals; surveillance). Sick and healthy poultry, pigs and cattle; animal foods and some food for human consumption (laboratory findings only, no surveillance) All isolates are serotyped and tested against 15 antimicrobials since 1992. Annual report with results Denmark Pathogenic: Staph. aureus Staph. (coagulase negative) Staph. hyicus Actinobacillus pleuropneumoniae Listeria monocytogenes Enteritidis Typhimurium Campylobacter coli / C. jejuni Yersinia enterocolitica Poultry, cattle, pigs (clinical cases) Cattle; food Cattle Food Food (animal origin) Poultry, cattle, pigs (1997) Poultry, cattle, pigs Broilers, cattle, pigs; food (1997) ; pork DANMAP-Project: started in 1995 Includes also data on consumption of antibiotics in animals and humans resistance and prevalence data healthy (slaughterhouse) and diseased animals. Resistance data from human isolated (differentiated by professions) E. faecium E. faecalis Broiler, cattle, pigs; food; ; pork Broilers, cattle, pigs (healthy animals); food Public EMEA 1999 1
Finland Pathogenic: Staphylococci Serpulina Aeromonas salmon. ssp. salm. Listeria monocytogenes Campylobacter France Pathogenic Pasteurella Gram -Positive cocci (all serovars) Zoonotic (all serovars) Swine, dogs Cattle (Mastitis) Swine Fish Food of broiler or fish origin (since 1998) Broiler (since 1998) Broiler, Swine (not annually) Cattle (clinical samples) Clinical outbreaks in adult cattle Non human sources (animals, food, feedstuffs, environment): strains collected from diagnostic labs RESABO Network (operating since 1982) RESSAB Network (collaboration with clinicians for documented cases), with postoutbreak surveillance RESEAU (operating since 1970) ca 13000 strains/year. Serotyping Public EMEA 1999 2
Germany Pathogenic: Pasteurella spp. Staphylococcus spp. Streptococcus spp. Actinomyces Actinobacillus Bordetella Clostridium spp. other pathogens. spp. Enteritidis Typhimurium Campylobacter spp. Greece No vet. resistance surveillance programme exists Enteritidis Cattle, pigs, sheep, poultry, dogs, cats Cattle, pigs etc Cattle, pigs etc Cattle, pigs etc Cattle Cattle, pigs ; slaughtering animals, meat, and other food of animal origin, feeding stuffs Cattle, poultry, pigs, etc. Few animal species; food of animal origin Isolates from livestock, food or other animals (limited data) No official monitoring programme. Collection of more than 30 000 bacterial isolates / year sent by 29-32 veterinary medicinal diagnostic institutes to the BgVV (since 1992), Antibiotic Resistance Programme ("Resi"). Resistance Monitoring at the National Reference Laboratory (NRL-SALM), several thousands isolates/year since more than 10 years Regional data from a Campylobacter Project Antibiotic Resistance Programme ("Resi"). Limited data from an Enterococcus Project Research programme of the Athen's University and the National School of Public Health (Nat. Reference Centre for e and Shigellae) since 1990; human data and only occasionally animal data Public EMEA 1999 3
Ireland, cattle, poultry Routine monitoring through Nat. Surveillance programme for since 1997. Propose to monitor campylobacter and coliform isolates during 1999 Italy Luxembourg No information provided The Netherlands spp. Campylobacter spp. Pathogens all vet. med. relevant strains Portugal No vet. resistance surveillance programme exists Campylobacter (mainly poultry), food Vancomycin resistance in poultry and pigs (faeces); meat (pork, chicken) Food borne pathogens isolated from healthy and diseased animals Farms animals (clinical samples) Healthy animals Birds, pigs (since 1993), cattle (since 1980) Isolates in NE-Italy only starting 1998 Limited to a study in 1997-98 Data collected in: National Resistance Monitoring Programme Reference Laboratory Campylobacter: start in 1998 Only limited data; Research data Public EMEA 1999 4
Spain Pathogenic (clinical samples) VAV network (since 1997) Zoonotics (clinical samples) VAV network (since 1998) Commensals E. faecium (faeces, sampled from abattoirs) VAV network (since 1998) Sweden Pathogens: udder pathogen bacteriae Commensals E. faecium E. faecalis UK Pathogenic: (O157) Dublin Enteritidis Typhimurium / DT104 Campylobacter coli / C. jejuni, cattle Dairy cows, poultry Cattle, pigs, poultry Poultry, cattle, pigs Poultry Parts of UK only, no surveillance programme Public EMEA 1999 5
EU-PROJECTS: FAIR action (ARBAO = Antibiotic Resistance in Bacteria of Animal Origin): 13 countries within the EU Starting 1 January 1998 for 3 years Office International des Epizooties (OIE) OIE collaborating centre for Veterinary Medicinal Products in 50 European countries First report expected in March 1999 FEFANA project Enterococcus faecium in pigs and poultry 1998-2000 6 Member States (DK, S, UK, NL, F, E) Danish Project FKP: Occurrence, development and spread of antimicrobial resistance in bacteria from food animals Public EMEA 1999 6