StatSpin, Inc. Toll-Free (8) 782-8774 85 Morse Street Phone (781) 551-1 Norwood, MA 262 Fax (781) 551-36 www.statspin.com info@statspin.com LipoClear Testing Don Newton, MS, MT Brockton Hospital Laboratory, Brockton, Massachusetts COPYRIGHT 24 DOCUMENT # 64-575-1 REV. A
Various Analytes Tested Before and After Treatment with LipoClear, StatSpin s Lipemic Clearing Agent Jessica Thibeault, MT (ASCP) Purpose To confirm that LipoClear, lipemic clearing agent does not interfere with the methodology used for determination of the most common chemistry analytes tested in the clinical laboratory. Materials and Methods Thirty volunteers each provided a Lithium Heparin plasma sample that was split into two aliquots. One aliquot was treated with LipoClear and the other was tested straight. These samples were all nonlipemic to maintain an accurate baseline. The tubes were separated using a StatSpin MP, which spins for 95 seconds at 15,8 rpm. Each sample was tested for the following chemistries: Glucose (Glu), BUN, Creatinine (Creat), Albumin (Alb), Total Protein (T. Prot), Calcium (Ca++), Uric Acid, Total Bilirubin (T. Bili), LDH, CPK, Alkaline Phosphatase (Alk. Phos.), SGPT, SGOT, GGPT, Amylase (Amy), Sodium (Na+), Potassium (K+), Chloride (Cl-), CO 2, TSH, T4, Troponin I, and CKMB. Various methodologies were used in the testing of the above analytes. TSH, T4, Troponin I, and CKMB were all tested on a Bayer Centaur. Electrolytes were performed via indirect ISE methodology and the remaining analytes were all determined with an Olympus AU 4. The samples were processed and treated according to the LipoClear Product Insert Sheet. Upon obtaining results, the values obtained on the treated samples were subsequently multiplied by a 1.2 dilution factor to account for the dilution of the actual reagent. Interpretation Most analytes tested presented acceptable correlation coefficients ranging from.886-.999. These analytes included Glu, BUN, Creat, Alb, Ca++, Uric Acid, T. Bili, LDH, CPK, Alk. Phos., SGPT, SGOT, GGPT, Amy, Na+, K+, Cl-, CO 2, TSH, T4 and CKMB. The p-values were mostly low however good correlation was noted and accepted based on the comparative values. Total protein was slightly decreased which has been noted in previous studies and was incorporated into the product insert. Troponin I was not calculated given that all samples analyzed were below detectable levels. Refer to Table 2.1 for all descriptive statistics Discussion The data reveals that Total Protein values are slightly decreased when treated with LipoClear however this data confirms previous studies. This error may be due to the binding of high density proteins. With exception to the above stated analyte, all other LipoClear treated samples tested produced acceptable correlation when compared to the untreated aliquots. COPYRIGHT 24 PAGE 1
Table 2.1 Statistical Summary Mean STD. Dev. Corr Coef P value Glucose 93.5 17.5.983.76 BUN 15.5 9.9.997.8 Creatinine.88.16.954.3 Albumin 4.43.22.89. Total Protein 7.26.5.659. Calcium 8.98.46.937. Uric Acid 5.18 1.63.993.6 Total Bilirubin.61.78.965. LDH 145. 18.2.953. CPK 127. 117.5.999. Alkaline Phosphatase 7.87 14.1.987. SGPT 17.73 6.8.936.96 SGOT 18.6 7.5.941.8 GGPT 25.83 21.6.999.1 Amylase 43.36 15.9.986. Sodium 136.9 3.5.886.456 Potassium 3.99.33.952.3 Chloride 12.27 2.9.92.443 CO2 24.6 1.8.888. TSH 1.45.89.991.446 T4 6.36 1.7.968. Troponin I NA NA NA NA CKMB 1.67 1.3.957. COPYRIGHT 24 PAGE 2
Table 3.1 Data Pat. No. Glu Glu BUN BUN Creat Creat Alb Alb T. Prot 1 84 85 7 7 1 1 4.4 4.2 6.9 6.2 8.5 8. 7.8 7.7.8.7 135 124 2 111 19 1 1 1 1 4.4 4.3 7.5 6.8 9.5 9. 8.4 8.2.9.5 132 121 3 98 98 13 13.8.8 4.4 4.2 7.4 6.4 9.1 8.5 4.5 4.4.2.2 14 128 4 73 73 11 11.7.7 4.4 4.2 7. 6.2 8.9 8.4 3.2 3.1 1.1 1. 144 13 5 86 85 13 13 1. 1. 4.2 4. 7.3 6.4 1.2 9.6 3.7 4.3 1.6 1.4 139 132 6 71 72 13 13.7.7 4.7 4.6 7.5 6.6 9.8 9.4 6.5 6.2.3.2 13 125 7 9 89 27 26 1.3 1.3 4.6 4.4 7.4 6.4 9. 8.4 6.3 6. 1.2 1.1 17 151 8 96 95 11 11.7.6 4.3 4.1 6.6 5.9 8.5 8. 3.8 3.6.4.5 124 114 9 83 8 12 12.9.8 4.6 4.3 7.8 6.6 9.1 8.5 3. 2.8.3.2 191 179 1 96 97 11 11.9.8 4.3 4.1 7.9 6.6 8.3 7.7 5.5 5.4.3.1 158 137 11 89 9 27 26.8.7 4.2 4. 7.4 6.1 8. 7.7 6.2 6..5.5 157 133 12 9 91 18 18.7.6 4.2 4.1 6.9 6.1 8.6 8.2 7. 7..4.4 15 144 13 134 136 9 1 1.1 1.1 4.2 4.2 7.6 6.9 9. 8.9 5.9 5.9.5.5 143 139 14 85 86 28 26.8.7 4.4 4.2 6.7 6.4 9.4 8.9 3.6 3.5.8.7 168 16 15 84 85 7 7 1. 1. 4.4 4.2 6.9 6.2 8.5 8. 7.8 7.7.8.7 135 129 16 98 98 13 13.8.8 4.4 4.2 7.4 6.9 9.1 8.5 4.5 4.4.2.2 14 128 17 73 73 11 11.7.7 4.4 4.2 7. 6.8 8.9 8.4 3.2 3.1 1.1 1. 144 13 18 132 131 8 9.9 1. 4.2 3.9 7.6 7.4 9. 8.8 5.9 5.4.5.4 143 141 19 85 72 28 26.8.6 4.4 3.9 6.3 6.4 9.4 9.1 3.6 3.3.8.6 168 153 2 88 87 55 53 1.2 1.2 4.3 4.4 7.7 7.5 8.5 8.5 6.5 6.8.4.3 169 166 21 17 14 15 14.8.7 4.2 4. 7.3 6.4 8.7 8.2 4.6 4.6.2.2 122 118 22 88 86 15 16.8.7 5. 4.7 8.3 7.2 9.1 8.5 5.6 5.5.4.4 113 1 23 91 89 11 12 1. 1. 4.8 4.7 7.9 7.1 9.3 8.8 5.3 5.2.5.4 157 146 24 143 146 13 13 1. 1. 4.8 4.7 7.9 7.1 9.3 8.8 5.3 5.2.5.4 157 146 25 16 12 11 1.7.7 5. 4.8 7.5 6.6 9.1 8.6 2.8 2.6.4.4 116 16 26 88 78 9 1 1.1 1.1 4.2 4.2 7.6 7.3 9. 8.9 5.9 5.9.5.5 143 14 27 85 86 28 25.8.7 4.4 4.1 6.3 6.6 9.4 9.1 3.6 3.6.8.8 168 16 28 84 84 7 6 1. 1. 4.4 4.2 6.7 6.2 8.4 8. 7.8 7.7.7.7 13 124 29 96 98 13 13.8.8 4.4 4.2 7. 6.4 9. 8.5 4.4 4.4.2.2 132 128 3 71 73 1 11.7.7 4.3 4.2 6.7 6.2 8.7 8.4 3.2 3.1 1.1 1. 134 13 T. Prot. Cal Cal UrAc UrAc T. Bili T. Bili LDH LDH COPYRIGHT 24 PAGE 3
Table 4.1 Data (cont.) Pat. No. CPK CPK Alk Phos Alk Phos SGPT SGPT SGOT SGOT 1 129 125 82 79 15 16 16 17 25 24 4 38 141 139 4. 4.1 16 14 2 41 42 4 38 12 12 12 13 18 19 29 28 138 137 4.6 4.6 1 1 3 86 84 68 65 16 2 2 17 29 29 71 66 137 138 4.6 4.6 1 1 4 7 67 69 68 6 14 15 5 7 6 49 47 138 137 4. 3.8 14 13 5 582 574 7 7 43 41 38 38 33 32 35 32 137 137 3.9 3.8 18 17 6 98 92 64 64 14 14 18 18 17 17 3 29 134 137 4.5 4.4 97 98 7 471 472 63 61 3 3 29 31 21 19 66 64 137 138 4.3 4.2 13 13 8 64 62 66 65 12 12 1 8.4 11 11 31 29 138 138 3.8 3.7 14 14 9 92 91 43 4 2 19 26 23 13 13 51 52 139 138 3.9 3.8 16 16 1 111 17 91 91 14 13 17 12 26 26 36 34 134 133 3.9 3.8 12 12 11 226 216 53 5 27 26 34 29 14 13 24 22 134 136 4.2 4.2 12 13 12 32 3 82 83 23 23 23 19 43 42 33 31 134 137 4.2 4.2 11 13 13 82 82 89 88 16 16 11 6 15 14 26 25 135 133 3.7 3.6 99 98 14 65 64 62 64 19 19 11 8.4 22 22 42 36 139 137 3.4 3.4 13 12 15 129 125 82 79 15 16 1 8.4 15 14 66 54 127 131 3.3 3.4 98 11 16 86 84 68 65 16 2 16 16 13 13 86 84 138 139 4.3 4.3 14 14 17 7 67 69 68 9 14 12 11 16 16 54 49 135 134 4.2 4.1 1 1 18 82 8 89 79 18 15 6 8.4 1 11 35 34 138 139 3.4 3.6 13 14 19 65 63 62 62 19 16 16 14 16 13 39 31 126 128 4.3 4. 95 97 2 78 84 68 65 23 26 21 18 28 26 33 31 139 136 4. 4. 12 1 21 121 12 97 96 2 2 19 18 114 11 27 25 136 136 4. 4. 12 12 22 12 12 73 73 14 13 27 28 29 29 46 44 14 14 3.9 3.8 12 12 23 148 143 64 61 13 14 12 13 15 14 4 36 139 14 3.5 3.5 13 13 24 29 24 52 48 21 19 3 32 25 25 19 18 138 138 4.4 4.4 11 11 25 14 138 9 91 16 17 18 19 8 79 32 3 139 138 3.6 3.6 13 12 26 82 81 89 88 18 16 24 24 36 35 57 54 14 14 4. 4. 12 14 27 65 64 62 64 19 19 16 16 24 23 51 52 141 14 3.9 3.8 17 16 28 129 125 82 79 16 16 16 17 24 24 4 38 141 139 4. 4.1 16 14 29 86 84 68 65 17 2 2 17 29 29 68 66 137 138 3.9 4. 14 13 3 7 67 69 68 11 14 15 15 7 6 45 47 138 137 4. 3.8 11 13 GGPT GGPT Amy Amy Na Na K K CL CL COPYRIGHT 24 PAGE 4
Table 5.1 Data (cont.) Pat. No. CO2 CO2 T4 T4 TSH TSH Trop I Trop I CKMB CKMB 1 25 24 7.1 7.7.47.46.. 2.13 2.99 2 28 26 8.4 9.6 1.29 1.25.2..77 1.9 3 24 23 5.4 6.1 1.41 1.34.. 2.36 3.29 4 25 24 5.2 5.6 2.38 2.39...73 1.13 5 21 19 4.6 5.4.6.61.. 5.95 7.72 6 27 25 7.5 8.5 2.53 2.62.. 2.2 5.29 7 27 25 6.7 7.3.6.62..4 4.1 5.29 8 27 25 6.9 7.9 1.68 2....97 1.39 9 24 22 8.1 8.4.58.64..2.36.64 1 22 22 5.1 6. 1.16 1.21...48.8 11 24 22 6.8 7.8 1.47 1.43.1.4 3.35 4.57 12 23 22 5.4 6.1 1.18 1.19.6..47.82 13 21 2 3.7 4.1 3.38 3.18..7 1.9 1.51 14 25 24 5.3 6. 1.4 1.21..1.96 1.26 15 22 2 5.7 6.4 2.92 3.2..2 1.27 1.63 16 24 24 8.1 1..93 1... 1.17 1.42 17 24 22 6.4 7.4 1.64 1.7...47.82 18 23 24 5.1 4.8.69.65...87 1.58 19 25 23 3.7 4.6 3.43 3.32.. 1.32 1.64 2 25 24 7.4 8.5 2.8 2.86.. 1.34 1.82 21 25 24 9.2 9.8.75.43.. 1.34 1.87 22 25 25 5.9 6.8 1.9 1.86...49.85 23 26 25 7.6 7.1.93.88.. 2. 2. 24 26 26 9.5 1.2.12.12.. 4.34 5.98 25 26 26 3.3 3.2 1. 1... 1.11 1.46 26 26 24 7.3 7.8 1.13 1.2.. 1.75 2.3 27 23 22 7.1 7.7.98 1... 1.27 1.32 28 25 24 7.1 7.7.47.46.. 2.13 2.29 29 24 23 5.8 6.1 1.37 1.34.. 2.36 2.39 3 26 24 5.3 5.6 2.28 2.39...93 1.13 COPYRIGHT 24 PAGE 5
Glucose Table 6.1 Table 6.2 Patient# Glu Glu 1 84 85 2 111 19 3 98 98 4 73 73 5 86 85 6 71 72 7 9 89 8 96 95 9 83 8 1 96 97 11 89 9 12 9 91 Gluc Gluc Mean 93.5 92.6 Variance 37.7759 331.9724 Pearson Correlation.98322 t Stat 1.473198 P(T<=t) one-tail.75735 P(T<=t) two-tail.15147 13 134 136 14 85 86 15 84 85 16 98 98 Table 6.3 17 73 73 18 132 131 19 85 72 2 88 87 21 17 14 22 88 86 23 91 89 24 143 146 25 16 12 26 88 78 27 85 86 28 84 84 29 96 98 Glucose 16 14 12 1 8 6 4 2 2 4 6 8 1 12 14 16 3 71 73 COPYRIGHT 24 PAGE 6
BUN Table 7.1 Table 7.2 Patient# BUN BUN 1 7 7 2 1 1 3 13 13 4 11 11 5 13 13 6 13 13 7 27 26 8 11 11 9 12 12 1 11 11 11 27 26 12 18 18 Bun Bun Mean 15.46667 15.2 Variance 99.63678 86.37241 Pearson Correlation.9971 t Stat 1.439246 P(T<=t) one-tail.8394 P(T<=t) two-tail.16788 13 9 1 14 28 26 15 7 7 16 13 13 Table 7.3 17 11 11 18 8 9 19 28 26 2 55 53 21 15 14 22 15 16 23 11 12 24 13 13 6 5 4 3 BUN 25 11 1 26 9 1 27 28 25 28 7 6 29 13 13 2 1 1 2 3 4 5 6 3 1 11 COPYRIGHT 24 PAGE 7
Creatinine Table 8.1 Table 8.2 Patient# Creat Creat 1 1 1 2 1 1 3.8.8 4.7.7 5 1 1 6.7.7 7 1.3 1.3 8.7.6 9.9.8 1.9.8 11.8.7 12.7.6 Creat Creat Mean.883333.85 Variance.26264.36379 Pearson Correlation.9538 t Stat 3.1399 P(T<=t) one-tail.2679 P(T<=t) two-tail.5358 13 1.1 1.1 14.8.7 15 1 1 16.8.8 17.7.7 18.9 1 19.8.6 2 1.2 1.2 21.8.7 22.8.7 23 1 1 24 1 1 25.7.7 26 1.1 1.1 27.8.7 28 1 1 Table 8.3 Creatinine 1.4 1.2 1.8.6.4.2.2.4.6.8 1 1.2 1.4 29.8.8 3.7.7 COPYRIGHT 24 PAGE 8
Albumin Table 9.1 Table 9.2 Patient# Alb Alb 1 4.4 4.2 2 4.4 4.3 3 4.4 4.2 4 4.4 4.2 5 4.2 4 6 4.7 4.6 7 4.6 4.4 8 4.3 4.1 9 4.6 4.3 1 4.3 4.1 11 4.2 4 12 4.2 4.1 Alb Alb Mean 4.43 4.25 Variance.51828.56379 Pearson Correlation.889889 t Stat 9 P(T<=t) one-tail P(T<=t) two-tail 13 4.2 4.2 14 4.4 4.2 15 4.4 4.2 16 4.4 4.2 Table 9.3 17 4.4 4.2 18 4.2 3.9 19 4.4 3.9 2 4.3 4.4 21 4.2 4 22 5 4.7 23 4.8 4.7 24 4.8 4.7 25 5 4.8 26 4.2 4.2 6 5.5 5 4.5 4 3.5 Albumin 27 4.4 4.1 28 4.4 4.2 3 3 3.5 4 4.5 5 5.5 6 29 4.4 4.2 3 4.3 4.2 COPYRIGHT 24 PAGE 9
Total Protein Table 1.1 Table 1.2 Patient# T. Prot T. Prot 1 6.9 6.2 2 7.5 6.8 3 7.4 6.4 4 7 6.2 5 7.3 6.4 6 7.5 6.6 7 7.4 6.4 8 6.6 5.9 9 7.8 6.6 1 7.9 6.6 11 7.4 6.1 12 6.9 6.1 T. Prot T. Prot Mean 7.266667 6.596667 Variance.24856.176885 Pearson Correlation.658979 t Stat 9.54774 P(T<=t) one-tail P(T<=t) two-tail 13 7.6 6.9 14 6.7 6.4 15 6.9 6.2 16 7.4 6.9 Table 1.3 17 7 6.8 18 7.6 7.4 19 6.3 6.4 2 7.7 7.5 21 7.3 6.4 22 8.3 7.2 23 7.9 7.1 24 7.9 7.1 25 7.5 6.6 26 7.6 7.3 27 6.3 6.6 28 6.7 6.2 Total Protein 8 7 6 5 4 3 2 1 2 4 6 8 1 29 7 6.4 3 6.7 6.2 COPYRIGHT 24 PAGE 1
Calcium Table 11.1 Table 11.2 Patient# Ca++ Ca++ 1 8.5 8 2 9.5 9 3 9.1 8.5 4 8.9 8.4 5 1.2 9.6 6 9.8 9.4 7 9 8.4 8 8.5 8 9 9.1 8.5 1 8.3 7.7 11 8 7.7 12 8.6 8.2 Ca++ Ca++ Mean 8.976667 8.543333 Variance.214954.213575 Pearson Correlation.93674 t Stat 14.4174 P(T<=t) one-tail P(T<=t) two-tail 13 9 8.9 14 9.4 8.9 15 8.5 8 16 9.1 8.5 Table 11.3 17 8.9 8.4 18 9 8.8 Calcium 19 9.4 9.1 2 8.5 8.5 21 8.7 8.2 22 9.1 8.5 23 9.3 8.8 24 9.3 8.8 25 9.1 8.6 26 9 8.9 27 9.4 9.1 28 8.4 8 1 9 8 7 6 5 5 6 7 8 9 1 11 29 9 8.5 3 8.7 8.4 COPYRIGHT 24 PAGE 11
Uric Acid Table 12.1 Table 12.2 Patient# UrAc UrAc 1 7.8 7.7 2 8.4 8.2 3 4.5 4.4 4 3.2 3.1 5 3.7 4.3 6 6.5 6.2 7 6.3 6 8 3.8 3.6 9 3 2.8 1 5.5 5.4 11 6.2 6 12 7 7 Uric Acid Uric Acid Mean 5.18 5.86667 Variance 2.67469 2.65757 Pearson Correlation.993287 t Stat 2.7121 P(T<=t) one-tail.578 P(T<=t) two-tail.11417 13 5.9 5.9 14 3.6 3.5 15 7.8 7.7 16 4.5 4.4 Table 12.3 17 3.2 3.1 18 5.9 5.4 19 3.6 3.3 2 6.5 6.8 21 4.6 4.6 22 5.6 5.5 23 5.3 5.2 24 5.3 5.2 25 2.8 2.6 26 5.9 5.9 27 3.6 3.6 28 7.8 7.7 9 8 7 6 5 4 3 2 1 Uric Acid 2 4 6 8 1 29 4.4 4.4 3 3.2 3.1 COPYRIGHT 24 PAGE 12
Total Bilirubin Table 13.1 Table 13.2 Patient# T. Bili T. Bili 1.8.7 2.9.5 3.2.2 4 1.1 1 5 1.6 1.4 6.3.2 7 1.2 1.1 8.4.5 9.3.2 1.3.1 11.5.5 12.4.4 T Bili T Bili Mean.613333.54 Variance.123264.1113 Pearson Correlation.964964 Df 29 t Stat 4.252955 P(T<=t) one-tail.1 P(T<=t) two-tail.21 13.5.5 14.8.7 15.8.7 Table 13.3 16.2.2 17 1.1 1 18.5.4 19.8.6 2.4.3 21.2.2 22.4.4 23.5.4 24.5.4 25.4.4 26.5.5 27.8.8 T. Bilirubin 1.6 1.4 1.2 1.8.6.4.2.5 1 1.5 2 28.7.7 29.2.2 3 1.1 1 COPYRIGHT 24 PAGE 13
LDH Table 14.1 Table 14.2 Patient# LDH LDH 1 135 124 2 132 121 3 14 128 4 144 13 5 139 132 6 13 125 7 17 151 8 124 114 9 191 179 1 158 137 11 157 133 12 15 144 LDH LDH Mean 145.667 135.4 Variance 33.1333 31.759 Pearson Correlation.953337 t Stat 9.651886 P(T<=t) one-tail P(T<=t) two-tail 13 143 139 14 168 16 15 135 129 16 14 128 Table 14.3 17 144 13 18 143 141 19 168 153 2 169 166 21 122 118 22 113 1 23 157 146 24 157 146 25 116 16 26 143 14 27 168 16 28 13 124 2 18 16 14 12 1 8 6 4 2 LDH 5 1 15 2 25 29 132 128 3 134 13 COPYRIGHT 24 PAGE 14
CPK Table 15.1 Table 15.2 Patient# CPK CPK 1 129 125 2 41 42 3 86 84 4 7 67 5 582 574 6 98 92 7 471 472 8 64 62 9 92 91 1 111 17 11 226 216 12 32 3 CPK CPK Mean 127.333 124.6333 Variance 13816.52 13584.1 Pearson Correlation.99973 t Stat 4.53932 P(T<=t) one-tail P(T<=t) two-tail 13 82 82 14 65 64 15 129 125 16 86 84 Table 15.3 17 7 67 18 82 8 19 65 63 2 78 84 21 121 12 22 12 12 23 148 143 24 29 24 25 14 138 26 82 81 27 65 64 28 129 125 29 86 84 CPK 7 6 5 4 3 2 1 1 2 3 4 5 6 7 3 7 67 COPYRIGHT 24 PAGE 15
Alkaline Phosphatase Table 16.1 Table 16.2 Patient# Alk Phos Alk Phos 1 82 79 2 4 38 3 68 65 4 69 68 5 7 7 6 64 64 7 63 61 8 66 65 9 43 4 1 91 91 11 53 5 12 82 83 Alk Phos Alk Phos Mean 7.86667 69.23333 Variance 2.1885 25.842 Pearson Correlation.987275 t Stat 3.92974 P(T<=t) one-tail.248 P(T<=t) two-tail.496 13 89 88 14 62 64 15 82 79 16 68 65 Table 16.3 17 69 68 18 89 79 19 62 62 2 68 65 21 97 96 22 73 73 23 64 61 24 52 48 25 9 91 26 89 88 27 62 64 28 82 79 29 68 65 Alkaline Phosphatase 12 1 8 6 4 2 2 4 6 8 1 12 3 69 68 COPYRIGHT 24 PAGE 16
SGPT Table 17.1 Table 17.2 Patient# SGPT SGPT 1 15 16 2 12 12 3 16 2 4 6 14 5 43 41 6 14 14 7 3 3 8 12 12 9 2 19 1 14 13 11 27 26 12 23 23 SGPT SGPT Mean 17.73333 18.33333 Variance 47.44368 37.1954 Pearson Correlation.93555 t Stat -1.3374 P(T<=t) one-tail.9582 P(T<=t) two-tail.19164 13 16 16 14 19 19 15 15 16 16 16 2 Table 17.3 17 9 14 18 18 15 19 19 16 2 23 26 21 2 2 22 14 13 23 13 14 24 21 19 25 16 17 26 18 16 27 19 19 28 16 16 29 17 2 SGPT 45 4 35 3 25 2 15 1 5 1 2 3 4 5 3 11 14 COPYRIGHT 24 PAGE 17
SGOT Table 18.1 Table 18.2 Patient# SGOT SGOT 1 16 17 2 12 13 3 2 17 4 15 5 5 38 38 6 18 18 7 29 31 8 1 8.4 9 26 23 1 17 12 11 34 29 12 23 19 SGOT SGOT Mean 18.6 17.32 Variance 56.93793 65.12993 Pearson Correlation.941249 t Stat 2.571924 P(T<=t) one-tail.7751 P(T<=t) two-tail.1553 13 11 6 14 11 8.4 15 1 8.4 16 16 16 Table 18.3 17 12 11 18 6 8.4 19 16 14 2 21 18 21 19 18 22 27 28 23 12 13 24 3 32 25 18 19 26 24 24 27 16 16 28 16 17 SGOT 4 35 3 25 2 15 1 5 5 1 15 2 25 3 35 4 29 2 17 3 15 15 COPYRIGHT 24 PAGE 18
GGPT Table 19.1 Table 19.2 Patient# GGPT GGPT 1 25 24 2 18 19 3 29 29 4 7 6 5 33 32 6 17 17 7 21 19 8 11 11 9 13 13 1 26 26 11 14 13 12 43 42 GGPT GGPT Mean 25.83333 25.13333 Variance 468.57 445.292 Pearson Correlation.99989 t Stat 3.632925 P(T<=t) one-tail.536 P(T<=t) two-tail.173 13 15 14 14 22 22 15 15 14 16 13 13 17 16 16 18 1 11 19 16 13 2 28 26 21 114 11 Table 19.3 12 1 GGPT 22 29 29 23 15 14 24 25 25 25 8 79 26 36 35 27 24 23 28 24 24 8 6 4 2 2 4 6 8 1 12 29 29 29 3 7 6 COPYRIGHT 24 PAGE 19
Amylase Table 2.1 Table 2.2 Patient# Amy Amy 1 4 38 2 29 28 3 71 66 4 49 47 5 35 32 6 3 29 7 66 64 8 31 29 9 51 52 1 36 34 11 24 22 12 33 31 Amy Amy Mean 43.36667 4.86667 Variance 253.678 237.223 Pearson Correlation.985921 t Stat 5.11964 P(T<=t) one-tail P(T<=t) two-tail 13 26 25 14 42 36 15 66 54 16 86 84 Table 2.3 17 54 49 18 35 34 19 39 31 2 33 31 21 27 25 22 46 44 23 4 36 24 19 18 25 32 3 26 57 54 27 51 52 28 4 38 29 68 66 Amylase 9 8 7 6 5 4 3 2 1 2 4 6 8 1 3 45 47 COPYRIGHT 24 PAGE 2
Sodium Table 21.1 Table 21.2 Patient# Na+ Na+ 1 141 139 2 138 137 3 137 138 4 138 137 5 137 137 6 134 137 7 137 138 8 138 138 9 139 138 1 134 133 11 134 136 12 134 137 Na+ Na+ Mean 136.9 136.9333 Variance 12.36897 7.58169 Pearson Correlation.885941 Df 29 t Stat -.1927 P(T<=t) one-tail.456872 P(T<=t) two-tail.913744 13 135 133 14 139 137 15 127 131 16 138 139 Table 21.3 17 135 134 18 138 139 19 126 128 2 139 136 21 136 136 22 14 14 23 139 14 24 138 138 25 139 138 26 14 14 27 141 14 28 141 139 29 137 138 Sodium 142 14 138 136 134 132 13 128 126 124 124 126 128 13 132 134 136 138 14 142 3 138 137 COPYRIGHT 24 PAGE 21
Potassium Table 22.1 Table 22.2 Patient# K+ K+ 1 4 4.1 2 4.6 4.6 3 4.6 4.6 4 4 3.8 5 3.9 3.8 6 4.5 4.4 7 4.3 4.2 8 3.8 3.7 9 3.9 3.8 1 3.9 3.8 11 4.2 4.2 12 4.2 4.2 K+ K+ Mean 3.99 3.953333 Variance.114724.14644 Pearson Correlation.952329 t Stat 1.943497 P(T<=t) one-tail.3859 P(T<=t) two-tail.61718 13 3.7 3.6 14 3.4 3.4 15 3.3 3.4 16 4.3 4.3 Table 22.3 17 4.2 4.1 18 3.4 3.6 19 4.3 4 Potassium 2 4 4 21 4 4 22 3.9 3.8 23 3.5 3.5 24 4.4 4.4 25 3.6 3.6 5 4 3 26 4 4 27 3.9 3.8 28 4 4.1 2 2 3 4 5 29 3.9 4 3 4 3.8 COPYRIGHT 24 PAGE 22
Chloride Table 23.1 Table 23.2 Patient# Cl Cl 1 16 14 2 1 1 3 1 1 4 14 13 5 18 17 6 97 98 7 13 13 8 14 14 9 16 16 1 12 12 11 12 13 12 11 13 Cl Cl Mean 12.2667 12.3 Variance 8.3423 5.527586 Pearson Correlation.91962 t Stat -.14346 P(T<=t) one-tail.443458 P(T<=t) two-tail.886916 13 99 98 14 13 12 15 98 11 16 14 14 Table 23.3 17 1 1 18 13 14 19 95 97 2 12 1 21 12 12 22 12 12 23 13 13 24 11 11 25 13 12 26 12 14 18 16 14 12 1 98 Chloride 27 17 16 28 16 14 96 94 96 98 1 12 14 16 18 11 29 14 13 3 11 13 COPYRIGHT 24 PAGE 23
CO2 Table 24.1 Table 24.2 Patient# CO2 CO2 1 25 24 2 28 26 3 24 23 4 25 24 5 21 19 6 27 25 7 27 25 8 27 25 9 24 22 1 22 22 11 24 22 12 23 22 CO2 CO2 Mean 24.6 23.43333 Variance 3.75862 3.15575 Pearson Correlation.888379 t Stat 7.662833 P(T<=t) one-tail P(T<=t) two-tail 13 21 2 14 25 24 15 22 2 16 24 24 Table 24.3 17 24 22 18 23 24 19 25 23 CO2 2 25 24 21 25 24 22 25 25 23 26 25 24 26 26 25 26 26 26 26 24 27 23 22 28 25 24 29 24 23 3 25 2 15 1 1 15 2 25 3 3 26 24 COPYRIGHT 24 PAGE 24
Thyroid Stimulating Hormone Table 25.1 Table 25.2 Patient# TSH TSH 1.47.46 2 1.29 1.25 3 1.41 1.34 4 2.38 2.39 5.6.61 6 2.53 2.62 7.6.62 8 1.68 2 9.58.64 1 1.16 1.21 11 1.47 1.43 12 1.18 1.19 TSH TSH Mean 1.449 1.452 Variance.788264.824548 Pearson Correlation.99148 t Stat -.13487 P(T<=t) one-tail.446821 P(T<=t) two-tail.893643 13 3.38 3.18 14 1.4 1.21 15 2.92 3.2 16.93 1 Table 25.3 17 1.64 1.7 18.69.65 19 3.43 3.32 2 2.8 2.86 21.75.43 22 1.9 1.86 23.93.88 24.12.12 25 1 1 26 1.13 1.2 27.98 1 28.47.46 29 1.37 1.34 TSH 3.5 3 2.5 2 1.5 1.5.5 1 1.5 2 2.5 3 3.5 4 3 2.28 2.39 COPYRIGHT 24 PAGE 25
T4 Table 26.1 Table 26.2 Patient# T4 T4 1 7.1 7.7 2 8.4 9.6 3 5.4 6.1 4 5.2 5.6 5 4.6 5.4 6 7.5 8.5 7 6.7 7.3 8 6.9 7.9 9 8.1 8.4 1 5.1 6 11 6.8 7.8 12 5.4 6.1 T4 T4 Mean 6.356667 7.6667 Variance 2.461161 3.64782 Pearson Correlation.967757 t Stat -7.7658 P(T<=t) one-tail P(T<=t) two-tail 13 3.7 4.1 14 5.3 6 15 5.7 6.4 16 8.1 1 Table 26.3 17 6.4 7.4 18 5.1 4.8 19 3.7 4.6 T4 2 7.4 8.5 21 9.2 9.8 22 5.9 6.8 23 7.6 7.1 24 9.5 1.2 25 3.3 3.2 26 7.3 7.8 27 7.1 7.7 28 7.1 7.7 12 1 8 6 4 2 2 4 6 8 1 29 5.8 6.1 3 5.3 5.6 COPYRIGHT 24 PAGE 26
CKMB Table 27.1 Table 27.2 Patient# CKMB CKMB 1 2.13 2.99 2.77 1.9 3 2.36 3.29 4.73 1.13 5 5.95 7.72 6 2.2 5.29 7 4.1 5.29 8.97 1.39 9.36.64 1.48.8 11 3.35 4.57 12.47.82 CKMB CKMB Mean 1.669333 2.276333 Variance 1.682289 3.1257 Pearson Correlation.957456 t Stat -5.19213 P(T<=t) one-tail P(T<=t) two-tail 13 1.9 1.51 14.96 1.26 15 1.27 1.63 16 1.17 1.42 Table 27.3 17.47.82 18.87 1.58 19 1.32 1.64 2 1.34 1.82 21 1.34 1.87 22.49.85 23 2 2 24 4.34 5.98 25 1.11 1.46 26 1.75 2.3 27 1.27 1.32 28 2.13 2.29 29 2.36 2.39 CKMB 9 8 7 6 5 4 3 2 1 1 2 3 4 5 6 7 3.93 1.13 COPYRIGHT 24 PAGE 27