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OIE Reference Laboratory Reports Activities Activities in 2017 This report has been submitted : 2018-01-03 08:50:56 Name of disease (or topic) for which you are a designated OIE Reference Laboratory: Enzootic abortion of ewes (Ovine chlamydiosis) Address of laboratory: 14 rue Pierre et Marie Curie 94701 Maisons-Alfort Cedex, FRANCE Tel.: +33 (0)-1 49.77.13.0 Fax: +33 (0)-1 49.77.13.4 E-mail address: karine.laroucau@anses.fr Website: Name (including Title) of Head of Laboratory (Responsible Official): Pascal Boireau Name (including Title and Position) of OIE Reference Expert: Karine Laroucau Which of the following defines your laboratory? Check all that apply: Governmental OIE Reference Laboratory Reports Activities, 2017 1

ToR 1: To use, promote and disseminate diagnostic methods validated according to OIE Standards 1. Did your laboratory perform diagnostic tests for the specified disease/topic for purposes such as disease diagnosis, screening of animals for export, surveillance, etc.? (t for quality control, proficiency testing or staff training) Diagnostic Test Indicated in OIE Manual (/) Total number of test performed last year Indirect diagnostic tests Nationally Internationally ELISA C. abortus oui 25 0 Direct diagnostic tests Nationally Internationally PCR C. abortus oui 84 0 Identification souche vaccinale par PCR- HRM oui 84 0 ToR 2: To develop reference material in accordance with OIE requirements, and implement and promote the application of OIE Standards. To store and distribute to national laboratories biological reference products and any other reagents used in the diagnosis and control of the designated pathogens or disease. 2. Did your laboratory produce or supply imported standard reference reagents officially recognised by the OIE? 3. Did your laboratory supply standard reference reagents (non OIE-approved) and/or other diagnostic reagents to OIE Member Countries? 4. Did your laboratory produce vaccines? 5. Did your laboratory supply vaccines to OIE Member Countries? 2 OIE Reference Laboratory Reports Activities, 2017

ToR 3: To develop, standardise and validate, according to OIE Standards, new procedures for diagnosis and control of the designated pathogens or diseases 6. Did your laboratory develop new diagnostic methods validated according to OIE Standards for the designated pathogen or disease? 7. Did your laboratory develop new vaccines according to OIE Standards for the designated pathogen or disease? ToR 4: To provide diagnostic testing facilities, and, where appropriate, scientific and technical advice on disease control measures to OIE Member Countries 8. Did your laboratory carry out diagnostic testing for other OIE Member Countries? 9. Did your laboratory provide expert advice in technical consultancies on the request of an OIE Member Country? ToR 5: To carry out and/or coordinate scientific and technical studies in collaboration with other laboratories, centres or organisations 10. Did your laboratory participate in international scientific studies in collaboration with OIE Member Countries other than the own? ToR 6: To collect, process, analyse, publish and disseminate epizootiological data relevant to the designated pathogens or diseases 11. Did your Laboratory collect epizootiological data relevant to international disease control? 12. Did your laboratory disseminate epizootiological data that had been processed and analysed? OIE Reference Laboratory Reports Activities, 2017 3

13. What method of dissemination of information is most often used by your laboratory? (Indicate in the appropriate box the number by category) a) Articles published in peer-reviewed journals: 2 Seth-Smith HMB, Busó LS, Livingstone M, Sait M, Harris SR, Aitchison KD, Vretou E, Siarkou VI, Laroucau K, Sachse K, Longbottom D, Thomson NR.European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures.bmc Genomics. 2017 May 4;18(1):344. doi: 10.1186/s12864-017-3657-y. Szymańska-Czerwińska M, Mitura A, Niemczuk K, Zaręba K, Jodełko A, Pluta A, Scharf S, Vitek B, Aaziz R, Vorimore F, Laroucau K, Schnee C.Dissemination and genetic diversity of chlamydial agents in Polish wildfowl: Isolation and molecular characterisation of avian Chlamydia abortus strains.plos One. 2017 Mar 28;12(3):e0174599. doi: 10.1371/journal.pone.0174599. ecollection 2017. b) International conferences: 0 c) National conferences: 0 d) Other: (Provide website address or link to appropriate information) 0 ToR 7: To provide scientific and technical training for personnel from OIE Member Countries To recommend the prescribed and alternative tests or vaccines as OIE Standards 14. Did your laboratory provide scientific and technical training to laboratory personnel from other OIE Member Countries? ToR 8: To maintain a system of quality assurance, biosafety and biosecurity relevant for the pathogen and the disease concerned 15. Does your laboratory have a Quality Management System certified according to an International Standard? Quality management system adopted COFRAC Certificate scan (PDF, JPG, PNG format) Annex_1.pdf 16. Is your laboratory accredited by an international accreditation body? 4 OIE Reference Laboratory Reports Activities, 2017

Test for which your laboratory is accredited PCR temps réel pour la détection des Chlamydiacea Accreditation body COFRAC 17. Does your laboratory maintain a biorisk management system for the pathogen and the disease concerned? (See Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, Chapter 1.1.4) ToR 9: To organise and participate in scientific meetings on behalf of the OIE 18. Did your laboratory organise scientific meetings on behalf of the OIE? 19. Did your laboratory participate in scientific meetings on behalf of the OIE? ToR 10: To establish and maintain a network with other OIE Reference Laboratories designated for the same pathogen or disease and organise regular inter-laboratory proficiency testing to ensure comparability of results 20. Did your laboratory exchange information with other OIE Reference Laboratories designated for the same pathogen or disease? 21. Was your laboratory involved in maintaining a network with OIE Reference Laboratories designated for the same pathogen or disease by organising or participating in proficiency tests? 22. Did your laboratory collaborate with other OIE Reference Laboratories for the same disease on scientific research projects for the diagnosis or control of the pathogen of interest? OIE Reference Laboratory Reports Activities, 2017 5

ToR 11: To organise inter-laboratory proficiency testing with laboratories other than OIE Reference Laboratories for the same pathogens and diseases to ensure equivalence of results 23. Did your laboratory organise or participate in inter-laboratory proficiency tests with laboratories other than OIE Reference Laboratories for the same disease? te: See Interlaboratory test comparisons in: Laboratory Proficiency Testing at: http://www.oie.int/en/our-scientific-expertise/reference-laboratories/proficiency-testing see point 1.3 ToR 12: To place expert consultants at the disposal of the OIE 24. Did your laboratory place expert consultants at the disposal of the OIE? 25. Additional comments regarding your report: 6 OIE Reference Laboratory Reports Activities, 2017