COUNTRY REPORT THAILAND Sasi Jaroenpoj Department of Livestock Development 1
DLD Organization Chart Director General Senior Veterinary and Livestock Experts Deputy DG (Animal Health) Deputy DG (Food Safety) Deputy DG (Animal Production) Deputy DG (Administration) Bureau of Disease Control and Veterinary Services Bureau of Livestock Products Quality Control Bureau of Livestock Extension Office of Department Secretary Division of Finance Bureau of Veterinary Biologics National Institute of Animal Health Bureau of Livestock Standard and Certification Bureau of Livestock Biotechnology Bureau of Animal Nutrition Division of Planning Division of Personnel Regional, Provincial and District level 7 Regional Veterinary Research and Development Centers 9 Regional Livestock Offices 77 Provincial Livestock Offices 888 District Livestock Offices Bureau of Animal Husbandry - 2,073 Sub-District Livestock Assistants + 80,000 Village Livestock Volunteers Bureau of Legislative Affairs Internal Auditing Unit Administrative Development Unit Information Technology center 2
I. Legal framework and institutional arrangements for regulating antimicrobial use in livestock production and instruments for enforcement 3
Drug Act B.E. 2510 (1967) and its five revised versions for licensing of manufacturing, importing and selling and registration of human and animal drugs (incl vaccine) Food and Drug Administration (FDA), Ministry of Public Health is responsible for licensing, registration and pharmacovigilance of veterinary medicinal products Department of Livestock Development (DLD), Ministry of Agriculture and Cooperatives is responsible for control the usage and post-marketing surveillance of veterinary medicinal products The FDA also empowers the DLD & DOF officials to enforce the Drug Act relating to the post-marketing of veterinary drugs/biologics 4
II. The extent of antimicrobial use in livestock production 5
The use of antimicrobial drugs is estimated from the quantities of antimicrobial agents manufactured and imported. Amount of use in animals in 2010 Antimicrobials Dosage form Amount (single prep.) Anti-infective Antidiarrhea Tetracycline Penicillins Cephalosporins 6,384 lit 1,111 MT 523 kg 17,668 lit 49,440 lit 5,218 MT 98,757 lit 1,162 MT 582 kg 1,424 lit 12 MT 6
Antimicrobials Dosage form Amount (single prep.) Macrolides Quinolones Aminoglycosides Tablet Spray 15,717 lit 8,417 MT 7,660 lit 880 MT 43,335 lit 291,238 lit 25 MT 1,398,690 tab 628 kg 82,175 lit 354 lit 29 MT 2,433 lit Other antibiotics 774 MT 7
Antimicrobials Dosage form Amount (single prep.) Sulphonamides 1,480 lit 23,087 lit 6 MT Coccidiostat Anthelmentics Tablet 20,832 lit 50,923 lit 3,749 MT 21,385 lit 162 MT 30,984 lit 166 MT 1,205,510 tab 8
Market size Products Percentage 1. Vit.-Min.es 12.88 2. Coccidiostats 0.73 3. Antimicrobial (F.A.) 11.41 4. Feed Additives 29.31 5. Vaccines 12.58 6. Antimicrobials (S.P.) 4.03 7. Antimicrobials (Inj.) 4.79 8. Supportives 3.34 9. Anthelminthice 5.83 10. Disinfectants 8.92 11. Others 6.19 TOTAL 100 9
III. Current (and planned) arrangements for monitoring of antimicrobial use in livestock, antimicrobial residues in livestock products and surveillance for antimicrobial resistance (AMR) in animal pathogens 10
Drug Acts B.E. 2510 (1967): manufacturer and importer must submit an annual report concerning the production or importation of drugs Estimate the use of antimicrobial drugs from the quantities of antimicrobials manufactured and imported 11
Control the use of VMP in farm animals through farm veterinarian Farm veterinarian: - qualified following the Veterinary Practitioner Act - passed the DLD training course & licensed by the DLD - required for livestock standard farms (GAP certified) according to Ministerial Notifications of MOAC on Livestock Farm Standard of Thailand - Animal trt. & Prescriptions comply with Code of Practice for Control of the Use of Veterinary Drugs (TAS 9032-2009) issued by MOAC - in compliance with the Code of Practice for Control of the Use of Veterinary Drugs (CAC/REP 38 1993) of Codex 12
Residue control plan Residue Monitoring Committee: appointed by DLD to draw up residue monitoring plan for livestock, coordinate the monitoring activities of the central, regional, provincial and district livestock offices and collect data to evaluate the results and the residue control system. Non-compliance result: immediately report to the officers who submitted the samples to take immediate action Non-compliant farm and farm vet: under investigation, apply measures according to the DLD Notification on Residues Control Measures 13
Surveillance of AMR in animal pathogens conducted by the DLD Samples from slaughterhouses (E.coli, Salmonella spp., Campylobacter spp. Staphylococcus aureus, Clostridium perfringens, Listeria monocytogenes, Enterococci) Samples from diagnostic cases (E.coli, Salmonella spp., Staphylococcus spp.) 14
IV. Patterns and extent of AMR in animal pathogens Methicillin-resistant Staphylococcus aureus (MRSA) in milk: test MRSA in 807 isolates of coagulase positive staphylococci from milk samples (multiplex PCR method), 10 isolates (1.2%) were +ve Vancomycin-resistant enterococci (VRE) in poultry meat production chain: test VRE in 17,363 samples collected from various sources of whole poultry meat production chain during 2007-2011, 3 samples (0.1%) were +ve 15
Thank You Very Much for Your Attention Department of Livestock Development 16