University of Trás-os-Montes e Alto Douro. Progress Report for EAEVE revisit Integrated Master of Veterinary Medicine

University of Trás-os-Montes e Alto Douro Progress Report for EAEVE revisit Integrated Master of Veterinary Medicine Vila Real, 2015

Index AUTHORS... I ACKNOWLEDGEMENTS... III ABBREVIATIONS... IV INTRODUCTION... 1 CHAPTER 1. LISTING OF MAJOR DEFICIENCIES... 2 1.1. INSUFFICIENT HANDS-ON CLINICAL TRAINING... 2 1.2. INSUFFICIENT OVERALL AWARENESS, INSTRUCTION AND ENFORCEMENT OF SAFETY AND BIOSECURITY PROTOCOLS INCLUDING, BUT NOT LIMITED TO, PHARMACY AND DRUG MANAGEMENT AND CONTROL... 2 CHAPTER 2. RESPONSE TO MAJOR DEFICIENCIES... 3 I. RESPONSES TO 1.1. a) Excessive student group size and b) Excessive ratio of students to clinical cases... 3 I.A. REDUCTION OF STUDENT GROUP SIZE AND STUDENTS PER CLINICAL CASE... 3 I.B. RATIOS RECALCULATION... 4 II. RESPONSE to 1.1. c) Over-reliance on laboratory and desk-based work in place of clinical work... 4 II.A. CURRICULAR CHANGES... 4 II.A.1. NEW CURRICULAR PLAN... 4 II.A.1.1. SCIENTIFIC AREAS... 7 II.A.1.2. SUBJECTS AND TYPES OF TRAINING... 8 II.A.1.3. CURRICULUM HOURS... 9 II.A.1.3.1. Main curricular adjustments... 13 II.A.1.3.2. Increase of clinical hours in some subjects... 14 III. RESPONSE to 1.1. d) Non-compulsory attendance in the 24/7 emergency service... 20 III.A. IMPLEMENTATION OF WEEKS OF CLINICAL ROTATION... 20 III.A.1. WEEKS OF HOSPITAL ROTATION... 20 III.A.1.1. Compulsory attendance in the 24/7 emergency service... 20 III.A.1.2. Students access to medical records of VTH... 21 III.A.2. EXTRAMURAL TRAINING... 21 IV. RESPONSE to 1.2. INSUFFICIENT OVERALL AWARENESS, INSTRUCTION AND ENFORCEMENT OF SAFETY AND BIOSECURITY PROTOCOLS INCLUDING, BUT NOT LIMITED TO, PHARMACY AND DRUG MANAGEMENT AND CONTROL... 23 1

IV.A. CREATION OF BIOSAFETY/BIOSECURITY COMMITTEES AND OTHER UNITS... 23 IV.A.1. IMVM BIOSAFETY COMMITTEE... 23 IV.A.2. UTAD BIOSAFETY COMMITTEE... 24 IV.A.3. BIOSAFETY/BIOSECURITY UNIT OF IMVM-UTAD... 24 IV.A.4. BIOSAFETY/BIOSECURITY GROUP FOR IMVM-UTAD GUIDEBOOK REDACTION... 25 IV.B. NEW FACILITIES AND INFRASTRUCTURAL IMPROVEMENTS... 26 IV.B.1. VETERINARY TEACHING HOSPITAL... 26 IV.B.1.1. Necropsy room Updated... 26 IV.B.1.2. Controlled access by digital means in some services New 27 IV.B.1.2. Isolation unit for small animals New... 28 IV.B.1.3. Dressing rooms for students- New... 28 IV.B.1.5. Conditioned access to VTH database by students -New... 31 IV.B.1.6. Other improvements... 31 IV.B.2. LABORATORY FACILITIES... 33 IV.B.2.1. Laboratory of Histology and Pathology New... 33 IV.B.2.2. Anatomy Laboratory Updated... 34 IV.B.2.3. Parasitology Laboratory New... 34 IV.B.2.4. Microbiology Laboratory New... 35 IV.B.2.5. Toxicology/Pharmacology and Clinical Pathology Laboratories Updated... 35 IV.B.2.6. Food Science and Technology laboratory New... 37 IV.B.2.7. Animal laboratory Facilities New... 38 IV.B.3. FARM IMPROVEMENTS... 38 IV.B.4. NEW AND UPDATED FACILITIES BUDGET... 39 IV.C. IMPLEMENTATION OF BIOSAFETY/BIOSECURITY RULES... 40 IV.D. IMPROVEMENT OF BIOSAFETY/BIOSECURITY KNOWLEDGE, ATTITUTES AND PRACTICES... 40 IV.D.1. INCREASE OF BIOSAFETY/BIOSECURITY SYLLABUS HOURS... 41 IV.D.2. TRAINING SESSIONS DIRECTED TO STUDENTS, PROFESSORS AND SUPPORT STAFF MEMBERS.... 42 ANNEXES... 44 ANNEX I: Recalculation of indicators.... 45 ANNEX II: New Veterinary curriculum (from 2015/16 course)... 46 ANNEX III: Veterinary records of Week Hospital Rotation and Extramural Traineeship... 47 ANNEX III.a WHR record (logbook)... 47 2

ANNEX III.b WHR Compulsive online student database (logbook)... 48 ANNEX III.c Compulsive 24/7 Emergence service Record... 51 ANNEX III.d Extramural training Evaluation by Practitioners (Invited professors)... 52 ANNEX IV... 53 IV.a - Biosafety/Biosecurity Best Practices Code of IMVM... 53 IV.b - Biosafety/Biosecurity Guidebook of IMVM... 53 ANNEX V: Facilities plants... 54 ANNEX V.a - Necropsy room updated... 54 ANNEX V.b - Plant Parasitology Lab - New... 55 ANNEX V.c - Plant Microbiology Lab - New... 56 3

Authors The present report was elaborated by the commission for the Revisit preparation of the Integrated Master in Veterinary Medicine (IMVM) of UTAD, presided by the Director of the Course. Alexandra Esteves, former Pro-rector for Assessment of Quality, Department of Veterinary Sciences. Adelina Gama Quaresma, Member of the Direction of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Anabela Alves, Commissioner of the Necropsy Room of the Veterinary Teaching Hospital, Department of Veterinary Sciences. Ana Cláudia Coelho, President of the Biosafety/Biosecurity Unit of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Carlos Viegas, Director of the Department of Veterinary Sciences, Department of Veterinary Sciences. Cristina Saraiva, Director/Dean of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Felisbina Luísa Queiroga, former Director/Dean of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Filipe Silva, Member of the Direction of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Laura Felício, Student, President of the Veterinary Medicine Students Association. Luís Cardoso, President of the Biosafety/Biosecurity Committee of UTAD, Department of Veterinary Sciences. Maria da Conceição Fontes, Vice-Director of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Maria dos Anjos Pires, Member of the Management Council of UTAD, Department of Veterinary Sciences. Maria Isabel Ribeiro Dias, Director of the Veterinary Teaching Hospital, Department of Veterinary Sciences. Nuno Alegria, Member of the Direction of the Integrated Master in Veterinary Medicine, Department of Veterinary Sciences. Patrícia Poeta, Full Professor, Department of Veterinary Sciences. i

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Acknowledgements We would like to express our most sincere thanks to all those who have assisted the preparation of this revisit report. A special thanks to: - The Rector of UTAD for the longstanding support to the IMVM evaluation process. - The Rector s team, for the availability and easy access to data requested. - The President of the ECAV School and the Presidents of the Scientific and Pedagogic Councils of ECAV for their support. - All the Teaching staff, Students, Support staff, who contributed with relevant data, comments and/or suggestions, which have been included in the present report. - All that contributed to the elaboration of the IMVM Biosafety/Biosecurity Code and Guidebook, especially to Prof. Paula Avelar Rodrigues, Prof. Ana Celeste Bessa and Prof. Maria de Lurdes Pinto. - Prof. José Manuel M.H. Almeida and Prof. José António de Oliveira e Silva for creation and management of the Biosafety/Biosecurity IMVM webpage. iii

Abbreviations BC-IMVM Biosafety Committee of IMVM BC-UTAD Biosafety committee of UTAD BU-IMVM - Biosafety/Biosecurity unit of IMVM BBG-IMVM - Biosafety/Biosecurity group of IMVM DGES - General Directorate of Higher Education EAEVE - European Association of Establishments for Veterinary Education ECAV - School of Agrarian and Veterinary Sciences ECOVE - European Committee of Veterinary Education EMT - Extramural training FTE Full-Time Equivalent IMVM - Integrated Master of Veterinary Medicine MEC - Ministry of Education and Science NVS Non Veterinary Surgeon PPE - Personal Protective Equipment R - Ratio SER Self-Evaluation Report VS - Veterinary Surgeon VTH Veterinary Teaching Hospital UTAD - University of Trás-os-Montes e Alto Douro WHR - Weeks of Hospital Rotation iv

INTRODUCTION The present report describes the quantitative and qualitative improvements introduced in the curriculum of the Integrated Master in Veterinary Medicine (IMVM) of the University of Trás-os-Montes e Alto Douro (UTAD) since the last European Association of Establishments for Veterinary Education (EAEVE) evaluation took place (November 2012). Throughout the past few years, the two major deficiencies appointed by the European Committee of Veterinary Education (ECOVE) have been properly corrected and some additional measures have been addressed to overcome other comments and suggestions (minor deficiencies) passed by the team in the final report. The misinterpreted Ratios appointed in the final report were also corrected. Prior to the description of the changes undergone by UTAD, we would like to remark that in 2012, when the EAEVE Evaluation team visited UTAD, three major deficiencies were appointed, but after the appeal, one of them was withdrawn and only two major deficiencies were kept by the ECOVE in March 2013. In 2013, an electoral process took place resulting in the election of a new Rector who started office on the 29 th of July 2013. In April 2013 a new Head of the Veterinary Sciences Department was elected, a new Dean of IMVM was nominated on the 6 th of May 2013 and a new Director of the Veterinary Teaching Hospital (VTH) was also nominated soon after. In order to rectify the major deficiencies the Dean and her team have worked with the Rectory with the Biosafety/Biosecurity unit of IMVM and the Veterinary Teaching Hospital s Director jointly with the support of Head of the Department and the School decision groups. The Dean, her team, the committee for preparation of the EAEVE Revisit, colleagues and student representatives worked together on solutions of the faced problems and the final report. Thus, the present report includes a description of the new Veterinary curriculum, a highly integrated study program clearly oriented towards the increase of hands-on clinical training, as recommended. Furthermore, a complete and detailed review of the clinical teaching hours of each subject in each academic year of the curriculum has been made, since some mistakes and misinterpretations were detected in our SER 2011/2012. The current report also includes all the improvements that have been made in order to overcome deficiencies in terms of biosafety/biosecurity that were previously detected in infrastructures, equipment and procedures. 1

Chapter 1. LISTING OF MAJOR DEFICIENCIES The EAEVE experts visited UTAD in November 2012. In the final report adopted by the ECOVE, two main deficiencies were identified which were considered as Major Deficiencies : 1.1. INSUFFICIENT HANDS-ON CLINICAL TRAINING a) Excessive student group size; b) Excessive ratio of students to clinical cases; c) Over-reliance on laboratory and desk-based work in place of clinical work; d) Non-compulsory attendance in the 24/7 emergency service. 1.2. INSUFFICIENT OVERALL AWARENESS, INSTRUCTION AND ENFORCEMENT OF SAFETY AND BIOSECURITY PROTOCOLS INCLUDING, BUT NOT LIMITED TO, PHARMACY AND DRUG MANAGEMENT AND CONTROL 2

Chapter 2. RESPONSE TO MAJOR DEFICIENCIES I. RESPONSES to 1.1. a) Excessive student group size and b) Excessive ratio of students to clinical cases I.A. REDUCTION OF STUDENT GROUP SIZE AND STUDENTS PER CLINICAL CASE The new IMVM-UTAD curriculum is a highly integrated study programme clearly oriented towards the increase of hands-on clinical training as required and desirable for the day-one skills. Furthermore, a complete and detailed review of the clinical teaching hours of each subject in each academic year of the curriculum has been made since, as mentioned above, some mistakes and misinterpretations were detected in our SER 2011/2012. In clinical practical s, there was a reduction of student group size to 5-6 students per group since the year 2013/2014, instead of 10 in the year 2012. This allowed the reduction of the ratio of students per clinical case and facilitated the hands on clinical training. Each academic year, students are grouped in five practical groups (15-18 students/group). Each one of these practical groups is then subdivided in three smaller groups (5-6 students/group) to follow the clinical rotation in the VTH and extramural training with professors at outside farms and other veterinary hospitals. These changes have implied an increase in the number of the academic teaching staff of 5.35 veterinary surgeons (VS) full-time equivalents (FTE) (3.05 VS FTE + 2.3 VS FTE invited professors) from 2012 to date (Table 4.1). Table 4.1. Academic staff in UTAD provided for veterinary training. Total (FTE) 2012 Total (FTE) 2015 1. Academic staff VS NVS VS NVS Teaching staff (total FTE) 39.74 12. 949 42.79 11.67 Research staff (total FTE) - - - - Others (FTE) (1) 0.69-2.99 - Total FTE 40.43 12.949 45.78 11.67 Total FTE (VS + NVS) 53.38 57.45 VS: Veterinary Surgeon; NVS: Non Veterinary Surgeon; FTE: Full-Time Equivalents 3

I.B. RATIOS RECALCULATION Taking into account these changes we have recalculated all ratios since 2013/1014 (See Table -Annex I). The R11 to R20 ratios were not calculated in 2015/2016 because we only have data from September until the 18 th of December. II. RESPONSE to 1.1. c) Over-reliance on laboratory and desk-based work in place of clinical work II.A. CURRICULAR CHANGES II.A.1. NEW CURRICULAR PLAN Considering the EAEVE final report, the evaluation team was satisfied with the balance of the curriculum of IMVM-UTAD, but minor changes were nevertheless in order to reinforce and increase clinical training and also to include in the curriculum the extramural training among other recommendations. As mentioned in SER 2012, in Portugal, all studies in higher education are regulated by the Ministry of Education and Science (MEC). This Ministry stands above the direct administration of the General Directorate of Higher Education (DGES), which is a MEC operational executive service with administrative autonomy. The new IMVM-UTAD curriculum was designed according to national and European legislation, as referred in SER 2012 (Table 4.1), except for deliberation no. 8545/2012 replaced by deliberation no. 2392/2013 and also considering the Rectoral order no. 100/2013 of 28 th November on the Standards for the change of accredited courses and the proposal of new courses" approved by the Academic Council. The new curriculum was applied in the academic year 2015/2016, (starting on the 7 th September 2015) after being presented to DGES and had official approval as deliberation no. 2306/2015 (Diário da República, 2.ª série No. 43 3 de março de 2015) (Annex III). The IMVM-UTAD conclusion requires the fulfilment of 330 ECTs, along 11 semesters, as described in Table 4.2.In this table the new curricular structure (2015/16) is presented comparatively to the previous one. 4

Table 4.2. Curricular structure of IMVM-UTAD until 2014/2015 versus 2015/2016. Subject ECTS Subject ECTS Curricular Structure (until 2014/2015) Curricular Structure (2015/2016) 1st semester 1st semester Biostatistics and Medical Informatics 4.5 Biostatistics and Medical Informatics 3.0 Veterinary Biophysics 4.0 Veterinary Biophysics 3.0 Structural Biochemistry 5.0 Structural Biochemistry 6.0 Cytomorphophysiology and General Veterinary Cytomorphophysiology and General Veterinary 5.0 Histology Histology 6.0 Embryology and Anatomy I 5.5 Embryology and Anatomy I 6.0 Ethology and Animal Welfare 4.0 Ethology and Animal Welfare 3.0 Introduction to Veterinary Medicine 2.0 Introduction to Veterinary Medicine 3.0 Total 1st semester 30.0 Total 1st semester 30.0 2nd semester 2nd semester Agriculture, Ecology and Environmental Agriculture, Ecology and Environmental 4.5 Management Management 3.0 Anatomy II 5.0 Anatomy II 6.0 Metabolic Biochemistry 5.0 Metabolic Biochemistry 6.0 Exognosis 4.0 Exognosis 3.0 Classical, Quantitative and Population Genetics 4.5 Classical, Quantitative and Population Genetics 6.0 Special Veterinary Histology 5.0 Special Veterinary Histology 6.0 Introduction to Scientific Investigation 2.0 - - Total 2nd semester 30.0 Total 2nd semester 30.0 Total 1st year 60.0 Total 1st year 60.0 3rd semester 3rd semester Anatomy III 5.0 Anatomy III 6.0 Physiology I 4.0 Physiology I 3.0 Molecular and Applied Genetics 4.5 Molecular and Applied Genetics 6.0 Immunology 4.0 Immunology 3.0 Medical Microbiology I 4.5 Medical Microbiology I 3.0 General Pathology I 4.0 General Pathology I 6.0 Optional I 2.0 - - Traineeship I 2.0 Traineeship I 3.0 Total 3rd semester 30,0 Total 3rd semester 30,0 4th semester 4th semester Physiology II 4.5 Physiology II 6.0 Medical Microbiology II 4.0 Medical Microbiology II 3,0 Animal Nutrition and Feeding 4.5 Animal Nutrition and Feeding 6.0 Parasitology I 4.5 Parasitology I 3.0 General Pathology II 4.0 General Pathology II 3.0 Zootechnics and Animal Production 4.5 Zootechnics and Animal Production 6.0 Optional II 2.0 Epidemiology 3.0 Traineeship II 2.0 - - Total 4th semester 30,0 Total 4th semester 30,0 Total 2nd year 60 Total 2nd year 60,0 5

Table 4.2. Curricular structure of IMVM-UTAD until 2014/2015 versus 2015/2016 (continue). Subject ECTS Subject ECTS Curricular Structure (until 2014/2015) Curricular Structure (2015/2016) 5th semester 5th semester Anaesthesia 4.0 Anaesthesia 4.5 Epidemiology 4.0 Imagiology 5.0 Pharmacology I and Pharmacy 4.5 Pharmacology I and Pharmacy 4.5 Parasitology II 4.5 Parasitology II 3.0 Medical Semiology I 4.5 Medical Semiology I 4.5 Technology of Animal Products I 4.5 Technology of Animal Products I 4.5 Optional III 2.0 Introduction to Scientific Investigation 2.0 Traineeship III 2.0 Optional I 2.0 Total 5th semester 30.0 Total 5th semester 30.0 6th semester 6th semester Anatomic Pathology I and Veterinary Forensic Anatomic Pathology I and Veterinary Forensic 4.5 Medicine Medicine 4.5 Pharmacology II and Therapeutics 4.5 Pharmacology II and Therapeutics 4.5 Animal Reproduction 4.0 Animal Reproduction 4.0 Introduction to surgery 4.0 Introduction to surgery 4.5 Medical Semiology II 4.5 Medical Semiology II 4.5 Technology of Animal Products II 4.5 Technology of Animal Products II 4.0 Optional IV 2.0 Economics, Administration and Marketing in Animal 2,0 Traineeship IV 2.0 Optional II 2.0 Total 6th semester 30.0 Total 6th semester 30.0 Total 3rd year 60.0 60.,0 7th semester 7th semester Anatomic Pathology II 4.5 Anatomic Pathology II 4.5 Small Animal Surgery I 4.5 Small Animal Surgery I 4.5 Infectious Diseases I 4.0 Infectious Diseases I 4.5 Parasitic Diseases I 4.5 Parasitic Diseases I 4.0 Medicine and Surgery of Ruminants 4.0 Medicine and Surgery of Ruminants 6.0 Internal Medicine of Small Animals I 4.5 Internal Medicine of Small Animals I 4.5 Optional V 2.0 - - Traineeship V 2.0 Traineeship II 2.0 Total 7th semester 30.0 Total 7th semester 30.0 8th semester 8th semester Small Animal Surgery II 4.5 Small Animal Surgery II 4.5 Infectious Diseases II 4.5 Infectious Diseases II 4.5 Parasitic Diseases II 4.0 Parasitic Diseases II 4.5 Imagiology 4.0 Equine Medicine and Surgery 6.0 Reproductive Medicine I 4.5 Reproductive Medicine I 4.0 Internal Medicine of Small Animals II 4.5 Internal Medicine of Small Animals II 4.5 Optional VI 2.0 - - Traineeship VI 2.0 Traineeship III 2.0 Total 8th semester 30.0 Total 8th semester 30.0 Total 4th year 60.0 Total 4th year 60.0 6

Table 4.2. Curricular structure of IMVM-UTAD until 2014/2015 versus 2015/2016 (continue). Subject ECT Subject ECTS Curricular Structure (until 2014/2015) Curricular Structure (2015/2016) 9th semester 9th semester Preventive Veterinary Medicine and Hygiene 4.0 Preventive Veterinary Medicine and Hygiene 4.0 Food Hygiene and Inspection I 5.0 Food Hygiene and Inspection I 6.0 Introduction to Small Animal Specialties I 5.0 Introduction to Small Animal Specialties I 5.0 Poultry, Rabbit and Swine Medicine 5.0 Poultry, Rabbit and Swine Medicine 5.0 Reproductive Medicine II 4.0 Reproductive Medicine II 4.0 Animal Breeding 5.0 Clinical Nutrition 2.0 Optional VII 2.0 Optional III 2.0 Traineeship IV 2.0 Total 9th semester 30.0 Total 9th semester 30.0 10th semester 10th semester Economics, Administration and Marketing in Animal 2.0 Animal Breeding 5.0 Food Hygiene and Inspection II 5.0 Food Hygiene and Inspection II 6.0 Introduction to Small Animal Specialities II 5.0 Introduction to Small Animal Specialities II 5.0 Veterinary Legislation 2.0 Veterinary Legislation 2.0 Veterinary Public Health 5.0 Veterinary Public Health 4.0 Toxicology 4.0 Toxicology 4.0 Equine Medicine and Surgery 5.0 Optional IV 2.0 Optional VIII 2.0 Traineeship V 2.0 Total 10th semester 30.0 Total 10th semester 30.0 Total 5th year 60.0 Total 5th year 60.0 11th semester - Master Thesis 30.0 11th semester - Master Thesis 30,0 Total Integrated Master in Veterinary Medicine 330.0 330.0 II.A.1.1. SCIENTIFIC AREAS According to deliberation no. 2392/2013, the curricular changes must be in agreement with the regulations and should not exceed 5% of the total ECTS of the course. Tables 4.3a and 4.3b present the scientific areas of IMVM and ECTS of the 2012 and 2015 curricular plan, respectively. Table 4.3a. Scientific areas of integrated Master in Veterinary Medicine (Deliberation no. 8545/2012). Scientific Area Acronym Credits Core subjects Elective subjects Animal Science CANIM 35.5 27 Agrarian Science CAGR 2.25 2 Biological Science CBIOL 35.75 4 Economic and Social Sciences CES 2 - Veterinarian Science CVET 196.5 53 Total 314 16 7

Table 4.3b. Scientific areas of the integrated Master in Veterinary Medicine (Deliberation no. 2306/2015). Scientific Area Acronym Credits Core subjects Elective subjects Animal Science CANIM 42.5 - Agrarian Science CAGR 1.5 - Biological Science CBIOL 39 - Economic and Social Sciences CES 2 - Veterinarian Science CVET 207 - From the different Scientific Areas of IMVM (1) - 30 8 Total 322 8 (1)The designation From the different Scientific Areas of IMVM includes the Master thesis (30 ECTs) and the elective subjects I, II, III and IV (8 ECTs). II.A.1.2. SUBJECTS AND TYPES OF TRAINING As was previously mentioned, a IMVM-UTAD veterinary graduate must pursue 330 ECTS distributed as addressed in tables 4.4a and 4.4b: - 322 ECTS in core subjects, including 11 ECTS from traineeship subjects (practical training that is mandatory) taken by every student; - 4 ECTS from the 11 ECTS of traineeship subjects correspond to obligatory extramural traineeship; - 8 ECTS that are taken from a list of elective subjects that are distributed between the 3 rd and the 5 th years (2 ECTS: each elective subject/semester); - 30 ECTS from the master s thesis. Table 4.4a. Distribution of the 330 ECTS for the IMVM-UTAD, along the 6 year period (11 semesters), according to the old curricular structure. 1 st Year 2 nd Year 3 rd Year 4 th year 5 th Year 6 th year* TOTAL Core subjects 60 52 52 52 56 0 314 Traineeship 0 4 4 4 4 0 16 Elective subjects 0 4 4 4 0 0 12 Master s Thesis 0 0 0 0 0 30 30 Total 60 60 60 60 60 30 330 6 th year* - only one semester Table 4.4b - Distribution of the 330 ECTS for the IMVM-UTAD, along the 6 year period (11 semesters), according to the new curricular structure. 1 st Year 2 nd Year 3 rd Year 4 th year 5 th Year 6 th year* TOTAL Core subjects 60 57 56 56 52 0 311 Traineeship 0 3 0 4 4 0 11 Elective subjects 0 0 4 0 4 0 8 Master s Thesis 0 0 0 0 0 30 30 Total 60 60 60 60 60 30 330 6 th year* - only one semester 8

II.A.1.3. CURRICULUM HOURS The current ECTS system makes an estimate of the total time that every student dedicates to any activity in each subject. In UTAD, one ECT corresponds to 27 hours. The whole IMVM-UTAD curriculum comprises a total of 330 ECTS. The amount of hours dedicated to lectures and supervised practical training at the IMVM Curriculum is described in Table 4.5 (indicated in SER guidelines as 4.1). Table 4.5. General table of curriculum hours taken by all students considering each semester with 15 weeks (indicated in SER guidelines as 4.1) 2015/2016. Year Lectures A Theoretical training Seminar s B Tutorial Selfdirected learning C Hours of training Supervised practical training Laboratory and desk-based work D Non-clinical animal work E Other G 2 1 st Year 316 4 38.5 14 248 95 0 4 719.5 60.0 2 nd Year 280.5 0 39.5 0 266 135.5 0 0 721.5 60.0 3 rd Year 358 0 52 4 183 46 122 0 765 56.0 Elective 0 3 0 0 0 0 0 52* 4.0 4 th Year 337.5 0 52 19 34 8 420.5 0 871 60.0 5 th Year 230 0 42 55 163 50 222 7 769 56.0 Elective 0 3 0 0 0 0 0 52* 4.0 6 th Year 0 0 0 0 0 0 0 0 606 30.0 Total 1522 4 (1) 224 (2) 92 894 334.5 764.5 11 (3) 4556 330 Clinic al work F 1 Seminars - Oral presentations given by guest speakers who are considered experts in the field. 2 Tutorials - Includes individual or group sessions (theoretical or practical) with the teacher for preparation of a work or to present questions and doubts about the topics given in the subject. 3- Field work, which must be included for calculation purpose, as supervised practical training *The 52 hours per year (in 3 rd and 5 th year) correspond to the elective subjects Total ECTS 9

The IMVM-UTAD curriculum hours in EU-listed subjects taken by all students is presented in Table 4.6 (indicated in SER guidelines as 4.2). Table 4.6. IMVM-UTAD curriculum hours in EU-listed subjects taken by all students considering 15 weeks per semester (indicated in SER guidelines as 4.2). Subject 1. Basic Subjects Theoretical training Lectures A Seminars B Tutorial Self-direct Learning Hours of training Supervised practical training Laboratory and desk- based work D Non-clinical animal work E Clinical work F Veterinary Biophysics 14 0 2 10 21 0 0 0 47 3 Biostatistics and Medical Informatics Other G 14 0 2 0 21 0 0 0 37 3 SUB_TOTAL 28 0 4 10 42 0 0 0 84 6 2. Basic Sciences Embryology and Anatomy I 28 0 4 0 0 42 0 0 74 6 Anatomy II 30 0 4 0 0 42 0 0 76 6 Anatomy III 30 0 3.5 0 0 28 0 0 61.5 6 Special Veterinary Histology Cytomorphophysiology and General Veterinary Histology 30 0 4 0 42 0 0 0 76 6 28 0 4 0 42 0 0 0 74 6 Exognosis 15 0 2 0 14 7 0 0 38 3 Physiology I 18 0 2.5 0 10.5 10.5 0 0 41.5 3 Physiology II 30 0 4 0 21 21 0 0 76 6 Structural Biochemistry Metabolic Biochemistry Classical, Quantitative and Population Genetics Molecular and Applied Genetics Pharmacology I and Pharmacy 28 0 3.5 0 28 0 0 0 59.5 6 30 0 3.5 0 28 0 0 0 61.5 6 30 0 3.5 0 28 0 0 0 61.5 6 30 0 3.5 0 28 0 0 0 61.5 6 30 0 4 0 14 10 6 0 64 4.5 Toxicology 14 0 4 0 22 0 6 0 46 4 Medical Microbiology I 15 0 2 0 21 0 0 0 38 3 Medical Microbiology II 15 0 2 0 21 0 0 0 38 3 Immunology 15 0 2 0 21 0 0 0 38 3 Epidemiology 15 0 2 0 21 0 0 0 38 3 Introduction to Veterinary Medicine 28 4 2 4 0 0 0 0 38 3 SUB_TOTAL 459 4 60 4 361.5 160.5 12 0 1061 89.5 Total ECTS 10

Table 4.6. IMVM-UTAD curriculum hours in EU-listed subjects taken by all students considering 15 weeks per semester (Indicated in SER guidelines as 4.2) (continue). Subject 3. Clinical Sciences Theoretical training Lectures A Seminars B Tutorial Self-direct Learning Hours of training Supervised practical training Laboratory and desk-based work D Non-clinical animal work E Clinical work F General Pathology I 15 0 5 0 35 0 0 0 55 6 General Pathology II 15 0 2 0 21 0 0 0 38 3 Anatomic Pathology I and Veterinary Forensic Medicine 30 0 4 4 10 0 20 0 68 4.5 Anatomic Pathology II 30 0 4 4 10 0 20 0 68 4.5 Parasitic Diseases I 15 0 3 0 6 0 24 0 48 4 Parasitology I 15 0 2 0 21 0 0 0 38 3 Parasitic Diseases II 30 0 4 0 6 0 24 0 64 4.5 Parasitology II 15 0 2 0 21 0 0 0 38 3 Infectious Disease I 30 0 4 5 6 0 24 0 69 4.5 Infectious Disease II 30 0 4 0 6 0 24 0 64 4.5 Small Animal Surgery I 30 0 4 0 0 0 30 0 64 4.5 Small Animal Surgery II 30 0 4 0 0 0 30 0 64 4.5 Anaesthesia 30 0 4 0 8 14 8 0 64 4.5 Medicine and Surgery of Ruminants Equine Medicine and Surgery Internal Medicine of Small Animals I Internal Medicine of Small Animals II Introduction to Small Animal Specialities I Introduction to Small Animal Specialities II Poultry, Rabbit and Swine Medicine Preventive Veterinary Medicine and Hygiene 30 0 5 0 0 0 45 0 80 6 37.5 0 5 0 0 0 37.5 0 80 6 30 0 5 4 0 0 30 0 69 4.5 30 0 5 0 0 0 30 0 65 4.5 28 0 4 10 0 0 28 0 70 5 28 0 4 10 0 0 28 0 70 5 28 0 4 0 4 0 24 0 60 5 14 0 3 8 7 0 14 7 (1) 53 4 Imagiology 30 0 4 0 0 0 30 0 64 5 Animal Reproduction 15 0 4 0 6 6 18 0 49 4 Reproductive Medicine I 15 0 4 6 0 14 16 0 56 4 Reproductive Medicine II 14 0 3 0 4 0 24 0 45 4 Veterinary Public Health 14 0 3 5 22 0 6 0 50 4 Veterinary Legislation and Regulation Pharmacology II and Therapeutics 14 0 2 6 14 0 0 0 36 2 15 0 3 0 26 0 4 0 48 4.5 Medical Semiology I 30 0 5 0 0 0 30 0 65 4.5 Medical Semiology II 30 0 5 0 30 0 0 0 65 4.5 Introduction to Surgery 30 0 4 0 8 16 6 0 64 4.5 Clinical Nutrition 14 0 2 0 0 0 14 0 30 2 SUB_TOTAL 761.5 0 119 62 271 44 596.5 7 1861 138 Other G Total ECTs 11

Table 4.6. IMVM-UTAD curriculum hours in EU-listed subjects taken by all students considering 15 weeks per semester (indicated in SER guidelines as 4.2)(continue). Subject Hours of training ECTs Theoretical training Lectures A Seminars B Tutorial Self-direct Learning Supervised practical training Laboratory and desk-based work D Non-clinical animal work E Clinical work F Other G Total 4. Animal Production Zootechnics and Animal Production 37.5 0 4 0 17.5 17.5 0 0 76.5 6 Animal Breeding 28 0 4 0 28 0 0 0 60 5 Animal Nutrition and Feeding 30 0 3.5 0 28 0 0 0 61.5 6 Agriculture, Ecology and Environmental Management Economics, Administration and Marketing in Animal Health 20 0 2 0 14 0 0 4 (1) 40 3 30 0 2 0 0 0 0 0 32 2 Ethology and Animal Welfare 21 0 2 0 10 4 0 0 37 3 SUB_TOTAL 166.5 0 17.5 0 97.5 21.5 0 4 307 25 5. Food Hygiene / Public Health Food Hygiene and inspection I Food Hygiene and inspection II Technology of Animal Products I Technology of Animal Products II 20 0 4 8 30 26 0 0 80 6 14 0 4 8 32 24 0 0 82 6 30 0 4 0 30 0 0 0 64 4.5 15 0 4 0 30 0 0 0 49 4 SUB_TOTAL 79 0 16 16 122 50 0 0 283 20.5 6. Professional Knowledge Animal Production traineeship (I) 0 0 1.5 0 0 58.5 0 0 60 3 Clinical traineeship (II) 0 0 1 0 0 0 39 0 40 2 Clinical traineeship (III) 0 0 1 0 0 0 39 0 40 2 Extramural traineeship (IV) 0 0 1 0 0 0 39 0 40 2 Extramural traineeship (V) 0 0 1 0 0 0 39 0 40 2 Introduction to Scientific Investigation 28 0 2 0 0 0 0 0 30 2 SUB_TOTAL 28 0 7.5 0 0 58.5 156 0 250 13 TOTAL 1522 4 224 92 894 334.5 764.5 11 (1) 3846 (2) 292 (1) Field work; (2) The total number of hours and ECTS does not correspond to the total number of hours reported in Table 4.6 because the hours (606) for the final thesis was not included in any EU-listed core subject. As in Table 4.1, also, in this Table, the hours for the elective subjects were not included for the same reason. 12

Table 4.7. presents the elective subjects available in the new IMVM-UTAD curricular plan. The contact hours in each elective subject correspond to 24.5 hours of lectures and 1.5 hours of tutorials. Table 4.7. Elective (optional) subjects available in IMVM-UTAD. Year/Semester Elective Subjects ECT 1 Bioinformatics and Molecular Analysis 2 2 Sustainable Management of Animal Effluents 2 Option I 3 Introduction to Food Quality and Safety 2 3 rd Year/ 1 st sem. 4 Nutrition and Feeding of Exotic Animals 2 5 Animal Teratology 2 6 Laboratory, Exotic and Wild Animals Physiology 2 7 Nucleic Acids Technology and GMOs 2 8 Option II Clinical Analysis 2 9 3 rd Year/ 2 nd sem. Diagnostic Cytology 2 10 Clinical Anatomy 2 11 Apiculture 2 12 Laboratory Animals Science 2 13 Pathology of Exotic, Wild and Laboratory Animals 2 Option III 14 Laboratorial analysis in Medical Microbiology and Parasitology 2 5 th Year/1 st sem. 15 Emergency and Critical Care 2 16 Quality Systems in Food Sector 2 17 Medicine and Surgery of Laboratory, Exotic and Wild Animals 2 18 Veterinary Dentistry in Small Animal Practice 2 19 Option IV Geriatrics and Oncology in Small Animals 2 20 5 th Year/2 nd sem. Neurology of Small Animals 2 21 Veterinary Forensic Tanatology 2 22 Aquaculture 2 II.A.1.3.1. Main curricular adjustments The most relevant adjustments in the curriculum are: 1. The core course of Imagiology (diagnostic imaging) was placed in the 1 st semester of the 3 rd year, prior to the clinical core courses; 2. The number of hours of Medicine and Surgery of Ruminants (1 st semester of the 4 th year) was increased (1 additional hour in lectures + 1 additional hour in practicals per week) to a total of 30 hours of lectures and 45 hours of practicals per semester and student; 3. The number of hours of Equine Medicine and Surgery was increased (0.5 hours in lectures + 0.5 hours in practicals per week), and has now been placed in the 2 nd semester of the 4 th year, accounting for a total of 37.5 hours of lectures and 37.5 hours of practicals per semester and student; 13

4. The core course of Clinical Nutrition, previously an elective subject, is now mandatory, being placed in the 1 st semester of the 5 th year; 5. Inclusion of the mandatory Extramural Training (Traineeship IV and V) in the 5 th year (39 clinical hours per semester and student); 6. Reduction of 6.7% in the total amount of lectures (from 1631 to 1522 hours) and of 28% in laboratory and desk-based work hours (from 1242 to 894); Increasing of 48.7% in the total amount of clinical practicals (from 514 to 764.5 hours). II.A.1.3.2. Increase of clinical hours in some subjects A complete and detailed review of the clinical teaching hours of each subject resulted in an increment of the practical hours in the following clinical subjects (Table 4.8). Table 4.8. Number of clinical teaching hours added by subject since 2013/2014. Subject Increased hours/student 2013/2014 Increased hours/student 2014/2015 Increased hours/student 2015-2016 Pharmacology I and Pharmacy 0 6 6 Pharmacology II and Therapeutics 0 4 4 Imagiology 6 6 14 Parasitic Diseases I 6 9 9 Infectious Diseases I 12 24 24 Medicine and Surgery of Ruminants 0 0 15 Parasitic Diseases II 6 6 6 Infectious Diseases II 12 24 24 Clinical Nutrition - - 14 Equine Medicine and Surgery 0 0 7.5 Reproductive Medicine I 6 6 6 Preventive Veterinary Medicine and Hygiene 4 4 4 Poultry, Rabbit and Swine Medicine 4 4 4 Reproductive Medicine II 4 4 4 Preventive Veterinary Medicine and Hygiene 4 4 4 Poultry, Rabbit and Swine Medicine 2 2 2 Toxicology 6 6 6 Veterinary Public Health 6 6 6 14

The detailed new teaching guides of subjects referred in table 4.8 are presented by academic year and semester, as follows: 3 rd Year 1 st semester Pharmacology I and Pharmacy Routes for drug administration in pigs and poultry (2 hours) New Routes for drug administration in equids (2 hours) New Routes for drug administration in dogs (2 hours) New In practical classes, students will perform the most common procedures concerning animal handling, tourniquets and drug administration in resident animals. Imagiology Computed tomography evaluation of small animal axial skeleton (2 hours) New Computed tomography evaluation of small animal thorax, abdomen appendicular skeleton (2 hours) New Ultrasound evaluation of equine flexor tendons (2 hours) New Ultrasound evaluation of equine thorax and abdomen (2 hours) New Radiographic evaluation of equine limbs and thorax (2 hours) New Radiographic evaluation of birds, exotic pets and wild animals (2 hours) New Radiographic evaluation of appendicular skeleton small animals (2 hours) Extended 3 rd Year 2 nd semester Pharmacology II and Therapeutics Safe handling of cytotoxic drugs and related waste (2 hours) New Practical training concern: how cytotoxic drugs are administered, hazards of cytotoxic drugs; preventing exposure, controlling exposure. Provision of adequate protective environment: suitable safety cabinets, suitable protective equipment. Personal protective equipment (PPE). Purchase and storage of cytotoxic drugs. Cytotoxic waste. Veterinary hospital pharmacy management (2 hours) New Students follow the operation of the pharmacy in order to learn about drugs acquisition, drugs storage conditions, drugs stock management. 4 th Year 1 st semester Parasitic Diseases I Parasitic diseases of horses prophylaxis and treatment (6 hours) New 15

Parasitological necropsy of cats (2 hours) New Prophylaxis of canine and feline parasitic diseases (1 hour) Extended Infectious Diseases I Infectious diseases of dogs and cats clinical evaluation, clinical diagnosis, prophylaxis and treatment (6 hours) New Infectious diseases of small ruminants clinical evaluation, clinical diagnosis, prophylaxis and treatment (4 hours) New Infectious diseases of large ruminants clinical evaluation, clinical diagnosis, prophylaxis and treatment (2 hours) New Infectious diseases of horses clinical evaluation, clinical diagnosis, prophylaxis and treatment (2 hours) New Prophylaxis of canine and feline infectious diseases (2 hours) New Prophylaxis of horses infectious diseases (2 hours) New Clinical training in hospital environment in infectious diseases (6 hours) New Medicine and Surgery of Ruminants Lectures Diseases of the Digestive System (2 hours) Extended Diseases of the Respiratory System (1 hour) Extended Common surgeries in ruminants (2 hours) Extended Metabolic diseases of ruminants (4 hours) Extended Clinical approach to bovine mastitis (2 hours) New Lameness in dairy cow (1 hour) Extended Diseases of the urinary tract, hemato-lymphopoietic and cardiovascular system (1 hour) Extended Pathology of young animals (2 hours) Extended Practical training Hoof trimming and surgery in Dairy cows of the University farm (3 hours) Extended Small ruminants metabolic diseases evaluation, Diagnosis and Prophylaxis in University small ruminant farm animals (3 hour) New Large dairy farm problem orientated approach (3 hours) Extended Teat and udder surgery (1 hour) Extended Cadaver surgery rumenotomy (1 hour) Extended 16

Cadaver surgery eye (1 hour) Extended Cadaver surgery hoof (3 hour) Extended 4 th Year 2 nd Semester Parasitic Diseases II Parasitic diseases of cattle clinical evaluation, diagnosis, prophylaxis and treatment (2 hours) New Parasitic diseases of small ruminants clinical evaluation, diagnosis, prophylaxis and treatment (2 hours) New Parasitic diseases of pigs clinical evaluation, diagnosis, prophylaxis and treatment (2 hours) New Infectious Diseases II Infectious diseases of dogs and cats clinical evaluation, clinical diagnosis, prophylaxis and treatment (6 hours) New Infectious diseases of small ruminants clinical evaluation, clinical diagnosis, prophylaxis and treatment (2 hours) New Infectious diseases of large ruminants clinical evaluation, clinical diagnosis, prophylaxis and treatment (4 hours) New Infectious diseases of horses clinical evaluation, clinical diagnosis, prophylaxis and treatment (4 hours) New Infectious diseases of psittacines clinical evaluation, clinical diagnosis, prophylaxis and treatment (2 hours) New Clinical training in hospital environment in infectious diseases (6 hours) New Clinical Nutrition Feeding and nutrition of healthy animals (1h) New Feeding and nutrition of ill animals (13h): Obesity (1h); Hyperlipidemia (1h); Diabetes mellitus (1h); Nutritional dermatosis (1h); Digestive diseases (1h); Hepatobiliary and pancreatic diseases (1h); Cardiovascular disease (1h); Kidney disease (1h); Lower urinary tract disease (1h); Pathology of oral cavity (1h); Critical patient (1h); Oncological patient (1h); Osteoarticular diseases (1h) New Equine Medicine and surgery Lectures Equine ophthalmology (2.5 hours) New Provide students with theoretical information regarding Equine ophthalmology. Addressing the most common ocular diseases of horses, study their history, physical examination and laboratory tests, diagnosis, prognosis and treatment. Equine cardiology (2.5 hours) New 17

Provide students with theoretical information regarding Equine cardiology. Provide information about cardiac equine sport medicine monitoring. Addressing the most frequent cardiac diseases of horses, study their history, physical examination and laboratory tests, diagnosis, prognosis and treatment. Digestive disorders (1 hour) - Extended Provide students with more theoretical information regarding surgical treatments. Musculoskeletal disorders (1 hour) Extended Provide students with more theoretical information regarding orthopedic diseases and lameness, pour performance. Study their history, lameness examination, diagnosis, and surgical treatments. Equine Neonatology (0.5 hour) Extended Provide students with theoretical information regarding more diseases that affect foals. Develop the study about particular digestive disorders of foals. Practical classes Equine ophthalmology (2.5 hours) New In practical classes, students will perform many common procedures in equine clinical ophthalmology and practice with the specific equipment in many resident animals. For the learning of some surgical techniques are used horse s heads obtained in slaughterhouse. Equine cardiology (2.5 hours) New In practical classes, students will perform and interpret many common complementary exams (electrocardiography, echocardiography) in many resident animals and some clients of the hospital. Equine dentistry (2.5 hours) New In practical classes, students will perform many common procedures in equine clinical dentistry and practice with the specific equipment in many resident animals. For the learning of some surgical techniques are used horse s heads obtained in slaughterhouse. Reproductive Medicine I Clinical training in hospital environment in reproductive diseases (6 hours) New 5 th Year 1 st Semester Preventive Veterinary Medicine and Hygiene Clinical training in ambulatory service or extramural training (4 hours) New Poultry, Rabbit and Swine Medicine Layer poultry biosecurity and health programs (2 hours) - Extended Clinical training in ambulatory service or extramural training (2 hours) New 18

Medicine of Reproduction II Artificial Insemination (AI) - Hands-on session (2 hours) New This practical class is designed to introduce skills that will prepare students for AI technique. Students are provided with the opportunity to practice in genital organs and develop clinical skills. Artificial insemination in Cattle (2 hours) New Students will spend one morning training AI method and reproductive management in a farm around Vila Real. 5 th Year 2 nd Semester Toxicology Given the frequent acute character of poisoning in animals, the frequency and difficulty in coincidence with the class period, students have clinical cases to examine and solve as most autonomously as possible. The clinical cases come from VTH and others where the Toxicology team was called to intervene, not only in clinical cases from the surrounding area of the VTH but also to the south of the country. This is particularly important in the production animals kept in field since poison plants can differ from north to south. Clinical case in small animals possible causes: some plants, pine processionary (Thaumetopoea pityocampa), acetaminofen/paracetamol - clinical evaluation, clinical diagnosis, treatment and prophylactic measures (2 hours) New Clinical case in production animals - possible causes: poisoning by plants (Oenanthe crocata, Ferula communis, Cistus salvifolius, Cistus lanadifer, Xolantha guttata)- clinical evaluation, clinical diagnosis, treatment and prophylactic measures (2 hours) New Clinical case in horses - possible causes: plants (Festuca,Lolium perenne, Trifolium subterraneum, Lupinus luteus,hypochaeris radicata, Pinus pinaster, Acer pseudoplatanus) fumonisins, lead, ionophores, rhabdomyolysis, lameness, colic, laminitis, nutritional myopathy, etc. - clinical evaluation, clinical diagnosis, treatment and prophylactic measures(2 hours) New Veterinary Public Health Clinical training in hospital environment in Veterinary Public Health or extramural trainning Education and Health Promotion of owners, veterinarians and other healthcare workers; Infection control and biosafety; Occupational Health - (6 hours) New 19

III. RESPONSE to 1.1. d) Non-compulsory attendance in the 24/7 emergency service III.A. IMPLEMENTATION OF WEEKS OF CLINICAL ROTATION In order to improve the clinical practice component of the students of IMVM-UTAD, a clinical rotation (including ambulatory clinic) was implemented on the 4 th and 5 th year of IMVM, with compulsory attendance in the 24-hour emergency service during 7 days was initiated in the academic year 2013/2014. This implies an active participation in the VTH clinical activities allowing the observation of a higher and diversified number of clinical cases and its follow up. III.A.1. WEEKS OF HOSPITAL ROTATION In the weeks of hospital rotation (WHR) students are divided in five rotation groups (15-18 students per group). Every 5 weeks of the academic year each rotation group is freed up, in turns, of all practical classes, so students can stay available for one week (6 weeks per academic year, per student), with full time dedication to rotate through different services at the VTH and ambulatory clinical services. During the WHR, students show up in VTH on Monday and throughout the week they are distributed by clinical cases, vaccination, farm visits, field necropsies, sample collection, admission and specialized services, and all kind of work which occurs in the hospital, without interfering in other ongoing practical classes. All clinical activity undertaken by students in WHR is registered in a personal document (the student logbook) (Annex III.a) that is validated for each event by the professor, clinician or veterinary technician of the hospital service who supervises the student. This registry is uploaded in an online database (Annex III.b) for further evaluation by professors of the clinical core courses. Students must track a minimum number of clinical hours (70%) to be allowed to sit for examination in each clinical course. During WHR, professors of clinical courses and veterinary technicians of the hospital service, by shifts, follow the students. III.A.1.1. Compulsory attendance in the 24/7 emergency service Students in the 4 th year must participate in a minimum of two weeks of the 24/7 emergency service (24/7), one week per semester. On a voluntary basis, students can follow four additional (two per semester) weeks the 24/7 emergency service. In the 24/7 emergency service, a group of 5-6 students have to stay in the facilities of VTH throughout the day. On night duties, they are on call to attend the emergencies at any of the three clinical services of the VTH. Their mission is to follow urgent cases for as long as the veterinarians in charge of the case find it necessary. 20

The assiduity of the students in the 24/7 emergency service is controlled through a record (Annex III.c) certified by the veterinarians on duty at the VTH during the week. The fulfillment of the 24/7 emergency service is mandatory for the approval in all clinical courses. III.A.1.2. Students access to medical records of VTH All clinical activity of VTH is recorded in QVET hospital management software, although there are also medical records on paper accompanying the animals during hospitalization or records on paper used in the outpatient mobile clinic. All data are then registered into the QVET. Students can access data from medical records in several ways: - Through the veterinarians responsible for the clinical case, during the students activity in the VTH; - Upon request and with written permission by a professor; - By intranet access with visualization of the records according clinical case number. Students have access to a cloud containing the records of the recent cases, without the owner s data to keep confidentiality. Access is made through computer terminals within the VTH. III.A.2. EXTRAMURAL TRAINING The extramural training (EMT) has been implemented in 2015/2016 for students of the 5 th year, whom must perform one week of 24 hours 7 days per semester as minimum, in: - Small animal clinics (1 st semester; 39 hours per student) and - Production animal and equine clinics (2 nd semester; 39 hours per student with a minimum of 24 hours in cattle). In the scope of EMT, students are divided in five rotation groups (15-18 students per group). Every 5 weeks each rotation group is freed up, in turns, of all classes, so students can attend it during entire one week (6 weeks per academic year, per student) with full time dedication. During EMT each group is divided into small groups of 2-4 students per practitioners (invited professors). The EMT takes place in: - Porto, Dr. Luis Montenegro (Veterinary Hospital Montenegro - Small Animals Practice); - Coimbra, Drª Mariana Portugal (Shelter Medicine); - Vila Real, Doutor Juan García Diez (Large Animals and Equines Practice); - Barcelos, Drª Ana Paula Peixoto (Large Animals Practice - Cattle); - Barcelos, Dr. Paulo Capêlo (Large Animals Practice - Cattle); - Serpa, Doutor Carlos Bettencourt (Large Animals Practice - Small Ruminants, Swine and Equines). All clinical activity undertaken by students in EMT and the number of hours done are registered in a personal document that is validated for each event by the invited professor. 21

The professors have also to fill a document (Annex III.d) with the classification they give to each student for his/her performance during the EMT. The final classification of the EMT takes into consideration the document filled by the invited professor and the evaluation done by the responsible professor in the UTAD. 22

IV. RESPONSE to 1.2. INSUFFICIENT OVERALL AWARENESS, INSTRUCTION AND ENFORCEMENT OF SAFETY AND BIOSECURITY PROTOCOLS INCLUDING, BUT NOT LIMITED TO, PHARMACY AND DRUG MANAGEMENT AND CONTROL In order to address the serious and unacceptable failures in terms of biosafety/biosecurity that were detected in infrastructures, equipment and procedures, several measures have been implemented: A) Creation of Biosafety Committees and other units; B) New facilities and infrastructural improvements; C) Implementation of biosafety and biosecurity rules; D) Improvement of biosafety/biosecurity knowledge, attitudes and practices. IV.A. CREATION OF BIOSAFETY/BIOSECURITY COMMITTEES AND OTHER UNITS With a view to resolve the biosafety and biosecurity deficiencies pointed out by the EAEVE team in November 2012, some committees and units were created in chronologic order: 1) IMVM-UTAD Biosafety Committee (BC-IMVM); 2) UTAD Biosafety Committee (BC-UTAD); 3) Biosafety/Biosecurity unit of IMVM-UTAD (BU-IMVM); 4) Biosafety/Biosecurity group (BBG-IMVM) for IMVM-UTAD guidebook redaction and IMVM-UTAD Biosafety/Biosecurity internet page. IV.A.1. IMVM BIOSAFETY COMMITTEE This IMVM-Biosafety Committee was created on 29 th January of 2013, by Rectoral order no 1716/2013 (Diário da República, 2.ª série, 29 th January, 2013). The IMVM-Biosafety Committee (BC-IMVM) has developed a set of activities, since January until July, 2013, in order to identify, correct or mitigate irregular situations within this course. In summary, below, some of these activities are highlighted: - Several visits to the VTH, laboratories and classrooms of the IMVM to identify irregular conditions related to biosafety/biosecurity that were communicated to the respective responsible specifying the required changes; - It was requested the collaboration of IMVM professors, indicating that they should be vigilant to ensure that all students in practical class environment; use appropriate protective clothing or any other additional protection necessary for the class in question; - Preparation and publication of provisional rules for the use of the necropsy room; - Training sessions were organized for professors, students and staff related to biosecurity rules in animal production and laboratories; - It was developed an upgrading to the plant necropsy room; - In July 2013 a report was made and sent to the Rector, with all the activities developed by the BC- IMVM. 23

IV.A.2. UTAD BIOSAFETY COMMITTEE The UTAD Biosafety committee (BC-UTAD) was officially set on the 25 th of November, 2013, with the first committee taking office on the 7 th of April, 2014. The UTAD Biosafety Committee is a collegiate and multidisciplinary body whose activity is governed by a specific regulation. CB-UTAD is composed of a chairman and other six or seven members (depending on whether the chairman has previously been appointed as a member or not). The chairman is appointed by the Rector after consulting the Academic Council. The seven members are appointed by the President of the School of Agrarian and Veterinary Sciences, the President of the School of Science and Technology, the President of the Life Sciences and Environment School, the President of the Nursing School, the Director of the VTH-UTAD, the Director of the Centre for Agrarian Management and Exploration, the Administrator of the Social Action Services. The term of the BC-UTAD chairman and its members coincides with that of the Rector. Members of BC- UTAD and its chairman do not receive any material compensation for their activity. BC-UTAD s mission is to ensure the observance and promotion of high biosafety and biosecurity standards among the structural units of the University in the scope of teaching, research or production activities, which may involve exposure to biohazardous material (including viruses, bacteria, fungi, protozoa, other parasites, animals, animal cells and blood) that may have a detrimental impact on human and animal health or create a risk of biological contamination of the environment (One Health concept). Among other actions, CB-UTAD has produced the Code for Good Biosafety Practices, which is intended to be a guideline for the whole UTAD community and a supporting document for sector manuals. IV.A.3. BIOSAFETY/BIOSECURITY UNIT OF IMVM-UTAD The Biosafety/Biosecurity unit of IMVM-UTAD (BU-IMVM) was created on 18 th of February of 2014, according to the Rectoral order no. 22/2014, to promote and encourage a biosecurity and biosafety environment, practices, attitudes and knowledge in the IMVM. The BU-IMVM status is defined by the respective Regulation published in the Diário da República 25 th November, 2013 (2 nd Série, no. 228, pp. 34504-34505). The BU-IMVM is composed of a chairman and other four members. The activity of BU- IMVM is regulated by the BC-UTAD. The duration of the BU-IMVM chairman and its members coincides with that of the Rector. Members of BU-IMVM and its chairman do not receive any material compensation for their activity. Between February of 2014 and December 2015 BU-IMVM promoted and developed the main following activities: - Elaboration of the Biosafety/Biosecurity Best Practices IMVM Code (See Annex IV.a); 24

- Elaboration of biosafety and biosecurity actions. Twenty-one free training sessions were done to students, professors, veterinarians, technical and operational assistants and to the academic community of UTAD (see Table 4.11); - Periodic meetings with members of the BU-UTAD members and other commissions and directors were done to analyze the evolution of the process; - Answer to individual questions and problems pointed by students, professors and staff about biosafety and biosecurity; - Development of a check-list for observation of irregularities in the teaching and research laboratories considered as Biosafety Level 2 associated with the IMVM; - Development of a check-list for the assessment of the biosafety/biosecurity practices and facilities and equipment in animal facilities associated with the IMVM; - Development of a check-list to register the improvements made in the teaching and research laboratories who manipulate microorganisms, parasites, cultures, tissues and organic fluids handling considered as Biosafety Level 2 associated with the IMVM; - Development of a check-list to register the improvements made in the animal/livestock facilities associated with the IMVM; - Visit to the anatomy, microbiology, parasitology, histopathology, clinical pathology, toxicology/pharmacology, food safety and technology laboratories and registration of needs of improvements in biosafety/ biosecurity; - Visit to livestock facilities and registration of needs of improvements in biosafety/ biosecurity; - Visit the necropsy room of the veterinary hospital and registration of needs of improvements in biosafety/ biosecurity; - Revisit to the anatomy, microbiology, parasitology, histopathology, clinical pathology, toxicology/pharmacology, food safety laboratories to verify the improvements made in terms of biosafety/ biosecurity; - Revisit the livestock facilities to verify the improvements made in terms of biosafety/ biosecurity; Revisit the necropsy room to verify the improvements made in terms of biosafety/ biosecurit; - Check the needs assessment of biosafety warning signs and their placement in the veterinary hospital, necropsy room and anatomy, microbiology, parasitology, histopathology, clinical pathology, toxicology/pharmacology, food safety and technology laboratories and in livestock facilities. IV.A.4. BIOSAFETY/BIOSECURITY GROUP FOR IMVM-UTAD GUIDEBOOK REDACTION The IMVM-UTAD Biosafety/Biosecurity Guidebook was prepared by a Biosafety/Biosecurity workgroup that includes the BU-IMVM, the Dean and her team, the President of CB-UTAD and also Professors and specialists from different IMVM Scientific areas. The guidebook is a result of the biosafety/biosecurity guides of different infrastructures associated to IMVM-UTAD. This guidebook is now available in Portuguese language (Annex IV.a), but a final version in English is being prepared and will be finished soon. 25

IV.B. NEW FACILITIES AND INFRASTRUCTURAL IMPROVEMENTS In the last few years, UTAD has been making an effort to provide the institution with new or updated infrastructures, particularly in the VTH, farms and laboratories, which give support to the IMVM. The main goal of this effort has been to create better conditions in terms of biosafety/biosecurity and occupational health, providing better and safer conditions of study/work to students and to academic and support staffs. IV.B.1. VETERINARY TEACHING HOSPITAL IV.B.1.1. Necropsy room Updated The necropsy room has been restructured/reshuffled (Annex V.a) and equipment/materials were acquired in view to comply with the biosafety and biosecurity rules: - Signage in the access restrict door to the antechamber (Figure 1) of the necropsy room; - The antechamber with a dressing room is separated from the dirty area by a door (Figure 2), and a foot bath; - In this dressing room there is footwear that belongs only to this room. The room users must wear here (in the dressing room) disposable coveralls that are eliminated when they leave the necropsy room; - The necropsy room was divided into two areas by a wall (Figure 3) with 15 cm height, to prevent body fluids leaving the dirty area (Figure 4); - The less clean area has an automatic washing boot, eye wash, washbasin and washing aprons; - The dirty area (where the necropsies are performed) now opens directly to the incinerator area; - The dirty area has a door to the outside protected by a foot bath, with this one being the only route of entry of dead bodies; - In the washing room an emergency shower was built; - After washing, the autopsy material is neat in a closet where it is disinfected by ozone; - The outer access area was sealed and was placed a balcony protection; - In the autopsy room there is a manual of procedures, as well as a permanent record of all the dead bodies that enter the room; - Only authorized personnel, with specific training in biosafety/biosecurity procedures and dressed properly, are allowed to enter the room. 26

Figure 1. Outside signage of the Necropsy service - VTH. Figure 2. Antechamber separated from the necropsy room by a door - VTH. Figure 3. Wall to prevent body fluids leaving the dirty area of necropsy room - VTH. Figure 4. Dirty area of necropsy room - VTH. IV.B.1.2. Controlled access by digital means in some services New A controlled access system by digital means was implemented in the following services: - Pharmacy/Medicines store room (Figure 5); - Surgery area (Figure 6); - Diagnostic imaging area (Radiology rooms and computerized tomography) (Figure 7); - Hospitalization room for exotic animals. 27

Figure 5. Pharmacy/Medicines store room - VTH. Figure 6. Surgery area - VTH. Figure 7. Diagnostic imaging area - VTH. IV.B.1.2. Isolation unit for small animals New The Transfer of the experimental animal laboratory for new facilities (Chapter IV of Biosafety/ Biosecurity Guidebook) and adaptation of the room for the unit of infectious diseases of small animals (isolation unit) was performed in 2014 (Figure 8). This new isolation unit helps veterinarians to provide the highest quality of care to infectious animals while reducing exposure risks to other animals at the hospital. This unit allows to manage an animal suspected or with confirmation of having an infectious illness. The unit has separate patient rooms. Each room ends in an antechamber were professors, students and veterinary technicians put on protective clothing. The antechamber (Figure 9) also provides a barrier between the rooms where the patients are housed and the large nursing station that supports the work in the isolation unit. IV.B.1.3. Dressing rooms for students- New Adaptation of rooms HV0.48 and HV0.55 of the VTH for two dressing rooms for students, one for women (Figure 10) and another for men. 28

Figure 8. Outside door of isolation unit of small animals - VTH. Figure 9. Antechamber with non-manual handwashing - VTH. Figure 10. Dressing room for women (students). IV.B.1.4. Signage - New Signage placement in all the VTH facilities (e.g. Figures 11, 12 and 13) were done, according to biosafety and biosecurity rules. 29

Figure 11. Entrance door with restrict access - VTH. Figure 12. Outside of large animal and equine radiodiagnostic room - VTH. Figure 13. Signage placement - VTH. 30

IV.B.1.5. Conditioned access to VTH database by students -New On the first floor of the VTH computers were placed for students and also technicians to have access to internet and to the VTH database (Qvet ) (Figure 14). Figure 14. VTH database access (Qvet ) (students). IV.B.1.6. Other improvements The VTH front entrance and reception areas (Figure 15) were remodeled/reshuffled, and a new space (HV0.62 room), located in the VTH hall was prepared for short meals of the non-teaching staff, senior technicians and trainees of VTH. During the last few years some equipment was acquired for the VTH: - Computerized tomography equipment (Figure 16) for small, exotic and wild animals advanced imaging diagnose - General Eletric Brivo CT Series TM - Model 325; - Two new ultrasonography apparatus CX30 TM from Philips for the Small and Large Animals Clinical Services were put in working function; - Two new anesthetic apparatus and ventilation equipment from Philips, the fluoroscopic equipment also from Philips that uses X-rays to obtain real -time moving images, and the new ceiling-mounted and floor surgical lights system from Trumpf were put in working function; - Remodeling of the emergency room with acquisition of new equipment for this area: crash cart, portable anesthetic apparatus from Philips, clinical signs monitor, defibrillator and exam table. 31

Figure 15. VTH entrance room and reception area. Figure 16. Computerized tomography equipment - VTH. 32

IV.B.2. LABORATORY FACILITIES IV.B.2.1. Laboratory of Histology and Pathology New The new Laboratory of Histology and Pathology was moved to new infrastructures with an adequate ventilation system to protect against formaldehyde exposure. This lab has two different rooms: 1) one room with a pathology workstation to formaldehyde-related manipulations, a hotte for formaldehyde preserved material and a place for waste containers. The material is cleaned in this room (Figure 17); 2) the other for histology and immunohistochemistry procedures, material registration and registry of diagnosis (Figure 18). Figure 17. Pathology workstation (on the right) and hotte with formalinized material (on the left). A support area with slides and blocks files and microscopes for diagnosis and image acquisition and analysis is available, near to this lab. Only authorized personnel are allowed to enter in this new facility and with specific training in biosafety clothing and procedures. 33

Figure 18. Room where the histology and immunohistochemistry techniques are performed. IV.B.2.2. Anatomy Laboratory Updated The laboratory of Anatomy was remodeled and reequipped. The use of formaldehyde as a mean of preserving anatomical parts fixed material was eliminated and replaced by the use of fresh corpses of small ruminants, body parts of ruminants and horses, since the academic year 2013/2014. Thus, regarding the limited structures and equipment in the Anatomy Laboratory, a new freezer compartment to enable use of a larger number of cadavers was purchased. The new infrastructures facilitate the cleaning and disinfection procedures. Only authorized personnel are allowed to enter in this new facility and with specific training in biosafety procedures. IV.B.2.3. Parasitology Laboratory New The allocation to a new specific and more suitable space, which has an adequate ventilation system and allows the installation of a hotte (E7 PA see plant, Annex V.b); biological safety chamber installed in its own physical space and sheltered (E4 PA); suitable location for the storage and collection of residues (E6 PA); dressing rooms (E9 PA) and an administrative area (E12 PA) separated from the laboratory working area. The classroom for the practical classes of parasitology is new (Figure 19). 34

Figure 19. Classroom of Parasitology. Only authorized personnel are allowed to enter in this new facility and with specific training in biosafety procedures. IV.B.2.4. Microbiology Laboratory New The microbiology laboratory was transferred to a new suitable space (Annex V.c) and equipped according to biosafety rules. The new facilities of the Microbiology Unit are composed by different laboratories and rooms with specific sections: Molecular Biology Lab.; Bacteriology Lab., Virology Lab., Mycology Lab., Water Analysis Lab.; Room of Media Preparation; Room of Sterilization of culture media; Inactivation (dirty room); VITEK; Warehouse culture media; Dressing room. Only authorized personnel are allowed to enter in this new facility and with specific training in biosafety and biosecurity procedures. IV.B.2.5. Toxicology/Pharmacology and Clinical Pathology Laboratories Updated The toxicology/pharmacology (Figure 20) and clinical pathology (Figure 21) laboratories (located in annexes of the VTH main build), have been subjected to a deep rehabilitation, which was in fact a construction from scratch of a laboratory space inside the external structure. This approach converted spaces without the minimal conditions to work in modern laboratories, divided in three spaces: a space for general washing of material and some for material storage; an antechamber for changing clothing; the laboratory working area. Two new classrooms were constructed. 35

The laboratories have now good conditions for classes with controlled temperature, chemical and microbiological safety conditions, easy to sanitize and with new equipment. Only authorized personnel are allowed to enter in this new facility and with specific training in safety procedures. Figure 20. Toxicology/pharmacology laboratory (classroom). Figure 21. Clinical pathology laboratory (classroom). 36

IV.B.2.6. Food Science and Technology laboratory New The laboratory of food science and technology was allocated in a new specific and more suitable space, which has an adequate ventilation system. The new facilities are composed by different laboratories and rooms: food microbiology Lab.; food chemistry Lab.; media preparation and sterilization of culture media room; Inactivation room; Food technology Lab; Food sector support Lab (Figure 22) and sensorial analysis room (Figure 23). Figure 22. Food sector support Lab. Figure 23. Sensorial analysis room. 37

IV.B.2.7. Animal laboratory Facilities New The new animal laboratory facilities were allocated in a specific and suitable space that was prepared for specific manipulations (e.g. surgery, necropsy, experimental procedures, behavioral testing) (e.g. Figure 24). There are rooms for washing and with sterilizing equipment including mechanical cage washers. Storage areas are provided for storage of food, bedding, supplies, as well as cold storage or disposal of carcasses. There is a room for administrative and animal care staff. Sanitary facilities and locker rooms are next to the entry in order to personnel put on appropriate clothing before entering inside the animal facility. Access to the animal laboratory facilities is limited or restricted at the discretion of the animal facility committee. So, a card-key system (Figure 25) is placed on the entry to ensure access control. Also, a record of entries and outs is kept. Personnel entry in animal housing areas (cleanest area) is restricted and personnel are appropriately trained to avoid the introduction of contaminants. Figure 25. Card-key electronic system - Animal Lab entrance. Figure 24. Animal laboratory room IV.B.3. FARM IMPROVEMENTS The farm facilities were improved in view to create the suitable and adequate housing animal conditions in terms of animal welfare quality in accordance with Portuguese and Europeans Animal welfare rules and take into account the biosafety/biosecurity rules. A biosafety/biosecurity manual was also prepared (Included in the biosafety/biosecurity guidebook of IMVM, Annex IV.b). Access to the animal farm facilities is limited or restricted to the authorization of the director of animal farms. 38

IV.B.4. NEW AND UPDATED FACILITIES BUDGET The investment done by UTAD in the new and updated infrastructures that give support to IMVM, as well as in some equipment is presented in Table 4.9. Table 4.9 - Investment done in the new and updated infrastructures. INFRASTRUCTURES BUDGET VTH-UTAD Necropsy room 12.973.00 Isolation Unit 4.500,00 Dressing Rooms 7.925.00 Controlled access by digital means in some services 10.487.14 Ventilation system 2.417.09 Fenced area to walk dogs 860.08 LABORATORIES Anatomy 72.847.36 Histology and Pathology 7.500,00 Parasitoloy 61.999.16 Microbiology 62.900.91 Toxicology/Pharmacology and Clinical Pathology 63.016.12 Clinical Pathology 67.297.93 Food Science and Technology 104.392.02 Experimental animal 93.590.39 FARMS 252.476.67 EQUIPMENTS Computerized Tomography equipment 101.806.00 Equipment for Food Science and Technology 193.285.42 Equipment for Experimental animal laboratory 44.713.57 Equipment for Clinical Pathology Laboratory 37.901.10 Equipments for the surgery room 150.000,00 Equipments for the emergency room 1.750,00 Equipments for the necropsy room 10.000,00 Subtotal 1.364.638,96 TOTAL (with taxes) 1.678.505,92 This investment was supported by The Norte Portugal Regional Coordination and Development Commission (CCDR-N) through the projects NORTE-07-0162-FEDER-000113 LabQuality, NORTE-07-0162-FEDER-000132 LabForward I and NORTE-07-0162-FEDER-000138 LabForward II and also by the Thematic Operational Programme for Territorial Enhancement (POVT) through the project POVT- 15-0439-FEDER-000045 39

IV.C. IMPLEMENTATION OF BIOSAFETY/BIOSECURITY RULES New operating measures and improved biosafety/biosecurity conditions in all infrastructures were implemented, highlighting an increased awareness and knowledge by the students, professors and staff for the fulfillment of these measures as exemplified by the disclosure in an online page of biosafety/biosecurity rules. A Biosafety/Biosecurity Best Practices Code of IMVM (annex IV.a) was written by the BU-IMVM and published in 2014. All students, professors and staff can have access to this document that is easy to use. This is available for students and professors in the official page of IMVM (SIDE) since 5 th November 2014 and was also distributed in paper for staff. A Biosafety/Biosecurity Guidebook (Annex IV,b,) of IMVM-UTAD has been prepared by a group created for this objective, and contains the manuals elaborated for the different laboratories, VTH and other facilities, and also the rules of intramural courses and extramural training. A biosafety/biosecurity webpage has been prepared as a summary of the biosafety/biosecurity guidebook http://ftp.mimvbiosseg.altervista.org/intro_pt.html and is also available in the official page of IMVM (SIDE) as a link. The guidebook and webpage are available in Portuguese language, but a final version in English is being prepared and will be finished soon. The biosafety/biosecurity procedures and movements of people, animals and equipment in VTH laboratories and farms are included in the Biosecurity/Biosafety Guidebook with the description of biosafety/biosecurity procedures in routine and exceptional or emergency situations (Annex V.b). IV.D. IMPROVEMENT OF BIOSAFETY/BIOSECURITY KNOWLEDGE, ATTITUTES AND PRACTICES In order to achieve a better knowledge and awareness in biosafety/biosecurity, several measures as the introduction of these topics in the syllabus of some courses and the organization of compulsive theoretical and practical training sessions have been implemented during the past three years. The training sessions should be a continuous process and provides a unique opportunity for students, professors and staff members to experience real-world, applied to biosafety and infection control. Training in these subjects enhances the quality of hospital and laboratory safety practices by providing a rigorous training experience that emphasizes the cognitive and practical aspects of safety procedures, such as donning and doffing appropriate personal protective equipment. Students had also the opportunity to practice moving and working in a laboratory or handling sharps in a correct way. 40

IV.D.1. INCREASE OF BIOSAFETY/BIOSECURITY SYLLABUS HOURS New classes about biosafety/biosecurity in the syllabus of some subjects were introduced or increased. For example in the Introduction to the Veterinary Medicine (1 st semester, 1 st year, increased 4h) and Introduction to the Scientific Investigation (1 st semester, 3 rd year, increased 6h) course as indicated in Table 4.10. The topics included in these courses are included in the student examination. Table 4.10. Increase of biosafety/biosecurity hours in syllbus since 2014/15. Course Date/Duration Syllabus Introduction to the Veterinary Medicine Introduction to Scientific Investigation 2h 2h 1h 45 min 1h 45 min Biosafety in Veterinary Hospitals I History of biosafety procedures. Aim of biosafety procedures. biosafety in Veterinary Medicine. Nosocomial infections. Cleaning and disinfection of veterinary medical care centers. Design of the facilities. Design of clean and dirty circuits. Hand hygiene. Biosafety in Veterinary Hospitals II Equipments for individual safety. Special demands. Laundry. Plans for cleaning and disinfection. Selection of disinfectants. Education and training in biosafety. Staff safety. "Good Laboratory Practice"; its importance in the scientific accuracy of the work performed in the laboratory, hygiene and quality of work for the employees and other operators, and its economic impact on laboratory management. Biosecurity and biosafety. Notion of hazard versus risk. Notion of risk and factors to consider in assessing the biological risk of laboratory procedures. Importance of establishing different risk areas and respective distribution of procedures performed in each area (examples). 1h 45 min Classification of pathogens in risk groups (WHO, 2004). Key differences and requirements of BSL-1, BSL-2, BSL-3 and BSL-4 level facilities. 1h 45 min Good laboratory practices when using chemicals (main general rules). Labeling of chemicals. GHS hazard pictograms. Examples. In other subjects as Infectious Diseases I and Infectious Diseases II additional practical training was performed with students. 41

IV.D.2. TRAINING SESSIONS DIRECTED TO STUDENTS, PROFESSORS AND SUPPORT STAFF MEMBERS. During the last three years several biosafety and biosecurity actions has been developed in view to achieve a high level of knowledge and correct practices and attitudes. These training sessions directed to students, professors and support staff members are compulsive and were organized since 2013. In total, 21 free training sessions was achieved to students, professors, veterinarians, technical and operational assistants and to the academic community of UTAD (Table 4.11). In some training sessions, experts discuss and highlight key issues with participants that include safety and prevention of laboratory risk hazards, community risk communication, and handling incidents in the laboratory. Participants received a certificate for each attendance Table 4.11.Training courses in biosafety/biosecurity organized since 2013. Training Course on Biosafety Target Audience Duration Date Biosafety in the Hospital Environment Students and Professors, veterinarians Technical and Operational Assistants 2 hours 29.11.2015 Best Practices in Infection Control Action 2 Hospital Waste Management Economic Issues and Biosafety Action 2 Best Practices in Infection Control Action 1 Hospital Waste Management Economic Issues and Biosafety Action 1 Technical staff and Operational Assistant Technical staff and Operational Assistant Technical staff and Operational Assistant Technical staff and Operational Assistant 45 minutes 7.10.2015 45 minutes 7.10.2015 45 minutes 21.07.2015 45 minutes 21.07.2015 Biosecurity in Ruminants s Farms Students and Professors, veterinarians Technical and Operational Assistants Open to the Academic Community of UTAD 1 hour 14.05.2015 Identification of Safety Signs and Symbols Action 2 Workshop cleaning and disinfecting the area and clinic equipment production animals Biosafety Veterinary Practice in Hospital Environment Action 2 Workshop Cleaning and disinfection of the area and Clinical Equipment Company- Animal Biosecurity Veterinary Practice in Hospital Environment Action 2 Hand hygiene and Personal Protective Equipment Biosafety Practice Veterinary in Hospital Environment Action 2 Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants 1 hour 01.07.2015 1 hour 01.07.2015 1 hour 01.07.2015 1 hour 01.07.2015 42

Table 4.11. Training courses in biosafety/biosecurity organized since 2013 (continue) Training Course on Biosafety Target Audience Duration Date Using disinfectants in Veterinary Medicine Biological Risk in Clinical Laboratories Identification of Safety Signs and Symbols Action 1 Workshop cleaning and disinfecting the area and clinic equipment production animals Biosafety Veterinary Practice in Hospital Environment Action 1 Workshop Cleaning and disinfection of the area and Clinical Equipment Company-Animal Biosecurity Veterinary Practice in Hospital Environment Action 1 Hand hygiene and Personal Protective Equipment Biosafety Practice Veterinary in Hospital Environment Action 1 Biosafety in Hospitals and Veterinary Clinics Biosafety in Level 2 Laboratories Biosecurity Procedures Medical Veterinary Service Centers of Small Animals Laboratory Biohazards Biosecurity rules in animal production and laboratory Professors, veterinarians Technical and Operational Assistants Students and Professors, veterinarians Technical and Operational Assistants Open to the Academic Community of UTAD Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Professors, veterinarians Technical and Operational Assistants Students and Professors, veterinarians Technical and Operational Assistants Open to the Academic Community of UTAD Students and Professors, veterinarians Technical and Operational Assistants Open to the Academic Community of UTAD Students and Professors, veterinarians Technical and Operational Assistants Open to the Academic Community of UTAD Students and Professors, veterinarians Technical and Operational Assistants 2.5 hours 01.07.2015 1 hour 03.12.2014 1 hour 30.06.2014 1 hour 30.06.2014 1 hour 30.06.2014 1 hour 30.06.2014 2.5 hours 30.06.2014 1 hour 14.05.2014 2 hours 23.04.2014 1 hour 09.04.2014 1h30 min 17.04.2013 43

ANNEXES 44

ANNEX I: Recalculation of indicators. Ratio 2013/2014 2014/2015 2015/2016* Recommended values R1 429/55.22 7.77 435/58.43 7.44 435/57.45 7.57 UL 8.381 R2 not applicable not applicable not applicable R3 429/44.38 9.67 435/45.84 9.49 435/45.78 9.50 UL 11.057 R4 62/44.38 1.39 62/45.84 1.35 62/45.78 1.35 UL 2.07 R5 56.89/55.22 1.03 59.36/58.43 1.02 57.9/57.45 1.01 Range 0.505-1.907 R6 2111/1795 1.18 2111/1795 1.18 2004/1842 1.09 LL 0.602 R7 1519/592 2.57 1482/629 2.36 1239.5/764.5 1.62 UL 1.809 R8 4434/78 56.85 4434/78 56.85 3846/92 41.80 Range 0.505-1.907 R9 5484/324 16.93 5484/324 16.93 4556/283 16.09 Range 0.870-90.029 R10 54/324 0.17 54/324 0.17 50/283 0.18 Range 0.069-0.924 R11 169/62 2.73 203/62 3.27 - * LL 0.758 R12 623/62 10.05 769/62 12.40 - * LL 8.325 R13 45/62 0.73 48/62 0.77 - * LL 0.326 R14 210/62 3.39 194/62 3.13 - * LL 2.7 R15 65/62 1.05 134/62 2.16 - * LL 0.407 R16 4259/62 68.70 4491/62 72.44 - * LL 48.061 R17 4/62 0.065 4/62 0.065 - * LL 0.035 R18 89/62 1.44 106/62 1.71 - * LL 1.036 R19 90/62 1.45 148/62 2.39 - * LL 0.601 R20 101/62 1.63 126/62 2.03 - * LL 1.589 * In 2015/2016, R11 to R20 ratios were not calculated because we only have data from September until 18 th of December. 45

ANNEX II: New Veterinary curriculum (from 2015/16 course) In a PDF Document in annex to this report. 46

ANNEX III: Veterinary records of Week Hospital Rotation and Extramural Traineeship ANNEX III.a WHR record (logbook) UTAD IMVM HTV Service - Week Hospital Rotation Name: Number: Year Semester Date Hour: from to Animal specie Case number Activities developed Supervisor Supervisor signature 47

ANNEX III.b WHR Compulsive online student database (logbook) 48

Online record of WHR activity - individual student data (logbook) 49

Online record of WHR activity e.g. one student Sara Brito 50

ANNEX III.c Compulsive 24/7 Emergence service Record UTAD IMVM HTV Emergence service Record - 24/7 Week Name: Number: Monday Day / /_ Tuesday Day / / Wednesday Day / /_ Thursday Day / /_ Friday Day / /_ Saturday Day / /_ Sunday Day / /_ Morning Afternoon Night 51

ANNEX III.d Extramural training Evaluation by Practitioners (Invited professors) INTEGRATED MASTER IN VETERINARY MEDICINE TRAINEESHIP IV - CLINICAL TRAINING (1 ST SEMESTER 5 TH YEAR) PRACTICAL EVALUATION STUDENT S NAME: PROFESSOR S NAME: START DATE: / /20 END DATE: / /20 ELEMENTS OF EVALUATION (IF APPLICABLE): 1. Attendance 2. Punctuality 3. Interest/Attitude 4. Responsibility 5. Technical or scientific performance (amount of work) 6. Technical or scientific performance (quality of work) 7. Spirit of initiative and innovation 8. Integration into the work team 9. Relationship with customers/owners 10. Program compliance 11. Acquisition of new knowledge 12. Application of new knowledge EVALUATION (0-20) Additional comments: FINAL EVALUATION (0-20): DATE: / /20 PROFESSOR S SIGNATURE: 52

ANNEX IV IV.a - Biosafety/Biosecurity Best Practices Code of IMVM In a PDF Document in annex to this report. IV.b - Biosafety/Biosecurity Guidebook of IMVM In a PDF Document in annex to this report. 53

ANNEX V: Facilities plants ANNEX V.a - Necropsy room updated 54

ANNEX V.b - Plant Parasitology Lab - New 55