Delfy Góchez Chargée de mission Result of the OIE data collection Lessons learned and expectations Beirut, November 8th 2017
Reporting Options The sections of the OIE Template named Reporting Options 1, 2 and 3, collect the quantities of antimicrobial agents intended for use in animals. Baseline Information Reporting Option 1 Reporting Option 2 Reporting Option 3 Parts A + B : for all Member Countries to respond Part C : for the Member Countries choosing a Reporting Option Antimicrobial agents Type of use* Antimicrobial agents Type of use* Group of animals** Antimicrobial agents Type of use Group of Animals** Routes of administration * Type of use: therapeutic or growth promotion **For the purposes of the OIE database, animal groups means: terrestrial food-producing animals, aquatic food-producing animals or Companion animals World Organisation for Animal Health Protecting animals, Preserving our future 2
Data types reported in the OIE data collection First year of data collection: Second year of data collection: 45% 32% 68% 21% 27% 73% 53% 9% 34% 38% Baseline Information Reporting Option 1 Reporting Option 2 Reporting Option 3 Baseline Information Reporting Option 1 Reporting Option 2 Reporting Option 3 N = 130 N = 89 N = 146 N = 107 World Organisation for Animal Health Protecting animals, Preserving our future 3
Data types reported in the OIE data collection in the Middle East First year of data collection: Second year of data collection: 0% 33% [PERCENTAGE] 25% 25% 25% 75% 33% 33% Baseline Information Reporting Option 1 Reporting Option 2 Reporting Option 3 Baseline Information Reporting Option 1 Reporting Option 2 Reporting Option 3 N = 5 N = 1 N = 4 N = 3 World Organisation for Animal Health Protecting animals, Preserving our future 4
Baseline Information: Part B. General Information World Organisation for Animal Health Protecting animals, Preserving our future 5
Second year of data collection: barriers for providing data on quantities of antimicrobial agents in animals 18 Nº Countries who submitted the template and did not report quantities of antimicrobial agentse used in animals 16 16 14 12 10 8 6 4 2 0 No regulatory framework N = 38 14 Lack of cooperation with other national authorities and private sector Categories Data available under other national authority: 8/10 : MoH 2/10: several agencies involved 8 Lack of tools and human resources 4 Insufficient regulatory enforcement World Organisation for Animal Health Protecting animals, Preserving our future 6
Antimicrobial agents as growth promoters First year of data collection Second year of data collection 63% 74% 60% 40% 26% 37% N = 130 N = 146 N = 60 Antimicrobial growth promoters authorised Antimicrobial growth promoters not authorised Antimicrobial growth promoters not authorised Antimicrobial growth promoters authorised Lack of legislation for antimicrobial growth promoters World Organisation for Animal Health Protecting animals, Preserving our future 7
Updates for third phase questionnaire Second year Updates for third phase questionnaire Third year (http://www.oie.int/en/our-scientific-expertise/veterinary-products/antimicrobials/) World Organisation for Animal Health Protecting animals, Preserving our future 8
Antimicrobial agents used as growth promoters in animals in 33 Member Countries, first year Nº of Member Countries who submitted the OIE Template, declared the authorisation of antimicrobial agents as growth promoters and provided a list of growth promoters in their countries 20 18 16 14 12 10 8 6 4 2 0 18 18 17 17 15 13 11 11 11 9 7 5 4 4 4 3 3 3 3 3 3 2 2 2 2 2 2 2 2 2 2 1 1 1 1 1 1 1 1 BACITRACIN FLAVOFOSFOLIPOL AVILAMYCIN TYLOSIN VIRGINIAMYCIN COLISTIN ENRAMYCIN LINCOMYCIN OXYTETRACYCLINE CHLORTETRACYCLINE TIAMULIN KITASAMYCIN LASALOCID OLAQUINDOX TETRACYCLINE AMOXICILLIN ERYTHROMYCIN ROXARSONE SPECTINOMYCIN SULFAMETHAZINE TILMICOSIN APRAMYCIN BICOZAMYCIN CARBADOX ENROFLOXACIN FLORFENICOL NEOMYCIN NOSIHEPTIDE BENCYL PENICILLIN PROCAINE SPIRAMYCIN STREPTOMYCIN EFROTOMYCIN FURALTADONE FURAZOLIDONE JOSAMYCIN OLEANDOMYCIN SULFACHLORPYRIDAZINE SULFATHIAZOLE TRIMETHROPRIM Antimicrobial agents used as growth promoters World Organisation for Animal Health Protecting animals, Preserving our future 9
Baseline Information: Part C. Data Collection of Antimicrobial Agents Intended for Use in Animals World Organisation for Animal Health Protecting animals, Preserving our future 10
Years of reported data First year of data collection Second year of data collection 5% 2% 3% 3% 36% 31% N = 89 N = 107 32% 39% 24% Year 2010 Year 2011 Year 2012 25% Year 2013 Year 2014 Year 2015 Year 2016 Year 2013 Year 2014 Year 2015 Number of Member Countries that filled in quantities of antimicrobial agents in 2016 Number of Member Countries that filled in templates for only one year between 2013 and 2016 Number of Member Countries that filled in templates for more than one year between 2013 and 2016 89 85 2 Number of Member Countries that filled in quantities of antimicrobial agents in 2016 Number of Member Countries that filled in templates for only one year between 2013 and 2016 Number of Member Countries that filled in templates for more than one year between 2013 and 2016 107 98 9 World Organisation for Animal Health Protecting animals, Preserving our future 11
Years of reported data in the Middle East First year of data collection Second year of data collection 0% 0% N = 3 One country provided quantities of antimicrobials for 2014 33% 67% Year 2013 Year 2014 Year 2015 Year 2016 World Organisation for Animal Health Protecting animals, Preserving our future 12
Data Sources Reported in the First Year of Data Collection A.WHOLESALERS & RETAILERS: a.sales data Wholesalers. b.sales data Retailers. c.purchase data Wholesalers. d.purchase data Retailers. e.purchase data Agricultural cooperatives. B.IMPORTS: a.import data Customs declarations-veterinary products. b.import data Customs declarations-active ingredients. C.MARKETING AUTHORISATIONS HOLDERS: a.sales data Marketing authorisations holders. b.sales data Registration authorities. D.VETERINARIANS: a.sales data-veterinarians. b.veterinary prescriptions data Sales. c.veterinary prescriptions data Prescriptions. d.veterinary prescriptions data Dispensing. E.PHARMACISTS: a.sales data Pharmacies. b.sales data Farm shops/agricultural suppliers. c.purchase data Pharmacies. F.FEED MANUFACTURERS: a.sales data Feed mills. b.purchase data Feed mills. G.MANUFACTURERS: a.sales data Industry trade associations. b.purchase data Producer organisations. H.FARMERS & OTHERS: a.antimicrobial use data Farm records. Nº Countries who submitted the template and reported quantities of antimicrobial agents used in animals 60 50 40 30 20 10 0 56 WHOLESALERS & RETAILERS 42 IMPORTS 33 MARKETING AUTHORISATIONS HOLDERS 17 16 VETERINARIANS PHARMACISTS Data sources 12 FEED MANUFACTURERS 9 MANUFACTURERS 7 FARMERS & OTHERS World Organisation for Animal Health Protecting animals, Preserving our future 13
Food-producing animal species covered by the data in105 Member Countries, 2013-2016, second year Nº Countries who submitted the template and reported quantities of antimicrobial agents used in animals 120 100 80 60 40 20 0 105 103 101 95 70 62 60 46 27 24 24 16 12 10 1 Food-producing animal species World Organisation for Animal Health Protecting animals, Preserving our future 14
Reporting Options: Kilograms of antimicrobial agents World Organisation for Animal Health Protecting animals, Preserving our future 15
Proportion of reported antimicrobial classes by Member Countries, 2010-2015, first year Aggregated class data Others Tetracyclines Sulfonamides (including trimethoprim) Streptogramins Quinoxalines Polypeptides Pleuromutilins Penicillins Other quinolones Orthosomycins Nitrofurans Macrolides Lincosamides Glycophospholipids Glycopeptides Fluoroquinolones 3-4 gen cephalosporins 1-2 gen. cephalosporins Cephalosporins (all generations) Arsenicals Amphenicols Aminoglycosides 1% 0% 0% 1% 0% 0% 0% 5% 1% 0% 0% 4% 0% 0% 1% 0% 1% 2% 7% 7% 7% 15% 48% 0% 5% 10% 15% 20% 25% 30% 35% 40% 45% 50% % of reported quantities of antimicrobial agents used in animals by 89 Member Countries World Organisation for Animal Health Protecting animals, Preserving our future 16
Work on the animal biomass (denominator) To analyse the data collected on antimicrobial use in the context of animal populations. This is done by using population data on different animal species, data-derived estimates of average weights of each species by subregion and country, and average reproductive rates of short-lived species. World Organisation for Animal Health Protecting animals, Preserving our future 17
Work on the animal biomass (denominator) The OIE ad hoc Group on AMR acknowledged the variability in production cycles and average weights in animals around the world and recognised that precise data may currently not be available by country or region. The Group therefore works on the animal biomass to calculate the use of antimicrobial agents in animals (mg/kg). World Organisation for Animal Health Protecting animals, Preserving our future 18
Final report First year www.oie.int/eng/amuglobaldatabase2016 www.oie.int/esp/amuglobaldatabase2016 www.oie.int/fr/amuglobaldatabase2016 Global analysis General information Quantity of antimicrobial agents reported Analysis by OIE Region (first phase) General Information by OIE Region Africa Americas Asia and the Pacific Europe Middle East Second phase upcoming World Organisation for Animal Health Protecting animals, Preserving our future 19
Conclusion The first OIE Annual Report shows great commitment. Member Countries need support to improve their national monitoring systems. In addition, the second OIE Annual Report will include quantitative analysis per region. Over time, the OIE database will be further developed to allow countries to provide their information through an electronic portal. World Organisation for Animal Health Protecting animals, Preserving our future 20
OIE Questionnaire: What changed? First year (2015) Second year (2016) Third year (2017) World Organisation for Animal Health Protecting animals, Preserving our future 21
Comparison of the proportion of OIE Member Countries submitting questionnaires by OIE Region % of Member Countries who submitted the template 100% 80% 60% 40% 20% 0% n=54 n=29 n=32 n=53 n=12 100% 87% 81% 81% 76% 72% 66% 68% 42% 33% Africa Americas Asia and the Pacific Europe Middle East OIE Region n = 180 2015 Questionnaire 2016 Questionnaire + 3 non Member Countries World Organisation for Animal Health Protecting animals, Preserving our future 22
Global Data Collection on Antimicrobial Agents Intended for Use in Animals More participation from Member Countries in the Middle East More information on type of use, animal groups and route of administration World Organisation for Animal Health Protecting animals, Preserving our future 23
Delfy Góchez 12, rue de Prony, 75017 Paris, France www.oie.int media@oie.int - oie@oie.int