Eastern Regional High School Honors iology Name: Period: Date: Unit 13 Non-Mendelian Genetics Review Packet 1. The phenotypes for 4 o clock flowers are white, red, and pink. Cross a purebred red flower with a hybrid 4 o clock flower. R R R RR RR W RW RW a. What are the possible phenotypes of the offspring? Red Pink b. What is the phenotypic ratio (p-ratio)? 1:1 c. What is the genotypic ratio (g-ratio)? 1:! 2. In certain species of chickens there are three phenotypes for feather color: black, white, and speckled. Cross two chickens one that is hybrid for feather color and one that is black. W W W a. What are the possible phenotypes of the offspring? lack and Speckled b. What is the phenotypic ratio (p-ratio)? 1:1 c. What is the genotypic ratio (g-ratio)? 1:1 1
3. Rabbits have several alleles for their fur color. Cross a rabbit that is a hybrid chinchilla (r ch r) with a rabbit that is a hybrid Himalayan (r h r). r eh r R = Full Color; dominant to all other alleles r h r eh r h r h r r ch = chinchilla; dominant to c h and c r r eh r rr r h = himalyan; dominant to c r = albino; recessive to all other alleles a. What are the possible phenotypes of the offspring? Chinchilla Himalyan Albino b. What is the phenotypic ratio (p-ratio)? 2:1:1 c. What is the genotypic ratio (g-ratio)? 1:1:1:1 4. Challenge: Hair color in mice is determined by a single gene with a series of alleles, each resulting in different coloration. There are alleles for black, brown, agouti, gray, and albino. The allelic series is written as follows: agouti > black > brown > grey > albino. List the phenotypes of the offspring from a cross between a purebred grey haired mouse and a hybrid agouti/brown mouse. Let = Agouti b bl = lack b br = rown b g = grey b = albino b g b g b g b g b br b br b g b br b g Pheno = rown or Agouti 2
5. Muscular dystrophy is a dominant sex-linked disorder. A female that does NT have muscular dystrophy marries a man who does have the disorder. Create a Punnett square to find the following X MD = MD X m = Normal X MD X m X MD X m X m X MD X m Y X m Y X m Y a. List all possible genotypes of the offspring: X MD X m X M Y b. What percentage of their offspring will have Muscular Dystrophy? 50% c. What is the probability in percent that they will have a female that has Muscular Dystrophy? 50% d. What is the probability in percent they will have a carrier of the disorder? 0% No Carriers_ 6. This pedigree shows the inheritance of albinism. Albinism is caused by an autosomal recessive allele. aa aa a. Identify the genotypes of all the individuals in the pedigree. b. How many males are affected by the disorder? 1 3
7. This pedigree shows the inheritance of cystic fibrosis. Cystic fibrosis is caused by an autosomal recessive allele. aa aa a. Find the genotypes of all the individuals in this pedigree. b. How many individuals are carriers for this disease? 6 8. Cross a man that has type A blood with a women that is hybrid for type blood. Create a Punnett square to find the following to show the results of this cross. A lood Groups Phenotype (lood Type) Genotyp e Transfusio ns T Transfusio ns FRM A I A I A or I A i A, A A, I I or I i, A, A I A I A ii I i I A I A I I A i I I I I i a. List the possible phenotypes of the offspring: A, A, b. What is the p-ratio for the offspring? 1:1:2 c. ased on your work, how many of their children (out of 4) will able to donate blood to their father? 100% 4
9. A women with blood type + (ii Rh + Rh - ) marries a man with blood type A + (I A I Rh + Rh - ). Determine the possible blood types of their children. Rh lood Types Phenotype (Rh Factor) Rh Positive Rh Negative Genotype T FRM Rh + /Rh + or Rh + /Rh - Rh + Rh + or Rh - Rh - /Rh - Rh + or Rh - Rh - irh + irh - A lood Groups Phenotype (lood Type) Genotype T FRM A I A I A or I A i A, A A, I I or I i, A, A I A I A ii I A Rh + I A irh + Rh + I A irh + Rh - I A Rh - I A irh + Rh - I A irh - Rh - I Rh + I irh + Rh + I irh + Rh - I Rh - I irh + Rh - I irh - Rh - a. What percentage of their children could take a blood transfusion from their father? 0% b. From their mother? 75% 5
10. This pedigree shows the inheritance of hemophilia. Hemophilia is caused by an sex-linked recessive allele. X N Y X N X n X n Y X N X? X N Y X n Y X N X n X N Y X N X? X n Y X n Y X N Y X N X? X N X? X N X n X N Y X N Y X N X n a. Identify the genotypes of all the individuals in the pedigree. b. How many females are carriers of the disorder? 4 hh hh hh hh hh hh H? H? hh hh hh 11. This pedigree shows the inheritance of Huntington s disease. Huntington s Disease is caused by an autosomal dominant allele. 6
a. Identify the genotypes of all the individuals in the pedigree. b. Exaplain why there are N carries in this pedigree. _Dominant Disease -> you either have the disease or you don t 12. Follow the directions below and draw the pedigree in the provided box. Indicate the genotypes of each individual in the pedigree. Hair color pedigree: Follow the pattern of inheritance for LNDE hair. Color in circles and squares of any person who has blond hair. rown hair is dominant over blonde (= brown hair a. Generation I: A man with dark brown hair marries a woman with blond hair. b= blond hair) b. Generation II: This couple has 5 children. The first born is a girl, who marries a man with blond hair. The second child is boy with blond hair. The third child is boy with blond hair. The fourth and fifth children are girls, both have brown hair. c. Generation III: The first born girl (from generation II) has three girls, they all have blond hair. Is it possible for this couple to have children with brown hair? Explain Yes, she could be hybrid for hair color, if so she has a 50/50 chance of having a child with brown hair. KEY: 7