Herbert L. DuPont (Ed.) Use of Quinolones in Travel Medicine Second Conference on International Travel Medicine Proceedings of the Ciprofioxacin Satellite Symposium "Use of Quinolones in Travel Medicine" Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Herbert L. DuPont, M. D. University of Texas Medical School at Houston 6431 Fannin, 1.729 JFB Houston, TX 77030, USA Library of Congress Cataloging-in-Publication Data Ciprofloxacin Satellite Symposium "Use of Quinolones in Travel Medicine" (1991 : Atlanta, Ga.) Use of quinolones in travel medicine : proceedings of the Ciprofloxacin Satellite Symposium "Use of Quinolones in Travel Medicine" I Second Conference on International Travel Medicine: Herbert L. Dupont (ed.). Includes bibliographical references and index. ISBN-13:978-3-540-54778-5 1. Quinolone antibacterical agents-congresses. 2. Travel - Health aspects - Congresses. I. Dupont, Herbert L., 1938 - II. Conference on International Travel Medicine (2nd: 1991 : Atlanta, Ga.) m. Title. [DNLM: 1. Quinolinones-therapeutic use - congresses. 2. Travel-congresses. QV 250 C5775u 1991] RM666.Q5556 1991 613.6'8 - dc20 DNLMIDLC for Library of Congress ISBN-13 :978-3-540-54778-5 DOl: 10.1007/978-3-642-77077-7 e-isbn-13 :978-3-642-77077-7 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only pennitted under the provisions of the German Copyright Law of September 9, 1965, in its version of June 24, 1985, and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law. Springer-Verlag Berlin Heidelberg 1992 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the fonner are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Product Liability: The publisher can give no guarantee for infonnation about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other phannaceutical literature. Typesetting: Mitterweger Werksatz GmbH, 6831 Plankstadt 27/3145/543210 - Printed on acid-free paper
Contents Ciprofloxacin in the Treatment of Salmonella Enterocolitis and Campylobacteriosis H. Pichler, G. Diridl, G. Seiberl, K. Stickler, E. Wallis, and D. Wolf. 1 Discussion 9 Results of a Double-Blind Placebo Controlled Study Using Ciprofloxacin for Prevention of Travelers' Diarrhea C. M. A. Rademaker 10 Discussion 14 Typhoid Fever: Evaluation of the Efficacy and Safety of Ciprofloxacin in Comparison with Chloramphenicol E. Gotuzzo and C.Carrillo 16 Discussion 23 The Use of Quinolones for the Treatment of Shigellosis in Travelers M. L. Bennish Discussion 25 33
VI Contents Quinolones for Empiric Therapy of Travelers' Diarrhea H. L. DuPont, C. D. Ericsson, J. J. Mathewson, and M. W. DuPont 35 Discussion 42 Subject Index... 47
Contributors Bennish, M. L. New England Medical Center, Departments of Pediatrics and Medicine, Division of Geographic Medicine and Infectious Disease, 750 Washington Street, Boston, MA 02111, USA Diridl, G. Kaiser Franz-Josef Spital, KundratstraBe 3, A-1100 Wi en DuPont, H. L. University of Texas, Medical School/School of Public Health at Houston, 6431 Fannin, 1.729 JFB, Houston, TX 77030, USA DuPont, M. W. Pharmaco Testing, Inc., New Braunfels, Texas 78/30 USA Ericsson, C. D. University of Texas, Medical SchooUSchool of Public Health, 1.728JFB, Houston, TX 11030, USA Gotuzzo, E. Universidad Peruana Cayetano Heredia, Apartado Postal 5045, Lima 100, Peru Mathewson, J. J. University of Texas, Medical SchooUSchool of Public Health, 1.730JFB, Houston, TX 11030, USA
VIII Contributors Pichler, H. Kaiser Franz-Josef Spital, Infektionsabteilung, KundratstraBe 3, A-llOO Wien Rademaker, C. M. A. Department of Clinical Microbiology and Laboratory of Infectious Diseases, University Hospital, P.O. Box 85.500, 3508 GA Utrecht, The Netherlands Seiberl, G. Stickler, K. Wallis, E. Wolf, D.