Atlas of Experimental Toxicological Pathology

Atlas of Experimental Toxicological Pathology

To Cora P. Cherry for sharing with us her wealth of experience in the field of toxicological pathology

Current Histopathology Consultant Editor Professor G. Austin Gresham, TO, SeD, MO, FRC Path. Professor of Morbid Anatomy and Histology, University of Cambridge Volume Thirteen & u [ @[2 1 & ~ EXPERIMENTAL TOXICOLOGICAL PATHOLOGY BY C. GOPINATH Director of Pathology Huntingdon Research Centre Huntingdon, UK D. E. PRENTICE Head of Pathology Group Deputy Head of Toxicology Department Pharmaceutical Division Sandoz Ltd Basle, Switzerland D. J. LEWIS Deputy Head of Pathology Huntingdon Research Centre Huntingdon, UK l\ti.tp PRESS LI.M.ITED... ~ ~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP 11111 ". LANCASTER / BOSTON / THE HAGUE / DORDRECHT.'IIIIIIII

Published in the UK and Europe by MTP Press Limited Falcon House Queen Square Lancaster. England Copyright 1987 C. Gopinath. D. E. Prentice and D. J. Lewis All rights reserved. No part of this publication may be reproduced. stored in a retrieval system. or transmitted in any form or by any means. electronic. mechanical. photocopying. recording or otherwise. without prior permission from the publishers. British Library Cataloguing in Publication Data Gopinath. C. Atlas of experimental toxicological pathology. - (Current histopathology; v.13) 1. Toxicology - Technique I. Title II. Prentice. D. E. III. Lewis. D. J. IV. Series 615.9'0028 RA 1211 ISBN-13: 978-94-010-7930-3 e-isbn-13: 978-94-009-3189-3 001: 10.1007/978-94-009-3189-3 Published in the USA by MTP Press A division of Kluwer Academic Publishers 101 Philip Drive Norwell. MA 02061. USA Library of Congress Cataloging in Publication Data Gopinath. C.. MRC Path. Atlas of experimental toxicological pathology. (Current histopathology; v. 13) Includes bibliographies and index. 1. Toxicology. Experimental-Atlases. 2. Histology. Pathological-Atlases. 3. Laboratory animals- Histology-Atlases. 4. Diseases-Animal models-atlases. I. Prentice. D. E. II. Lewis. D. J. III. Title. IV. Series. [DNLM: 1. Pathology-atlases. 2. Toxicology-atlases. WI CU788JBA v.13 /QZ 17 G659al RA1199.G67 1987 615.9'07 87-21448 Phototypesetting by Titus Wilson. Kendal. Colour origination by Laserscan. Stretford. Manchester.

Contents Consultant Editor's Note 7 Acknowledgements 8 Introduction 9 1 The cardiovascular system 11 2 The respiratory system 22 3 The liver 43 4 The alimentary system and pancreas 61 5 The urinary system 77 6 The reproductive system 91 7 The endocrine glands 104 8 The lymphoid system 122 9 The nervous system 137 10 The eye and ear 145 11 The musculoskeletal system and skin 156 Index 167

Cu rrent Histopathology Series Already published in this series: Volume 1 Atlas of Lymph Node Pathology Volume 2 Atlas of Renal Pathology Volume 3 Atlas of Pulmonary Pathology Volume 4 Atlas of Liver Pathology Volume 5 Atlas of Gynaecological Pathology Volume 6 Atlas of Gastrointestinal Pathology Volume 7 Atlas of Breast Pathology Volume 8 Atlas of Oral Pathology Volume 9 Atlas of Skeletal Muscle Pathology Volume 10 Atlas of Male Reproductive Pathology Volume 11 Atlas of Skin Pathology Volume 12 Atlas of Cardiovascular Pathology Other volumes currently scheduled in this series include the following titles: Atlas of Articular Pathology Atlas of Bone Pathology Atlas of Connective Tissue Pathology Atlas of ENT Pathology Atlas of General Cytology Atlas of Neuropathology Atlas of Ophthalmic Pathology Atlas of Serous Fluid Cytology

Consultant Editor's Note Toxicological pathology is a subject which attracts the interests of a wide variety of workers. Human and veterinary pathologists often need access to the information provided by this book. It will be of especial value to those working in the fields of drug testing, experimental pathology and clinical pharmacology. This is a comprehensive volume dealing with changes that are induced by a wide variety of agents in many species of animals. An extensive bibliography has contributed greatly to the usefulness of this book. Texts on toxicological pathology are not numerous. This is a welcome addition to the series and follows the tradition of being a bench manual for workers in the field. G. Austin Gresham

Acknowledgements We are greatly indebted to many people who have assisted us over several years in the preparation of this atlas. Our helpers are too numerous to mention individually, but we are particularly grateful to Huntingdon Research Centre and Sandoz pathologists for ideas and histological slides, and to the technical staff of both companies for excellent assistance. We also wish to thank our wives for their tolerance during the long preparation of the book and we particularly wish to thank Mrs Ann Lewis for typing the various forms of the manuscript.