Table S1. Rank, breed, proportion (%) of bitches in different breeds that had developed pyometra by the age of ten years. The 0 breeds are listed in ranking order. Rank Breed % 1 2 3 4 5 9 1 Bernese Mountain Dog Great Dane Rottweiler Irish Wolfhound Staffordshire Bull Terrier Keeshond Bull Terrier Bouvier des Flandres Newfoundland Airedale Terrier Cavalier King Charles Spaniel Pug Basset hound Collie Pyrenean Mountain Dog Dobermann Old English Sheepdog Scottish Terrier Swedish Elkhound 2 1 5 5 52 52 50 50 49 4 4 44 44 43 43 41
2 29 31 34 3 3 40 41 43 44 Alaskan Malamute Swedish Lapphund American Cocker Spaniel Golden Retriever Chinese Crested Dog Powder Puff Swiss Hound/Lucerne Belgian Shepherd Dog Large Poodle English Cocker Spaniel English Springer Spaniel Samoyed German Shepherd Dog Drever (Swedish hound) Japanese Spitz Labrador Retriever Boxer Flat Coated Retriever Basset Artesien Normand Groenendaeler Welsh Springer Spaniel Nova Scotia Duck Tolling Retriever Lhasa Apso Dachshund (long-haired) Toy Poodle Chihuahua (smooth-haired) 40 40 3 31 31 2 2 2 2
45 4 4 4 49 50 51 52 53 55 5 5 5 59 0 1 2 3 4 5 9 Elkhound Munsterlander Schipperke Kelpie West Highland White Terrier Borzoi Mixed breed German Spaniel Chihuahua (long-haired) Shetland Sheepdog Whippet Irish Setter Cairn Terrier Norfolk Terrier Border Terrier Hovawart Leonberger Yorkshire Terrier English Setter Petit Basset Griffon Vendeen Welsh Terrier Rhodesian Ridgeback Finnish Hound Beagle Pomeranian
0 1 2 3 4 5 9 0 1 2 3 4 5 9 90 91 92 93 94 Norwegian Buhund German Jagde Terrier English Pointer Schiller Hound Briard Hamilton Hound Bearded Collie Shiba Bedlington Terrier Miniature Pinscher Afghan Dalmatian Havanese Bichon Frisé Shih Tzu Danish/Swedish Farmdog Papillon Icelandic Sheepdog Swedish Vallhund Siberian Husky Papillon Drop Ear Karelian Bear Dog German Longhaired Pointer Border Collie Småland Hound 1 1 1
95 9 9 9 99 0 1 2 3 4 5 9 0 Irish Soft Coated Wheaten Terrier Jack Russel Terrier Finnish Lapphund Tibetan Spaniel Basenji Greyhound Norwich Terrier Lancashire Heeler Tibetan Terrier Saluki East Siberian Laika Gordon Setter Maltese Coton de Tulear Norrbotten Spitz Finnish Spitz 5 4 3 Table S2. Rank, breed, proportion (%) of bitches in different breeds that had developed mammary tumours by the age of ten years. The 0 breeds are listed in ranking order. Rank Breed % 1 2 Leonberger Dobermann 4
3 4 5 9 1 Irish Wolfhound Welsh Terrier English Springer Spaniel American Cocker Spaniel Boxer Bedlington Terrier Old English Sheepdog Irish Soft Coated Wheaten Terrier Hovawart Airedale Terrier Great Dane Swedish Elkhound German Spaniel English Cocker Spaniel Afghan German Shepherd Dog Saluki Rhodesian Ridgeback Staffordshire Bull Terrier Basset hound Papillon Drop Ear Yorkshire Terrier Bouvier des Flandres Bull Terrier Pyrenean Mountain Dog 41 3 29 2 2 2
2 29 31 34 3 3 40 41 43 44 45 4 4 4 49 50 51 52 Rottweiler Papillon English Setter Coton de Tulear Alaskan Malamute Irish Setter Bichon Frisé Nova Scotia Duck Tolling Retriever Tibetan Terrier Welsh Springer Spaniel Maltese Jack Russel Terrier Petit Basset Griffon Vendeen Mixed breed Norfolk Terrier Borzoi Dachshund (long-haired) Cairn Terrier Flat Coated Retriever Beagle English Pointer Munsterlander Large Poodle Chinese Crested Dog Powder Puff Cavalier King Charles Spaniel 1
53 55 5 5 5 59 0 1 2 3 4 5 9 0 1 2 3 4 5 German Longhaired Pointer Samoyed Danish/Swedish Farmdog Gordon Setter Bernese Mountain Dog Scottish Terrier Småland Hound Border Terrier Miniature Pinscher Elkhound Shih Tzu German Jagde Terrier Lhasa Apso Briard Norrbotten Spitz Swedish Lapphund Drever (Swedish hound) Toy Poodle Labrador Retriever Dalmatian Chihuahua (smooth-haired) Karelian Bear Dog Kelpie Keeshond Belgian Shepherd Dog
9 0 1 2 3 4 5 9 90 91 92 93 94 95 9 9 9 99 0 1 2 Golden Retriever Schiller Hound Whippet Swedish Vallhund Japanese Spitz Havanese West Highland White Terrier Newfoundland Swiss Hound/Lucerne Tibetan Spaniel Border Collie Hamilton Hound Schipperke Finnish Hound Shetland Sheepdog Groenendaeler Finnish Spitz Greyhound Icelandic Sheepdog Shiba Chihuahua (long-haired) Basset Artesien Normand Bearded Collie Basenji Siberian Husky 9 9 9 5 5
3 4 5 9 0 Pomeranian Norwegian Buhund Finnish Lapphund Pug East Siberian Laika Lancashire Heeler Collie Norwich Terrier 4 4 3 3 2 2 2 1 Table S3. Rank, breed, proportion (%) of bitches in different breeds that had developed either pyometra or mammary tumours or both of the two diseases by the age of ten. The 0 breeds are listed in ranking order. Rank Breed % 1 2 3 4 5 Leonberger Irish Wolfhound Bernese Mountain Dog Great Dane Staffordshire Bull Terrier Rottweiler Bull Terrier Dobermann 3 9 9 5 2 2
9 1 2 29 31 Bouvier des Flandres Airedale Terrier Keeshond American Cocker Spaniel Basset hound English Springer Spaniel Cavalier King Charles Spaniel Swedish Elkhound Newfoundland Old English Sheepdog Pyrenean Mountain Dog Boxer Pug Alaskan Malamute Welsh Terrier English Cocker Spaniel German Shepherd Dog Scottish Terrier Collie German Spaniel Large Poodle Golden Retriever Chinese Crested Dog Powder Puff Bedlington Terrier Hovawart 0 0 5 5 5 55 53 51 49 49 4 4 4 4 45 43
34 3 3 40 41 43 44 45 4 4 4 49 50 51 52 53 55 5 5 5 Swedish Lapphund Belgian Shepherd Dog Yorkshire Terrier Samoyed Nova Scotia Duck Tolling Retriever Welsh Springer Spaniel Rhodesian Ridgeback Swiss Hound/Lucerne Flat coated Retriever Irish Setter Drever (Swedish hound) English Setter Irish Soft Coated Wheaten Terrier Japanese Spitz Munsterlander Labrador Retriever Mixed breed Borzoi Lhasa Apso Norfolk Terrier Elkhound Afghan Toy Poodle Saluki Cairn Terrier 3 3 3 3 34 34 34 34
59 0 1 2 3 4 5 9 0 1 2 3 4 5 9 0 1 2 3 Chihuahua (smooth-haired) Papillon Petit Basset Griffon Vendeen Groenendaeler Bichon Frisé Border Terrier Kelpie Basset Artesien Normand Beagle Papillon Drop Ear English Pointer Whippet West Highland White Terrier Schipperke Miniature Pinscher Shetland Sheepdog Dachshund (long-haired) Tibetan Terrier Jack Russel Terrier Chihuahua (long-haired) German Jagde Terrier Briard German Longhaired Pointer Shih Tzu Schiller Hound 31 29 2 2 2
4 5 9 90 91 92 93 94 95 9 9 9 99 0 1 2 3 4 5 Danish/Swedish Farmdog Finnish Hound Dalmatian Coton de Tulear Småland Hound Hamilton Hound Havanese Bearded Collie Shiba Maltese Norwegian Buhund Swedish Vallhund Karelian Bear Dog Pomeranian Gordon Setter Border Collie Icelandic Sheepdog Siberian Husky Tibetan Spaniel Greyhound Basenji Finnish Lapphund Norrbotten Spitz Lancashire Heeler Norwich Terrier 1 1
9 0 East Siberian Laika Finnish Spitz 9