OVITROL X-TEND FLEA & TICK SPOT ON FOR CATS TECHNICAL MONOGRAPH

OVITROL X-TEND FLEA & TICK SPOT ON FOR CATS TECHNICAL MONOGRAPH TM

TM Dear Colleague, Fleas, ticks and other biting parasites continue to be a problem for pets. Clients look to you, their veterinary professional, for products that are not only powerful, but affordable. Veterinary Products Laboratories is continually striving to develop innovative solutions that provide veterinarians new advantages in the battle against fleas, ticks and mosquitoes. We are pleased to add Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs and Ovitrol X-Tend Flea & Tick Spot On for Cats to our complete system of flea and tick control products that deliver highly efficacious formulations that are gentle on the environment with a very low acute mammalian and avian toxicity. Ovitrol X-Tend brand products contain the molecule Etofenprox, for quick and permanent knockdown of fleas, ticks, and mosquitoes that is combined with a proven IGR for extended control of flea eggs and flea larvae. Unlike traditional pyrethroids, Etofenprox is a non-ester (ether) pyrethroid chemical. As such, it is a non-organophosphate, non-carbamate proven to reduce the toxic risks to all pets (particularly cats). It provides the rapid termination of parasites that is demanded, along with the extended control that is desired. Ovitrol Includes Designed to make application precise and neat. See side of package for details. Applicator Patent Pending ACTIVE INGREDIENTS: (S)-Methoprene (CAS # 65733-16-6) 3.6% Etofenprox (CAS # 80844-07-1) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner KEEP OUT OF REACH OF CHILDREN See side/back panels for additional Precautionary Statements Flea & Tick Spot On EPA Reg. No. 2724-813 EPA Est. No. 2724-TX-1 Product code: 100511784 RM# 300514169 13-0006 3 Month Supply NET CONTENTS: 0.183 fl oz total (Three 0.061 fl oz/1.8 cc tubes) For Use Only on Cats and Kittens 5 lbs. & over & 12 weeks of age or older LARGE for Cats STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Deer Ticks Flea Larvae Mosquitoes Flea Eggs Offered exclusively to licensed, practicing veterinarians, Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Dogs and Ovitrol X-Tend Flea & Tick Spot On for Cats provide veterinary professionals with the ideal combination of efficacy for the patient and cost effectiveness for the client. With these new additions, the Vet-Kem Ovitrol X-Tend family of products makes it possible for veterinarians to prescribe a combination of products to solve each pet owner s parasite challenge on the pet, in the home and in the yard. Laura Petree, DVM Director of Technical Services 1-888-241-9545 2

Table of Contents Parasites....................................... 4 Fleas................................................ 4 Ticks................................................. 5 Mosquitoes... 7 Active Ingredients in Ovitrol X-Tend Flea & Tick Spot On for Cats...8 Etofenprox Toxicology Profile...9 Studies........................................ 10 Application...14 Complete System...16 Product Label...18 3

FLEAS, TICKS AND MOSQUITOES Fleas, ticks and mosquitoes are among the most common ecto-parasites of dogs and cats. They are more than just a nuisance; they can be a health risk to both pets and their owners. Understanding their life cycles and habits can help in understanding how to combat them. Fleas Fleas are small wingless insects that are flattened laterally. The flea most commonly found on both dogs and cats in North America is Ctenocephalides felis, the cat flea. 1 The cat flea has a very wide host range and can be found on wild animals including raccoons, opossums, skunks, and foxes as well as our pets. Flea bites are very irritating to pets, but they can also lead to serious medical conditions. Heavy infestations, particularly in young animals, may lead to iron deficiency, anemia or even death. Flea allergy dermatitis, a hypersensitivity reaction to the antigens in flea saliva, is one of the most common causes of skin disease in dogs and cats. In some cases, they may act as vectors of disease. Fleas are also the intermediate host for the tapeworm Dipylidium caninum and the filarial worm Acanthocheilonema reconditum (formerly Dipetalonema reconditum). Fleas are also capable of transmitting several pathogens including Mycoplasma spp, Bartonella spp and Rickettsia spp. Some of these have zoonotic potential. In order to understand the steps needed to completely eliminate a flea infestation, it is important to understand their life cycle. Eliminating adult fleas seen on the dog or cat is one key step in controlling and preventing an infestation of this fast-multiplying parasite. It can also require a complete program that effectively kills the often unseen immature stages that are in the pet s environment. Adult fleas begin feeding immediately when on the host and must feed before mating. Egg production begins within 20 to 24 hours of females taking their first blood meal. A female flea can produce 40 to 50 eggs per day and she may live 4 to 25 days. The eggs fall off wherever the animal is, whether moving around or at rest. The eggs, pearly white ovals, are deposited into the environment. Indoors, eggs hatch into tiny (0.5 mm), light-colored, worm-like larvae which live deep in carpet fibers, cracks and crevices, or in bedding or furniture. 1. Biology, treatment and control of flea and tick infestations. Blagburn BL, Dryden MW. VCNA 39:1173-1200, 2009 Where fleas live 4

Outdoors, the larvae are more likely to be found in shady locations, often where the pet rests. The larvae feed on organic material including flea feces, flea eggshells, other flea larvae, and organic debris. After several larval stages, the larva spins a silken cocoon and pupates. The pupae can be found in the same locations as the larvae. The adult C felis can begin emerging as early as 8 days after initiation of the pupal stage or can remain in the cocoon Pupal Stage for up to a year. Adult emergence is stimulated by vibration, mechanical pressure, increases in carbon dioxide, and increases in temperature. Adults may remain quiescent in the cocoon for up to 50 weeks at cooler temperatures (11 C [51.8 F]) and when there are no appropriate environmental stimuli. Ticks Larval Stage FLEA life cycle Adult Flea Egg Stage Ticks are another important pest of pets and people. The majority of ticks infesting dogs and cats belong to the Ixodidae family, which include the Deer tick (Ixodes scapularis), Brown Dog tick (Rhipicephalus sanguineus), Lone Star tick (Amblyomma americanum), and American Dog tick (Dermacentor variabilis). Ixodid ticks are flattened dorsally and have a highly sclerotized dorsal shield. The dorsal shield in males covers the entire dorsal surface and in females only extends part of the way. The capitulum or head with mouthparts of ixodid ticks can be seen when ticks are examined dorsally. Ticks are identified based on various criteria such as size, body shape, location of the head, appearance of mouth parts, and ornamentation. Female adult ticks have a partial dorsal shield that allows them to expand as they feed. They may grow as much as 100 times their original weight before they detach from the host. Male adult ticks also take blood meals, but because they have a complete dorsal shield they will not increase in size as much as females and still appear flat after feeding. Example of Ixodidae Ticks Ticks have 4 developmental stages: egg, larva, nymph, and adult. Ticks are obligate blood feeders with every life stage except the egg taking blood meals. Most ixodid ticks are 3-host ticks that molt off the host between their blood meals. They may or may not feed on a different host during each stage. The entire life cycle of some ticks may take 3 years to complete. Ticks are not only voracious blood feeders, and an infestation can cause anemia, they are important vectors of disease. They transmit pathogens that cause diseases such as anaplasmosis, ehrlichiosis, cytauxzoonosis, rickettsiosis and Lyme disease. A neurotoxin produced by females of several tick species can cause tick paralysis. 5

Typical life cycle of 3-host tick Nymph Eggs Larva Adult Adult females drop off the host and lay eggs. Eggs hatch within a few weeks to a month. 6 Larvae 6-legged larvae feed on a host for several days and can live in the environment for days (6 to 90) before molting. Nymphs 8-legged nymphs feed on the host for several days and can live in the environment for days (17 to 100) before molting to adults. Adult Adult ticks may live for an extended period of time, before feeding.

Mosquitoes Mosquitoes require water to complete their life cycle. Some mosquitoes lay their eggs on the surface of fresh or stagnant water either singularly or in rafts. These eggs hatch within 24 to 48 hours. Others species of mosquitoes lay eggs which only hatch when flooded with water after a drying period. The legless larvae, commonly called wigglers, live in the water for 4 to 14 days depending on water temperature. The larvae grow larger, primarily feeding on algae, plankton, and fungi and molt 4 times. At the final molt, they become a pupa. The mosquito pupae, commonly called tumblers, also live in the water. The pupa floats at the surface and does not feed during this stage. The pupal stage lasts from 1 to 4 days depending upon species and temperature. The metamorphosis of the mosquito into an adult is completed within the pupal case. Adult male and female mosquitoes feed on nectar, but only female adult mosquitoes require blood meals. Acquiring a blood meal is necessary for egg production. Mosquitoes are vectors for several diseases important to companion animals and humans such as heartworm disease and West Nile Virus. Egg Stage Larval Stage Pupal Stage Adult Mosquito 7

ACTIVE INGREDIENTS ETOFENPROX Vet-Kem X-Tend branded products contain the molecule Etofenprox, for quick and permanent knockdown of fleas, ticks, and mosquitoes, in combination with an IGR to offer extended control of flea eggs and flea larvae. Unlike traditional pyrethrin-based products that have limited killing power and are potentially harmful to dogs and cats (especially cats), the Vet-Kem X-Tend products impart the rapid termination of fleas and ticks that is demanded with the extended control that is desired, all in formulations that are proven to reduce the toxic risks to all pets and the environment. Etofenprox [2-(4-ethoxyphenyl)-2-methylpropyl 3-phonoxybenzyl ether] is a pyrethroid-like insecticide. It is not a traditional pyrethroid. n Black: Carbon, C n White: Hydrogen, H n Red: Oxygen, O The molecule contains carbon, hydrogen, and oxygen and is an ether rather than an ester. All of the other commercially available pyrethroids are esters. The Environmental Protection Agency (EPA) classifies Etofenprox as a non-ester pyrethroid. Mode of action Etofenprox has a similar mode of action to traditional pyrethroids in that it is a sodium channel blocker. It acts on the nervous system of ecto-parasites and disturbs the function of neurons by interfering with the sodium channels. Etofenprox has a broad spectrum of activity including fleas, ticks, and mosquitoes. (S)-Methoprene is an insect growth regulator (IGR) that disrupts the flea life cycle. It acts by mimicking natural juvenile hormone. In the life cycle of insects, decreases in juvenile hormone levels promote the next stage to emerge. Juvenile hormone is present when flea eggs are formed, and a decrease in juvenile hormone causes a flea egg to hatch into a flea larva. Juvenile hormone must be absent for a pupa to molt to an adult. Treatment with (S)-Methoprene breaks the life cycle of the parasite, controlling potential infestations. Ovitrol X-Tend Flea & Tick Spot On for Cats provides flea, Deer tick, and mosquito protection for cats and kittens over 12 weeks of age for up to 30 days. Do not retreat more than once a month. 8

TOXICOLOGY Profile Etofenprox has been tested for safety in dogs, puppies, cats and kittens. In cat and kitten testing at up to 5X, no adverse events were observed. Etofenprox essentially has very low toxicity in mammals by oral, dermal or inhalation routes. The oral toxicity of Etofenprox in avian species is very low. Comparison of Acute Toxicity of Ingestion of Several Compounds Including Etofenprox Fipronil Imidacloprid Pyrethrin Dinotefuran Resmethrin Phenothrin Pyriproxyfen PBO (S)-Methoprene Etofenprox 97 450 1,030 > 2,000 4,240 > 5,000 > 5,000 7,500 Acute Toxicity = LD 50 Measured in mg/kg body weight > 34,000 0 10,000 20,000 30,000 40,000 > 42,880 Etofenprox is classified in the lowest acute toxicity category by the EPA. Larger Value = Least Toxicity. LD 50 s are of active ingredient only. Source: *The Pesticide Manual 13th Edition 2003 Editor: CDS Tomlin; Publisher: British Crop Protection Council 9

10 studies

Efficacy Against Fleas Study Design A trial was conducted to evaluate the efficacy of Ovitrol X-Tend Flea & Tick Spot On for Cats. The cats were either untreated (control group) or treated at the labeled rate. The cats were infested with 100 fleas on the day prior to treatment and again on days 14, 21, and 28. Product efficacy was first evaluated at 48 hours post treatment and then on days 14, 21, and 28. Results Efficacy of Ovitrol X-Tend Flea & Tick Spot On for Cats Against Adult Cat Fleas (Ctenocephalides felis) 100 80 Day 2 Day 14 Day 21 Day 28 Geometric Mean % Reduction 60 40 20 0 Time Post Infestation Wellmark Study 2943 11

Efficacy Against Ticks Study Design This trial was conducted to evaluate the efficacy against Deer ticks. The cats were treated with Ovitrol X-Tend Flea & Tick Spot On for Cats applied according to label directions and rates. In this in vitro test, on study day 4, the ticks were exposed to the treated cat fur and counts for tick mortality were made at 48 hours. At 30 days post-treatment, ticks were again challenged and a 48-hour count was made to evaluate for the number of dead ticks. Results Reduction of Adult Ixodes on Cat Fur with Ovitrol X-Tend Flea & Tick Spot On for Cats 100 Day 6 Day 32 Geometric Mean % Reduction 80 60 40 20 Days post treatment Wellmark Study 2983 12

Efficacy Against Mosquitoes Study Design Repellency and efficacy against Aedes and Culex mosquitoes were evaluated. On study days 1, 11, 18, 25, and 32, the cats were separately exposed to 25 Aedes albopictus and 25 Culex quinquefasciatus mosquitoes. Results Geometric Mean % Reduction in Blood Feeding Rates with Ovitrol X-Tend Flea & Tick Spot On for Cats 100 80 Day 1 Day 11 Day 18 Day 25 Geometric Mean % Reduction 60 40 20 0 Aedes Culex Days post treatment Wellmark Study 2983 13

APPLICATION The formulation of Ovitrol X-Tend Flea & Tick Spot On for Cats offers the advantages of Etofenprox and (S)-Methoprene, but also the innovative design of the X-Tender Applicator. The X-Tender Applicator is ergonomically contoured for easy handling and designed for clean dosing. The action of closing the applicator door automatically opens the tube. The tube is sealed inside, and once tube is opened, the liquid can be placed on the cat. If the applicator is laid down on a table, counter or other flat surface, it will not run out or drip. The tip is used to part the hair and get next to the cat s skin. It is important for the product to be applied directly to the cat s skin for proper translocation and optimal protection against parasites. FOR LARGE Cats To apply this product, use one disposable liquid tube for each application with the applicator device. 1. OPEN: Use finger scoop to lift open yellow door. 2. LOAD: To load, place tube WHITE SIDE UP under the yellow tab. 3. CLOSE: Close the yellow door and the tube will snap open. 14

4. APPLY: The cat/kitten should be standing for easy application. To apply, use tip to part hair and get next to cat s/kitten s skin at the base of the skull. Press square on yellow door and squeeze out the entire contents of the tube onto the cat s/kitten s skin. Do not spread this product by hand over the cat/kitten. Do not bathe the cat/kitten within the first 24 hours after product has been applied. Households with more than one cat/kitten should prevent cats/kittens from grooming each other until solution has dried. 5. DISPOSE: To dispose of empty tube, open yellow door and drop empty tube into trash or offer for recycling, if available. Close applicator device door and store in original package. 6. RETREAT AFTER 30 DAYS: Do not reapply product for 30 days. Do not treat more than once per month. Note: Each package contains tubes for 3 applications. To view application for Large Cats, scan here. To view all application videos, please visit www.ovitrolxtend.com. 15

Includes Designed to make application precise and neat. See side of package for details. Applicator Patent Pending ACTIVE INGREDIENTS: (S)-Methoprene (CAS # 65733-16-6) 3.6% Etofenprox (CAS # 80844-07-1) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner KEEP OUT OF REACH OF CHILDREN See side/back panels for additional Precautionary Statements EPA Reg. No. 2724-813 EPA Est. No. 2724-TX-1 Product code: 100511784 RM# 300514169 13-0006 3 Month Supply NET CONTENTS: 0.183 fl oz total (Three 0.061 fl oz/1.8 cc tubes) STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Deer Ticks Flea Larvae Mosquitoes Flea Eggs total Management system to control FLEAS, TICKS and MOSQUITOES For Use Only on Cats and Kittens 5 lbs. & over & 12 weeks of age or older LARGE Ovitrol Flea & Tick Spot On for Cats A total flea and tick management program should include products for management on pets, as well as in the home and yard. The Vet-Kem X-Tend brand offers a fully-integrated Etofenprox system. The Vet-Kem X-Tend family of products provides veterinarians and pet owners a new advantage in the battle against fleas, ticks and mosquitoes. All products in the Vet-Kem X-Tend family contain the molecule Etofenprox. Classified as a non-ester pyrethroid by the EPA, Etofenprox kills fleas, ticks and mosquitoes, while offering very low toxicity for the pet. Combined with an IGR such as (S)-Methoprene, the Vet-Kem X-Tend products offer extended control of flea eggs and flea larvae. TM Get, em with the system. 16 www.ovitrolxtend.com

Flea & Tick Spot On for Cats PRODUCT LABEL Ovitrol Flea & Tick Spot On SMALL over 2.5 lbs. but under 5 lbs. For Use Only on Cats and Kittens 12 weeks of age or older STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Flea Larvae Flea Eggs ACTIVE INGREDIENTS: (S)-Methoprene (CAS # 65733-16-6) 3.6% Etofenprox (CAS # 80844-07-1) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner Deer Ticks Mosquitoes for Cats CAUTION KEEP OUT OF REACH OF CHILDREN READ ENTIRE LABEL BEFORE USE. USE ONLY ON CATS OR KITTENS 12 WEEKS OF AGE AND OLDER AND OVER 2.5 LBS. AND UNDER 5 LBS. The X-Tender Applicator is specially designed to make applying flea and tick control easier, more precise - and neater - than ever before. You simply insert the appropriate tube for your cat/kitten into the applicator, close it and squeeze to apply. The applicator s ergonomic, contoured shape makes it easy to grip and a built-in tip helps to spread the cat s/kitten s hair to allow the liquid to more readily reach the skin. The tube is sealed inside, so you can be confident that the liquid goes onto your cat/kitten and not your hand. Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Cats provides relief from flea infestations for up to 30 days by killing adult fleas and flea eggs on your cat or kitten. This product is most effective when used as part of a total flea and tick management program. Use other Vet-Kem products registered for residential area control of these pests in conjunction with this treatment. Monthly treatments are required for optimal control and prevention of fleas. The successive feeding activity of fleas on cats may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Treatment of cats with this product rapidly kills fleas and may reduce the incidence of this condition. DIRECTIONS FOR USE: It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Read and follow all directions and precautions on this product label. USE RESTRICTIONS: This product contains 3 monthly dosages, each 0.034 fl oz. Do not apply more than once every month. Do not use more than one tube per cat. Do not get this product in your cat s eyes or mouth. Do not allow your cat to ingest this product. Do not apply to cats weighing less than 2.5 lbs. Vet-Kem Ovitrol X-Tend Flea & Tick Spot On for Cats works by application directly to the cat s/kitten s skin, not to the hair. When applying, use applicator device tip to push aside cat s/kitten s hair to allow direct application to the skin. Do not get this product in cat s/kitten s eyes or mouth. FOR CATS & KITTENS To apply this product, use one disposable liquid tube for each application with the applicator device. Do not use more than one tube per cat. 1. OPEN: Use finger scoop to lift open yellow door. 2. LOAD: To load, place tube WHITE SIDE UP under the yellow tab. 3. CLOSE: Close the yellow door and the tube will snap open. 4. APPLY: The cat/kitten should be standing for easy application. To apply, use tip to part hair and get next to cat s/kitten s skin at the base of the skull. Press square on yellow door and squeeze out the entire contents of the tube onto the cat s/kitten s skin. 1 Do not spread this product by hand over the cat/kitten. Do not bathe the cat/kitten within the first 24 hours after product has been applied. Households with more than one cat/kitten should prevent cats/kittens from grooming each other until solution has dried. 5. DISPOSE: To dispose of empty tube, open yellow door and drop empty tube into trash or offer for recycling, if available. Close applicator device door and store in original package. 6. RETREAT AFTER 30 DAYS: Do not reapply product for 30 days. Do not treat more than once per month. NOTE: Each package contains sufficient tubes for 3 applications. In case of emergency or for product information, call 1-800-766-7661 or contact your veterinarian if your cat/kitten is experiencing an adverse event. STORAGE AND DISPOSAL: Storage: Store in a cool, dry area away from children and animals. Do not store unused tubes separately from their packaging. Liquid Tube Disposal: If empty: Do not reuse empty tube. Place in trash or offer for recycling, if available. If partly filled: Call your local solid waste agency for disposal instructions. Never place unused product down any indoor or outdoor drain. PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS HAZARDS TO HUMANS: Repeated exposure to etofenprox can cause skin irritation. HAZARDS TO DOMESTIC ANIMALS: For External Use on Cats Only. Do not use on kittens weighing less than 2.5 pounds. Do not use on kittens less than 12 weeks old. Consult a veterinarian before using this product on debilitated, aged, pregnant or nursing animals. Certain medications can interact with pesticides. Consult a veterinarian before using on medicated animals. Sensitivities may occur after using ANY pesticide product for pets. If signs of sensitivity occur, bathe your pet with mild soap and rinse with large amounts of water. If signs continue, consult a veterinarian immediately. Side Effects: Monitor your cat after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects occur, consult your veterinarian or Vet-Kem at 1-800-766-7661. WARRANTY AND CONDITIONS OF SALE: Seller warrants that this product conforms to the chemical specifications expressed on the label. To the extent consistent with applicable law, Seller makes no other warranties, and disclaims all other warranties, express or implied, including but not limited to warranties of merchantability and fitness for the intended purpose. To the extent consistent with applicable law, Seller s liability for default, breach, or failure under this label shall be limited to the amount of the purchase price. To the extent consistent with applicable law, Seller shall have no liability for consequential damages. EPA Reg. No. 2724-813 EPA Est. No. 2724-TX-1 Product code: 100511786 RM# 300514136 13-0007 Wellmark International 1501 East Woodfield Road 200W Schaumburg, Illinois 60173 2012, 2013 Veterinary Products Laboratories Product Code: 100511786 Ovitrol, Spot On, Vet-Kem and the Vet-Kem design are registered trademarks of Wellmark International. All other trademarks are the property of their respective owners. Flea & Tick Spot On for Cats Label from Small Cat. 18

The powerful and affordable solution For the veterinarian and the pet owner, the Vet-Kem X-Tend system of products provides a complete portfolio of flea and tick control products that deliver highly efficacious formulations that are gentle on the environment with a very low acute mammalian and avian toxicity. Ovitrol Includes Designed to make application precise and neat. See side of package for details. Applicator Patent Pending For Use Only on Cats and Kittens & 12 weeks of age or older LARGE 5 lbs. & over Flea & Tick Spot On for Cats STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Deer Ticks Flea Larvae Mosquitoes Flea Eggs OVITROL X-TEND FLEA & TICK SPOT ON FOR CATS ACTIVE INGREDIENTS: (S)-Methoprene (CAS # 65733-16-6) 3.6% Etofenprox (CAS # 80844-07-1) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner KEEP OUT OF REACH OF CHILDREN See side/back panels for additional Precautionary Statements EPA Reg. No. 2724-813 EPA Est. No. 2724-TX-1 Product code: 100511784 RM# 300514169 13-0006 Provides the veterinarian an affordable brand only offered to licensed, practicing veterinarians. 3 Month Supply NET CONTENTS: 0.183 fl oz total (Three 0.061 fl oz/1.8 cc tubes) Providing a proven solution that works for pets AND clients, Ovitrol X-Tend Flea & Tick Spot On for Cats is a monthly topical flea, Deer tick and mosquito ecto-parasiticide containing Etofenprox and (S)-Methoprene. Starts killing fleas within 15 minutes. Kills fleas, Deer ticks, flea eggs and flea larvae. Also kills mosquitoes. Powerful combination. Kills adult fleas AND flea eggs AND flea larvae with Etofenprox adulticide and (S)-Methoprene IGR. Long-lasting. Extended protection for up to one month. Same price, any size 3-pack. Etofenprox is classified by the EPA as a non-ester pyrethroid with very low acute toxicity for mammals and birds. Environmentally friendly. Low toxicity profile. Ideal for homes with both dogs and cats. Available in 2 sizes for cats: For cats over 2.5 pounds, but under 5 pounds and cats 5 pounds and over. X-Tender Applicator included with every 3-pack. 19

The powerful and affordable solution for veterinary management of fleas and ticks. For Use Only on Cats and Kittens 5 lbs. & over & 12 weeks of age or older LARGE Ovitrol Flea & Tick Spot On for Cats Includes Designed to make application precise and neat. See side of package for details. Applicator Patent Pending STARTS KILLING FLEAS WITHIN 15 MINUTES KILLS Fleas Deer Ticks Flea Larvae Mosquitoes Flea Eggs ACTIVE INGREDIENTS: (S)-Methoprene (CAS # 65733-16-6) 3.6% Etofenprox (CAS # 80844-07-1) 40.0% OTHER INGREDIENTS: 56.4% Total 100.0% Contains a Coat Conditioner KEEP OUT OF REACH OF CHILDREN See side/back panels for additional Precautionary Statements EPA Reg. No. 2724-813 EPA Est. No. 2724-TX-1 Product code: 100511784 RM# 300514169 13-0006 3 Month Supply NET CONTENTS: 0.183 fl oz total (Three 0.061 fl oz/1.8 cc tubes) Get, em with the system. www.ovitrolxtend.com For technical service support, please call 1-888-241-9545 2013 Veterinary Products Laboratories Ovitrol, Spot On, Vet-Kem and Vet-Kem with design are registered trademarks of Wellmark International. All other trademarks are the property of their respective owners. 12-0956 #300514050