Antibiotics & treatment of Acute Bcterial Sinusitis Walid Reda Product Manager Do your antimicrobial options meet your needs?
Antimicrobial Effects: What s involved? Effect in Humans: Serum concentration profile Penetration to site of infection Pharmacokinetics Effect in Bacteria: Potency (MICs) Mechanism of killing Pharmacodynamics Clinical Effectiveness Evaluating antibiotic options in the treatment of Bacterial sinusitis Spectrum of bacterial coverage Resolution of signs and symptoms High penetration at the site of infection (Higher concentration than the MIC s) Low potential for Bacterial resistance development Fast relief Tolerable An antibiotic that can help both acute and chronic sinusitis patients
Acute Bacterial Sinusitis One of the most common conditions treated in outpatient setting The 5 th most common diagnosis for which an antibiotic was prescribed Etiology rarely established therefore initial management is empiric Sinus and Allergy Health Partnership. Otolaryngol Head Neck Surg. 2004;130:1 44. Goals of Therapy Eradicate bacterial infection Re-establish patency of osteomeatal complex Reduce inflammation Restore drainage of affected sinuses Minimize risk of complications Sinus and Allergy Health Partnership. Otolaryngol Head Neck Surg. 2004;130:1 44.
Current challenges Recent national and international surveillance studies have shown Increase in isolation frequency of B-lactamase producing strains 30% of H. influenzae 90% of M. Catarrhalis Journal of international medical research 2003, 3:434-447 Current challenges Decreased susceptibility of pneumococcal strains to penicillin s 40% ( Intermediate susceptibility or resistant strains) Journal of international medical research 2003, 3:434-447
Mechanism of Action of Moxifloxacin Topoisomerase IV (parc, pare) Fluoroquinolone Moxifloxacin bind the 2 enzymes DNA gyrase (gyra( gyra, gyrb)
Moxifloxacin: Metabolism and Elimination Metabolites Sulfo-compound (M-1) Acyl-glucuronide (M-2) inactive LIVER Elimination Hepatic ~ 60% Renal ~ 40% Parent + M-1, M-2 Enterohepatic cycling: Parent + M-2 BILE STOMACH Fecal excretion: M-1 (35% of dose) BLOOD KIDNEY Fecal excretion: unchanged 26% of dose Urine: M-1 (2.5% of dose) M-2 (14% of dose) Urinary excretion: ~ 20% of dose unchanged Effective against most causative organisms
Avalox MIC 90 s Against Common Respiratory Pathogens Organism S. pneumoniae (PenS) Moxifloxacin 0.06-0.25 S. pneumoniae (PenR) 0.12-0.25 H. influenzae BL ( ) 0.03-0.06 H. influenzae BL (+) 0.03-0.06 M. catarrhalis BL ( ) 0.012-0.06 M. catarrhalis BL (+) 0.012-0.06 BL = -lactamase; MIC = minimum inhibitory concentration (mg/l). Blondeau JM. J Antimicrob Chemother. 1999;43(suppl B):1-11. Moxifloxacin: Excellent Activity Against Atypicals Pathogen Atypical micro-organisms C.pneumoniae M.pneumoniae L.pneumophila MIC 90 (µg/ml) 0.2 0.12.015 Blondeau JM. J Antimicrob Chemother. 1999;43 (suppl B):1 11. Wise R. Clin Drug Invest 1999;17:365 387. Ackermann A. Eur J Clin Microbiol Infect Dis. 2000;19:228-232.
Moxifloxacin: Excellent Activity Against Respiratory Pathogens, Including Less Common Pathogens Saureus Anaerobes Pathogen MIC 90 (µg/ml) 0.12 Bacteroides fragilis Peptostreptococcus spp Prevotella spp 2 <0.25 2 Blondeau JM. J Antimicrob Chemother. 1999;43 (suppl B):1 11. Wise R. Clin Drug Invest 1999;17:365 387. Ackermann A. Eur J Clin Microbiol Infect Dis. 2000;19:228-232. Avalox - Superior Antimicrobials activity MIC 90 (mg/l) range Avalox Amoxycillinclavulanate Clarithromycin Levofloxacin S. pneumoniae 0.12 0.015 0.06 1.0 H. influenzae 0.06 0.5 16 0.03 M. catarrhalis 0.06 0.015 0.12 0.06 M. pneumoniae 0.12 >32 0.031 0.5 C. pneumoniae 0.12 >32 0.007 0.5 L. pneumophila 0.015 >32 0.5 0.015 Bayer, data on file
Fluoroquinolone MIC 90 s Against Common Respiratory Pathogens Organism Moxifloxacin Gatifloxacin Levofloxacin S. pneumoniae (PenS) 0.06-0.25 0.5 1-2 S. pneumoniae (PenR) 0.12-0.25 0.5 1-2 H. influenzae BL ( ) 0.03-0.06 <0.03 0.03-0.32 H. influenzae BL (+) 0.03-0.06 <0.03 0.03-0.47 M. catarrhalis BL ( ) 0.012-0.06 <0.03 0.06 M. catarrhalis BL (+) 0.012-0.06 <0.03 0.06-0.094 BL = -lactamase; MIC = minimum inhibitory concentration (mg/l). Blondeau JM. J Antimicrob Chemother. 1999;43(suppl B):1-11. Avalox - Antimicrobials vs. Resistant Pathogens MIC 90 (mg/l) range Avalox Amoxycillinclavulanate Cefuroxime axetil Clarithromycin S. pneumoniae Pen-S 0.12 0.015 0.03 0.06 S. pneumoniae Pen-R 0.12 1 4 >64 S. pneumoniae Erythrom-R 0.12 1 4 >64 H. influenzae Beta lactam - ve 0.06 0.5 1 16 H. influenzae Beta lactam +ve 0.06 2 2 16 Bayer, data on file
Avalox Rapidly Penetrates Hard-to-Reach Respiratory Tract Tissues and Fluids 8 Mean Serum and Tissue Concentrations (3 hours post dosing, 400 mg) Mean Concentration (g/ml or g/g) 7 6 5 4 3 2 1 0 3.3 (serum) 5.5 (tissue/ fluid) Bronchial Mucosa 3.7 (serum) 7.6 (tissue/ fluid) Maxillary Sinus Mucosa Organism (MIC 90 ) S pneumoniae (0.25 g/m) M pneumoniae (0.12 g/m) M catarrhalis (0.06 g/m) H influenzae (0.06 g/m) Moxifloxacin provides Adequate plasma concentration that fights against dislodged micro-organisms Plasma Concentration (g/ml) at steady state 5 4 3 2 1 0 High C max Zone of Confidence Plasma levels remain above MICs needed to kill respiratory pathogens over 24 hours 0 4 8 12 16 20 24 Time (h) Organism MIC 1 90 S pneumoniae (0.25 g/ml) M catarrhalis (0.06 g/ml) H influenzae (0.06 g/ml)
Fast Resolution Of Symptoms Moxifloxacin Achieves Rapid Killing of S pneumoniae in Vitro Rapidly bactericidal: 99.9% kill within 2 h Increased potency and more favorable PK vs levofloxacin enhanced PD activity 10 Control Log 10 CFU/mL 99.9% Levofloxacin 1 0 Moxifloxacin 2 4 8 12 16 20 24 Time (hours) Lister PD, Sanders CC. J Antimicrob Chemother. 2001;47:811 818.
Moxifloxacin: Rapid Killing of Drug-Resistant S pneumoniae in an in Vitro Pharmacodynamic Model Two-compartment PD model; simulated po 400-mg od moxifloxacin Rapidly bactericidal: 99.99% kill of all strains within 6 h regardless of resistance phenotype 7 S pneumoniae strain Log CFU/mL Zinner S et al. ICAAC 1998. Poster A-26. 6 5 4 3 2 1 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Time (hours) 6691 (PEN-R, ERY-S) 2309A (PEN-R, ERY-S) 3190 (PEN-R, ERY-R) 5056A (PEN-R, ERY-S) 5182 (PEN-S, ERY-S) 8737 (PEN-R, ERY-R) Antimicrobial activity against H. influenzae in vitro at 44 MIC 10 Beta-Lactamase Positive Log 10 (CFU/mL) 9 8 7 6 5 4 3 2 1 Moxifloxacin Azithromycin Clarithromycin Levofloxacin Telithromycin Control 0 0 2 4 6 Hours Herrington et al. Submitted to ECCMID 2004.
Moxifloxacin in the treatment of acute maxillary sinusitis after first-line treatment failure and acute sinusitis with high risk of complications Authors: P. GEHANNO, P. BERCHE, A. PERRIN- Otorhinolaryngology unit, Bichat Claude-Bernard Hospital, Paris, France; Microbiology Laboratory, Necker-Enfants Malades Hospital, Paris, France Published in The Journal of International Medical Research: September 26, 2003, volume 31 Introduction Multicentre, Prospective and non-comparative clinical study The study was conducted in France by community-based ear, nose and throat specialists: 52 investigators 258 patients with radiologically confirmed acute sinusitis were enrolled 216 patients (83.7%) Qualified for per protocol efficacy analysis (Group 1, no. 175 ; Group 2, no. 41), and 92 for bacteriological analysis Samples were collected from the middle meatus
Study population Patients with maxillary sinusitis after first-line treatment therapy failure ( n = 175). Patients with high risk of complications defined as frontal or sphenoidal and pansinusitis (n = 41). Patients 255 eligible patients. Above 18 years of age. Purulent rhinorrhoea confirmed by nasal endoscopy. Symptoms included nasal congestion and at least one of the following: Spontaneous/induced infra-orbital pain. Frontal cephalalgia. Cough or frequent throat-clearing. Temperature > 38.0 C Radiological and/or tomodensitometric tests were conducted within 48 h prior to treatment initiation and were evaluated by the study co-ordinator (centralized review). First-line therapy failure was defined as persistence of symptoms after administration of a systemic antimicrobial (not a fluoroquinolone) course of therapy for at least 3 days.
Treatment All patients were treated with 400 mg/day of moxifloxacin orally for 7 days. Profile of the antibiotics administered to patients in the per protocol population to treat the current episode of sinusitis before entry into this study: 1st 1st Generation Cephalosporins 2.1% Cefatrizine Cefadroxil Cefaclor 2nd 2nd Generation Cephalosporins 7.5% Macrolides 14.4% 3rd 3rd Generation Cephalosporins 14.4% Penicillins 48.1% Cefuroxime axetil Pristinamycin Spiramycin Josamycin Roxithromycin Clarithromycin Cefixime Cefpodoxime proxetil Cefotiam hexetil Oxacillin Bacampicillin Amoxicillin Amoxicillin Clavulanate 0 5 10 15 20 25 30 Antibiotics administered (%)
Bacteriological Isolates Main bacterial species isolated from sinus secretions from 92 of the 216 patients in the per protocol population at inclusion. 11.8% 9.8% 4.9% S. Pneumoniae H. influenzae 29.4% Enterobacteriaceae 17.6% M. catarrhalis S. aureus Other Gram-ve Bacilli 26.5% Efficacy Evaluation V2: Day 3 or 4 V3: Day 7 or 10 Phone contact: 4-5 weeks Clinical response Clinical Success Follow-Up Bacteriological response Complete resolution of all clinical signs and symptoms Bacteriological eradication
Clinical Efficacy At Day 7-10 Avalox offers the high clinical response rate Patients with risk of complications group 82.9% First-Line treatment failure group 94.9% 0 20 40 60 80 100 P = 0.02 Clinical Efficacy At 4-5 weeks Post-treatment 99% 0 20 40 60 80 100 P = 0.01 Avalox insures Maintained clinical efficacy & Continued resolution at 4-5 weeks Posttreatment
Bacteriological Analysis At Day 3 95.7% At Day 7-10 20 40 60 80 100 First-Line treatment failure group Patients with risk of complications group 97.2% 95.2% 20 40 60 80 100 20 40 60 80 100 Tolerability Drug related adverse events, including Adverse event % Abdominal pain Nausea Diarrhoea Dizziness Arthralgia 2.4% 2.4% 1.2% 0.8% 0.8%
Conclusion Overall, Moxifloxacin therapy resulted in rapid bacteriological eradication, with a high rate of clinical success. Avalox demonstrated superiority to other commonly used antimicrobial, Although this was not a comparative study Among the group of patients with first-line treatment failure, approximately 25% had failed Amoxicillin-Clavulanate therapy 24% had failed Cephalosporin therapy 14% had failed Macrolide therapy The mean duration of prior antimicrobial therapy was 7.2 days Conclusion To conclude, The results of this study demonstrate that oral administration of 400 mg/day moxifloxacin for 7 days is an effective & well tolerated treatment for acute maxillary sinusitis after first-line treatment failure, and acute sinusitis with high risk of complications.
The Potent & Fast Choice for Acute Bacterial Sinusitis Avalox: The Potent & Fast Choice for ABS Potent Therapy in ABS Fast Recovery in Record Time Excellent Safety Profile Avalox 400 mg Once Daily for 7 days
Guidelines for Treatment US Sinus Allergy Health Partnership 2004 patients with: mild Patient with mild + no antibiotics for past 4 to 6 weeks + antibiotics for past 4 to 6 weeks Moderate infection: Sinus and Allergy Health Partnership. Otolaryngol Head Neck Surg. 2004;130:1 44. Guidelines for Treatment US Sinus Allergy Health Partnership 2004 For patients with mild symptoms, with no antibiotics for past 4 to 6 weeks: Amoxicillin/clavulanate Amoxicillin Cefuroxime axetil Cefpodoxime proxetil Cefdinir If mild symptoms and antibiotics in past 4 to 6 weeks or moderate disease: Moxifloxacin, gatifloxacin, levofloxacin Amoxicillin (high dose) /clavulanate Ceftriaxone Combination therapy: high dose amoxicillin or clindamycin, plus cefixime or rifampin Macrolides for H.influenzae: Most of the available eradication and efficacy studies suggest an activity that is similar to or marginally higher than that of placebo Sinus and Allergy Health Partnership. Otolaryngol Head Neck Surg. 2004;130:1 44.
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